HUMAN:PSA6

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PSMA6 (synonyms: PROS27)
Protein Name(s)	Proteasome subunit alpha type-6 27 kDa prosomal protein PROS-27 p27K Macropain iota chain Multicatalytic endopeptidase complex iota chain Proteasome iota chain
External Links
UniProt	P60900
EMBL	X59417 CR456944 AK298920 AK302008 AK313011 AK316223 AL121594 AL133163 CH471078 CH471078 BC002979 BC017882 BC022354 BC023659 BC070137 X61972
CCDS	CCDS61437.1 CCDS61438.1 CCDS9655.1
PIR	S30274
RefSeq	NP_001269161.1 NP_001269162.1 NP_001269163.1 NP_002782.1
UniGene	Hs.446260
ProteinModelPortal	P60900
SMR	P60900
BioGrid	111660
DIP	DIP-29367N
IntAct	P60900
MINT	MINT-5001118
STRING	9606.ENSP00000261479
ChEMBL	CHEMBL2364701
MEROPS	T01.971
PhosphoSite	P60900
DMDM	46397659
REPRODUCTION-2DPAGE	IPI00029623
SWISS-2DPAGE	P60900
UCD-2DPAGE	P60900
MaxQB	P60900
PaxDb	P60900
PeptideAtlas	P60900
PRIDE	P60900
DNASU	5687
Ensembl	ENST00000261479 ENST00000540871 ENST00000555764 ENST00000622405
GeneID	5687
KEGG	hsa:5687
UCSC	uc001wtd.3
CTD	5687
GeneCards	GC14P035747
HGNC	HGNC:9535
HPA	HPA003049
MIM	602855
neXtProt	NX_P60900
PharmGKB	PA33880
eggNOG	COG0638
GeneTree	ENSGT00550000074807
HOGENOM	HOG000091084
HOVERGEN	HBG107363
InParanoid	P60900
KO	K02730
PhylomeDB	P60900
TreeFam	TF106210
Reactome	REACT_11063 REACT_111056 REACT_111178 REACT_1156 REACT_118656 REACT_1221 REACT_13464 REACT_13565 REACT_150471 REACT_1614 REACT_172638 REACT_1949 REACT_200766 REACT_200841 REACT_20549 REACT_206597 REACT_228111 REACT_228209 REACT_231645 REACT_25325 REACT_267605 REACT_4 REACT_6761 REACT_6785 REACT_6821 REACT_6871 REACT_75842 REACT_9003 REACT_9031 REACT_9453
GeneWiki	PSMA6
GenomeRNAi	5687
NextBio	22090
PRO	PR:P60900
Proteomes	UP000005640
Bgee	P60900
CleanEx	HS_PSMA6
ExpressionAtlas	P60900
Genevestigator	P60900
GO	GO:0005737 GO:0000932 GO:0005829 GO:0070062 GO:0030016 GO:0016363 GO:0005654 GO:0005634 GO:0005844 GO:0000502 GO:0005839 GO:0019773 GO:0030017 GO:0004175 GO:0051059 GO:0035639 GO:0003723 GO:0004298 GO:0031145 GO:0042590 GO:0002479 GO:0002474 GO:0006915 GO:0034641 GO:0006977 GO:0000082 GO:0010467 GO:0000278 GO:0016071 GO:0043066 GO:0051436 GO:0051092 GO:0051437 GO:0000209 GO:0051603 GO:0042981 GO:0006521 GO:0050727 GO:0051439 GO:0016070 GO:0044281 GO:0016032
Gene3D	3.60.20.10
InterPro	IPR029055 IPR000426 IPR023332 IPR001353
Pfam	PF00227 PF10584
SMART	SM00948
SUPFAM	SSF56235
PROSITE	PS00388 PS51475

