HUMAN:PAK2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PAK2
Protein Name(s)	Serine/threonine-protein kinase PAK 2 Gamma-PAK PAK65 S6/H4 kinase p21-activated kinase 2 PAK-2 p58 PAK-2p27 p27 PAK-2p34 p34 C-t-PAK2
External Links
UniProt	Q13177
EMBL	U24153 BC069613 U25975
CCDS	CCDS3321.1
PIR	S58682
RefSeq	NP_002568.2
UniGene	Hs.518530
PDB	3PCS
PDBsum	3PCS
ProteinModelPortal	Q13177
SMR	Q13177
BioGrid	111098
DIP	DIP-38249N
IntAct	Q13177
MINT	MINT-235655
STRING	9606.ENSP00000314067
BindingDB	Q13177
ChEMBL	CHEMBL4487
GuidetoPHARMACOLOGY	2134
PhosphoSite	Q13177
DMDM	143811432
OGP	Q13177
MaxQB	Q13177
PaxDb	Q13177
PRIDE	Q13177
DNASU	5062
Ensembl	ENST00000327134
GeneID	5062
KEGG	hsa:5062
UCSC	uc003fwy.4
CTD	5062
GeneCards	GC03P196466
H-InvDB	HIX0030815
HGNC	HGNC:8591
HPA	CAB007794 HPA036205
MIM	605022
neXtProt	NX_Q13177
PharmGKB	PA32918
eggNOG	COG0515
GeneTree	ENSGT00760000119176
HOGENOM	HOG000234202
HOVERGEN	HBG108518
InParanoid	Q13177
KO	K04410
OMA	NIDSGAK
PhylomeDB	Q13177
TreeFam	TF105351
BRENDA	2.7.11.1
Reactome	REACT_11068 REACT_12623 REACT_13464 REACT_13528 REACT_13532 REACT_163701 REACT_19226 REACT_19236 REACT_19238 REACT_228016 REACT_228166 REACT_228226
SignaLink	Q13177
ChiTaRS	PAK2
EvolutionaryTrace	Q13177
GeneWiki	PAK2
GenomeRNAi	5062
NextBio	19496
PMAP-CutDB	Q13177
PRO	PR:Q13177
Proteomes	UP000005640
Bgee	Q13177
CleanEx	HS_PAK2
ExpressionAtlas	Q13177
Genevestigator	Q13177
GO	GO:0005737 GO:0005829 GO:0005634 GO:0048471 GO:0005886 GO:0005524 GO:0042802 GO:0004672 GO:0019901 GO:0004674 GO:0030296 GO:0006915 GO:0007411 GO:0006921 GO:0038095 GO:0045087 GO:0043066 GO:2001271 GO:0006469 GO:0018105 GO:0016310 GO:2001238 GO:0050731 GO:0061098 GO:0046777 GO:0006468 GO:0042981 GO:0050690 GO:0040008 GO:0007165 GO:0031295 GO:0050852 GO:0016032
Gene3D	3.90.810.10
InterPro	IPR000095 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00786 PF00069
SMART	SM00285 SM00220
SUPFAM	SSF56112
PROSITE	PS50108 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0019901	protein kinase binding	PMID 11121037	ECO:0000021		UniProtKB:P00519	F		Figure 1	Missing: reference
	GO:0030296	protein tyrosine kinase activator activity	PMID 11121037	ECO:0000314			F		Figure 2 b and c	Missing: reference
enables	GO:0045296	cadherin binding	PMID:25468996^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25468996^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	PMID:8625410^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63000	F		Seeded From UniProt	complete
enables	GO:0031267	small GTPase binding	PMID:8625410^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60953	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:8625410^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000775)	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:11121037^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030296	protein tyrosine kinase activator activity	PMID:11121037^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:11121037^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P00519	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:11121037^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11121037^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	PMID:21555521^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P55210)	Seeded From UniProt	complete
involved_in	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	PMID:19240112^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21555521^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P55210) has_input:(UniProtKB:P09874)	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	PMID:21555521^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P55210)\|happens_during(GO:0043066)	Seeded From UniProt	complete
involved_in	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000685300 UniProtKB:Q13177	P		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267698 PANTHER:PTN002390586 UniProtKB:A0A0B4KGS4 UniProtKB:Q13153 UniProtKB:Q13177 WB:WBGene00003144	F		Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339975 PANTHER:PTN002390586	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919399 PANTHER:PTN000684825 RGD:727905 UniProtKB:Q7RTN6 UniProtKB:Q9C0K7	P		Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 UniProtKB:A0A1D8PKE2 UniProtKB:A0A1D8PM87	P		Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 TAIR:locus:2205523 UniProtKB:Q9UEW8	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002390586 WB:WBGene00003144 WB:WBGene00003911	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0267698 MGI:MGI:1339975 MGI:MGI:1344404 MGI:MGI:1346867 MGI:MGI:1346875 MGI:MGI:1891638 MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN000684825 PomBase:SPAC1F3.02c PomBase:SPBC17F3.02 PomBase:SPBC1D7.05 PomBase:SPBC409.07c PomBase:SPBC543.07 RGD:3780 RGD:620966 RGD:621643 SGD:S000000999 SGD:S000002318 SGD:S000002931 SGD:S000003664 SGD:S000004354 SGD:S000005757 SGD:S000006061 TAIR:locus:2017662 TAIR:locus:2074835 TAIR:locus:2087130 TAIR:locus:2170578 UniProtKB:A0A0B4KGS4 UniProtKB:O00506 UniProtKB:O95819 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q57Y61 UniProtKB:Q7RTN6 UniProtKB:Q8N4C8 UniProtKB:Q96PY6 UniProtKB:Q9C0K7 UniProtKB:Q9H2G2 UniProtKB:Q9P289 UniProtKB:Q9S7U9 