HUMAN:PTN11

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PTPN11 (synonyms: PTP2C, SHPTP2)
Protein Name(s)	Tyrosine-protein phosphatase non-receptor type 11 Protein-tyrosine phosphatase 1D PTP-1D Protein-tyrosine phosphatase 2C PTP-2C SH-PTP2 SHP-2 Shp2 SH-PTP3
External Links
UniProt	Q06124
EMBL	D13540 L03535 L07527 L08807 X70766 BT007106 AK289854 CH471054 BC008692
CCDS	CCDS58280.1 CCDS9163.1
PIR	JN0805
RefSeq	NP_002825.3 NP_542168.1 XP_006719589.1
UniGene	Hs.506852
PDB	2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 3ZM0 3ZM1 3ZM2 3ZM3 4DGP 4DGX 4GWF 4H1O 4H34 4JE4 4JEG 4JMG 4OHD 4OHE 4OHH 4OHI 4OHL
PDBsum	2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 3ZM0 3ZM1 3ZM2 3ZM3 4DGP 4DGX 4GWF 4H1O 4H34 4JE4 4JEG 4JMG 4OHD 4OHE 4OHH 4OHI 4OHL
ProteinModelPortal	Q06124
SMR	Q06124
BioGrid	111745
DIP	DIP-516N
IntAct	Q06124
MINT	MINT-199832
STRING	9606.ENSP00000340944
BindingDB	Q06124
ChEMBL	CHEMBL3864
DEPOD	Q06124
PhosphoSite	Q06124
DMDM	84028248
MaxQB	Q06124
PaxDb	Q06124
PRIDE	Q06124
DNASU	5781
Ensembl	ENST00000351677 ENST00000392597
GeneID	5781
KEGG	hsa:5781
UCSC	uc001ttw.1 uc001ttx.3
CTD	5781
GeneCards	GC12P112856
GeneReviews	PTPN11
HGNC	HGNC:9644
HPA	CAB005377
MIM	151100 156250 163950 176876 607785
neXtProt	NX_Q06124
Orphanet	86834 500 2499 648
PharmGKB	PA33986
eggNOG	COG5599
GeneTree	ENSGT00770000120452
HOGENOM	HOG000273907
HOVERGEN	HBG000223
InParanoid	Q06124
KO	K07293
OMA	KEYGAMR
OrthoDB	EOG7NPFST
PhylomeDB	Q06124
TreeFam	TF351632
Reactome	REACT_111040 REACT_111080 REACT_111184 REACT_115697 REACT_1183 REACT_12519 REACT_12578 REACT_12621 REACT_1391 REACT_147727 REACT_169118 REACT_17025 REACT_19324 REACT_19344 REACT_19405 REACT_21247 REACT_21270 REACT_22384 REACT_23837 REACT_23879 REACT_23916 REACT_24980 REACT_25148 REACT_25162 REACT_25216 REACT_27307 REACT_75829 REACT_976
SignaLink	Q06124
ChiTaRS	PTPN11
EvolutionaryTrace	Q06124
GeneWiki	PTPN11
GenomeRNAi	5781
NextBio	22484
PRO	PR:Q06124
Proteomes	UP000005640
Bgee	Q06124
CleanEx	HS_PTPN11
ExpressionAtlas	Q06124
Genevestigator	Q06124
GO	GO:0005737 GO:0005829 GO:0005739 GO:0005634 GO:0043234 GO:0005158 GO:0004726 GO:0004721 GO:0004725 GO:0005070 GO:0033277 GO:0000187 GO:0036302 GO:0007411 GO:0007596 GO:0007420 GO:0019221 GO:0000077 GO:0048013 GO:0007173 GO:0038127 GO:0060325 GO:0038095 GO:0008543 GO:0048806 GO:0042593 GO:0007507 GO:0042445 GO:0009755 GO:0045087 GO:0048839 GO:0008286 GO:0007229 GO:0060333 GO:0050900 GO:0035855 GO:0048609 GO:0033629 GO:0051463 GO:0060125 GO:0046676 GO:0048011 GO:0035265 GO:0035335 GO:0048015 GO:0030220 GO:2001275 GO:0046887 GO:0033628 GO:0060334 GO:0040014 GO:0046825 GO:0060338 GO:0031295 GO:0006641 GO:0060337
Gene3D	3.30.505.10 3.90.190.10
InterPro	IPR029021 IPR000980 IPR000387 IPR016130 IPR012152 IPR000242
Pfam	PF00017 PF00102
PIRSF	PIRSF000929
PRINTS	PR00700 PR00401
SMART	SM00194 SM00252
SUPFAM	SSF52799 SSF55550
PROSITE	PS50001 PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004725	protein tyrosine phosphatase activity	PMID:23029125^[1]	ECO:0000314			F		Figure 7	complete CACAO 6590
involved_in	GO:0046326	positive regulation of glucose import	PMID:7493946^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	PMID:12051764^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96P31	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	PMID:12051764^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:10206955^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35235	F	occurs_in:(CL:0000235) part_of:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35235	P	occurs_in:(CL:0000235) regulates_o_occurs_in:(CL:0000235) part_of:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35235	P	occurs_in:(CL:0000235) regulates_o_occurs_in:(CL:0000235) part_of:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35235	P	occurs_in:(CL:0000235) regulates_o_occurs_in:(CL:0000235) part_of:(GO:0071222)	Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	PMID:11986327^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96RL6	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:28074573^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:28074573^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	PMID:28074573^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17562706^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:17562706^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:17562706^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26742426^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:26742426^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:26742426^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005070	SH3/SH2 adaptor activity	PMID:7493946^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06213,UniProtKB:P35568	F		Seeded From UniProt	complete
involved_in	GO:0043254	regulation of protein complex assembly	PMID:7493946^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:23029125^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	PMID:7493946^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	positively_regulates:(GO:0046326)	Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	PMID:11704759^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	PMID:12058348^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048806	genitalia development	PMID:12058348^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	PMID:12058348^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:12058348^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:11704759^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	PMID:7493946^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06213-2	F		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	PMID:10655584^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038127	ERBB signaling pathway	PMID:15133037^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:10655584^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:15133037^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q14764) happens_during:(GO:0070849) occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0033628	regulation of cell adhesion mediated by integrin	PMID:10655584^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10940933^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15133037^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15133037^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	PMID:10655584^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:15133037^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	PMID:15133037^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:22759635^[14]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0061582	intestinal epithelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0060125	negative regulation of growth hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0060020	Bergmann glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0051463	negative regulation of cortisol secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	F		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	F		Seeded From UniProt	complete
