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PMID:17210132

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Citation

Kim, KH, Gao, Y, Walder, K, Collier, GR, Skelton, J and Kissebah, AH (2007) SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis. Biochem. Biophys. Res. Commun. 354:127-32

Abstract

Selenoprotein S (SEPS1) is a novel endoplasmic reticulum (ER) resident protein and it is known to play an important role in production of inflammatory cytokines. Here, we show evidence that SEPS1 is stimulated by pharmacological ER stress agents in RAW264.7 macrophages as well as other cell types. Overexpression studies reveal a protective action of SEPS1 in macrophages against ER stress-induced cytotoxicity and apoptosis, resulting in promoting cell survival during ER stress. The protective action of SEPS1 is largely dependent on ER stress-mediated cell death signal with less effect on non-ER stress component cell death signals. Conversely, suppression of SEPS1 in macrophages results in sensitization of cells to ER stress-induced cell death. These findings suggest that SEPS1 could be a new ER stress-dependent survival factor that protects macrophage against ER stress-induced cellular dysfunction.

Links

PubMed PMC1855283 Online version:10.1016/j.bbrc.2006.12.183

Keywords

Animals; Apoptosis/drug effects; Apoptosis/physiology; Cell Line; Cell Survival/drug effects; Cell Survival/physiology; Endoplasmic Reticulum/drug effects; Endoplasmic Reticulum/metabolism; Macrophages/cytology; Macrophages/drug effects; Macrophages/physiology; Membrane Proteins/metabolism; Mice; Oxidative Stress/drug effects; Oxidative Stress/physiology; Selenoproteins/metabolism; Thapsigargin/pharmacology; Tunicamycin/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:SELS

involved_in

GO:2000110: negative regulation of macrophage apoptotic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:SELS

involved_in

GO:1902236: negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:SELS

involved_in

GO:0006983: ER overload response

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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