UniProtKB:Q9UKE5 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 UniProtKB:Q9Y6R4 WB:WBGene00002177 WB:WBGene00002201 WB:WBGene00003368 WB:WBGene00013355 dictyBase:DDB_G0284181 dictyBase:DDB_G0286359	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0031030 FB:FBgn0035001 FB:FBgn0261456 FB:FBgn0267698 MGI:MGI:1344404 MGI:MGI:1346882 MGI:MGI:1349394 MGI:MGI:1355329 MGI:MGI:1858416 MGI:MGI:1917378 MGI:MGI:1920334 PANTHER:PTN000684825 PomBase:SPBC1604.14c PomBase:SPBC21.06c RGD:3250 RGD:3251 RGD:621643 RGD:708455 RGD:727905 SGD:S000005242 TAIR:locus:2035989 TAIR:locus:2045658 TAIR:locus:2080394 TAIR:locus:2116417 TAIR:locus:2133559 TAIR:locus:2174969 TAIR:locus:2205523 TAIR:locus:2206885 UniProtKB:A0A0B4KGS4 UniProtKB:C0H4N8 UniProtKB:O75914 UniProtKB:O94804 UniProtKB:O95747 UniProtKB:O95819 UniProtKB:O96013 UniProtKB:Q02750 UniProtKB:Q12851 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q13233 UniProtKB:Q8IVH8 UniProtKB:Q8N4C8 UniProtKB:Q92918 UniProtKB:Q99558 UniProtKB:Q9H2G2 UniProtKB:Q9H2K8 UniProtKB:Q9UEW8 UniProtKB:Q9UKE5 UniProtKB:Q9UL54 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 WB:WBGene00013355 WB:WBGene00017472 dictyBase:DDB_G0276459 dictyBase:DDB_G0286359	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11278486^[7]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:11805089^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:11805089^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11805089^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16837009^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13177	F		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030296	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIN4 ensembl:ENSMUSP00000023467	C		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIN4 ensembl:ENSMUSP00000023467	P		Seeded From UniProt	complete
involved_in	GO:0060996	dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIN4 ensembl:ENSMUSP00000023467	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIN4 ensembl:ENSMUSP00000023467	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIN4 ensembl:ENSMUSP00000023467	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033923 InterPro:IPR035064 InterPro:IPR035065	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR035064	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR035065	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:7744004^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	PMID:10748018^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:7744004^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10748018^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	Reactome:R-HSA-202403	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050690	regulation of defense response to virus by virus	Reactome:R-HSA-164943	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:R-HSA-194138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035722	interleukin-12-mediated signaling pathway	Reactome:R-HSA-9020591	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	Reactome:R-HSA-389356	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-164943	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8981931 Reactome:R-HSA-8950190 Reactome:R-HSA-5687086 Reactome:R-HSA-5668984 Reactome:R-HSA-5668932 Reactome:R-HSA-5627775 Reactome:R-HSA-5624492 Reactome:R-HSA-5357483 Reactome:R-HSA-5357477 Reactome:R-HSA-5357472 Reactome:R-HSA-5357445 Reactome:R-HSA-5218847 Reactome:R-HSA-5218832 Reactome:R-HSA-5218814 Reactome:R-HSA-5218812 Reactome:R-HSA-5218804 Reactome:R-HSA-430183 Reactome:R-HSA-399952 Reactome:R-HSA-399939 Reactome:R-HSA-399930 Reactome:R-HSA-389788 Reactome:R-HSA-2730889 Reactome:R-HSA-2730856	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-5668932 Reactome:R-HSA-399952 Reactome:R-HSA-399939	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0341	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Symons, M et al. (1996) Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 84 723-34 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Roig, J et al. (2000) Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc. Natl. Acad. Sci. U.S.A. 97 14346-51 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Li, X et al. (2011) Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines. J. Biol. Chem. 286 22291-9 PubMed GONUTS page
↑ Luo, S & Rubinsztein, DC (2009) Huntingtin promotes cell survival by preventing Pak2 cleavage. J. Cell. Sci. 122 875-85 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Chong, C et al. (2001) The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J. Biol. Chem. 276 17347-53 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Lee, KK & Yonehara, S (2002) Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J. Biol. Chem. 277 12351-8 PubMed GONUTS page
↑ Pirruccello, M et al. (2006) A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J. Mol. Biol. 361 312-26 PubMed GONUTS page
↑ ^10.0 ^10.1 Martin, GA et al. (1995) A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J. 14 1970-8 PubMed GONUTS page
↑ ^11.0 ^11.1 Goeckeler, ZM et al. (2000) Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2. J. Biol. Chem. 275 18366-74 PubMed GONUTS page

