GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:SAA1

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SAA1
Protein Name(s) Serum amyloid A-1 protein

SAA Amyloid protein A Amyloid fibril protein AA Serum amyloid protein A(2-104) Serum amyloid protein A(3-104) Serum amyloid protein A(2-103) Serum amyloid protein A(2-102) Serum amyloid protein A(4-101)

External Links
UniProt P0DJI8
EMBL M10906
M23698
X56652
CR542241
AC107948
BC007022
BC105796
X51439
X51441
X51442
CCDS CCDS7835.1
PIR A22342
I39456
RefSeq NP_000322.2
NP_001171477.1
NP_954630.1
UniGene Hs.632144
Hs.731376
Hs.734161
PDB 4IP8
4IP9
PDBsum 4IP8
4IP9
ProteinModelPortal P0DJI8
SMR P0DJI8
DrugBank DB00062
DB00064
DMDM 395406826
UCD-2DPAGE P02735
PeptideAtlas P02735
PRIDE P0DJI8
DNASU 6288
Ensembl ENST00000356524
ENST00000405158
GeneID 6288
KEGG hsa:6288
CTD 6288
GeneCards GC11P018287
H-InvDB HIX0009484
HGNC HGNC:10513
MIM 104750
neXtProt NX_P0DJI8
Orphanet 85445
eggNOG NOG26520
HOVERGEN HBG016327
InParanoid P0DJI8
KO K17310
OrthoDB EOG7QVM4V
PhylomeDB P0DJI8
TreeFam TF332544
Reactome REACT_118563
REACT_163679
REACT_18283
REACT_19231
REACT_21264
REACT_21281
REACT_24969
REACT_25195
REACT_75925
ChiTaRS SAA1
GeneWiki Serum_amyloid_A1
GenomeRNAi 6288
NextBio 24415
PMAP-CutDB Q6FG67
PRO PR:P0DJI8
Proteomes UP000005640
Bgee P0DJI8
CleanEx HS_SAA1
ExpressionAtlas P0DJI8
Genevestigator P02735
GO GO:0071682
GO:0005576
GO:0070062
GO:0034364
GO:0001664
GO:0008201
GO:0006953
GO:0045087
GO:0048247
GO:0048246
GO:0050728
GO:0030593
GO:0030168
GO:0045785
GO:0050715
GO:0007204
GO:0050716
GO:0050708
InterPro IPR000096
Pfam PF00277
PIRSF PIRSF002472
PRINTS PR00306
SMART SM00197
PROSITE PS00992

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0000187

activation of MAPK activity

PMID:22532826[1]

ECO:0000314

P

Fig.5 B

complete
CACAO 6693

GO:0005881

cytoplasmic microtubule

PMID:22131810[2]

ECO:0000314

C

Fig. 1 C and E

complete
CACAO 6705

part_of

GO:0005881

cytoplasmic microtubule

PMID:22131810[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000187

activation of MAPK activity

PMID:22532826[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

involved_in

GO:0050728

negative regulation of inflammatory response

PMID:9823935[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050716

positive regulation of interleukin-1 secretion

PMID:12857601[6]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050715

positive regulation of cytokine secretion

PMID:12857601[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050708

regulation of protein secretion

PMID:9605178[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048247

lymphocyte chemotaxis

PMID:7636186[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048246

macrophage chemotaxis

PMID:7561109[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045785

positive regulation of cell adhesion

PMID:11830469[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045785

positive regulation of cell adhesion

PMID:9252455[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0045087

innate immune response

PMID:27058895[12]

ECO:0000317

PMID:27058895[12] UniProtKB:P0DJ18


P

The acute-phase protein, Serum amyloid A (SAA1) is usually found in the liver and has been recently been proven to be found in cancer tissues. SAA1's content in breast cancer hadn't been described hence the researchers of this protein decided to study the protein's abundance. Immunohistochemistry was applied in this investigation to determine the quantity of SAA1 in tumor-associated macrophage (TAM). Fluorescent in situ hybridization (FISH) was performed to examine the expression and location of the mRNA of SAA1. The results of this investigation showed that TAM's may be the main source of SAA1's in breast cancer. Therefore presence of SAA1 in TAM's could correlate with the occurrence of breast cancer.