involved_in	GO:0048873	homeostasis of number of cells within a tissue	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0048609	multicellular organismal reproductive process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0048011	neurotrophin TRK receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0046888	negative regulation of hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0046887	positive regulation of hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0046825	regulation of protein export from nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0042445	hormone metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0035855	megakaryocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0035265	organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0035264	multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0033629	negative regulation of cell adhesion mediated by integrin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0033277	abortive mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0032528	microvillus organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	F		Seeded From UniProt	complete
involved_in	GO:0030220	platelet formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0021697	cerebellar cortex formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	F		Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0009755	hormone-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0006641	triglyceride metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35235 ensembl:ENSMUSP00000058757	P		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	C		Seeded From UniProt	complete
enables	GO:0031748	D1 dopamine receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	C		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41499 ensembl:ENSRNOP00000041842	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR012152 InterPro:IPR016130	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR012152	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	Reactome:R-HSA-9008059	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	Reactome:R-HSA-1059683	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060338	regulation of type I interferon-mediated signaling pathway	Reactome:R-HSA-912694	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	Reactome:R-HSA-202733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	Reactome:R-HSA-388841	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	Reactome:R-HSA-76002	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-8854691 Reactome:R-HSA-512988	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:R-HSA-5654743 Reactome:R-HSA-5654741 Reactome:R-HSA-5654738 Reactome:R-HSA-5654736	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	Reactome:R-HSA-422475	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	Reactome:R-HSA-177929	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-997309 Reactome:R-HSA-914036 Reactome:R-HSA-909738 Reactome:R-HSA-8987236 Reactome:R-HSA-8987132 Reactome:R-HSA-8987070 Reactome:R-HSA-8987014 Reactome:R-HSA-8865994 Reactome:R-HSA-8855508 Reactome:R-HSA-5684169 Reactome:R-HSA-5654734 Reactome:R-HSA-5654730 Reactome:R-HSA-5654729 Reactome:R-HSA-5654714 Reactome:R-HSA-5654709 Reactome:R-HSA-5654697 Reactome:R-HSA-5654692 Reactome:R-HSA-5654684 Reactome:R-HSA-5654679 Reactome:R-HSA-5654677 Reactome:R-HSA-5654673 Reactome:R-HSA-5654672 Reactome:R-HSA-5654669 Reactome:R-HSA-5654667 Reactome:R-HSA-5654658 Reactome:R-HSA-5654655 Reactome:R-HSA-5654643 Reactome:R-HSA-5654641 Reactome:R-HSA-5654633 Reactome:R-HSA-5654631 Reactome:R-HSA-5654622 Reactome:R-HSA-5654620 Reactome:R-HSA-5654608 Reactome:R-HSA-5654607 Reactome:R-HSA-5654596 Reactome:R-HSA-5654594 Reactome:R-HSA-5654587 Reactome:R-HSA-5654584 Reactome:R-HSA-389941 Reactome:R-HSA-389759 Reactome:R-HSA-389758 Reactome:R-HSA-388829 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434 Reactome:R-HSA-210294 Reactome:R-HSA-205238 Reactome:R-HSA-205234 Reactome:R-HSA-204873 Reactome:R-HSA-186778 Reactome:R-HSA-177944 Reactome:R-HSA-177935 Reactome:R-HSA-177926 Reactome:R-HSA-177924 Reactome:R-HSA-177923 Reactome:R-HSA-1562641 Reactome:R-HSA-1549564 Reactome:R-HSA-1433514 Reactome:R-HSA-1433488 Reactome:R-HSA-1433454 Reactome:R-HSA-1433428 Reactome:R-HSA-1112708 Reactome:R-HSA-1112703 Reactome:R-HSA-1112690 Reactome:R-HSA-109699	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9008894 Reactome:R-HSA-8937767 Reactome:R-HSA-8937744	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	Reactome:R-HSA-177935 Reactome:R-HSA-177926 Reactome:R-HSA-177924 Reactome:R-HSA-177923	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	Reactome:R-HSA-997309 Reactome:R-HSA-914036 Reactome:R-HSA-389758 Reactome:R-HSA-1549564	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Mamik, MK & Ghorpade, A (2012) Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytes. PLoS ONE 7 e45596 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kharitonenkov, A et al. (1995) Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction. J. Biol. Chem. 270 29189-93 PubMed GONUTS page
↑ ^3.0 ^3.1 Xu, MJ et al. (2002) SPAP2, an Ig family receptor containing both ITIMs and ITAMs. Biochem. Biophys. Res. Commun. 293 1037-46 PubMed GONUTS page
↑ Taylor, VC et al. (1999) The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. J. Biol. Chem. 274 11505-12 PubMed GONUTS page
↑ Angata, T et al. (2002) Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. J. Biol. Chem. 277 24466-74 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Pannone, L et al. (2017) Structural, Functional, and Clinical Characterization of a Novel PTPN11 Mutation Cluster Underlying Noonan Syndrome. Hum. Mutat. 38 451-459 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Hoffmann, SC et al. (2007) Identification of CLEC12B, an inhibitory receptor on myeloid cells. J. Biol. Chem. 282 22370-5 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Noda, S et al. (2016) Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling. Biochem. Biophys. Res. Commun. 469 1133-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Tartaglia, M et al. (2001) Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat. Genet. 29 465-8 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Digilio, MC et al. (2002) Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene. Am. J. Hum. Genet. 71 389-94 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Miao, H et al. (2000) Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat. Cell Biol. 2 62-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Kolli, S et al. (2004) The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. J. Biol. Chem. 279 29374-85 PubMed GONUTS page
↑ Gjörloff-Wingren, A et al. (2000) Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Eur. J. Immunol. 30 2412-21 PubMed GONUTS page
↑ Huang, H et al. (2012) A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev. 26 1587-601 PubMed GONUTS page

