HUMAN:SNP23

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SNAP23
Protein Name(s)	Synaptosomal-associated protein 23 SNAP-23 Vesicle-membrane fusion protein SNAP-23
External Links
UniProt	O00161
EMBL	U55936 Y09567 Y09568 AJ011915 AJ278972 AJ278973 AJ278974 BT006916 CR457212 BC000148 BC003686 BC022890
CCDS	CCDS10087.1 CCDS10088.1
PIR	JC5296 JC5297
RefSeq	NP_003816.2 NP_570710.1 XP_011520432.1
UniGene	Hs.511149
PDB	1NHL 3ZUS
PDBsum	1NHL 3ZUS
ProteinModelPortal	O00161
SMR	O00161
BioGrid	114303
IntAct	O00161
MINT	MINT-4999382
STRING	9606.ENSP00000249647
TCDB	1.F.1.1.1
iPTMnet	O00161
PhosphoSite	O00161
SwissPalm	O00161
BioMuta	SNAP23
OGP	O00161
EPD	O00161
MaxQB	O00161
PaxDb	O00161
PRIDE	O00161
DNASU	8773
Ensembl	ENST00000249647 ENST00000349777 ENST00000397138
GeneID	8773
KEGG	hsa:8773
UCSC	uc001zpz.3
CTD	8773
GeneCards	SNAP23
HGNC	HGNC:11131
HPA	CAB037083 CAB037317 HPA001214
MIM	602534
neXtProt	NX_O00161
PharmGKB	PA35979
eggNOG	KOG3065 ENOG410Y3Y0
GeneTree	ENSGT00390000012186
HOGENOM	HOG000231599
HOVERGEN	HBG056971
InParanoid	O00161
KO	K08508
OMA	CPCNRFS
PhylomeDB	O00161
TreeFam	TF315125
Reactome	R-HSA-1445148 R-HSA-421837
ChiTaRS	SNAP23
EvolutionaryTrace	O00161
GeneWiki	SNAP23
GenomeRNAi	8773
NextBio	32894
PMAP-CutDB	O00161
PRO	PR:O00161
Proteomes	UP000005640
Bgee	O00161
CleanEx	HS_SNAP23
ExpressionAtlas	O00161
Genevisible	O00161
GO	GO:0042582 GO:0005737 GO:0070062 GO:0005925 GO:0042629 GO:0043005 GO:0005654 GO:0005886 GO:0098793 GO:0031201 GO:0042581 GO:0005484 GO:0019905 GO:0002553 GO:0061025 GO:0061024 GO:0006892 GO:0015031 GO:0031629 GO:0016082 GO:0006903
InterPro	IPR000928 IPR000727
Pfam	PF00835
SMART	SM00397
PROSITE	PS50192

