HUMAN:RAN

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RAN (synonyms: ARA24)
Protein Name(s)	GTP-binding nuclear protein Ran Androgen receptor-associated protein 24 GTPase Ran Ras-like protein TC4 Ras-related nuclear protein
External Links
UniProt	P62826
EMBL	M31469 AF052578 AF054183 AF501887 BT007271 CR450347 AK290763 AK312466 CH471054 BC004272 BC014518 BC014901 BC016654 BC051908 BC072000 AB062399
CCDS	CCDS9271.1
PIR	A44393
RefSeq	NP_001287725.1 NP_001287726.1 NP_006316.1
UniGene	Hs.10842
PDB	1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 2MMC 2MMG 2N1B 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4C0Q 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4 4OL0 4WVF 5CIQ 5CIT 5CIW 5CJ2 5CLL 5CLQ 5DH9 5DHA 5DHF 5DI9 5DIF 5DIS 5DLQ 5FYQ 5JLJ
PDBsum	1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 2MMC 2MMG 2N1B 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4C0Q 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4 4OL0 4WVF 5CIQ 5CIT 5CIW 5CJ2 5CLL 5CLQ 5DH9 5DHA 5DHF 5DI9 5DIF 5DIS 5DLQ 5FYQ 5JLJ
ProteinModelPortal	P62826
SMR	P62826
BioGrid	111837
DIP	DIP-5929N
IntAct	P62826
MINT	MINT-94188
STRING	9606.ENSP00000376176
DrugBank	DB04315
TCDB	9.A.60.1.1
iPTMnet	P62826
PhosphoSitePlus	P62826
SwissPalm	P62826
BioMuta	RAN
DMDM	51338598
OGP	P62826
REPRODUCTION-2DPAGE	P62826
UCD-2DPAGE	P62826
EPD	P62826
MaxQB	P62826
PaxDb	P62826
PeptideAtlas	P62826
PRIDE	P62826
TopDownProteomics	P62826
DNASU	5901
Ensembl	ENST00000392369 ENST00000543796
GeneID	5901
KEGG	hsa:5901
UCSC	uc001uir.4
CTD	5901
DisGeNET	5901
GeneCards	RAN
HGNC	HGNC:9846
HPA	HPA063353
MIM	601179
neXtProt	NX_P62826
OpenTargets	ENSG00000132341
PharmGKB	PA34205
eggNOG	KOG0096 ENOG410XNRS
GeneTree	ENSGT00840000129836
HOVERGEN	HBG107376
InParanoid	P62826
KO	K07936
PhylomeDB	P62826
TreeFam	TF106302
Reactome	[www.reactome.org/content/detail/R-HSA-165054 R-HSA-165054] [www.reactome.org/content/detail/R-HSA-1655829 R-HSA-1655829] [www.reactome.org/content/detail/R-HSA-168333 R-HSA-168333] [www.reactome.org/content/detail/R-HSA-180746 R-HSA-180746] [www.reactome.org/content/detail/R-HSA-203927 R-HSA-203927] [www.reactome.org/content/detail/R-HSA-5578749 R-HSA-5578749] [www.reactome.org/content/detail/R-HSA-6784531 R-HSA-6784531]
SignaLink	P62826
SIGNOR	P62826
ChiTaRS	RAN
EvolutionaryTrace	P62826
GeneWiki	Ran_(biology)
GenomeRNAi	5901
PRO	PR:P62826
Proteomes	UP000005640
Bgee	ENSG00000132341
ExpressionAtlas	P62826
Genevisible	P62826
GO	GO:0005814 GO:0005737 GO:0005829 GO:0070062 GO:0031012 GO:0001673 GO:0002177 GO:0042470 GO:0016020 GO:0030496 GO:0005643 GO:0005730 GO:0005654 GO:0005634 GO:0055037 GO:0042565 GO:0036126 GO:0050681 GO:0045296 GO:0003682 GO:0019003 GO:0005525 GO:0003924 GO:0003723 GO:0003713 GO:0030036 GO:0030521 GO:0051301 GO:0034629 GO:0071389 GO:0006259 GO:0031047 GO:0021766 GO:0075733 GO:0007067 GO:0007052 GO:0032092 GO:0045893 GO:0035281 GO:0006611 GO:0006606 GO:0000060 GO:1902570 GO:0071806 GO:0000055 GO:0000056 GO:0007264 GO:0007286 GO:0006409 GO:0016032
Gene3D	3.40.50.300
InterPro	IPR027417 IPR002041 IPR005225 IPR001806
Pfam	PF00071
PRINTS	PR00627
SUPFAM	SSF52540
TIGRFAMs	TIGR00231
PROSITE	PS51418

