HUMAN:RHOA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RHOA (synonyms: ARH12, ARHA, RHO12)
Protein Name(s)	Transforming protein RhoA Rho cDNA clone 12 h12
External Links
UniProt	P61586
EMBL	X05026 L25080 AF498970 BT019870 AK222556 BX647063 AC104452 AC121247 AC137114 BC001360 BC005976 L09159 M83094
CCDS	CCDS2795.1
PIR	A26675
RefSeq	NP_001655.1
UniGene	Hs.247077
PDB	1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06 4D0N
PDBsum	1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06 4D0N
ProteinModelPortal	P61586
SMR	P61586
BioGrid	106880
DIP	DIP-29642N
IntAct	P61586
MINT	MINT-4999683
STRING	9606.ENSP00000400175
BindingDB	P61586
ChEMBL	CHEMBL6052
PhosphoSite	P61586
DMDM	47606458
MaxQB	P61586
PaxDb	P61586
PeptideAtlas	P61586
PRIDE	P61586
DNASU	387
Ensembl	ENST00000418115
GeneID	387
KEGG	hsa:387
UCSC	uc003cwu.3
CTD	387
GeneCards	GC03M049397
HGNC	HGNC:667
HPA	CAB005052
MIM	165390
neXtProt	NX_P61586
PharmGKB	PA134865095
eggNOG	COG1100
GeneTree	ENSGT00760000119020
HOGENOM	HOG000233974
HOVERGEN	HBG009351
InParanoid	P61586
KO	K04513
OMA	RNDEHAR
OrthoDB	EOG73FQPD
PhylomeDB	P61586
TreeFam	TF300837
Reactome	REACT_11051 REACT_120726 REACT_12464 REACT_13779 REACT_13815 REACT_1695 REACT_172581 REACT_18407 REACT_19266 REACT_19277 REACT_19290 REACT_228063 REACT_228085 REACT_228166
SignaLink	P61586
ChiTaRS	RHOA
EvolutionaryTrace	P61586
GeneWiki	RHOA
GenomeRNAi	387
NextBio	1611
PMAP-CutDB	P61586
PRO	PR:P61586
Proteomes	UP000005640
Bgee	P61586
CleanEx	HS_RHOA
ExpressionAtlas	P61586
Genevestigator	P61586
GO	GO:0043296 GO:0005938 GO:0030054 GO:0032154 GO:0005856 GO:0005829 GO:0070062 GO:0005925 GO:0030027 GO:0030496 GO:0005886 GO:0005525 GO:0003924 GO:0017022 GO:0030036 GO:0043297 GO:0038027 GO:0007411 GO:0007596 GO:0036089 GO:0006184 GO:0050919 GO:0050771 GO:0048011 GO:0043931 GO:0048015 GO:0030168 GO:0050772 GO:0032467 GO:0043123 GO:0045666 GO:0042346 GO:0051496 GO:0050770 GO:0030334 GO:0033688 GO:0051056 GO:0007266 GO:0007264 GO:0090307 GO:0021762 GO:0061383 GO:0007179 GO:0016032
Gene3D	3.40.50.300
InterPro	IPR027417 IPR005225 IPR001806 IPR003578
Pfam	PF00071
PRINTS	PR00449
SMART	SM00174
SUPFAM	SSF52540
TIGRFAMs	TIGR00231
PROSITE	PS51420

