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PMID:3194393
| Citation |
Julkunen, M, Seppälä, M and Jänne, OA (1988) Complete amino acid sequence of human placental protein 14: a progesterone-regulated uterine protein homologous to beta-lactoglobulins. Proc. Natl. Acad. Sci. U.S.A. 85:8845-9 |
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| Abstract |
Placental protein 14 (PP14), also known as progestagen-dependent endometrial protein and pregnancy-associated endometrial alpha 2-globulin, is synthesized by the human secretory endometrium and decidua. We have isolated from a human decidual cDNA library clones corresponding to PP14 and deduced its entire amino acid sequence. PP14 contains 180 amino acids, 18 of which correspond to a putative signal peptide. The predicted molecular weight of the pre-PP14 is 20,555 and that of the mature protein is 18,787. PP14 is encoded by a 1-kilobase-pair mRNA that is expressed in human secretory endometrium and decidua but not in postmenopausal endometrium, placenta, liver, kidney, and adrenals. The 162-residue-long sequence of PP14 is highly homologous to beta-lactoglobulins, with a 53.4% identity with the amino acid sequence of horse beta-lactoglobulin I. The four cysteinyl residues (positions 66, 106, 119, and 160) responsible for intramolecular disulfide bridges in beta-lactoglobulins are all conserved in PP14. Southern blot analysis of human DNA suggested that PP14 gene sequences encompass some 20 kilobase pairs of the human genomic DNA. |
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| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; DNA/genetics; Decidua/metabolism; Endometrium/metabolism; Female; Genes; Glycoproteins; Horses; Humans; Lactoglobulins/genetics; Molecular Sequence Data; Pregnancy; Pregnancy Proteins/genetics; Pregnancy Proteins/isolation & purification; Pregnancy Trimester, First; Protein Biosynthesis; RNA, Messenger/genetics; Sequence Homology, Nucleic Acid |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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involved_in |
GO:0007275: multicellular organism development |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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