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0000502	proteasome complex	PMID:17323924^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
involved_in	GO:0051603	proteolysis involved in cellular protein catabolic process	PMID:16845397^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:16845397^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	PMID:14743216^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00653-2	F		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	PMID:16845397^[4]	ECO:0000305	curator inference used in manual assertion	GO:0051092	P		Seeded From UniProt	complete
enables	GO:0035639	purine ribonucleoside triphosphate binding	PMID:7681138^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60901	C		Seeded From UniProt	complete
part_of	GO:0030016	myofibril	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60901	C		Seeded From UniProt	complete
part_of	GO:0019773	proteasome core complex, alpha-subunit complex	PMID:9096325^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUM9	C		Seeded From UniProt	complete
part_of	GO:0005844	polysome	PMID:7681138^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7681138^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:7681138^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0019773	proteasome core complex, alpha-subunit complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40302	C		Seeded From UniProt	complete
part_of	GO:0005839	proteasome core complex	PMID:1888762^[8]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005839	proteasome core complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUM9	C		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:7681138^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:7681138^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUM9	C		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002284 FB:FBgn0016697 FB:FBgn0023174 FB:FBgn0023175 FB:FBgn0026380 FB:FBgn0029134 FB:FBgn0032596 FB:FBgn0086134 FB:FBgn0263121 MGI:MGI:1194513 PANTHER:PTN000174701 SGD:S000000137 SGD:S000000814 SGD:S000000896 SGD:S000001946 SGD:S000002979 SGD:S000003367 SGD:S000003485 SGD:S000003538 SGD:S000004557 SGD:S000004931 SGD:S000005398 SGD:S000005683 SGD:S000005889 SGD:S000006307 UniProtKB:Q5B698	P		Seeded From UniProt	complete
part_of	GO:0019773	proteasome core complex, alpha-subunit complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000174852 PomBase:SPBC646.16 SGD:S000002979 UniProtKB:P60900	C		Seeded From UniProt	complete
involved_in	GO:0010499	proteasomal ubiquitin-independent protein catabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000174701 SGD:S000000137 SGD:S000000814 SGD:S000000896 SGD:S000001946 SGD:S000002979 SGD:S000003367 SGD:S000003485 SGD:S000003538 SGD:S000004557 SGD:S000004931 SGD:S000005398 SGD:S000005683 SGD:S000005889 SGD:S000006307	P		Seeded From UniProt	complete
involved_in	GO:0010498	proteasomal protein catabolic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002266517 UniProtKB:P9WHT9 UniProtKB:P9WHU1 UniProtKB:Q58634 UniProtKB:Q60177	P		Seeded From UniProt	complete
part_of	GO:0005839	proteasome core complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002284 FB:FBgn0004066 FB:FBgn0010590 FB:FBgn0016697 FB:FBgn0023174 FB:FBgn0023175 FB:FBgn0026380 FB:FBgn0029134 FB:FBgn0032596 FB:FBgn0086134 FB:FBgn0250746 FB:FBgn0261394 FB:FBgn0263121 MGI:MGI:104880 MGI:MGI:104883 MGI:MGI:104884 MGI:MGI:104885 MGI:MGI:107637 MGI:MGI:1096380 MGI:MGI:1098257 MGI:MGI:1194513 MGI:MGI:1346526 MGI:MGI:1346527 MGI:MGI:1347005 MGI:MGI:1347006 MGI:MGI:1347009 MGI:MGI:1347014 MGI:MGI:1347045 MGI:MGI:1347060 MGI:MGI:1347070 MGI:MGI:1921152 PANTHER:PTN002266517 UniProtKB:A0A1D8PQW1 UniProtKB:A0A1D8PRH6 UniProtKB:P25788	C		Seeded From UniProt	complete