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:25515214^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000044)	Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	PMID:25515214^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000044)	Seeded From UniProt	complete
involved_in	GO:0010812	negative regulation of cell-substrate adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUI0	P	occurs_in:(CL:0000129) has_regulation_target:(UniProtKB:P05107) has_input:(CHEBI:64647)	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:24352656^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	PMID:8625410^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045792	negative regulation of cell size	PMID:8625410^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:12777804^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:26529257^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	PMID:26529257^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:26529257^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035385	Roundabout signaling pathway	PMID:26529257^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:19787194^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:19734146^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:19734146^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	PMID:8617235^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:1328215^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:1328215^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045198	establishment of epithelial cell apical/basal polarity	PMID:22891260^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034329	cell junction assembly	PMID:22891260^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	PMID:23241886^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000406	positive regulation of T cell migration	PMID:23241886^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990869	cellular response to chemokine	PMID:23241886^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903673	mitotic cleavage furrow formation	PMID:16103226^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0032154	cleavage furrow	PMID:16103226^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	PMID:25911094^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000059)	Seeded From UniProt	complete
involved_in	GO:0060193	positive regulation of lipase activity	PMID:22740689^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9FD10)	Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:19887681^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060193	positive regulation of lipase activity	PMID:19887681^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9FD10)	Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:19887681^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	PMID:24431302^[16]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	PMID:25911094^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(CL:0000059)	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:15601624^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902766	skeletal muscle satellite cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1CG58	P		Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1CG58	P		Seeded From UniProt	complete
involved_in	GO:1902766	skeletal muscle satellite cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G1MTS2	P		Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G1MTS2	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:19782033^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043149	stress fiber assembly	PMID:19782033^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	PMID:19782033^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050919	negative chemotaxis	PMID:23726972^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000192)	Seeded From UniProt	complete
involved_in	GO:0038027	apolipoprotein A-I-mediated signaling pathway	PMID:23726972^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000192)	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[20]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[21]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[22]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:0021762	substantia nigra development	PMID:22926577^[23]	ECO:0007007	high throughput expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090307	mitotic spindle assembly	PMID:19635168^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061383	trabecula morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUI0	P		Seeded From UniProt	complete
involved_in	GO:0043931	ossification involved in bone maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUI0	P		Seeded From UniProt	complete
involved_in	GO:0033688	regulation of osteoblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUI0	P		Seeded From UniProt	complete
involved_in	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	PMID:25515214^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_agent:(CL:0000084) has_agent:(CL:2000044) part_of:(GO:0071345)	Seeded From UniProt	complete
involved_in	GO:0043297	apical junction assembly	PMID:20974804^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043296	apical junction complex	PMID:20974804^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12761501^[26]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:12761501^[26]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036089	cleavage furrow formation	PMID:16103226^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032467	positive regulation of cytokinesis	PMID:17115030^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032467	positive regulation of cytokinesis	PMID:16103226^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	PMID:19934221^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUI0	C		Seeded From UniProt	complete
enables	GO:0017022	myosin binding	PMID:15644318^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13459	F		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:16103226^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	PMID:21423166^[30]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:24352656^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21423166^[30]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:24352656^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:24352656^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:21423166^[30]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:24352656^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0051017	actin filament bundle assembly	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 UniProtKB:O00212	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632672 UniProtKB:Q92730	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632769 UniProtKB:P61586	C		Seeded From UniProt	complete
involved_in	GO:0043149	stress fiber assembly	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096342 PANTHER:PTN000632769 UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096342 PANTHER:PTN000632672 PomBase:SPAC16A10.04 PomBase:SPAC1F7.04 UniProtKB:P61586 ZFIN:ZDB-GENE-040322-2	P		Seeded From UniProt	complete