complete
CACAO 11570

involved_in

GO:0045785

positive regulation of cell adhesion

PMID:7561109[9]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030593

neutrophil chemotaxis

PMID:12557751[13]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030168

platelet activation

PMID:1697614[14]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:9892621[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:7561109[9]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006953

acute-phase response

PMID:9815279[16]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:7516407[17]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:14718574[18]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001664

G protein-coupled receptor binding

PMID:9892621[15]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060326

cell chemotaxis

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98223
PANTHER:PTN000603423

P

Seeded From UniProt

complete

enables

GO:0042056

chemoattractant activity

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98223
PANTHER:PTN000603423

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98221
MGI:MGI:98223
PANTHER:PTN001159395

C

Seeded From UniProt

complete

involved_in

GO:0050918

positive chemotaxis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0042056

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000096

C

Seeded From UniProt

complete

part_of

GO:0071682

endocytic vesicle lumen

Reactome:R-HSA-2512800

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

Reactome:R-HSA-168249

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044267

cellular protein metabolic process

Reactome:R-HSA-392499

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

Reactome:R-HSA-6785807

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006898

receptor-mediated endocytosis

Reactome:R-HSA-3000471

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-NUL-997411
Reactome:R-HSA-977136
Reactome:R-HSA-976734
Reactome:R-HSA-879411
Reactome:R-HSA-749456
Reactome:R-HSA-749454
Reactome:R-HSA-749452
Reactome:R-HSA-749448
Reactome:R-HSA-6789615
Reactome:R-HSA-391913
Reactome:R-HSA-380073
Reactome:R-HSA-379048
Reactome:R-HSA-2512800
Reactome:R-HSA-2197646

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

part_of

GO:0034364

high-density lipoprotein particle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0345

C

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0358

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0006953

acute-phase response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0011

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Faty, A et al. (2012) The acute phase protein Serum Amyloid A induces lipolysis and inflammation in human adipocytes through distinct pathways. PLoS ONE 7 e34031 PubMed GONUTS page
  2. 2.0 2.1 Lakota, K et al. (2011) Colocalization of serum amyloid a with microtubules in human coronary artery endothelial cells. J. Biomed. Biotechnol. 2011 528276 PubMed GONUTS page
  3. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  4. Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  5. Gatt, ME et al. (1998) Effect of serum amyloid A on selected in vitro functions of isolated human neutrophils. J. Lab. Clin. Med. 132 414-20 PubMed GONUTS page
  6. 6.0 6.1 Ribeiro, FP et al. (2003) mRNA expression and release of interleukin-8 induced by serum amyloid A in neutrophils and monocytes. Mediators Inflamm. 12 173-8 PubMed GONUTS page
  7. Migita, K et al. (1998) Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts. Lab. Invest. 78 535-9 PubMed GONUTS page
  8. Xu, L et al. (1995) A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion. J. Immunol. 155 1184-90 PubMed GONUTS page
  9. 9.0 9.1 9.2 Badolato, R et al. (1995) Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway. J. Immunol. 155 4004-10 PubMed GONUTS page
  10. Urieli-Shoval, S et al. (2002) Adhesion of human platelets to serum amyloid A. Blood 99 1224-9 PubMed GONUTS page
  11. Hershkoviz, R et al. (1997) Extracellular matrix-anchored serum amyloid A preferentially induces mast cell adhesion. Am. J. Physiol. 273 C179-87 PubMed GONUTS page
  12. 12.0 12.1 Yang, M et al. (2016) Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis. Oncotarget PubMed GONUTS page
  13. Kumon, Y et al. (2002) Acute-phase, but not constitutive serum amyloid A (SAA) is chemotactic for cultured human aortic smooth muscle cells. Amyloid 9 237-41 PubMed GONUTS page
  14. Zimlichman, S et al. (1990) Serum amyloid A, an acute phase protein, inhibits platelet activation. J. Lab. Clin. Med. 116 180-6 PubMed GONUTS page
  15. 15.0 15.1 Su, SB et al. (1999) A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells. J. Exp. Med. 189 395-402 PubMed GONUTS page
  16. Urieli-Shoval, S et al. (1998) Widespread expression of serum amyloid A in histologically normal human tissues. Predominant localization to the epithelium. J. Histochem. Cytochem. 46 1377-84 PubMed GONUTS page
  17. Badolato, R et al. (1994) Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes. J. Exp. Med. 180 203-9 PubMed GONUTS page
  18. Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
  19. 19.0 19.1 19.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page