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HUMAN:RBM10

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RBM10 (synonyms: DXS8237E, GPATC9, GPATCH9, KIAA0122)
Protein Name(s) RNA-binding protein 10

G patch domain-containing protein 9 RNA-binding motif protein 10 RNA-binding protein S1-1 S1-1

External Links
UniProt P98175
EMBL D50912
AK292758
AL137421
AL513366
CH471164
CH471164
CH471164
CH471164
BC003089
BC004181
BC008733
BC024153
U35373
CCDS CCDS14274.1
CCDS56600.1
CCDS78478.1
RefSeq NP_001191395.1
NP_001191396.1
NP_005667.2
NP_690595.1
UniGene Hs.401509
PDB 2LXI
2M2B
2MXV
2MXW
PDBsum 2LXI
2M2B
2MXV
2MXW
ProteinModelPortal P98175
SMR P98175
BioGrid 113869
IntAct P98175
MINT MINT-2864879
STRING 9606.ENSP00000366829
iPTMnet P98175
PhosphoSitePlus P98175
BioMuta RBM10
DMDM 218512116
EPD P98175
MaxQB P98175
PaxDb P98175
PeptideAtlas P98175
PRIDE P98175
DNASU 8241
Ensembl ENST00000345781
ENST00000377604
ENST00000628161
GeneID 8241
KEGG hsa:8241
UCSC uc004dhf.4
CTD 8241
DisGeNET 8241
GeneCards RBM10
HGNC HGNC:9896
HPA HPA034972
HPA057372
MalaCards RBM10
MIM 300080
311900
neXtProt NX_P98175
OpenTargets ENSG00000182872
Orphanet 2886
PharmGKB PA34259
eggNOG KOG0154
ENOG410YNFQ
GeneTree ENSGT00510000046476
HOVERGEN HBG000318
InParanoid P98175
KO K13094
PhylomeDB P98175
TreeFam TF315789
ChiTaRS RBM10
GeneWiki RBM10
GenomeRNAi 8241
PRO PR:P98175
Proteomes UP000005640
Bgee ENSG00000182872
CleanEx HS_RBM10
ExpressionAtlas P98175
Genevisible P98175
GO GO:0016607
GO:0005634
GO:0042802
GO:0000166
GO:0032403
GO:0003723
GO:0008270
GO:0006397
GO:0000381
GO:0042981
GO:0008380
Gene3D 3.30.70.330
4.10.1060.10
InterPro IPR000467
IPR012677
IPR033095
IPR000504
IPR013087
IPR001876
PANTHER PTHR13948:SF33
Pfam PF01585
PF00076
PF00641
SMART SM00443
SM00360
SM00547
SUPFAM SSF54928
SSF90209
PROSITE PS50174
PS50102
PS01358
PS50199
PS50157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0035198

miRNA binding

PMID:28431233[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000054

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:17707232[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P52732,UniProtKB:Q5VVJ2,UniProtKB:Q92831

C

Seeded From UniProt

complete

involved_in

GO:0008150

biological_process

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22365833[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P98175

F

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070935

3'-UTR-mediated mRNA stabilization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99KG3
ensembl:ENSMUSP00000111032

P

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:28091594[5]

ECO:0000314

C

Following transfection of HEK293 cells with RBM10-EGFP WT, the fusion protein was readily detected by western blot analysis (Fig. 4b) and predominantly localized to the nucleus (Fig. 4c)

complete
CACAO 12835

involved_in

GO:0048025

negative regulation of mRNA splicing, via spliceosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99KG3
ensembl:ENSMUSP00000111032

P

Seeded From UniProt

complete

involved_in

GO:0034393

positive regulation of smooth muscle cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99KG3
ensembl:ENSMUSP00000111032

P

Seeded From UniProt

complete

involved_in

GO:0034391

regulation of smooth muscle cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99KG3
ensembl:ENSMUSP00000111032

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99KG3
ensembl:ENSMUSP00000111032

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99KG3
ensembl:ENSMUSP00000111032

P

Seeded From UniProt

complete

involved_in

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033095

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000467
InterPro:IPR000504
InterPro:IPR013087
InterPro:IPR035979

F

Seeded From UniProt

complete

involved_in

GO:0008380

RNA splicing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033095

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033095

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0008380

RNA splicing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0508

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Treiber, T et al. (2017) A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Mol. Cell 66 270-284.e13 PubMed GONUTS page
  2. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  3. ↑ Zhu, P et al. (2007) A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. Mol. Cell 27 609-21 PubMed GONUTS page
  4. ↑ Hegele, A et al. (2012) Dynamic protein-protein interaction wiring of the human spliceosome. Mol. Cell 45 567-80 PubMed GONUTS page
  5. ↑ Zhao, J et al. (2017) Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing. Sci Rep 7 40488 PubMed GONUTS page
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