colocalizes_with	GO:0032154	cleavage furrow	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632769 UniProtKB:P61586	C		Seeded From UniProt	complete
colocalizes_with	GO:0032154	cleavage furrow	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632769 UniProtKB:I3LVS7 UniProtKB:P61586	C		Seeded From UniProt	complete
part_of	GO:0032153	cell division site	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632672 PomBase:SPAC16.01 PomBase:SPAC16A10.04 PomBase:SPAC20H4.11c PomBase:SPAC23C4.08	C		Seeded From UniProt	complete
involved_in	GO:0030950	establishment or maintenance of actin cytoskeleton polarity	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 PomBase:SPAC16.01 PomBase:SPAC1F7.04 SGD:S000001380 UniProtKB:I3LVS7	P		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 UniProtKB:P61586 UniProtKB:P62745	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108446 PANTHER:PTN000632672 WB:WBGene00004357	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001178055 UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632672 PomBase:SPAC16A10.04	P		Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 FB:FBgn0014011 MGI:MGI:1931551 PANTHER:PTN000632671 RGD:619921 UniProtKB:I3LVS7 UniProtKB:P61586 UniProtKB:P84095	P		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 UniProtKB:Q92730 UniProtKB:Q9HBH0	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 PomBase:SPAC16A10.04 UniProtKB:I3LVS7 UniProtKB:P61586 WB:WBGene00004357	C		Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000192659 MGI:MGI:106028 MGI:MGI:107949 MGI:MGI:1096342 PANTHER:PTN000632672 PomBase:SPAC23C4.08 SGD:S000001763 UniProtKB:A0A1D8PH96 UniProtKB:P62745 UniProtKB:Q92730	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 RGD:619921	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039140 MGI:MGI:108446 MGI:MGI:97845 PANTHER:PTN000632671 RGD:619755 RGD:619921 RGD:71043 SGD:S000001380 TAIR:locus:2131606 TAIR:locus:2204380 UniProtKB:A0A1D8PDV5 UniProtKB:P15153 UniProtKB:P60953 UniProtKB:P61586 UniProtKB:P63000 UniProtKB:Q15669 UniProtKB:Q9SSX0 WB:WBGene00000390 WB:WBGene00000424 WB:WBGene00004287 WB:WBGene00004357	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010333 FB:FBgn0010341 FB:FBgn0014011 FB:FBgn0014020 MGI:MGI:106211 MGI:MGI:1096342 MGI:MGI:1916831 MGI:MGI:97845 MGI:MGI:97846 PANTHER:PTN000632671 PomBase:SPAC110.03 PomBase:SPAC16.01 PomBase:SPAC16A10.04 PomBase:SPAC1F7.04 PomBase:SPAC23C4.08 RGD:619755 RGD:619921 SGD:S000000046 SGD:S000001380 SGD:S000001763 SGD:S000004219 SGD:S000005034 SGD:S000005124 SGD:S000006369 TAIR:locus:2099232 TAIR:locus:2131606 UniProtKB:A0A1D8PCX9 UniProtKB:A0A1D8PH96 UniProtKB:P17081 UniProtKB:P60763 UniProtKB:P60953 UniProtKB:P61586 UniProtKB:P63000 UniProtKB:P84095 UniProtKB:Q5A904 WB:WBGene00000390 WB:WBGene00000424 WB:WBGene00003239 WB:WBGene00004287 WB:WBGene00004357	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:18829532^[32]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097498	endothelial tube lumen extension	PMID:20208559^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9Y3M8	P		Seeded From UniProt	complete
involved_in	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	PMID:20208559^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9Y3M8	P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	PMID:15467718^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:17488780^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	PMID:20208559^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9Y3M8	P		Seeded From UniProt	complete
involved_in	GO:1905244	regulation of modification of synaptic structure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0051924	regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
enables	GO:0051022	Rho GDP-dissociation inhibitor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	F		Seeded From UniProt	complete
involved_in	GO:0050773	regulation of dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0046039	GTP metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0045987	positive regulation of smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0030838	positive regulation of actin filament polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	F		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	C		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0008064	regulation of actin polymerization or depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:2000177	regulation of neural precursor cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:1904695	positive regulation of vascular smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0090324	negative regulation of oxidative phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0071803	positive regulation of podosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0061383	trabecula morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0046638	positive regulation of alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0043931	ossification involved in bone maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0043366	beta selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0043297	apical junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0043149	stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0042476	odontogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0033688	regulation of osteoblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	C		Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	C		Seeded From UniProt	complete
involved_in	GO:0021861	forebrain radial glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0021795	cerebral cortex cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0010975	regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0010812	negative regulation of cell-substrate adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0007519	skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0007160	cell-matrix adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	F		Seeded From UniProt	complete
involved_in	GO:0003100	regulation of systemic arterial blood pressure by endothelin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0002363	alpha-beta T cell lineage commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0001998	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUI0 ensembl:ENSMUSP00000007959	P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR003578 InterPro:IPR005225	F		Seeded From UniProt	complete
involved_in	GO:0007264	small GTPase mediated signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003578	P		Seeded From UniProt	complete
