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HUMAN:SF3B1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SF3B1 (synonyms: SAP155)
Protein Name(s) Splicing factor 3B subunit 1

Pre-mRNA-splicing factor SF3b 155 kDa subunit SF3b155 Spliceosome-associated protein 155 SAP 155

External Links
UniProt O75533
EMBL AF054284
AF086296
AC010746
AF070540
CCDS CCDS33356.1
CCDS46479.1
RefSeq NP_036565.2
UniGene Hs.632554
PDB 2F9D
2F9J
2FHO
2PEH
3LQV
4OZ1
PDBsum 2F9D
2F9J
2FHO
2PEH
3LQV
4OZ1
ProteinModelPortal O75533
SMR O75533
BioGrid 117017
DIP DIP-29411N
IntAct O75533
MINT MINT-1185911
STRING 9606.ENSP00000335321
PhosphoSite O75533
MaxQB O75533
PaxDb O75533
PRIDE O75533
Ensembl ENST00000335508
ENST00000409915
ENST00000414963
GeneID 23451
KEGG hsa:23451
UCSC uc002uue.3
uc002uuf.3
CTD 23451
GeneCards GC02M198256
HGNC HGNC:10768
HPA HPA050275
HPA054596
MIM 605590
neXtProt NX_O75533
PharmGKB PA35686
eggNOG COG5181
GeneTree ENSGT00390000018393
HOGENOM HOG000166737
HOVERGEN HBG079173
InParanoid O75533
KO K12828
OMA AFWVRRM
OrthoDB EOG7R2BHR
PhylomeDB O75533
TreeFam TF105680
Reactome REACT_1753
REACT_467
ChiTaRS SF3B1
EvolutionaryTrace O75533
GeneWiki SF3B1
GenomeRNAi 23451
NextBio 45735
PMAP-CutDB O75533
PRO PR:O75533
Proteomes UP000005640
Bgee O75533
CleanEx HS_SF3B1
ExpressionAtlas O75533
Genevestigator O75533
GO GO:0071013
GO:0043231
GO:0016607
GO:0005654
GO:0005634
GO:0005681
GO:0005689
GO:0003682
GO:0044822
GO:0009952
GO:0010467
GO:0000398
GO:0008380
GO:0000375
Gene3D 1.25.10.10
InterPro IPR011989
IPR016024
IPR015016
Pfam PF08920
SUPFAM SSF48371

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0071005

U2-type precatalytic spliceosome

PMID:29360106[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:29360106[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

PMID:29360106[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0071005

U2-type precatalytic spliceosome

PMID:28781166[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:28781166[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

PMID:28781166[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0071013

catalytic step 2 spliceosome

PMID:11991638[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005689

U12-type spliceosomal complex

PMID:15146077[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005681

spliceosomal complex

PMID:9585501[7]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

PMID:11991638[3]

ECO:0000305

curator inference used in manual assertion

GO:0071013

P

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

PMID:9585501[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000375

RNA splicing, via transesterification reactions

PMID:9585501[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0071013

catalytic step 2 spliceosome

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000250426
UniProtKB:O75533

C

Seeded From UniProt

complete

part_of

GO:0071004

U2-type prespliceosome

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000250426
SGD:S000004901

C

Seeded From UniProt

complete

part_of

GO:0005689

U12-type spliceosomal complex

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000250426
UniProtKB:O75533

C

Seeded From UniProt

complete

part_of

GO:0005686

U2 snRNP

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000250426
PomBase:SPAC27F1.09c
SGD:S000004901
UniProtKB:O75533

C

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000250426
SGD:S000004901

F

Seeded From UniProt

complete

part_of

GO:0034693

U11/U12 snRNP

PMID:11252167[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005686

U2 snRNP

PMID:11252167[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18559850[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

PMID:11252167[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G3V7T6
ensembl:ENSRNOP00000019126

C

Seeded From UniProt

complete

involved_in

GO:0000245

spliceosomal complex assembly

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038737

P

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038737

F

Seeded From UniProt

complete

involved_in

GO:0045815

positive regulation of gene expression, epigenetic

Reactome:R-HSA-5250924

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-75083
Reactome:R-HSA-75082
Reactome:R-HSA-75081
Reactome:R-HSA-75080
Reactome:R-HSA-75079
Reactome:R-HSA-72160
Reactome:R-HSA-72143
Reactome:R-HSA-72139
Reactome:R-HSA-72130
Reactome:R-HSA-72127
Reactome:R-HSA-72124
Reactome:R-HSA-5250947
Reactome:R-HSA-5250938
Reactome:R-HSA-5250930
Reactome:R-HSA-156661

ECO:0000304

author statement supported by traceable reference used in manual assertion















C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

Reactome:R-HSA-72165
Reactome:R-HSA-72163

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005681

spliceosomal complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0747

C

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

involved_in

GO:0008380

RNA splicing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0508

P

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0186

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Zhang, X et al. (2018) Structure of the human activated spliceosome in three conformational states. Cell Res. 28 307-322 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Bertram, K et al. (2017) Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Cell 170 701-713.e11 PubMed GONUTS page
  3. ↑ 3.0 3.1 Jurica, MS et al. (2002) Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. RNA 8 426-39 PubMed GONUTS page
  4. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  5. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  6. ↑ Will, CL et al. (2004) The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. RNA 10 929-41 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Wang, C et al. (1998) Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. Genes Dev. 12 1409-14 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Isono, K et al. (2001) Molecular cloning, genetic mapping, and expression of the mouse Sf3b1 (SAP155) gene for the U2 snRNP component of spliceosome. Mamm. Genome 12 192-8 PubMed GONUTS page
  10. ↑ Pessa, HK et al. (2008) Minor spliceosome components are predominantly localized in the nucleus. Proc. Natl. Acad. Sci. U.S.A. 105 8655-60 PubMed GONUTS page
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