HUMAN:SAA1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SAA1
Protein Name(s)	Serum amyloid A-1 protein SAA Amyloid protein A Amyloid fibril protein AA Serum amyloid protein A(2-104) Serum amyloid protein A(3-104) Serum amyloid protein A(2-103) Serum amyloid protein A(2-102) Serum amyloid protein A(4-101)
External Links
UniProt	P0DJI8
EMBL	M10906 M23698 X56652 CR542241 AC107948 BC007022 BC105796 X51439 X51441 X51442
CCDS	CCDS7835.1
PIR	A22342 I39456
RefSeq	NP_000322.2 NP_001171477.1 NP_954630.1
UniGene	Hs.632144 Hs.731376 Hs.734161
PDB	4IP8 4IP9
PDBsum	4IP8 4IP9
ProteinModelPortal	P0DJI8
SMR	P0DJI8
DrugBank	DB00062 DB00064
DMDM	395406826
UCD-2DPAGE	P02735
PeptideAtlas	P02735
PRIDE	P0DJI8
DNASU	6288
Ensembl	ENST00000356524 ENST00000405158
GeneID	6288
KEGG	hsa:6288
CTD	6288
GeneCards	GC11P018287
H-InvDB	HIX0009484
HGNC	HGNC:10513
MIM	104750
neXtProt	NX_P0DJI8
Orphanet	85445
eggNOG	NOG26520
HOVERGEN	HBG016327
InParanoid	P0DJI8
KO	K17310
OrthoDB	EOG7QVM4V
PhylomeDB	P0DJI8
TreeFam	TF332544
Reactome	REACT_118563 REACT_163679 REACT_18283 REACT_19231 REACT_21264 REACT_21281 REACT_24969 REACT_25195 REACT_75925
ChiTaRS	SAA1
GeneWiki	Serum_amyloid_A1
GenomeRNAi	6288
NextBio	24415
PMAP-CutDB	Q6FG67
PRO	PR:P0DJI8
Proteomes	UP000005640
Bgee	P0DJI8
CleanEx	HS_SAA1
ExpressionAtlas	P0DJI8
Genevestigator	P02735
GO	GO:0071682 GO:0005576 GO:0070062 GO:0034364 GO:0001664 GO:0008201 GO:0006953 GO:0045087 GO:0048247 GO:0048246 GO:0050728 GO:0030593 GO:0030168 GO:0045785 GO:0050715 GO:0007204 GO:0050716 GO:0050708
InterPro	IPR000096
Pfam	PF00277
PIRSF	PIRSF002472
PRINTS	PR00306
SMART	SM00197
PROSITE	PS00992

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043410	positive regulation of MAPK cascade	PMID:22532826^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Fig.5 B	complete CACAO 6693
	GO:0005881	cytoplasmic microtubule	PMID:22131810^[2]	ECO:0000314			C		Fig. 1 C and E	complete CACAO 6705
part_of	GO:0005881	cytoplasmic microtubule	PMID:22131810^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:9823935^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050716	positive regulation of interleukin-1 secretion	PMID:12857601^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	PMID:12857601^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050708	regulation of protein secretion	PMID:9605178^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048247	lymphocyte chemotaxis	PMID:7636186^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048246	macrophage chemotaxis	PMID:7561109^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	PMID:11830469^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	PMID:9252455^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0045087	innate immune response	PMID:27058895^[12]	ECO:0000317		PMID:27058895^[12] UniProtKB:P0DJ18	P		The acute-phase protein, Serum amyloid A (SAA1) is usually found in the liver and has been recently been proven to be found in cancer tissues. SAA1's content in breast cancer hadn't been described hence the researchers of this protein decided to study the protein's abundance. Immunohistochemistry was applied in this investigation to determine the quantity of SAA1 in tumor-associated macrophage (TAM). Fluorescent in situ hybridization (FISH) was performed to examine the expression and location of the mRNA of SAA1. The results of this investigation showed that TAM's may be the main source of SAA1's in breast cancer. Therefore presence of SAA1 in TAM's could correlate with the occurrence of breast cancer.	complete CACAO 11570
involved_in	GO:0045785	positive regulation of cell adhesion	PMID:7561109^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	PMID:12557751^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	PMID:1697614^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:9892621^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:7561109^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	PMID:9815279^[16]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:7516407^[17]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:14718574^[18]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	PMID:9892621^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98223 PANTHER:PTN000603423	P		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98223 PANTHER:PTN000603423	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98221 MGI:MGI:98223 PANTHER:PTN001159395	C		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042056	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000096	C		Seeded From UniProt	complete
part_of	GO:0071682	endocytic vesicle lumen	Reactome:R-HSA-2512800	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	Reactome:R-HSA-168249	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	Reactome:R-HSA-3000471	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-997411 Reactome:R-HSA-977136 Reactome:R-HSA-976734 Reactome:R-HSA-879411 Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-749452 Reactome:R-HSA-749448 Reactome:R-HSA-6789615 Reactome:R-HSA-391913 Reactome:R-HSA-380073 Reactome:R-HSA-379048 Reactome:R-HSA-2512800 Reactome:R-HSA-2197646	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0345	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0011	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Faty, A et al. (2012) The acute phase protein Serum Amyloid A induces lipolysis and inflammation in human adipocytes through distinct pathways. PLoS ONE 7 e34031 PubMed GONUTS page
↑ ^2.0 ^2.1 Lakota, K et al. (2011) Colocalization of serum amyloid a with microtubules in human coronary artery endothelial cells. J. Biomed. Biotechnol. 2011 528276 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gatt, ME et al. (1998) Effect of serum amyloid A on selected in vitro functions of isolated human neutrophils. J. Lab. Clin. Med. 132 414-20 PubMed GONUTS page
↑ ^6.0 ^6.1 Ribeiro, FP et al. (2003) mRNA expression and release of interleukin-8 induced by serum amyloid A in neutrophils and monocytes. Mediators Inflamm. 12 173-8 PubMed GONUTS page
↑ Migita, K et al. (1998) Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts. Lab. Invest. 78 535-9 PubMed GONUTS page
↑ Xu, L et al. (1995) A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion. J. Immunol. 155 1184-90 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Badolato, R et al. (1995) Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway. J. Immunol. 155 4004-10 PubMed GONUTS page
↑ Urieli-Shoval, S et al. (2002) Adhesion of human platelets to serum amyloid A. Blood 99 1224-9 PubMed GONUTS page
↑ Hershkoviz, R et al. (1997) Extracellular matrix-anchored serum amyloid A preferentially induces mast cell adhesion. Am. J. Physiol. 273 C179-87 PubMed GONUTS page
↑ ^12.0 ^12.1 Yang, M et al. (2016) Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis. Oncotarget PubMed GONUTS page
↑ Kumon, Y et al. (2002) Acute-phase, but not constitutive serum amyloid A (SAA) is chemotactic for cultured human aortic smooth muscle cells. Amyloid 9 237-41 PubMed GONUTS page
↑ Zimlichman, S et al. (1990) Serum amyloid A, an acute phase protein, inhibits platelet activation. J. Lab. Clin. Med. 116 180-6 PubMed GONUTS page
↑ ^15.0 ^15.1 Su, SB et al. (1999) A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells. J. Exp. Med. 189 395-402 PubMed GONUTS page
↑ Urieli-Shoval, S et al. (1998) Widespread expression of serum amyloid A in histologically normal human tissues. Predominant localization to the epithelium. J. Histochem. Cytochem. 46 1377-84 PubMed GONUTS page
↑ Badolato, R et al. (1994) Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes. J. Exp. Med. 180 203-9 PubMed GONUTS page
↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22532826-1] Faty, A et al. (2012) The acute phase protein Serum Amyloid A induces lipolysis and inflammation in human adipocytes through distinct pathways. PLoS ONE 7 e34031 PubMed GONUTS page

