PMID:27058895

Citation	Yang, M, Liu, F, Higuchi, K, Sawashita, J, Fu, X, Zhang, L, Zhang, L, Fu, L, Tong, Z and Higuchi, K' (2016) Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis. Oncotarget '
Abstract	Serum amyloid A (SAA), an acute-phase protein, is expressed primarily in the liver, and recently found also expressed in cancer tissues. However, its expression and prognostic value in breast cancer have not been described.
Links	PubMed Online version:10.18632/oncotarget.8561
Keywords
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:SAA1		GO:0045087: innate immune response	ECO:0000317:	PMID:27058895 UniProtKB:P0DJ18	P		The acute-phase protein, Serum amyloid A (SAA1) is usually found in the liver and has been recently been proven to be found in cancer tissues. SAA1's content in breast cancer hadn't been described hence the researchers of this protein decided to study the protein's abundance. Immunohistochemistry was applied in this investigation to determine the quantity of SAA1 in tumor-associated macrophage (TAM). Fluorescent in situ hybridization (FISH) was performed to examine the expression and location of the mRNA of SAA1. The results of this investigation showed that TAM's may be the main source of SAA1's in breast cancer. Therefore presence of SAA1 in TAM's could correlate with the occurrence of breast cancer.	complete CACAO 11570

References

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