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HUMAN:PARL

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PARL (synonyms: PSARL)
Protein Name(s) Presenilins-associated rhomboid-like protein, mitochondrial

Mitochondrial intramembrane cleaving protease PARL P-beta Pbeta

External Links
UniProt Q9H300
EMBL AF197937
BC003653
BC014058
AF116692
CCDS CCDS3248.1
CCDS33897.1
RefSeq NP_001032728.1
NP_061092.3
UniGene Hs.478469
ProteinModelPortal Q9H300
BioGrid 120678
STRING 9606.ENSP00000325421
MEROPS S54.009
PhosphoSite Q9H300
DMDM 143811433
MaxQB Q9H300
PaxDb Q9H300
PRIDE Q9H300
DNASU 55486
Ensembl ENST00000311101
ENST00000317096
GeneID 55486
KEGG hsa:55486
UCSC uc003fmd.3
uc003fme.3
CTD 55486
GeneCards GC03M183547
HGNC HGNC:18253
HPA HPA019545
MIM 607858
neXtProt NX_Q9H300
PharmGKB PA134939789
eggNOG COG0705
GeneTree ENSGT00390000013063
HOGENOM HOG000230670
HOVERGEN HBG082107
InParanoid Q9H300
KO K09650
OMA HEMRTNS
OrthoDB EOG7NGQBT
PhylomeDB Q9H300
TreeFam TF313603
ChiTaRS PARL
GeneWiki PARL
GenomeRNAi 55486
NextBio 59867
PMAP-CutDB Q9H300
PRO PR:Q9H300
Proteomes UP000005640
Bgee Q9H300
CleanEx HS_PARL
ExpressionAtlas Q9H300
Genevestigator Q9H300
GO GO:0016021
GO:0005743
GO:0005739
GO:0005634
GO:0004175
GO:0004252
GO:0033619
GO:2001243
GO:0090201
GO:0006508
GO:1903214
GO:2000377
Gene3D 1.20.1540.10
InterPro IPR002610
IPR022764
PANTHER PTHR22936
Pfam PF01694

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005739

mitochondrion

PMID:17116872[1]

ECO:0000315

C

Fig 5

complete
CACAO 3858

involved_in

GO:0010821

regulation of mitochondrion organization

PMID:21355049[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903214

regulation of protein targeting to mitochondrion

PMID:21355049[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60260
UniProtKB:Q9BXM7

P

has_regulation_target:(UniProtKB:O60260)|has_regulation_target:(UniProtKB:Q9BXM7)

Seeded From UniProt

complete

involved_in

GO:0030162

regulation of proteolysis

PMID:21355049[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9BXM7

P

has_regulation_target:(UniProtKB:Q9BXM7)

Seeded From UniProt

complete

involved_in

GO:1903214

regulation of protein targeting to mitochondrion

PMID:24522549[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

has_regulation_target:(UniProtKB:Q9BXM7)

Seeded From UniProt

complete

involved_in

GO:2000377

regulation of reactive oxygen species metabolic process

PMID:21138942[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:21138942[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q5XJY4

P

has_input:(UniProtKB:Q9BXM7)

Seeded From UniProt

complete

enables

GO:0004175

endopeptidase activity

PMID:21138942[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q5XJY4

F

has_input:(UniProtKB:Q9BXM7)

Seeded From UniProt

complete

involved_in

GO:0033619

membrane protein proteolysis

PMID:21426348[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

has_input:(UniProtKB:Q9BXM7)

Seeded From UniProt

complete

enables

GO:0004175

endopeptidase activity

PMID:21426348[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:21426348[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010821

regulation of mitochondrion organization

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1277152
PANTHER:PTN001292090
SGD:S000003333
UniProtKB:Q9H300

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1277152
PANTHER:PTN001292090
SGD:S000003333

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0033672
MGI:MGI:1277152
PANTHER:PTN001292090
RGD:1306191
SGD:S000003333
TAIR:locus:2027448

C

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002464329
SGD:S000003333

F

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR022764

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR022764

C

Seeded From UniProt

complete

involved_in

GO:0033619

membrane protein proteolysis

PMID:24522549[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

has_input:(UniProtKB:Q9BXM7)

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

PMID:21426348[5]
Reactome:R-HSA-8949668

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0006851

mitochondrial calcium ion transmembrane transport

Reactome:R-HSA-8949215

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0720

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Jeyaraju, DV et al. (2006) Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology. Proc. Natl. Acad. Sci. U.S.A. 103 18562-7 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Shi, G et al. (2011) Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease. Hum. Mol. Genet. 20 1966-74 PubMed GONUTS page
  3. ↑ 3.0 3.1 Gaki, GS & Papavassiliou, AG (2014) Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease. Neuromolecular Med. 16 217-30 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Deas, E et al. (2011) PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum. Mol. Genet. 20 867-79 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Meissner, C et al. (2011) The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. J. Neurochem. 117 856-67 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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