[PMID:23029125-1] 1.0 ^1.1 Mamik, MK & Ghorpade, A (2012) Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytes. PLoS ONE 7 e45596 PubMed GONUTS page

[PMID:7493946-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kharitonenkov, A et al. (1995) Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction. J. Biol. Chem. 270 29189-93 PubMed GONUTS page

[PMID:12051764-3] 3.0 ^3.1 Xu, MJ et al. (2002) SPAP2, an Ig family receptor containing both ITIMs and ITAMs. Biochem. Biophys. Res. Commun. 293 1037-46 PubMed GONUTS page

[PMID:10206955-4] Taylor, VC et al. (1999) The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. J. Biol. Chem. 274 11505-12 PubMed GONUTS page

[PMID:11986327-5] Angata, T et al. (2002) Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. J. Biol. Chem. 277 24466-74 PubMed GONUTS page

[PMID:28074573-6] 6.0 ^6.1 ^6.2 Pannone, L et al. (2017) Structural, Functional, and Clinical Characterization of a Novel PTPN11 Mutation Cluster Underlying Noonan Syndrome. Hum. Mutat. 38 451-459 PubMed GONUTS page

[PMID:17562706-7] 7.0 ^7.1 ^7.2 Hoffmann, SC et al. (2007) Identification of CLEC12B, an inhibitory receptor on myeloid cells. J. Biol. Chem. 282 22370-5 PubMed GONUTS page

[PMID:26742426-8] 8.0 ^8.1 ^8.2 Noda, S et al. (2016) Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling. Biochem. Biophys. Res. Commun. 469 1133-9 PubMed GONUTS page

[PMID:11704759-9] 9.0 ^9.1 Tartaglia, M et al. (2001) Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat. Genet. 29 465-8 PubMed GONUTS page

[PMID:12058348-10] 10.0 ^10.1 ^10.2 ^10.3 Digilio, MC et al. (2002) Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene. Am. J. Hum. Genet. 71 389-94 PubMed GONUTS page

[PMID:10655584-11] 11.0 ^11.1 ^11.2 ^11.3 Miao, H et al. (2000) Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat. Cell Biol. 2 62-9 PubMed GONUTS page

[PMID:15133037-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Kolli, S et al. (2004) The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. J. Biol. Chem. 279 29374-85 PubMed GONUTS page

[PMID:10940933-13] Gjörloff-Wingren, A et al. (2000) Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Eur. J. Immunol. 30 2412-21 PubMed GONUTS page

[PMID:22759635-14] Huang, H et al. (2012) A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev. 26 1587-601 PubMed GONUTS page

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