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0061015	snRNA import into nucleus	PMID:8636225^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:8636225^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	PMID:8636225^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000070	mitotic sister chromatid segregation	PMID:29040603^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:29040603^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:26272610^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046039	GTP metabolic process	PMID:26272610^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	PMID:26272610^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	PMID:18691641^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P61266-2)	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:27541860^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	PMID:27541860^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:27541860^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9822603^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	PMID:11336674^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:11336674^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	PMID:11336674^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:11336674^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:11336674^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P18754	F		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	PMID:9822603^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:10557333^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0005049	nuclear export signal receptor activity	PMID:14681208^[10]	ECO:0000305	curator inference used in manual assertion	GO:0042565 GO:0070883	F		Seeded From UniProt	complete
NOT\|part_of	GO:0090543	Flemming body	PMID:19166812^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:19166812^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:19166812^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902570	protein localization to nucleolus	PMID:18938132^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P40121)	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:18938132^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:18938132^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	PMID:18938132^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:18938132^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035281	pre-miRNA export from nucleus	PMID:14681208^[10]	ECO:0000305	curator inference used in manual assertion	GO:0042565 GO:0070883	P		Seeded From UniProt	complete
contributes_to	GO:0070883	pre-miRNA binding	PMID:14681208^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0042565	RNA nuclear export complex	PMID:14681208^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	PMID:24561039^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000087)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[14]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000056	ribosomal small subunit export from nucleus	PMID:12773398^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000055	ribosomal large subunit export from nucleus	PMID:12773398^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[16]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[17]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[18]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:16449645^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006611	protein export from nucleus	PMID:16449645^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	PMID:15572661^[20]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15572661^[20]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[21]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[22]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	PMID:15572661^[20]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:1961752^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	PMID:8421051^[24]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:1961752^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0000785	chromatin	PMID:1961752^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1333112 PANTHER:PTN000632582 UniProtKB:P62826	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0020255 FB:FBgn0036497 MGI:MGI:1333112 PANTHER:PTN000632582 RGD:620367 TAIR:locus:2147715 UniProtKB:P62826	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0020255 MGI:MGI:1333112 PANTHER:PTN000632582 RGD:620367 SGD:S000004284 SGD:S000005711 TAIR:locus:2147715 UniProtKB:P62826	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632582 PomBase:SPBC1289.03c SGD:S000004284 SGD:S000005711 UniProtKB:P62826	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:26308891^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26308891^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043657	host cell	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0075733	C		Seeded From UniProt	complete
involved_in	GO:0034629	cellular protein-containing complex localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62827 ensembl:ENSMUSP00000106975	P		Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62827 ensembl:ENSMUSP00000106975	P		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62827 ensembl:ENSMUSP00000106975	P		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62827 ensembl:ENSMUSP00000106975	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62827 ensembl:ENSMUSP00000106975	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62827 ensembl:ENSMUSP00000106975	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62827 ensembl:ENSMUSP00000106975	C		Seeded From UniProt	complete
involved_in	GO:0071389	cellular response to mineralocorticoid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	P		Seeded From UniProt	complete
enables	GO:0061676	importin-alpha family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	F		Seeded From UniProt	complete
