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HUMAN:SOSB1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NABP2 (synonyms: OBFC2B, SSB1)
Protein Name(s) SOSS complex subunit B1

Nucleic acid-binding protein 2 Oligonucleotide/oligosaccharide-binding fold-containing protein 2B Sensor of single-strand DNA complex subunit B1 Sensor of ssDNA subunit B1 SOSS-B1 Single-stranded DNA-binding protein 1 hSSB1

External Links
UniProt Q9BQ15
EMBL AY203942
CH471054
AC073896
BC001079
BC006171
CCDS CCDS8911.1
RefSeq NP_076973.1
XP_005269205.1
XP_005269206.1
UniGene Hs.240170
PDB 4OWT
4OWW
4OWX
5D8E
5D8F
PDBsum 4OWT
4OWW
4OWX
5D8E
5D8F
DisProt DP00864
ProteinModelPortal Q9BQ15
SMR Q9BQ15
BioGrid 122500
IntAct Q9BQ15
STRING 9606.ENSP00000267023
iPTMnet Q9BQ15
PhosphoSitePlus Q9BQ15
BioMuta NABP2
DMDM 74761196
EPD Q9BQ15
MaxQB Q9BQ15
PaxDb Q9BQ15
PeptideAtlas Q9BQ15
PRIDE Q9BQ15
DNASU 79035
Ensembl ENST00000267023
ENST00000341463
ENST00000380198
GeneID 79035
KEGG hsa:79035
UCSC uc001ski.4
CTD 79035
DisGeNET 79035
GeneCards NABP2
HGNC HGNC:28412
HPA HPA044615
HPA057213
MIM 612104
neXtProt NX_Q9BQ15
OpenTargets ENSG00000139579
PharmGKB PA143485567
eggNOG KOG3416
ENOG4111MBP
GeneTree ENSGT00390000001913
HOGENOM HOG000006622
InParanoid Q9BQ15
OMA NPEYNTQ
OrthoDB EOG091G0YHH
PhylomeDB Q9BQ15
TreeFam TF313902
Reactome [www.reactome.org/content/detail/R-HSA-6807505 R-HSA-6807505]
GenomeRNAi 79035
PRO PR:Q9BQ15
Proteomes UP000005640
Bgee ENSG00000139579
CleanEx HS_OBFC2B
ExpressionAtlas Q9BQ15
Genevisible Q9BQ15
GO GO:0005829
GO:0000784
GO:0005654
GO:0005634
GO:0070876
GO:0019899
GO:0098505
GO:0003697
GO:0006974
GO:0006281
GO:0000724
GO:0070200
GO:0007093
GO:1904355
GO:0010212
GO:0042795
InterPro IPR012340
IPR004365
Pfam PF01336
SUPFAM SSF50249

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

NOT|involved_in

GO:0051972

regulation of telomerase activity

PMID:25589350[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070182

DNA polymerase binding

PMID:25589350[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O14746

F

Seeded From UniProt

complete

enables

GO:0098505

G-rich strand telomeric DNA binding

PMID:25589350[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8R2Y9

P

happens_during:(GO:0000084)

Seeded From UniProt

complete

involved_in

GO:0070200

establishment of protein localization to telomere

PMID:25589350[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

transports_or_maintains_localization_of:(UniProtKB:O14746)

Seeded From UniProt

complete

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:25589350[1]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000084)

Seeded From UniProt

complete

involved_in

GO:1904355

positive regulation of telomere capping

PMID:25589350[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|enables

GO:0061730

C-rich strand telomeric DNA binding

PMID:25589350[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0071168

protein localization to chromatin

PMID:26261212[2]

ECO:0000314

P

In figure 1, hSSB1 localizes to chromatin following oxidative stress.

complete
CACAO 12559

part_of

GO:0070876

SOSS complex

PMID:18449195[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070876

SOSS complex

PMID:19683501[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010212

response to ionizing radiation

PMID:19683501[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010212

response to ionizing radiation

PMID:19605351[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007093

mitotic cell cycle checkpoint

PMID:19683501[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:19683501[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:18449195[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:19683501[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:18449195[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18449195[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19683501[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:19683501[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:18449195[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000724

double-strand break repair via homologous recombination

PMID:19605351[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070876

SOSS complex

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000331761
UniProtKB:Q96AH0
UniProtKB:Q9BQ15

C

Seeded From UniProt

complete

involved_in

GO:0010212

response to ionizing radiation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000331760
UniProtKB:Q96AH0
UniProtKB:Q9BQ15

P

Seeded From UniProt

complete

involved_in

GO:0007093

mitotic cell cycle checkpoint

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000331760
UniProtKB:Q96AH0
UniProtKB:Q9BQ15

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1923258
PANTHER:PTN000331760
UniProtKB:Q9BQ15

F

Seeded From UniProt

complete

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1917167
MGI:MGI:1923258
PANTHER:PTN000331761
UniProtKB:Q9BQ15

C

Seeded From UniProt

complete

involved_in

GO:0000724

double-strand break repair via homologous recombination

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000331760
UniProtKB:Q96AH0
UniProtKB:Q9BQ15

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1904355

positive regulation of telomere capping

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2Y9
ensembl:ENSMUSP00000128634

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2Y9
ensembl:ENSMUSP00000128634

P

Seeded From UniProt

complete

part_of

GO:0000784

nuclear chromosome, telomeric region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2Y9
ensembl:ENSMUSP00000128634

C

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004365

F

Seeded From UniProt

complete

involved_in

GO:0042795

snRNA transcription by RNA polymerase II

Reactome:R-HSA-6807505

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6814885
Reactome:R-HSA-6814559
Reactome:R-HSA-6814555
Reactome:R-HSA-6814549

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Pandita, RK et al. (2015) Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Res. 75 858-69 PubMed GONUTS page
  2. ↑ Paquet, N et al. (2015) hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway. Nucleic Acids Res. 43 8817-29 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Richard, DJ et al. (2008) Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature 453 677-81 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Huang, J et al. (2009) SOSS complexes participate in the maintenance of genomic stability. Mol. Cell 35 384-93 PubMed GONUTS page
  5. ↑ 5.0 5.1 Li, Y et al. (2009) HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. J. Biol. Chem. 284 23525-31 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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