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005886	plasma membrane	PMID:26733245^[1]	ECO:0000314			C		Figure 3	complete CACAO 11790
	GO:0005739	mitochondrion	PMID:26733245^[1]	ECO:0000314			C		Figure 3	complete CACAO 11793
part_of	GO:0005913	cell-cell adherens junction	PMID:25468996^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	PMID:16677249^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12846	F		Seeded From UniProt	complete
involved_in	GO:0002553	histamine secretion by mast cell	PMID:18253931^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031201	SNARE complex	PMID:18253931^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000097)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18253931^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000097)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18457912^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001132)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18457912^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001132)	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
part_of	GO:0042582	azurophil granule	PMID:18588921^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042581	specific granule	PMID:18588921^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011288 PANTHER:PTN000447754	P		Seeded From UniProt	complete
part_of	GO:0031201	SNARE complex	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011288 FB:FBgn0034913 MGI:MGI:109356 PANTHER:PTN000447753 RGD:3728 RGD:620221 SGD:S000003241 SGD:S000004619 UniProtKB:O00161 UniProtKB:O95721 UniProtKB:P60880	C		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000447753 RGD:620221 UniProtKB:O00161	F		Seeded From UniProt	complete
involved_in	GO:0016082	synaptic vesicle priming	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011288 PANTHER:PTN000447754	P		Seeded From UniProt	complete
involved_in	GO:0006906	vesicle fusion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011288 PANTHER:PTN000447753 SGD:S000003241	P		Seeded From UniProt	complete
involved_in	GO:0006887	exocytosis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109356 PANTHER:PTN000447753 SGD:S000003241	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109356 PANTHER:PTN000447752 RGD:3728 RGD:620221 SGD:S000004619 TAIR:locus:2159426 UniProtKB:O00161 UniProtKB:Q17QQ3 WB:WBGene00004364 WB:WBGene00006454	C		Seeded From UniProt	complete
enables	GO:0005484	SNAP receptor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011288 FB:FBgn0034913 PANTHER:PTN000447753 RGD:620221 SGD:S000003241	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042629	mast cell granule	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0002553	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016082	C		Seeded From UniProt	complete
involved_in	GO:0061025	membrane fusion	PMID:10839363^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006903	vesicle targeting	PMID:8663154^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006892	post-Golgi vesicle-mediated transport	PMID:9727496^[13] Reactome:R-HSA-199992	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:9727496^[13] Reactome:R-HSA-6799350 Reactome:R-HSA-6798747 Reactome:R-HSA-376369 Reactome:R-HSA-376364 Reactome:R-HSA-376357	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070821	tertiary granule membrane	Reactome:R-HSA-6798747	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035579	specific granule membrane	Reactome:R-HSA-6799350	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030670	phagocytic vesicle membrane	Reactome:R-HSA-8863973 Reactome:R-HSA-8863895	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Reactome:R-HSA-1236974	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0771 UniProtKB-SubCell:SL-0261	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Strauss, JA et al. (2016) Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria. Physiol Rep 4 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ Logan, MR et al. (2006) A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils. Allergy 61 777-84 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Sander, LE et al. (2008) Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur. J. Immunol. 38 855-63 PubMed GONUTS page
↑ ^5.0 ^5.1 Lu, M et al. (2008) Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissue. Mol. Cell. Endocrinol. 287 72-80 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^9.0 ^9.1 Brochetta, C et al. (2008) Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. Biochim. Biophys. Acta 1783 1781-91 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Scales, SJ et al. (2000) SNAREs contribute to the specificity of membrane fusion. Neuron 26 457-64 PubMed GONUTS page
↑ Ravichandran, V et al. (1996) Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. J. Biol. Chem. 271 13300-3 PubMed GONUTS page
↑ ^13.0 ^13.1 Guo, Z et al. (1998) Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells. Cell 94 537-48 PubMed GONUTS page

[PMID:26733245-1] 1.0 ^1.1 Strauss, JA et al. (2016) Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria. Physiol Rep 4 PubMed GONUTS page

[PMID:25468996-2] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:16677249-3] Logan, MR et al. (2006) A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils. Allergy 61 777-84 PubMed GONUTS page

[PMID:18253931-4] 4.0 ^4.1 ^4.2 Sander, LE et al. (2008) Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur. J. Immunol. 38 855-63 PubMed GONUTS page

[PMID:18457912-5] 5.0 ^5.1 Lu, M et al. (2008) Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissue. Mol. Cell. Endocrinol. 287 72-80 PubMed GONUTS page

[PMID:21423176-6] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:19056867-7] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-8] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:18588921-9] 9.0 ^9.1 Brochetta, C et al. (2008) Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. Biochim. Biophys. Acta 1783 1781-91 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10839363-11] Scales, SJ et al. (2000) SNAREs contribute to the specificity of membrane fusion. Neuron 26 457-64 PubMed GONUTS page

[PMID:8663154-12] Ravichandran, V et al. (1996) Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. J. Biol. Chem. 271 13300-3 PubMed GONUTS page

[PMID:9727496-13] 13.0 ^13.1 Guo, Z et al. (1998) Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells. Cell 94 537-48 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

HUMAN:SNP23

Contents

Annotations

Notes

References

a

c

e

f

h

m

n

p

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools