HUMAN:PK3CD

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PIK3CD
Protein Name(s)	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform PI3-kinase subunit delta PI3K-delta PI3Kdelta PtdIns-3-kinase subunit delta Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta PtdIns-3-kinase subunit p110-delta p110delta
External Links
UniProt	O00329
EMBL	Y10055 U86453 JN190435 DQ263594 AL691449 BC132919 BC132921
CCDS	CCDS104.1
RefSeq	NP_005017.3 XP_006710749.1 XP_006710750.1 XP_006710751.1 XP_006710752.1
UniGene	Hs.518451
ProteinModelPortal	O00329
SMR	O00329
BioGrid	111311
IntAct	O00329
STRING	9606.ENSP00000366563
BindingDB	O00329
ChEMBL	CHEMBL3130
DrugBank	DB00201
GuidetoPHARMACOLOGY	2155
PhosphoSite	O00329
MaxQB	O00329
PaxDb	O00329
PRIDE	O00329
DNASU	5293
Ensembl	ENST00000377346
GeneID	5293
KEGG	hsa:5293
UCSC	uc001aqb.4
CTD	5293
GeneCards	GC01P009711
HGNC	HGNC:8977
HPA	CAB015420
MIM	602839 615513
neXtProt	NX_O00329
Orphanet	397596
PharmGKB	PA33310
eggNOG	COG5032
GeneTree	ENSGT00760000119110
HOGENOM	HOG000252911
HOVERGEN	HBG052721
InParanoid	O00329
KO	K00922
OrthoDB	EOG70CR65
PhylomeDB	O00329
TreeFam	TF102031
BioCyc	MetaCyc:ENSG00000171608-MONOMER
BRENDA	2.7.1.137
Reactome	REACT_118700 REACT_121025 REACT_147727 REACT_1695 REACT_19290 REACT_23787 REACT_23837 REACT_23891 REACT_75829
SignaLink	O00329
UniPathway	UPA00220
ChiTaRS	PIK3CD
GeneWiki	P110%CE%B4
GenomeRNAi	5293
NextBio	20454
PRO	PR:O00329
Proteomes	UP000005640
Bgee	O00329
CleanEx	HS_PIK3CD
ExpressionAtlas	O00329
Genevestigator	O00329
GO	GO:0005829 GO:0042629 GO:0005942 GO:0005886 GO:0016303 GO:0035005 GO:0005524 GO:0035004 GO:0046934 GO:0002250 GO:0042113 GO:0035754 GO:0001782 GO:0050853 GO:0001816 GO:0007173 GO:0038095 GO:0008543 GO:0006954 GO:0045087 GO:0002551 GO:0043303 GO:0060374 GO:0030101 GO:0035747 GO:0001779 GO:0048011 GO:0030593 GO:0072672 GO:0014065 GO:0006661 GO:0036092 GO:0048015 GO:0006644 GO:0006468 GO:0002679 GO:0007165 GO:0044281 GO:0042110 GO:0010818 GO:0030217 GO:0050852
Gene3D	1.10.1070.11 1.25.40.70 2.60.40.150
InterPro	IPR016024 IPR000008 IPR011009 IPR000403 IPR018936 IPR003113 IPR002420 IPR000341 IPR015433 IPR001263 IPR029071
PANTHER	PTHR10048
Pfam	PF00454 PF00792 PF02192 PF00794 PF00613
SMART	SM00142 SM00143 SM00144 SM00145 SM00146
SUPFAM	SSF48371 SSF49562 SSF54236 SSF56112
PROSITE	PS00915 PS00916 PS50290 PS51544 PS51547 PS51546 PS51545

