HUMAN:NOX4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NOX4 (synonyms: RENOX)
Protein Name(s)	NADPH oxidase 4 Kidney oxidase-1 KOX-1 Kidney superoxide-producing NADPH oxidase Renal NAD(P)H-oxidase
External Links
UniProt	Q9NPH5
EMBL	AF261943 AF254621 AB041035 AY288918 AJ704725 AJ704726 AJ704727 AJ704728 AJ704729 AK291830 AK298323 AP003400 AP001815 AP002404 BC040105 BC051371
CCDS	CCDS44695.1 CCDS44696.1 CCDS73361.1 CCDS8285.1
RefSeq	NP_001137308.1 NP_001137309.1 NP_001278855.1 NP_001278856.1 NP_001287924.1 NP_058627.1
UniGene	Hs.371036
ProteinModelPortal	Q9NPH5
SMR	Q9NPH5
BioGrid	119078
STRING	9606.ENSP00000263317
BindingDB	Q9NPH5
ChEMBL	CHEMBL1250375
PeroxiBase	5967
TCDB	5.B.1.1.2
PhosphoSite	Q9NPH5
DMDM	212276447
PaxDb	Q9NPH5
PRIDE	Q9NPH5
DNASU	50507
Ensembl	ENST00000263317 ENST00000343727 ENST00000375979 ENST00000393282 ENST00000424319 ENST00000527956 ENST00000529343 ENST00000531342 ENST00000532825 ENST00000534731
GeneID	50507
KEGG	hsa:50507
UCSC	uc001pcu.3 uc001pcv.3 uc001pcw.3 uc001pcx.3
CTD	50507
GeneCards	GC11M089057
HGNC	HGNC:7891
HPA	HPA015475
MIM	605261
neXtProt	NX_Q9NPH5
PharmGKB	PA31692
eggNOG	NOG265816
GeneTree	ENSGT00550000074350
HOVERGEN	HBG003760
InParanoid	Q9NPH5
OrthoDB	EOG7RZ5PZ
PhylomeDB	Q9NPH5
TreeFam	TF105354
GeneWiki	NOX4
GenomeRNAi	50507
NextBio	35499451
PRO	PR:Q9NPH5
Proteomes	UP000005640
Bgee	Q9NPH5
CleanEx	HS_NOX4
ExpressionAtlas	Q9NPH5
Genevestigator	Q9NPH5
GO	GO:0016324 GO:0005789 GO:0005925 GO:0016021 GO:0005739 GO:0043020 GO:0005730 GO:0048471 GO:0001725 GO:0009055 GO:0050660 GO:0020037 GO:0072341 GO:0016174 GO:0000166 GO:0019826 GO:0016175 GO:0045453 GO:0055007 GO:0007569 GO:0000902 GO:0071320 GO:0071480 GO:0071333 GO:0071560 GO:0050667 GO:0006954 GO:0008285 GO:0055114 GO:0043065 GO:2000573 GO:0070374 GO:0043406 GO:0051897 GO:2000379 GO:0014911 GO:0051496 GO:0072593 GO:0001666 GO:0042554
InterPro	IPR000778 IPR013112 IPR017927 IPR013130 IPR013121 IPR017938
Pfam	PF08022 PF01794 PF08030
PRINTS	PR00466
SUPFAM	SSF63380
PROSITE	PS51384

