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HUMAN:SELS
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | VIMP (synonyms: SELS) | |
| Protein Name(s) | Selenoprotein S
SelS VCP-interacting membrane protein | |
| External Links | ||
| UniProt | Q9BQE4 | |
| EMBL | AY324824 AF157317 AF328864 AC023024 BC005840 BC107774 | |
| CCDS | CCDS53979.1 | |
| RefSeq | NP_060915.2 NP_982298.2 | |
| UniGene | Hs.32148 | |
| PDB | 2Q2F | |
| PDBsum | 2Q2F | |
| ProteinModelPortal | Q9BQE4 | |
| SMR | Q9BQE4 | |
| BioGrid | 120934 | |
| IntAct | Q9BQE4 | |
| STRING | 9606.ENSP00000381282 | |
| PhosphoSite | Q9BQE4 | |
| DMDM | 172045769 | |
| MaxQB | Q9BQE4 | |
| PaxDb | Q9BQE4 | |
| PRIDE | Q9BQE4 | |
| DNASU | 55829 | |
| Ensembl | ENST00000398226 ENST00000526049 | |
| GeneID | 55829 | |
| KEGG | hsa:55829 | |
| UCSC | uc021sxu.1 | |
| CTD | 55829 | |
| GeneCards | GC15M101813 | |
| HGNC | HGNC:30396 | |
| HPA | HPA010025 | |
| MIM | 607918 | |
| neXtProt | NX_Q9BQE4 | |
| eggNOG | NOG76592 | |
| GeneTree | ENSGT00390000015688 | |
| HOGENOM | HOG000168422 | |
| HOVERGEN | HBG044521 | |
| InParanoid | Q9BQE4 | |
| KO | K14025 | |
| OMA | YGWYILF | |
| OrthoDB | EOG72VH83 | |
| PhylomeDB | Q9BQE4 | |
| TreeFam | TF329454 | |
| EvolutionaryTrace | Q9BQE4 | |
| GeneWiki | SELS_(gene) | |
| GenomeRNAi | 55829 | |
| NextBio | 61032 | |
| PRO | PR:Q9BQE4 | |
| Proteomes | UP000005640 | |
| ExpressionAtlas | Q9BQE4 | |
| Genevestigator | Q9BQE4 | |
| GO | GO:0005881 GO:0005783 GO:0030176 GO:0034362 GO:0005886 GO:0034361 GO:0016209 GO:0019899 GO:0004872 GO:0008430 GO:0045454 GO:0032869 GO:0071222 GO:0034599 GO:0030968 GO:0006983 GO:0030433 GO:0045184 GO:0002865 GO:1902236 GO:0046325 GO:0045719 GO:0050728 GO:0032715 GO:2000110 GO:0051771 GO:0032720 GO:0006111 GO:0080164 GO:0009749 GO:0051775 GO:0030970 | |
| InterPro | IPR009703 | |
| Pfam | PF06936 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0051117 |
ATPase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0036502 |
Derlin-1-VIMP complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0036513 |
Derlin-1 retrotranslocation complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:1990381 |
ubiquitin-specific protease binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000110 |
negative regulation of macrophage apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902236 |
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0080164 |
regulation of nitric oxide metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051771 |
negative regulation of nitric-oxide synthase biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050728 |
negative regulation of inflammatory response |
ECO:0000305 |
curator inference used in manual assertion |
GO:0032720 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034362 |
low-density lipoprotein particle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034361 |
very-low-density lipoprotein particle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009749 |
response to glucose |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006983 |
ER overload response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006983 |
ER overload response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002865 |
negative regulation of acute inflammatory response to antigenic stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051775 |
response to redox state |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045454 |
cell redox homeostasis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030970 |
retrograde protein transport, ER to cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030968 |
endoplasmic reticulum unfolded protein response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030433 |
ubiquitin-dependent ERAD pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030176 |
integral component of endoplasmic reticulum membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016209 |
antioxidant activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009749 |
response to glucose |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005881 |
cytoplasmic microtubule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0036513 |
Derlin-1 retrotranslocation complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002007460 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0036502 |
Derlin-1-VIMP complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002007460 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030970 |
retrograde protein transport, ER to cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002007460 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030968 |
endoplasmic reticulum unfolded protein response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002007460 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030433 |
