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PMID:22532826
| Citation |
Faty, A, Ferré, P and Commans, S (2012) The acute phase protein Serum Amyloid A induces lipolysis and inflammation in human adipocytes through distinct pathways. PLoS ONE 7:e34031 |
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| Abstract |
The acute phase response (APR) is characterized by alterations in lipid and glucose metabolism leading to an increased delivery of energy substrates. In adipocytes, there is a coordinated decrease in Free Fatty acids (FFAs) and glucose storage, in addition to an increase in FFAs mobilization. Serum Amyloid A (SAA) is an acute phase protein mainly associated with High Density Lipoproteins (HDL). We hypothesized that enrichment of HDL with SAA, during the APR, could be implicated in the metabolic changes occurring in adipocytes. |
| Links |
PubMed PMC3331860 Online version:10.1371/journal.pone.0034031 |
| Keywords |
Adipocytes/drug effects; Adipocytes/metabolism; Adipocytes/secretion; Adiponectin/secretion; Cells, Cultured; Chemokines/secretion; Cytokines/secretion; Humans; Inflammation/chemically induced; Inflammation/metabolism; Lipid Metabolism/drug effects; Lipolysis/drug effects; Mitogen-Activated Protein Kinases/genetics; Mitogen-Activated Protein Kinases/metabolism; NF-kappa B/genetics; NF-kappa B/metabolism; Serum Amyloid A Protein/metabolism; Serum Amyloid A Protein/pharmacology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0043410: positive regulation of MAPK cascade |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Fig.5 B |
complete | ||||
See also
References
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