part_of	GO:0005839	proteasome core complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002284 FB:FBgn0004066 FB:FBgn0010590 FB:FBgn0016697 FB:FBgn0023174 FB:FBgn0023175 FB:FBgn0026380 FB:FBgn0029134 FB:FBgn0032596 FB:FBgn0086134 FB:FBgn0250746 FB:FBgn0261394 FB:FBgn0263121 MGI:MGI:104880 MGI:MGI:104883 MGI:MGI:104884 MGI:MGI:104885 MGI:MGI:107637 MGI:MGI:1096380 MGI:MGI:1098257 MGI:MGI:1194513 MGI:MGI:1346526 MGI:MGI:1346527 MGI:MGI:1347005 MGI:MGI:1347006 MGI:MGI:1347009 MGI:MGI:1347014 MGI:MGI:1347045 MGI:MGI:1347060 MGI:MGI:1347070 MGI:MGI:1921152 PANTHER:PTN000174701 UniProtKB:A0A1D8PQW1 UniProtKB:A0A1D8PRH6 UniProtKB:P25788	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0032492 FB:FBgn0250843 FB:FBgn0261394 MGI:MGI:1347006 PANTHER:PTN000174701 PomBase:SPBC106.16 UniProtKB:Q8IJT1 WB:WBGene00003928 dictyBase:DDB_G0267390 dictyBase:DDB_G0267408 dictyBase:DDB_G0268538 dictyBase:DDB_G0269472 dictyBase:DDB_G0269772 dictyBase:DDB_G0272831 dictyBase:DDB_G0272969 dictyBase:DDB_G0273163 dictyBase:DDB_G0278847 dictyBase:DDB_G0280969 dictyBase:DDB_G0282363 dictyBase:DDB_G0283679 dictyBase:DDB_G0292122 dictyBase:DDB_G0293784	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0032492 FB:FBgn0250843 FB:FBgn0261394 PANTHER:PTN000174701 PomBase:SPBC106.16 SGD:S000000814 SGD:S000005398 SGD:S000005683 TAIR:locus:2059319 TAIR:locus:2197071 UniProtKB:P20618 UniProtKB:P25786 UniProtKB:P25789 UniProtKB:P28074 UniProtKB:P30186 UniProtKB:P60900 UniProtKB:Q8IJT1 WB:WBGene00003928 dictyBase:DDB_G0267390 dictyBase:DDB_G0267408 dictyBase:DDB_G0268538 dictyBase:DDB_G0269472 dictyBase:DDB_G0269772 dictyBase:DDB_G0272831 dictyBase:DDB_G0272969 dictyBase:DDB_G0273163 dictyBase:DDB_G0278847 dictyBase:DDB_G0280969 dictyBase:DDB_G0282363 dictyBase:DDB_G0283679 dictyBase:DDB_G0292122 dictyBase:DDB_G0293784	C		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000174701 SGD:S000003538 SGD:S000005683 SGD:S000006307 UniProtKB:Q58634 UniProtKB:Q60177	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60901 ensembl:ENSRNOP00000009666	C		Seeded From UniProt	complete
part_of	GO:0030016	myofibril	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60901 ensembl:ENSRNOP00000009666	C		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUM9 ensembl:ENSMUSP00000021412	C		Seeded From UniProt	complete
part_of	GO:0005839	proteasome core complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUM9 ensembl:ENSMUSP00000021412	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUM9 ensembl:ENSMUSP00000021412	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUM9 ensembl:ENSMUSP00000021412	F		Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QUM9 ensembl:ENSMUSP00000021412	C		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000426	F		Seeded From UniProt	complete
enables	GO:0004298	threonine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001353	F		Seeded From UniProt	complete
part_of	GO:0005839	proteasome core complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001353	C		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000426	P		Seeded From UniProt	complete
part_of	GO:0019773	proteasome core complex, alpha-subunit complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000426 InterPro:IPR034642	C		Seeded From UniProt	complete
involved_in	GO:0051603	proteolysis involved in cellular protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001353	P		Seeded From UniProt	complete
part_of	GO:0019773	proteasome core complex, alpha-subunit complex	PMID:11917093^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902036	regulation of hematopoietic stem cell differentiation	Reactome:R-HSA-8939236	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901990	regulation of mitotic cell cycle phase transition	Reactome:R-HSA-174113	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	Reactome:R-HSA-4641257	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	Reactome:R-HSA-4641258	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	Reactome:R-HSA-9020702	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	Reactome:R-HSA-1234174	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	Reactome:R-HSA-4086400	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	Reactome:R-HSA-382556	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	Reactome:R-HSA-202403	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	Reactome:R-HSA-450408	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Reactome:R-HSA-8852354 Reactome:R-HSA-2130282 Reactome:R-HSA-174255	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038061	NIK/NF-kappaB signaling	Reactome:R-HSA-5676590	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	Reactome:R-HSA-5668541	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Reactome:R-HSA-8854071	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031145	anaphase-promoting complex-dependent catabolic process	Reactome:R-HSA-174178 Reactome:R-HSA-174154 Reactome:R-HSA-174143	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	