ubiquitin-dependent ERAD pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002007460 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030176 |
integral component of endoplasmic reticulum membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002007460 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0098869 |
cellular oxidant detoxification |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0016209 |
P |
Seeded From UniProt |
complete | ||
| GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000315 |
C |
Organism : homo sapiens Protein: VIMP // Selenos Figure 1B shows the localization of the protein to the ER membrane. |
complete | |||||
|
involved_in |
GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BCZ4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BCZ4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006886 |
intracellular protein transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030176 |
integral component of endoplasmic reticulum membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046325 |
negative regulation of glucose import |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045719 |
negative regulation of glycogen biosynthetic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006111 |
regulation of gluconeogenesis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045184 |
establishment of protein localization |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
Reactome:R-HSA-8866654 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
Reactome:R-HSA-8943083 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Liu, Y et al. (2014) USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation. Elife 3 e01369 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Ye, Y et al. (2004) A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature 429 841-7 PubMed GONUTS page
- ↑ Wang, Q et al. (2006) Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3. J. Cell Biol. 174 963-71 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Kim, KH et al. (2007) SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis. Biochem. Biophys. Res. Commun. 354 127-32 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Zeng, J et al. (2008) Role of SelS in lipopolysaccharide-induced inflammatory response in hepatoma HepG2 cells. Arch. Biochem. Biophys. 478 1-6 PubMed GONUTS page
- ↑ 6.0 6.1 Gao, Y et al. (2006) Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells. Cytokine 33 246-51 PubMed GONUTS page
- ↑ 7.0 7.1 Gao, Y et al. (2007) Secretion of the glucose-regulated selenoprotein SEPS1 from hepatoma cells. Biochem. Biophys. Res. Commun. 356 636-41 PubMed GONUTS page
- ↑ Walder, K et al. (2002) Tanis: a link between type 2 diabetes and inflammation? Diabetes 51 1859-66 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Gao, Y et al. (2004) Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein. FEBS Lett. 563 185-90 PubMed GONUTS page
- ↑ Fong, KW et al. (2013) MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. J. Cell. Sci. 126 825-37 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Noda, C et al. (2014) Valosin-containing protein-interacting membrane protein (VIMP) links the endoplasmic reticulum with microtubules in concert with cytoskeleton-linking membrane protein (CLIMP)-63. J. Biol. Chem. 289 24304-13 PubMed GONUTS page
- ↑ Ye, Y et al. (2005) Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc. Natl. Acad. Sci. U.S.A. 102 14132-8 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 Gao, Y et al. (2003) Elevation in Tanis expression alters glucose metabolism and insulin sensitivity in H4IIE cells. Diabetes 52 929-34 PubMed GONUTS page
c
- Catarrhini
- GO:0098869 ! cellular oxidant detoxification
- GO:0032869 ! cellular response to insulin stimulus
- GO:0071222 ! cellular response to lipopolysaccharide
- GO:0034599 ! cellular response to oxidative stress
- GO:0045454 ! cell redox homeostasis
- Chordata
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005881 ! cytoplasmic microtubule
e
- GO:0005783 ! endoplasmic reticulum
- GO:0005789 ! endoplasmic reticulum membrane
- GO:0030968 ! endoplasmic reticulum unfolded protein response
- GO:0019899 ! enzyme binding
- GO:0006983 ! ER overload response
- GO:0045184 ! establishment of protein localization
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
n
- GO:0050728 ! negative regulation of inflammatory response
- GO:0032720 ! negative regulation of tumor necrosis factor production
- GO:0032715 ! negative regulation of interleukin-6 production
- GO:0002865 ! negative regulation of acute inflammatory response to antigenic stimulus
- GO:1902236 ! negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
- GO:2000110 ! negative regulation of macrophage apoptotic process
- GO:0046325 ! negative regulation of D-glucose import
- GO:0045719 ! negative regulation of glycogen biosynthetic process
o
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