enables	GO:0045505	dynein intermediate chain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	F		Seeded From UniProt	complete
involved_in	GO:0043393	regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	P		Seeded From UniProt	complete
part_of	GO:0036126	sperm flagellum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	C		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	F		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	P		Seeded From UniProt	complete
involved_in	GO:0007286	spermatid development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	C		Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	F		Seeded From UniProt	complete
part_of	GO:0002177	manchette	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	C		Seeded From UniProt	complete
part_of	GO:0001673	male germ cell nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P62828 ensembl:ENSRNOP00000001247	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR002041	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR002041 InterPro:IPR005225	F		Seeded From UniProt	complete
involved_in	GO:0006913	nucleocytoplasmic transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002041	P		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:8421051^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007052	mitotic spindle organization	PMID:10408446^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006259	DNA metabolic process	PMID:8421051^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:10400640^[28] Reactome:R-HSA-165055	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:1961752^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0075733	intracellular transport of virus	Reactome:R-HSA-168880	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045540	regulation of cholesterol biosynthetic process	Reactome:R-HSA-1655829	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	Reactome:R-HSA-162599	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010586	miRNA metabolic process	Reactome:R-HSA-203927	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006409	tRNA export from nucleus	Reactome:R-HSA-6785478	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-6783483 Reactome:R-HSA-5578744 Reactome:R-HSA-203906 Reactome:R-HSA-180739 Reactome:R-HSA-168880 Reactome:R-HSA-165055 Reactome:R-HSA-165047 Reactome:R-HSA-165028	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6785478 Reactome:R-HSA-6783483 Reactome:R-HSA-5578744 Reactome:R-HSA-2065539 Reactome:R-HSA-203922 Reactome:R-HSA-203906 Reactome:R-HSA-180736 Reactome:R-HSA-180728 Reactome:R-HSA-180687 Reactome:R-HSA-168880 Reactome:R-HSA-165047 Reactome:R-HSA-165043 Reactome:R-HSA-165034	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0178	C		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0161	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Palacios, I et al. (1996) RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus. J. Cell Biol. 133 485-94 PubMed GONUTS page
↑ ^2.0 ^2.1 Bao, X et al. (2018) Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation. J Mol Cell Biol 10 18-32 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Rudack, T et al. (2015) Catalysis of GTP hydrolysis by small GTPases at atomic detail by integration of X-ray crystallography, experimental, and theoretical IR spectroscopy. J. Biol. Chem. 290 24079-90 PubMed GONUTS page
↑ Pereira, S et al. (2008) Nuclear localization of a novel human syntaxin 1B isoform. Gene 423 160-71 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Vijayaraghavan, B et al. (2016) Samp1, a RanGTP binding transmembrane protein in the inner nuclear membrane. Nucleus 7 415-23 PubMed GONUTS page
↑ ^6.0 ^6.1 Ribbeck, K et al. (1998) NTF2 mediates nuclear import of Ran. EMBO J. 17 6587-98 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Renault, L et al. (2001) Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). Cell 105 245-55 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ Yang, J et al. (1999) An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein. Proc. Natl. Acad. Sci. U.S.A. 96 13404-8 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Yi, R et al. (2003) Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17 3011-6 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Hubert, T et al. (2009) The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle. Biochem. Biophys. Res. Commun. 380 166-70 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Hubert, T et al. (2008) The F-actin filament capping protein CapG is a bona fide nucleolar protein. Biochem. Biophys. Res. Commun. 377 699-704 PubMed GONUTS page
↑ Hehnly, H & Doxsey, S (2014) Rab11 endosomes contribute to mitotic spindle organization and orientation. Dev. Cell 28 497-507 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^15.0 ^15.1 Trotta, CR et al. (2003) Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates. EMBO J. 22 2841-51 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ ^19.0 ^19.1 Kurisaki, A et al. (2006) The mechanism of nuclear export of Smad3 involves exportin 4 and Ran. Mol. Cell. Biol. 26 1318-32 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Bischoff, FR & Ponstingl, H (1991) Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide. Proc. Natl. Acad. Sci. U.S.A. 88 10830-4 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Ren, M et al. (1993) Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis. J. Cell Biol. 120 313-23 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^26.0 ^26.1 Zhang, K et al. (2015) The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature 525 56-61 PubMed GONUTS page
↑ Carazo-Salas, RE et al. (1999) Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature 400 178-81 PubMed GONUTS page
↑ Hsiao, PW et al. (1999) The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator. J. Biol. Chem. 274 20229-34 PubMed GONUTS page