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0030335	positive regulation of cell migration	PMID:22079609^[1]	ECO:0000315			P	Fig. 3AD, Fig. 5A, and Supplemental Fig. 4A	complete CACAO 3053
	GO:0010628	positive regulation of gene expression	PMID:22079609^[1]	ECO:0000315			P	Fig. 3C	complete CACAO 3054
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:25339672^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033031	positive regulation of neutrophil apoptotic process	PMID:25339672^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:22079609^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:22079609^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:9235916^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:9113989^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9113989^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:9235916^[3]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:9113989^[4]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 RGD:620899 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	P	Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015277 FB:FBgn0015278 FB:FBgn0015279 FB:FBgn0267350 MGI:MGI:2448506 PANTHER:PTN000005673 RGD:620916 RGD:620917 SGD:S000004230 SGD:S000004296 SGD:S000005211 UniProtKB:A0A1D8PDV7 UniProtKB:P32871	P	Seeded From UniProt	complete
involved_in	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1203729 MGI:MGI:2685045 PANTHER:PTN000005674 WB:WBGene00009552	P	Seeded From UniProt	complete
enables	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015278 FB:FBgn0015279 PANTHER:PTN000005674 RGD:620231	F	Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1922019 PANTHER:PTN000799655	P	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005674 UniProtKB:O42391	P	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015278 FB:FBgn0015279 MGI:MGI:1203729 MGI:MGI:1206581 MGI:MGI:1922019 PANTHER:PTN000005674 RGD:620916 RGD:620917 UniProtKB:P42336	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 PomBase:SPAC458.05 TAIR:locus:2164401 UniProtKB:P48736	C	Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015279 PANTHER:PTN000005674 UniProtKB:O00329 UniProtKB:P42338 UniProtKB:P48736 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1206581 MGI:MGI:1353576 PANTHER:PTN000799655	P	Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1206581 PANTHER:PTN000005674 RGD:620916 RGD:620917 UniProtKB:P32871 WB:WBGene00000090	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005674 RGD:620231 UniProtKB:O00443 UniProtKB:P48736 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 RGD:621214 UniProtKB:O00443 UniProtKB:P42356 UniProtKB:P48736 WB:WBGene00000090 WB:WBGene00006932 WB:WBGene00009552 dictyBase:DDB_G0291093	C	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	PMID:25327288^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:25327288^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0042629	mast cell granule	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0043303	C	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A5Q1 ensembl:ENSRNOP00000061674	P	Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037703	P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018936 InterPro:IPR036940	F	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290	F	Seeded From UniProt	complete
enables	GO:0035004	phosphatidylinositol 3-kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037703	F	Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290 InterPro:IPR015433	P	Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290 InterPro:IPR015433	P	Seeded From UniProt	complete
enables	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.153	F	Seeded From UniProt	complete
enables	GO:0052812	phosphatidylinositol-3,4-bisphosphate 5-kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.153	F	Seeded From UniProt	complete
involved_in	GO:0072672	neutrophil extravasation	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060374	mast cell differentiation	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:20940048^[7] PMID:17290298^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043303	mast cell degranulation	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042113	B cell activation	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035754	B cell chemotaxis	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035747	natural killer cell chemotaxis	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0035004	phosphatidylinositol 3-kinase activity	PMID:17290298^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030101	natural killer cell activation	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:17290298^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010818	T cell chemotaxis	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:20940048^[7] PMID:17290298^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002679	respiratory burst involved in defense response	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002551	mast cell chemotaxis	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	PMID:17290298^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001816	cytokine production	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001779	natural killer cell differentiation	PMID:20940048^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-512988 Reactome:R-HSA-451927	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Reactome:R-HSA-9027276	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	Reactome:R-HSA-422475	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006661	phosphatidylinositol biosynthetic process	Reactome:R-HSA-1660499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-9606887 Reactome:R-HSA-914182 Reactome:R-HSA-912627 Reactome:R-HSA-8854905 Reactome:R-HSA-879917 Reactome:R-HSA-508247 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434 Reactome:R-HSA-2076220 Reactome:R-HSA-2045911	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9606887 Reactome:R-HSA-9027275 Reactome:R-HSA-9021627 Reactome:R-HSA-9012657 Reactome:R-HSA-1676109 Reactome:R-HSA-1676048	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Luk, SK et al. (2012) The catalytic phosphoinositol 3-kinase isoform p110δ is required for glioma cell migration and invasion. Eur. J. Cancer 48 149-57 PubMed GONUTS page
↑ ^2.0 ^2.1 Wehrli, M et al. (2014) Human IgA Fc receptor FcαRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment. J. Immunol. 193 5649-59 PubMed GONUTS page
↑ ^3.0 ^3.1 Chantry, D et al. (1997) p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J. Biol. Chem. 272 19236-41 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Vanhaesebroeck, B et al. (1997) P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc. Natl. Acad. Sci. U.S.A. 94 4330-5 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 Fung-Leung, WP (2011) Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function. Cell. Signal. 23 603-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Rommel, C et al. (2007) PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Nat. Rev. Immunol. 7 191-201 PubMed GONUTS page

[PMID:22079609-1] 1.0 ^1.1 ^1.2 ^1.3 Luk, SK et al. (2012) The catalytic phosphoinositol 3-kinase isoform p110δ is required for glioma cell migration and invasion. Eur. J. Cancer 48 149-57 PubMed GONUTS page

[PMID:25339672-2] 2.0 ^2.1 Wehrli, M et al. (2014) Human IgA Fc receptor FcαRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment. J. Immunol. 193 5649-59 PubMed GONUTS page

[PMID:9235916-3] 3.0 ^3.1 Chantry, D et al. (1997) p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J. Biol. Chem. 272 19236-41 PubMed GONUTS page

[PMID:9113989-4] 4.0 ^4.1 ^4.2 Vanhaesebroeck, B et al. (1997) P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc. Natl. Acad. Sci. U.S.A. 94 4330-5 PubMed GONUTS page

[PMID:21873635-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25327288-6] 6.0 ^6.1 Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page

[PMID:20940048-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 Fung-Leung, WP (2011) Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function. Cell. Signal. 23 603-8 PubMed GONUTS page

[PMID:17290298-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Rommel, C et al. (2007) PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Nat. Rev. Immunol. 7 191-201 PubMed GONUTS page

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HUMAN:PK3CD

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