HUMAN:Q6I9V6

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CDKN1B (ECO:0000313 with EMBL:CAG33680.1)
Protein Name(s)	CDKN1B protein (ECO:0000313 with EMBL:CAG33680.1) Cyclin-dependent kinase inhibitor 1B (ECO:0000313 with EMBL:BAG70105.1) Cyclin-dependent kinase inhibitor 1B (P27, Kip1), isoform CRA_a (ECO:0000313 with EMBL:EAW96275.1) cDNA, FLJ92816, Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1)(CDKN1B), mRNA (ECO:0000313 with EMBL:BAG35368.1)
External Links
UniProt	Q6I9V6
EMBL	AK312461 AB451291 AB451423 CR457399 CH471094
RefSeq	NP_004055.1
SMR	Q6I9V6
PRIDE	Q6I9V6
DNASU	1027
GeneID	1027
KEGG	hsa:1027
UCSC	uc001rat.3
CTD	1027
PharmGKB	PA105
eggNOG	KOG4743 ENOG410XXN5
KO	K06624
OMA	YPKPSAC
OrthoDB	1595421at2759
ChiTaRS	CDKN1B
GenomeRNAi	1027
Bgee	ENSG00000111276
GO	GO:0005829 GO:0043231 GO:0005634 GO:0032991 GO:0051087 GO:0030332 GO:0004861 GO:0030544 GO:0016301 GO:0044877 GO:0008219 GO:0071236 GO:0071407 GO:0000082 GO:0007507 GO:0048839 GO:0071850 GO:0043066 GO:1905179 GO:0051271 GO:0060770 GO:0007219 GO:0001890 GO:0008284 GO:0045737 GO:0031116 GO:0006813 GO:0007096 GO:1902746 GO:0043200 GO:0046686 GO:0042493 GO:0032355 GO:0009749 GO:0001666 GO:0043434 GO:0007605
InterPro	IPR003175 IPR029843
PANTHER	PTHR10265:SF9
Pfam	PF02234

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	C	Seeded From UniProt
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	F	Seeded From UniProt
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:0008219	cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	C	Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	C	Seeded From UniProt
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:1905179	negative regulation of cardiac muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:1902746	regulation of lens fiber cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0071850	mitotic cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0071236	cellular response to antibiotic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0051271	negative regulation of cellular component movement	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0048839	inner ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0031116	positive regulation of microtubule polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
enables	GO:0030332	cyclin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	F	Seeded From UniProt
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0007096	regulation of exit from mitosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0006813	potassium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	C	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	C	Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	C	Seeded From UniProt
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	F	Seeded From UniProt
involved_in	GO:0001890	placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
enables	GO:0051087	chaperone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	F	Seeded From UniProt
involved_in	GO:0046686	response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	F	Seeded From UniProt
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003175 InterPro:IPR029843	F	Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003175 InterPro:IPR029843	C	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029843	C	Seeded From UniProt
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003175	P	Seeded From UniProt
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029843	P	Seeded From UniProt
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	C	Seeded From UniProt
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	F	Seeded From UniProt
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:0008219	cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	C	Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	C	Seeded From UniProt
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:1905179	negative regulation of cardiac muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:1902746	regulation of lens fiber cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0071850	mitotic cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0071236	cellular response to antibiotic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0051271	negative regulation of cellular component movement	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0048839	inner ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0031116	positive regulation of microtubule polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
enables	GO:0030332	cyclin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	F	Seeded From UniProt
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0007096	regulation of exit from mitosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0006813	potassium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	C	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	C	Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	C	Seeded From UniProt
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	F	Seeded From UniProt
involved_in	GO:0001890	placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt
enables	GO:0051087	chaperone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	F	Seeded From UniProt
involved_in	GO:0046686	response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	F	Seeded From UniProt
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P	Seeded From UniProt
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003175 InterPro:IPR029843	F	Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003175 InterPro:IPR029843	C	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029843	C	Seeded From UniProt
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003175	P	Seeded From UniProt
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029843	P	Seeded From UniProt
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt
	GO:0097472	cyclin-dependent protein kinase activity	PMID:31489901^[1]	ECO:0000180	clinical study evidence		F	Figure 1. Effects of increasing doses of gentamicin on NCI-N87 cells. (a) The cells were counted 24 and 72 h after treatment with increasing concentrations of the drug (0.25–2.0 mM) (lines referred to the ordinate on the right). Cell death was evaluated by trypan blue staining (histograms referred to the ordinate on the left). Ctr, untreated sample. (b) Cell viability was assessed by MTT method and expressed as a percentage relative to that of the control cells set at 100%. (c) FACS analysis. (d) CDKN1A, CDKN1B gene expression, data are referred to the gentamicin (GM)-untreated sample (control) set at 1.	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Albi, E et al. (2019) Gentamicin Targets Acid Sphingomyelinase in Cancer: The Case of the Human Gastric Cancer NCI-N87 Cells. Int J Mol Sci 20 PubMed GONUTS page

[PMID:31489901-1] Albi, E et al. (2019) Gentamicin Targets Acid Sphingomyelinase in Cancer: The Case of the Human Gastric Cancer NCI-N87 Cells. Int J Mol Sci 20 PubMed GONUTS page

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HUMAN:Q6I9V6

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