Reactome:R-HSA-8854044	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006521	regulation of cellular amino acid metabolic process	Reactome:R-HSA-350562	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-9011324 Reactome:R-NUL-5610751 Reactome:R-NUL-212917 Reactome:R-HSA-983150 Reactome:R-HSA-8957265 Reactome:R-HSA-8956184 Reactome:R-HSA-8956140 Reactome:R-HSA-8866858 Reactome:R-HSA-8866553 Reactome:R-HSA-8854071 Reactome:R-HSA-8854044 Reactome:R-HSA-8852354 Reactome:R-HSA-8850992 Reactome:R-HSA-75825 Reactome:R-HSA-69600 Reactome:R-HSA-69016 Reactome:R-HSA-68948 Reactome:R-HSA-68825 Reactome:R-HSA-5689539 Reactome:R-HSA-5687112 Reactome:R-HSA-5668520 Reactome:R-HSA-5668481 Reactome:R-HSA-5665871 Reactome:R-HSA-5665854 Reactome:R-HSA-5658430 Reactome:R-HSA-5635868 Reactome:R-HSA-5610760 Reactome:R-HSA-5610758 Reactome:R-HSA-5610754 Reactome:R-HSA-5607731 Reactome:R-HSA-5607724 Reactome:R-HSA-5387392 Reactome:R-HSA-5362448 Reactome:R-HSA-4641260 Reactome:R-HSA-4641256 Reactome:R-HSA-4608855 Reactome:R-HSA-450466 Reactome:R-HSA-3640874 Reactome:R-HSA-353125 Reactome:R-HSA-264458 Reactome:R-HSA-2130282 Reactome:R-HSA-209061 Reactome:R-HSA-188191 Reactome:R-HSA-180603 Reactome:R-HSA-180573 Reactome:R-HSA-174255 Reactome:R-HSA-174203 Reactome:R-HSA-174202 Reactome:R-HSA-174105 Reactome:R-HSA-1504193 Reactome:R-HSA-1236970 Reactome:R-HSA-1234159 Reactome:R-HSA-1168640	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9604648 Reactome:R-HSA-8952408 Reactome:R-HSA-8939801 Reactome:R-HSA-5635854 Reactome:R-HSA-187574 Reactome:R-HSA-174058	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Reactome:R-HSA-1236978	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	Reactome:R-HSA-983168	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0000502	proteasome complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0647	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004298	threonine-type endopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0888	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wang, X et al. (2007) Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry 46 3553-65 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Ozaki, K et al. (2006) A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population. Nat. Genet. 38 921-5 PubMed GONUTS page
↑ Bouwmeester, T et al. (2004) A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat. Cell Biol. 6 97-105 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Bey, F et al. (1993) The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family. Mol. Gen. Genet. 237 193-205 PubMed GONUTS page
↑ Kopp, F et al. (1997) Subunit arrangement in the human 20S proteasome. Proc. Natl. Acad. Sci. U.S.A. 94 2939-44 PubMed GONUTS page
↑ DeMartino, GN et al. (1991) The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous. Biochim. Biophys. Acta 1079 29-38 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Glickman, MH & Ciechanover, A (2002) The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol. Rev. 82 373-428 PubMed GONUTS page

[PMID:17323924-1] Wang, X et al. (2007) Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry 46 3553-65 PubMed GONUTS page

[PMID:20458337-2] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:21630459-3] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:16845397-4] 4.0 ^4.1 ^4.2 Ozaki, K et al. (2006) A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population. Nat. Genet. 38 921-5 PubMed GONUTS page

[PMID:14743216-5] Bouwmeester, T et al. (2004) A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat. Cell Biol. 6 97-105 PubMed GONUTS page

[PMID:7681138-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Bey, F et al. (1993) The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family. Mol. Gen. Genet. 237 193-205 PubMed GONUTS page

[PMID:9096325-7] Kopp, F et al. (1997) Subunit arrangement in the human 20S proteasome. Proc. Natl. Acad. Sci. U.S.A. 94 2939-44 PubMed GONUTS page

[PMID:1888762-8] DeMartino, GN et al. (1991) The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous. Biochim. Biophys. Acta 1079 29-38 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11917093-10] Glickman, MH & Ciechanover, A (2002) The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol. Rev. 82 373-428 PubMed GONUTS page

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