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HUMAN:PAEP
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PAEP | |
| Protein Name(s) | Glycodelin
GD Placental protein 14 PP14 Pregnancy-associated endometrial alpha-2 globulin PAEG PEG Progestagen-associated endometrial protein Progesterone-associated endometrial protein | |
| External Links | ||
| UniProt | P09466 | |
| EMBL | J04129 M34046 M61886 M61886 AL050169 AL354761 BC069451 BC069562 BC112304 BC113728 | |
| CCDS | CCDS35173.1 | |
| PIR | A35570 | |
| RefSeq | NP_001018059.1 NP_002562.2 XP_005263462.1 | |
| UniGene | Hs.532325 | |
| ProteinModelPortal | P09466 | |
| SMR | P09466 | |
| BioGrid | 111084 | |
| IntAct | P09466 | |
| MINT | MINT-1209116 | |
| STRING | 9606.ENSP00000277508 | |
| PhosphoSite | P09466 | |
| UniCarbKB | P09466 | |
| DMDM | 130701 | |
| PaxDb | P09466 | |
| PRIDE | P09466 | |
| DNASU | 5047 | |
| Ensembl | ENST00000277508 ENST00000371766 ENST00000479141 | |
| GeneID | 5047 | |
| KEGG | hsa:5047 | |
| UCSC | uc004cgd.1 uc011mdp.1 | |
| CTD | 5047 | |
| GeneCards | GC09P138453 | |
| HGNC | HGNC:8573 | |
| HPA | CAB016762 HPA020108 HPA029473 | |
| MIM | 173310 | |
| neXtProt | NX_P09466 | |
| PharmGKB | PA32904 | |
| eggNOG | NOG73754 | |
| GeneTree | ENSGT00620000088158 | |
| HOGENOM | HOG000113272 | |
| HOVERGEN | HBG104361 | |
| InParanoid | P09466 | |
| OMA | SMMCQYL | |
| PhylomeDB | P09466 | |
| TreeFam | TF342475 | |
| GeneWiki | PAEP | |
| GenomeRNAi | 5047 | |
| NextBio | 19446 | |
| PRO | PR:P09466 | |
| Proteomes | UP000005640 | |
| Bgee | P09466 | |
| CleanEx | HS_PAEP | |
| ExpressionAtlas | P09466 | |
| Genevestigator | P09466 | |
| GO | GO:0005576 GO:0036094 GO:0007275 GO:0006810 | |
| Gene3D | 2.40.128.20 | |
| InterPro | IPR002447 IPR012674 IPR011038 IPR002345 IPR022272 IPR000566 | |
| Pfam | PF00061 | |
| PRINTS | PR01172 PR00179 | |
| SUPFAM | SSF50814 | |
| PROSITE | PS00213 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006915 |
apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Figure 4: DNA fragmentation is a key feature of apoptosis. DNA of THP1 cells underwent fragmentation upon treatment with Gd |
complete | ||||
| GO:2000778 |
positive regulation of interleukin-6 secretion |
ECO:0000314 |
P |
Table 1 |
complete | |||||
| GO:2000667 |
positive regulation of interleukin-13 secretion |
ECO:0000314 |
P |
Table 1 |
complete | |||||
| GO:0032725 |
positive regulation of granulocyte macrophage colony-stimulating factor production |
ECO:0000314 |
P |
Table 1 |
complete | |||||
|
involved_in |
GO:1902491 |
negative regulation of sperm capacitation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000359 |
regulation of binding of sperm to zona pellucida |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032725 |
positive regulation of granulocyte macrophage colony-stimulating factor production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000667 |
positive regulation of interleukin-13 secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000778 |
positive regulation of interleukin-6 secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036094 |
small molecule binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Alok, A et al. (2009) Glycodelin A, an immunomodulatory protein in the endometrium, inhibits proliferation and induces apoptosis in monocytic cells. Int. J. Biochem. Cell Biol. 41 1138-47 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Lee, CL et al. (2010) Glycodelin-A modulates cytokine production of peripheral blood natural killer cells. Fertil. Steril. 94 769-71 PubMed GONUTS page
- ↑ Chiu, PC et al. (2005) Glycodelin-S in human seminal plasma reduces cholesterol efflux and inhibits capacitation of spermatozoa. J. Biol. Chem. 280 25580-9 PubMed GONUTS page
- ↑ Chiu, PC et al. (2007) Cumulus oophorus-associated glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding. J. Biol. Chem. 282 5378-88 PubMed GONUTS page
- ↑ Chiu, PC et al. (2003) Zona-binding inhibitory factor-1 from human follicular fluid is an isoform of glycodelin. Biol. Reprod. 69 365-72 PubMed GONUTS page
- ↑ Bell, SC et al. (1987) Pregnancy-associated endometrial alpha 2-globulin, the major secretory protein of the luteal phase and first trimester pregnancy endometrium, is not glycosylated prolactin but related to beta-lactoglobulins. J. Clin. Endocrinol. Metab. 65 1067-71 PubMed GONUTS page
- ↑ Julkunen, M et al. (1988) Complete amino acid sequence of human placental protein 14: a progesterone-regulated uterine protein homologous to beta-lactoglobulins. Proc. Natl. Acad. Sci. U.S.A. 85 8845-9 PubMed GONUTS page
