HUMAN:PADI4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PADI4 (synonyms: PADI5, PDI5)
Protein Name(s)	Protein-arginine deiminase type-4 HL-60 PAD Peptidylarginine deiminase IV Protein-arginine deiminase type IV
External Links
UniProt	Q9UM07
EMBL	AB017919 AJ549502 AK290507 AK314839 AL590644 AC004824 BC025718
CCDS	CCDS180.1
RefSeq	NP_036519.2
UniGene	Hs.522969
PDB	1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT
PDBsum	1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT
DisProt	DP00321
ProteinModelPortal	Q9UM07
SMR	Q9UM07
BioGrid	117111
IntAct	Q9UM07
STRING	9606.ENSP00000364597
BindingDB	Q9UM07
ChEMBL	CHEMBL6111
DrugBank	DB00155
PhosphoSite	Q9UM07
DMDM	296439260
PaxDb	Q9UM07
PRIDE	Q9UM07
DNASU	23569
Ensembl	ENST00000375448
GeneID	23569
KEGG	hsa:23569
UCSC	uc001baj.2
CTD	23569
GeneCards	GC01P017634
H-InvDB	HIX0000182
HGNC	HGNC:18368
HPA	HPA017007
MIM	180300 605347
neXtProt	NX_Q9UM07
PharmGKB	PA32903
eggNOG	NOG42085
GeneTree	ENSGT00390000008680
HOGENOM	HOG000220908
HOVERGEN	HBG053016
InParanoid	Q9UM07
KO	K01481
OMA	VLGPQQP
OrthoDB	EOG7P5T09
PhylomeDB	Q9UM07
TreeFam	TF331952
BioCyc	MetaCyc:HS08389-MONOMER
BRENDA	3.5.3.15
ChiTaRS	PADI4
EvolutionaryTrace	Q9UM07
GeneWiki	PADI4
GenomeRNAi	23569
NextBio	35463997
PRO	PR:Q9UM07
Proteomes	UP000005640
Bgee	Q9UM07
CleanEx	HS_PADI4
ExpressionAtlas	Q9UM07
Genevestigator	Q9UM07
GO	GO:0005737 GO:0005634 GO:0016990 GO:0005509 GO:0004668 GO:0006464 GO:0016568 GO:0006338 GO:0036414 GO:0036413 GO:0045087 GO:0006334 GO:0018101 GO:0006355 GO:0019827 GO:0006351
InterPro	IPR008972 IPR004303 IPR013530 IPR013732 IPR013733 IPR016296
PANTHER	PTHR10837
Pfam	PF03068 PF08527 PF08526
PIRSF	PIRSF001247
SUPFAM	SSF110083 SSF49503