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006801	superoxide metabolic process	PMID:18760347^[1]	ECO:0000314			P		Figure 2C show oxygen production levels	complete CACAO 5112
	GO:0043020	NADPH oxidase complex	PMID:23144758^[2]	ECO:0000314			C		Figure 2 shows "Nox4 is involved in insulin-stimulated insulin receptor and IRS tyrosine phosphorylation, ERK1/2, and AKT activation".	complete CACAO 6095
	GO:0010467	gene expression	PMID:23144758^[2]	ECO:0000315			P		Figure 4 shows Nox4 mediates insulin-induced HIF-1α mRNA and protein expression	complete CACAO 6096
	GO:0043020	NADPH oxidase complex	PMID:23144758^[2]	ECO:0000314			C		Figure 6 shows Nox4 mediates insulin-induced HMVEC migration, proliferation, and angiogenesis in vitro.	complete CACAO 6097
	GO:0043020	NADPH oxidase complex	PMID:10869423^[3]	ECO:0000247		UniProtKB:Q9NPH5	C		Figure 1 shows a comparison of the deduced amino acid sequences.	complete CACAO 10114
enables	GO:1990782	protein tyrosine kinase binding	PMID:27525436^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JHI8	F	occurs_in:(CL:0000746) occurs_in:(GO:0048471)\|occurs_in:(CL:0000746) occurs_in:(GO:0005739)\|occurs_in:(CL:0000746) occurs_in:(GO:0005634)\|occurs_in:(CL:0000746) occurs_in:(GO:0097038)\|occurs_in:(CL:0000746) part_of:(GO:0006979)	Seeded From UniProt	complete
part_of	GO:0097038	perinuclear endoplasmic reticulum	PMID:27525436^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q924V1	C	part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:27525436^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q924V1	C	part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:27525436^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q924V1	C	part_of:(CL:0000746) part_of:(GO:0048471)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:27525436^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q924V1	C	part_of:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:27525436^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JHI8	P	occurs_in:(CL:0000746) regulates_o_occurs_in:(CL:0000746) has_input:(UniProtKB:P06241) part_of:(GO:0006979)	Seeded From UniProt	complete
involved_in	GO:0003015	heart process	PMID:27525436^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P06241	P		Seeded From UniProt	complete
involved_in	GO:0010467	gene expression	PMID:23144758^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	PMID:18760347^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903409	reactive oxygen species biosynthetic process	PMID:27525436^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	PMID:10869423^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0072341	modified amino acid binding	PMID:20031578^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	PMID:10869423^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050667	homocysteine metabolic process	PMID:20031578^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	PMID:10869423^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JHI8	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:10869423^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JHI8	P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	PMID:10869423^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JHI8	P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	PMID:10869423^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JHI8	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283531 MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN001735877 PomBase:SPBC1683.09c RGD:620600 SGD:S000003128 SGD:S000004037 SGD:S000005512 TAIR:locus:2017789 TAIR:locus:2024603 TAIR:locus:2025351 TAIR:locus:2025366 TAIR:locus:2157032 TAIR:locus:2157348 TAIR:locus:2157697 TAIR:locus:2160917 TAIR:locus:2178677 TAIR:locus:2178687 UniProtKB:P04839 UniProtKB:Q96PH1 UniProtKB:Q9NPH5 UniProtKB:Q9NRD8 UniProtKB:Q9SBI0 UniProtKB:Q9Y5S8 WB:WBGene00000253 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653	P		Seeded From UniProt	complete
part_of	GO:0043020	NADPH oxidase complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2681162 MGI:MGI:88574 PANTHER:PTN000239643 RGD:620574 RGD:620598 RGD:620600 UniProtKB:P04839 UniProtKB:Q9Y5S8	C		Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN000239643 RGD:620598 UniProtKB:P04839 UniProtKB:Q96PH1 UniProtKB:Q9Y5S8 dictyBase:DDB_G0287101	P		Seeded From UniProt	complete
enables	GO:0016175	superoxide-generating NADPH oxidase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN000239643 UniProtKB:Q96PH1 UniProtKB:Q9Y5S8 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653	F		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283531 MGI:MGI:88574 PANTHER:PTN000239643 UniProtKB:P04839 ZFIN:ZDB-GENE-091117-14 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653 dictyBase:DDB_G0291117	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2139422 MGI:MGI:2681162 MGI:MGI:88574 PANTHER:PTN001735877 RGD:620574 RGD:620598 RGD:620600 SGD:S000005512 TAIR:locus:2024603 TAIR:locus:2025351 TAIR:locus:2157027 TAIR:locus:2157348 TAIR:locus:2157697 TAIR:locus:2160917 UniProtKB:O81209 UniProtKB:P04839 UniProtKB:Q9Y5S8 WB:WBGene00000253	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0022900	electron transport chain	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0009055	P		Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
part_of	GO:0097038	perinuclear endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
enables	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
part_of	GO:0043020	NADPH oxidase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
enables	GO:0016174	NAD(P)H oxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	F		Seeded From UniProt	complete
involved_in	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	F		Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	C		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
involved_in	GO:0055007	cardiac muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	C		Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
enables	GO:0016175	superoxide-generating NADPH oxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
involved_in	GO:0003015	heart process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHI8 ensembl:ENSMUSP00000032781	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000778	C		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000778 InterPro:IPR013112 InterPro:IPR013121 InterPro:IPR017927	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000778 InterPro:IPR013112 InterPro:IPR013121 InterPro:IPR017927	P		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:10869423^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:10869423^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019826	oxygen sensor activity	PMID:10869423^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016174	NAD(P)H oxidase activity	PMID:10869423^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:10869423^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0009055	electron transfer activity	PMID:10869423^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:10869423^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	PMID:10869423^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	Reactome:R-HSA-3299685	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-6807557	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0118	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Dikalov, SI et al. (2008) Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Free Radic. Biol. Med. 45 1340-51 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Meng, D et al. (2012) NADPH oxidase 4 mediates insulin-stimulated HIF-1α and VEGF expression, and angiogenesis in vitro. PLoS ONE 7 e48393 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 Geiszt, M et al. (2000) Identification of renox, an NAD(P)H oxidase in kidney. Proc. Natl. Acad. Sci. U.S.A. 97 8010-4 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Matsushima, S et al. (2016) Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. J. Clin. Invest. 126 3403-16 PubMed GONUTS page
↑ ^5.0 ^5.1 Paré, G et al. (2009) Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study. Circ Cardiovasc Genet 2 142-50 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18760347-1] 1.0 ^1.1 Dikalov, SI et al. (2008) Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Free Radic. Biol. Med. 45 1340-51 PubMed GONUTS page

[PMID:23144758-2] 2.0 ^2.1 ^2.2 ^2.3 Meng, D et al. (2012) NADPH oxidase 4 mediates insulin-stimulated HIF-1α and VEGF expression, and angiogenesis in vitro. PLoS ONE 7 e48393 PubMed GONUTS page

[PMID:10869423-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 Geiszt, M et al. (2000) Identification of renox, an NAD(P)H oxidase in kidney. Proc. Natl. Acad. Sci. U.S.A. 97 8010-4 PubMed GONUTS page

[PMID:27525436-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Matsushima, S et al. (2016) Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. J. Clin. Invest. 126 3403-16 PubMed GONUTS page

[PMID:20031578-5] 5.0 ^5.1 Paré, G et al. (2009) Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study. Circ Cardiovasc Genet 2 142-50 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:NOX4

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