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HUMAN:PRDM9

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PRDM9 (synonyms: PFM6)
Protein Name(s) Histone-lysine N-methyltransferase PRDM9

PR domain zinc finger protein 9 PR domain-containing protein 9

External Links
UniProt Q9NQV7
EMBL DQ388610
AK301776
AC025451
AF275816
CCDS CCDS43307.1
RefSeq NP_064612.2
UniGene Hs.283096
PDB 4IJD
PDBsum 4IJD
ProteinModelPortal Q9NQV7
SMR Q9NQV7
STRING 9606.ENSP00000296682
PhosphoSite Q9NQV7
DMDM 212276459
PaxDb Q9NQV7
PRIDE Q9NQV7
Ensembl ENST00000296682
GeneID 56979
KEGG hsa:56979
UCSC uc003jgo.3
CTD 56979
GeneCards GC05P023558
HGNC HGNC:13994
HPA HPA059555
MIM 609760
neXtProt NX_Q9NQV7
PharmGKB PA33721
eggNOG COG5048
GeneTree ENSGT00770000120502
HOGENOM HOG000234617
HOVERGEN HBG108291
InParanoid Q9NQV7
OMA RECGWGF
OrthoDB EOG7KSX7Q
PhylomeDB Q9NQV7
TreeFam TF338096
Reactome REACT_27271
GeneWiki PRDM9
GenomeRNAi 56979
NextBio 62639
PRO PR:Q9NQV7
Proteomes UP000005640
Bgee Q9NQV7
CleanEx HS_PRDM9
ExpressionAtlas Q9NQV7
Genevestigator Q9NQV7
GO GO:0005694
GO:0005654
GO:0042800
GO:0046872
GO:0010844
GO:0043565
GO:0006311
GO:0010845
GO:0045944
GO:0007283
GO:0006351
Gene3D 3.30.160.60
InterPro IPR001909
IPR003655
IPR001214
IPR019041
IPR007087
IPR015880
IPR013087
Pfam PF01352
PF09514
SMART SM00349
SM00317
SM00355
SUPFAM SSF109640
PROSITE PS50806
PS50280
PS00028
PS50157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0016584

nucleosome positioning

PMID:29072575[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:29072575[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0010844

recombination hotspot binding

PMID:20044539[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q8VIG1

F

Seeded From UniProt

complete

enables

GO:0018024

histone-lysine N-methyltransferase activity

PMID:29072575[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:29072575[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2384854
MGI:MGI:99655
PANTHER:PTN001818762
UniProtKB:Q9NQV7
UniProtKB:Q9NQX1
UniProtKB:Q9Y462

F

Seeded From UniProt

complete

enables

GO:0042800

histone methyltransferase activity (H3-K4 specific)

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2384854
PANTHER:PTN000421245

F

Seeded From UniProt

complete

enables

GO:0031490

chromatin DNA binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:3588194
PANTHER:PTN001818762

F

Seeded From UniProt

complete

involved_in

GO:0010845

positive regulation of reciprocal meiotic recombination

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2384854
PANTHER:PTN000421245
UniProtKB:Q9NQV7

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035625
MGI:MGI:1920093
MGI:MGI:1930121
MGI:MGI:2448528
MGI:MGI:2684938
MGI:MGI:3588194
MGI:MGI:99655
PANTHER:PTN001818762
RGD:1594531
RGD:619929
UniProtKB:Q13029
UniProtKB:Q9H4Q4
UniProtKB:Q9NQX1
UniProtKB:Q9Y462
WB:WBGene00003847

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001818762
ZFIN:ZDB-GENE-030131-2193

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:3588194
PANTHER:PTN001818762
UniProtKB:Q13029

F

Seeded From UniProt

complete

involved_in

GO:0010845

positive regulation of reciprocal meiotic recombination

PMID:21750151[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006311

meiotic gene conversion

PMID:21750151[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000981

P

Seeded From UniProt

complete

involved_in

GO:0034968

histone lysine methylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0018024

P

Seeded From UniProt

complete

involved_in

GO:0034968

histone lysine methylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0018024

P

Seeded From UniProt

complete

involved_in

GO:0051568

histone H3-K4 methylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0042800

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001909
InterPro:IPR013087
InterPro:IPR036051

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019041

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001909
InterPro:IPR003655
InterPro:IPR019041
InterPro:IPR036051

P

Seeded From UniProt

complete

enables

GO:0018024

histone-lysine N-methyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.43

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-912363
Reactome:R-HSA-5244692

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

involved_in

GO:0051321

meiotic cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0469

P

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158
UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Altemose, N et al. (2017) A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis. Elife 6 PubMed GONUTS page
  2. ↑ Baudat, F et al. (2010) PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Science 327 836-40 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 Berg, IL et al. (2011) Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations. Proc. Natl. Acad. Sci. U.S.A. 108 12378-83 PubMed GONUTS page
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