[PMID:8636225-1] 1.0 ^1.1 ^1.2 Palacios, I et al. (1996) RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus. J. Cell Biol. 133 485-94 PubMed GONUTS page

[PMID:29040603-2] 2.0 ^2.1 Bao, X et al. (2018) Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation. J Mol Cell Biol 10 18-32 PubMed GONUTS page

[PMID:26272610-3] 3.0 ^3.1 ^3.2 Rudack, T et al. (2015) Catalysis of GTP hydrolysis by small GTPases at atomic detail by integration of X-ray crystallography, experimental, and theoretical IR spectroscopy. J. Biol. Chem. 290 24079-90 PubMed GONUTS page

[PMID:18691641-4] Pereira, S et al. (2008) Nuclear localization of a novel human syntaxin 1B isoform. Gene 423 160-71 PubMed GONUTS page

[PMID:27541860-5] 5.0 ^5.1 ^5.2 Vijayaraghavan, B et al. (2016) Samp1, a RanGTP binding transmembrane protein in the inner nuclear membrane. Nucleus 7 415-23 PubMed GONUTS page

[PMID:9822603-6] 6.0 ^6.1 Ribbeck, K et al. (1998) NTF2 mediates nuclear import of Ran. EMBO J. 17 6587-98 PubMed GONUTS page

[PMID:11336674-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Renault, L et al. (2001) Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). Cell 105 245-55 PubMed GONUTS page

[PMID:25468996-8] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:10557333-9] Yang, J et al. (1999) An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein. Proc. Natl. Acad. Sci. U.S.A. 96 13404-8 PubMed GONUTS page

[PMID:14681208-10] 10.0 ^10.1 ^10.2 ^10.3 Yi, R et al. (2003) Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17 3011-6 PubMed GONUTS page

[PMID:19166812-11] 11.0 ^11.1 ^11.2 Hubert, T et al. (2009) The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle. Biochem. Biophys. Res. Commun. 380 166-70 PubMed GONUTS page

[PMID:18938132-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Hubert, T et al. (2008) The F-actin filament capping protein CapG is a bona fide nucleolar protein. Biochem. Biophys. Res. Commun. 377 699-704 PubMed GONUTS page

[PMID:24561039-13] Hehnly, H & Doxsey, S (2014) Rab11 endosomes contribute to mitotic spindle organization and orientation. Dev. Cell 28 497-507 PubMed GONUTS page

[PMID:19946888-14] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:12773398-15] 15.0 ^15.1 Trotta, CR et al. (2003) Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates. EMBO J. 22 2841-51 PubMed GONUTS page

[PMID:19056867-16] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-17] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:21630459-18] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:16449645-19] 19.0 ^19.1 Kurisaki, A et al. (2006) The mechanism of nuclear export of Smad3 involves exportin 4 and Ran. Mol. Cell. Biol. 26 1318-32 PubMed GONUTS page

[PMID:15572661-20] 20.0 ^20.1 ^20.2 Lin, DY et al. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24 10529-41 PubMed GONUTS page

[PMID:22681889-21] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:22658674-22] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:1961752-23] 23.0 ^23.1 ^23.2 ^23.3 Bischoff, FR & Ponstingl, H (1991) Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide. Proc. Natl. Acad. Sci. U.S.A. 88 10830-4 PubMed GONUTS page

[PMID:8421051-24] 24.0 ^24.1 ^24.2 Ren, M et al. (1993) Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis. J. Cell Biol. 120 313-23 PubMed GONUTS page

[PMID:21873635-25] 25.0 ^25.1 ^25.2 ^25.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26308891-26] 26.0 ^26.1 Zhang, K et al. (2015) The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature 525 56-61 PubMed GONUTS page

[PMID:10408446-27] Carazo-Salas, RE et al. (1999) Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature 400 178-81 PubMed GONUTS page

[PMID:10400640-28] Hsiao, PW et al. (1999) The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator. J. Biol. Chem. 274 20229-34 PubMed GONUTS page

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