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0019546	arginine deiminase pathway	PMID:15247907^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018101	protein citrullination	PMID:15247907^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004668	protein-arginine deiminase activity	PMID:15247907^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0034618	arginine binding	PMID:15247907^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:15247907^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:15247907^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:15247907^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0036414	histone citrullination	PMID:16567635^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036414	histone citrullination	PMID:15339660^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036413	histone H3-R26 citrullination	PMID:16567635^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036413	histone H3-R26 citrullination	PMID:15339660^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z183	P		Seeded From UniProt	complete
involved_in	GO:0018101	protein citrullination	PMID:21584310^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P15880)	Seeded From UniProt	complete
enables	GO:0016990	arginine deiminase activity	PMID:21584310^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P15880) activated_by:(CHEBI:3312)	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z183	P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z183	P		Seeded From UniProt	complete
involved_in	GO:0006334	nucleosome assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z183	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15339660^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:16567635^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004668	protein-arginine deiminase activity	PMID:16567635^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004668	protein-arginine deiminase activity	PMID:15339660^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0036414	histone citrullination	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338898 PANTHER:PTN000851400 UniProtKB:Q9UM07	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2655198 PANTHER:PTN000851400 UniProtKB:Q6TGC4 UniProtKB:Q9ULW8 UniProtKB:Q9Y2J8	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000851400 UniProtKB:Q9UM07	C		Seeded From UniProt	complete
enables	GO:0004668	protein-arginine deiminase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338898 MGI:MGI:2655198 PANTHER:PTN000851400 RGD:3287 RGD:3288 RGD:3289 RGD:3290 UniProtKB:E1C0W6 UniProtKB:F1NP39 UniProtKB:Q9ULW8 UniProtKB:Q9UM07 UniProtKB:Q9Y2J8	F		Seeded From UniProt	complete
involved_in	GO:0018101	protein citrullination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88807 ensembl:ENSRNOP00000009081	P		Seeded From UniProt	complete
enables	GO:0004668	protein-arginine deiminase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88807 ensembl:ENSRNOP00000009081	F		Seeded From UniProt	complete
involved_in	GO:0036414	histone citrullination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z183 ensembl:ENSMUSP00000026381	P		Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z183 ensembl:ENSMUSP00000026381	P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z183 ensembl:ENSMUSP00000026381	P		Seeded From UniProt	complete
involved_in	GO:0006334	nucleosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z183 ensembl:ENSMUSP00000026381	P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z183 ensembl:ENSMUSP00000026381	P		Seeded From UniProt	complete
enables	GO:0004668	protein-arginine deiminase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z183 ensembl:ENSMUSP00000026381	F		Seeded From UniProt	complete
enables	GO:0004668	protein-arginine deiminase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004303 InterPro:IPR013530 InterPro:IPR013732 InterPro:IPR013733 InterPro:IPR036556	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013530 InterPro:IPR013732 InterPro:IPR013733 InterPro:IPR036556	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013530 InterPro:IPR013732 InterPro:IPR013733 InterPro:IPR036556	C		Seeded From UniProt	complete
involved_in	GO:0018101	protein citrullination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004303 InterPro:IPR013733 InterPro:IPR036556	P		Seeded From UniProt	complete
enables	GO:0004668	protein-arginine deiminase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.3.15	F		Seeded From UniProt	complete
involved_in	GO:0006464	cellular protein modification process	PMID:10488123^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004668	protein-arginine deiminase activity	PMID:10488123^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	Reactome:R-HSA-4839726	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-1183128	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-3247569	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Arita, K et al. (2004) Structural basis for Ca(2+)-induced activation of human PAD4. Nat. Struct. Mol. Biol. 11 777-83 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Arita, K et al. (2006) Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4. Proc. Natl. Acad. Sci. U.S.A. 103 5291-6 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Cuthbert, GL et al. (2004) Histone deimination antagonizes arginine methylation. Cell 118 545-53 PubMed GONUTS page
↑ ^4.0 ^4.1 Guo, Q et al. (2011) Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. Mol Biosyst 7 2286-95 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 Nakashima, K et al. (1999) Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3). J. Biol. Chem. 274 27786-92 PubMed GONUTS page

[PMID:15247907-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Arita, K et al. (2004) Structural basis for Ca(2+)-induced activation of human PAD4. Nat. Struct. Mol. Biol. 11 777-83 PubMed GONUTS page

[PMID:16567635-2] 2.0 ^2.1 ^2.2 ^2.3 Arita, K et al. (2006) Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4. Proc. Natl. Acad. Sci. U.S.A. 103 5291-6 PubMed GONUTS page

[PMID:15339660-3] 3.0 ^3.1 ^3.2 ^3.3 Cuthbert, GL et al. (2004) Histone deimination antagonizes arginine methylation. Cell 118 545-53 PubMed GONUTS page

[PMID:21584310-4] 4.0 ^4.1 Guo, Q et al. (2011) Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. Mol Biosyst 7 2286-95 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10488123-6] 6.0 ^6.1 Nakashima, K et al. (1999) Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3). J. Biol. Chem. 274 27786-92 PubMed GONUTS page

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HUMAN:PADI4

Contents

Annotations

Notes

References

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