involved_in	GO:0051893	regulation of focal adhesion assembly	PMID:18981818^[36]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	PMID:10436159^[37]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	PMID:10436159^[37]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:10436159^[37]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000145	regulation of cell motility	Reactome:R-HSA-6785631	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0101003	ficolin-1-rich granule membrane	Reactome:R-HSA-6800426	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	Reactome:R-HSA-4086400	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051056	regulation of small GTPase mediated signal transduction	Reactome:R-HSA-194840	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050772	positive regulation of axonogenesis	Reactome:R-HSA-209563	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050771	negative regulation of axonogenesis	Reactome:R-HSA-193634	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	Reactome:R-HSA-198203	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	Reactome:R-HSA-2682334	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:R-HSA-194138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	Reactome:R-HSA-6798743	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	Reactome:R-NUL-2161165 Reactome:R-NUL-2161160 Reactome:R-NUL-2161147 Reactome:R-HSA-2160935 Reactome:R-HSA-2160932 Reactome:R-HSA-2160931	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	Reactome:R-HSA-2173791	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-350485 Reactome:R-HSA-9012761 Reactome:R-HSA-8985594 Reactome:R-HSA-8849085 Reactome:R-HSA-8849082 Reactome:R-HSA-6800426 Reactome:R-HSA-6798743 Reactome:R-HSA-6785648 Reactome:R-HSA-5671993 Reactome:R-HSA-5671970 Reactome:R-HSA-5667008 Reactome:R-HSA-5666216 Reactome:R-HSA-5666197 Reactome:R-HSA-5665989 Reactome:R-HSA-5665982 Reactome:R-HSA-5623667 Reactome:R-HSA-5623632 Reactome:R-HSA-5623622 Reactome:R-HSA-5228992 Reactome:R-HSA-419166 Reactome:R-HSA-419049 Reactome:R-HSA-416588 Reactome:R-HSA-416559 Reactome:R-HSA-3928651 Reactome:R-HSA-3928647 Reactome:R-HSA-3928592 Reactome:R-HSA-3928576 Reactome:R-HSA-202692 Reactome:R-HSA-194922 Reactome:R-HSA-194913 Reactome:R-HSA-194894 Reactome:R-HSA-194854 Reactome:R-HSA-194518 Reactome:R-HSA-193696 Reactome:R-HSA-193668 Reactome:R-HSA-193646 Reactome:R-HSA-114544	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5690843 Reactome:R-HSA-5228992 Reactome:R-HSA-5218826 Reactome:R-HSA-442314 Reactome:R-HSA-442291 Reactome:R-HSA-3858495 Reactome:R-HSA-195146 Reactome:R-HSA-194854	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-5672083 Reactome:R-HSA-5625959	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C		Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0467	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0291	C		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0469	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Wu, D et al. (2015) Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. J. Cereb. Blood Flow Metab. 35 412-23 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Raynaud, F et al. (2014) Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis. J. Biol. Chem. 289 2600-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Symons, M et al. (1996) Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 84 723-34 PubMed GONUTS page
↑ Longenecker, K et al. (2003) Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution. Acta Crystallogr. D Biol. Crystallogr. 59 876-80 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Kong, R et al. (2015) Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression. J. Clin. Invest. 125 4407-20 PubMed GONUTS page
↑ Araya, N et al. (2009) Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase. Int. J. Mol. Med. 24 605-11 PubMed GONUTS page
↑ ^7.0 ^7.1 Richter, K et al. (2009) Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. J. Biol. Chem. 284 30652-61 PubMed GONUTS page
↑ Ishizaki, T et al. (1996) The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J. 15 1885-93 PubMed GONUTS page
↑ ^9.0 ^9.1 Nemoto, Y et al. (1992) A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein. J. Biol. Chem. 267 20916-20 PubMed GONUTS page
↑ ^10.0 ^10.1 Elbediwy, A et al. (2012) Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. J. Cell Biol. 198 677-93 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Rougerie, P et al. (2013) Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration. J. Immunol. 190 748-55 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Yüce, O et al. (2005) An ECT2-centralspindlin complex regulates the localization and function of RhoA. J. Cell Biol. 170 571-82 PubMed GONUTS page
↑ ^13.0 ^13.1 Lee, HK et al. (2015) Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling. J. Biol. Chem. 290 14740-53 PubMed GONUTS page
↑ LaRock, DL et al. (2012) A Salmonella typhimurium-translocated glycerophospholipid:cholesterol acyltransferase promotes virulence by binding to the RhoA protein switch regions. J. Biol. Chem. 287 29654-63 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Christen, M et al. (2009) Activation of a bacterial virulence protein by the GTPase RhoA. Sci Signal 2 ra71 PubMed GONUTS page
↑ Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
↑ Xie, X et al. (2005) TIM, a Dbl-related protein, regulates cell shape and cytoskeletal organization in a Rho-dependent manner. Cell. Signal. 17 461-71 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Chen, Y et al. (2009) Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol. Cell 35 841-55 PubMed GONUTS page
↑ ^19.0 ^19.1 Riches, K et al. (2013) Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms. Int. J. Biochem. Cell Biol. 45 1776-83 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ Chen, S et al. (2012) Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Neurochem. Res. 37 2805-13 PubMed GONUTS page
↑ Aoki, T et al. (2009) Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10. BMC Cell Biol. 10 56 PubMed GONUTS page
↑ ^25.0 ^25.1 Wallace, SW et al. (2011) The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. Mol. Cell. Biol. 31 81-91 PubMed GONUTS page
↑ ^26.0 ^26.1 Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
↑ Wolf, A et al. (2006) The armadillo protein p0071 regulates Rho signalling during cytokinesis. Nat. Cell Biol. 8 1432-40 PubMed GONUTS page
↑ Bristow, JM et al. (2009) The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration. J. Cell. Sci. 122 4535-46 PubMed GONUTS page
↑ Saeki, N et al. (2005) BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. J. Biol. Chem. 280 10128-34 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Murakoshi, H et al. (2011) Local, persistent activation of Rho GTPases during plasticity of single dendritic spines. Nature 472 100-4 PubMed GONUTS page
↑ ^31.00 ^31.01 ^31.02 ^31.03 ^31.04 ^31.05 ^31.06 ^31.07 ^31.08 ^31.09 ^31.10 ^31.11 ^31.12 ^31.13 ^31.14 ^31.15 ^31.16 ^31.17 ^31.18 ^31.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Shen, CH et al. (2008) Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. Cancer Res. 68 7779-87 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 Lin, Y et al. (2010) DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Oncogene 29 3010-6 PubMed GONUTS page
↑ Jacinto, E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6 1122-8 PubMed GONUTS page
↑ Berto, G et al. (2007) The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase. J. Cell. Sci. 120 1859-67 PubMed GONUTS page
↑ Jeon, YJ et al. (2008) Interaction of microglia and amyloid-beta through beta2-integrin is regulated by RhoA. Neuroreport 19 1661-5 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 Maekawa, M et al. (1999) Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285 895-8 PubMed GONUTS page