[PMID:25468996-1] 1.0 ^1.1 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:8625410-2] 2.0 ^2.1 ^2.2 Symons, M et al. (1996) Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 84 723-34 PubMed GONUTS page

[PMID:11121037-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Roig, J et al. (2000) Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc. Natl. Acad. Sci. U.S.A. 97 14346-51 PubMed GONUTS page

[PMID:21555521-4] 4.0 ^4.1 ^4.2 Li, X et al. (2011) Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines. J. Biol. Chem. 286 22291-9 PubMed GONUTS page

[PMID:19240112-5] Luo, S & Rubinsztein, DC (2009) Huntingtin promotes cell survival by preventing Pak2 cleavage. J. Cell. Sci. 122 875-85 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11278486-7] Chong, C et al. (2001) The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J. Biol. Chem. 276 17347-53 PubMed GONUTS page

[PMID:11805089-8] 8.0 ^8.1 ^8.2 Lee, KK & Yonehara, S (2002) Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J. Biol. Chem. 277 12351-8 PubMed GONUTS page

[PMID:16837009-9] Pirruccello, M et al. (2006) A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J. Mol. Biol. 361 312-26 PubMed GONUTS page

[PMID:7744004-10] 10.0 ^10.1 Martin, GA et al. (1995) A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J. 14 1970-8 PubMed GONUTS page

[PMID:10748018-11] 11.0 ^11.1 Goeckeler, ZM et al. (2000) Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2. J. Biol. Chem. 275 18366-74 PubMed GONUTS page

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HUMAN:PAK2

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