[PMID:22131810-2] 2.0 ^2.1 Lakota, K et al. (2011) Colocalization of serum amyloid a with microtubules in human coronary artery endothelial cells. J. Biomed. Biotechnol. 2011 528276 PubMed GONUTS page

[PMID:23533145-3] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19199708-4] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:9823935-5] Gatt, ME et al. (1998) Effect of serum amyloid A on selected in vitro functions of isolated human neutrophils. J. Lab. Clin. Med. 132 414-20 PubMed GONUTS page

[PMID:12857601-6] 6.0 ^6.1 Ribeiro, FP et al. (2003) mRNA expression and release of interleukin-8 induced by serum amyloid A in neutrophils and monocytes. Mediators Inflamm. 12 173-8 PubMed GONUTS page

[PMID:9605178-7] Migita, K et al. (1998) Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts. Lab. Invest. 78 535-9 PubMed GONUTS page

[PMID:7636186-8] Xu, L et al. (1995) A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion. J. Immunol. 155 1184-90 PubMed GONUTS page

[PMID:7561109-9] 9.0 ^9.1 ^9.2 Badolato, R et al. (1995) Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway. J. Immunol. 155 4004-10 PubMed GONUTS page

[PMID:11830469-10] Urieli-Shoval, S et al. (2002) Adhesion of human platelets to serum amyloid A. Blood 99 1224-9 PubMed GONUTS page

[PMID:9252455-11] Hershkoviz, R et al. (1997) Extracellular matrix-anchored serum amyloid A preferentially induces mast cell adhesion. Am. J. Physiol. 273 C179-87 PubMed GONUTS page

[PMID:27058895-12] 12.0 ^12.1 Yang, M et al. (2016) Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis. Oncotarget PubMed GONUTS page

[PMID:12557751-13] Kumon, Y et al. (2002) Acute-phase, but not constitutive serum amyloid A (SAA) is chemotactic for cultured human aortic smooth muscle cells. Amyloid 9 237-41 PubMed GONUTS page

[PMID:1697614-14] Zimlichman, S et al. (1990) Serum amyloid A, an acute phase protein, inhibits platelet activation. J. Lab. Clin. Med. 116 180-6 PubMed GONUTS page

[PMID:9892621-15] 15.0 ^15.1 Su, SB et al. (1999) A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells. J. Exp. Med. 189 395-402 PubMed GONUTS page

[PMID:9815279-16] Urieli-Shoval, S et al. (1998) Widespread expression of serum amyloid A in histologically normal human tissues. Predominant localization to the epithelium. J. Histochem. Cytochem. 46 1377-84 PubMed GONUTS page

[PMID:7516407-17] Badolato, R et al. (1994) Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes. J. Exp. Med. 180 203-9 PubMed GONUTS page

[PMID:14718574-18] Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page

[PMID:21873635-19] 19.0 ^19.1 ^19.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:SAA1

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