[PMID:25515214-1] 1.0 ^1.1 ^1.2 Wu, D et al. (2015) Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. J. Cereb. Blood Flow Metab. 35 412-23 PubMed GONUTS page

[PMID:24352656-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Raynaud, F et al. (2014) Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis. J. Biol. Chem. 289 2600-9 PubMed GONUTS page

[PMID:8625410-3] 3.0 ^3.1 Symons, M et al. (1996) Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 84 723-34 PubMed GONUTS page

[PMID:12777804-4] Longenecker, K et al. (2003) Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution. Acta Crystallogr. D Biol. Crystallogr. 59 876-80 PubMed GONUTS page

[PMID:26529257-5] 5.0 ^5.1 ^5.2 ^5.3 Kong, R et al. (2015) Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression. J. Clin. Invest. 125 4407-20 PubMed GONUTS page

[PMID:19787194-6] Araya, N et al. (2009) Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase. Int. J. Mol. Med. 24 605-11 PubMed GONUTS page

[PMID:19734146-7] 7.0 ^7.1 Richter, K et al. (2009) Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. J. Biol. Chem. 284 30652-61 PubMed GONUTS page

[PMID:8617235-8] Ishizaki, T et al. (1996) The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J. 15 1885-93 PubMed GONUTS page

[PMID:1328215-9] 9.0 ^9.1 Nemoto, Y et al. (1992) A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein. J. Biol. Chem. 267 20916-20 PubMed GONUTS page

[PMID:22891260-10] 10.0 ^10.1 Elbediwy, A et al. (2012) Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. J. Cell Biol. 198 677-93 PubMed GONUTS page

[PMID:23241886-11] 11.0 ^11.1 ^11.2 Rougerie, P et al. (2013) Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration. J. Immunol. 190 748-55 PubMed GONUTS page

[PMID:16103226-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Yüce, O et al. (2005) An ECT2-centralspindlin complex regulates the localization and function of RhoA. J. Cell Biol. 170 571-82 PubMed GONUTS page

[PMID:25911094-13] 13.0 ^13.1 Lee, HK et al. (2015) Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling. J. Biol. Chem. 290 14740-53 PubMed GONUTS page

[PMID:22740689-14] LaRock, DL et al. (2012) A Salmonella typhimurium-translocated glycerophospholipid:cholesterol acyltransferase promotes virulence by binding to the RhoA protein switch regions. J. Biol. Chem. 287 29654-63 PubMed GONUTS page

[PMID:19887681-15] 15.0 ^15.1 ^15.2 Christen, M et al. (2009) Activation of a bacterial virulence protein by the GTPase RhoA. Sci Signal 2 ra71 PubMed GONUTS page

[PMID:24431302-16] Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

[PMID:15601624-17] Xie, X et al. (2005) TIM, a Dbl-related protein, regulates cell shape and cytoskeletal organization in a Rho-dependent manner. Cell. Signal. 17 461-71 PubMed GONUTS page

[PMID:19782033-18] 18.0 ^18.1 ^18.2 Chen, Y et al. (2009) Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol. Cell 35 841-55 PubMed GONUTS page

[PMID:23726972-19] 19.0 ^19.1 Riches, K et al. (2013) Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms. Int. J. Biochem. Cell Biol. 45 1776-83 PubMed GONUTS page

[PMID:21423176-20] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:19056867-21] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-22] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:22926577-23] Chen, S et al. (2012) Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Neurochem. Res. 37 2805-13 PubMed GONUTS page

[PMID:19635168-24] Aoki, T et al. (2009) Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10. BMC Cell Biol. 10 56 PubMed GONUTS page

[PMID:20974804-25] 25.0 ^25.1 Wallace, SW et al. (2011) The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. Mol. Cell. Biol. 31 81-91 PubMed GONUTS page

[PMID:12761501-26] 26.0 ^26.1 Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page

[PMID:17115030-27] Wolf, A et al. (2006) The armadillo protein p0071 regulates Rho signalling during cytokinesis. Nat. Cell Biol. 8 1432-40 PubMed GONUTS page

[PMID:19934221-28] Bristow, JM et al. (2009) The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration. J. Cell. Sci. 122 4535-46 PubMed GONUTS page

[PMID:15644318-29] Saeki, N et al. (2005) BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. J. Biol. Chem. 280 10128-34 PubMed GONUTS page

[PMID:21423166-30] 30.0 ^30.1 ^30.2 Murakoshi, H et al. (2011) Local, persistent activation of Rho GTPases during plasticity of single dendritic spines. Nature 472 100-4 PubMed GONUTS page

[PMID:21873635-31] 31.00 ^31.01 ^31.02 ^31.03 ^31.04 ^31.05 ^31.06 ^31.07 ^31.08 ^31.09 ^31.10 ^31.11 ^31.12 ^31.13 ^31.14 ^31.15 ^31.16 ^31.17 ^31.18 ^31.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18829532-32] Shen, CH et al. (2008) Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. Cancer Res. 68 7779-87 PubMed GONUTS page

[PMID:20208559-33] 33.0 ^33.1 ^33.2 Lin, Y et al. (2010) DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Oncogene 29 3010-6 PubMed GONUTS page

[PMID:15467718-34] Jacinto, E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6 1122-8 PubMed GONUTS page

[PMID:17488780-35] Berto, G et al. (2007) The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase. J. Cell. Sci. 120 1859-67 PubMed GONUTS page

[PMID:18981818-36] Jeon, YJ et al. (2008) Interaction of microglia and amyloid-beta through beta2-integrin is regulated by RhoA. Neuroreport 19 1661-5 PubMed GONUTS page

[PMID:10436159-37] 37.0 ^37.1 ^37.2 Maekawa, M et al. (1999) Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285 895-8 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

HUMAN:RHOA

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

l

m

n

o

p

r

s

t

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools