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HUMAN:NLRC4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NLRC4 (synonyms: CARD12, CLAN, CLAN1, IPAF)
Protein Name(s) NLR family CARD domain-containing protein 4

CARD, LRR, and NACHT-containing protein Clan protein Caspase recruitment domain-containing protein 12 Ice protease-activating factor Ipaf

External Links
UniProt Q9NPP4
EMBL AY032589
AY027787
AY027788
AY027789
AY027790
AY035391
AF376061
AY358152
AK095467
AK292673
AK314762
AL121653
CH471053
CH471053
CH471053
CH471053
BC031555
AL389934
CCDS CCDS33174.1
CCDS77400.1
RefSeq NP_001186067.1
NP_001186068.1
NP_001289433.1
NP_067032.3
UniGene Hs.574741
ProteinModelPortal Q9NPP4
SMR Q9NPP4
BioGrid 121814
DIP DIP-38428N
IntAct Q9NPP4
MINT MINT-201147
STRING 9606.ENSP00000354159
iPTMnet Q9NPP4
PhosphoSite Q9NPP4
BioMuta NLRC4
DMDM 20138032
PaxDb Q9NPP4
PRIDE Q9NPP4
DNASU 58484
Ensembl ENST00000342905
ENST00000360906
ENST00000402280
ENST00000404025
GeneID 58484
KEGG hsa:58484
UCSC uc002roi.3
uc010ezt.2
CTD 58484
GeneCards NLRC4
HGNC HGNC:16412
HPA HPA006592
MalaCards NLRC4
MIM 606831
616050
616115
neXtProt NX_Q9NPP4
PharmGKB PA162397671
eggNOG ENOG410IHIG
ENOG410YI2E
GeneTree ENSGT00500000044782
HOGENOM HOG000059630
HOVERGEN HBG050790
InParanoid Q9NPP4
KO K12805
OMA DLFVWNV
OrthoDB EOG73BVBV
PhylomeDB Q9NPP4
TreeFam TF336864
Reactome R-HSA-844623
GeneWiki NLRC4
GenomeRNAi 58484
NextBio 35464642
PRO PR:Q9NPP4
Proteomes UP000005640
Bgee Q9NPP4
CleanEx HS_NLRC4
Genevisible Q9NPP4
GO GO:0005829
GO:0005622
GO:0072557
GO:0005634
GO:0005876
GO:0005524
GO:0004869
GO:0042802
GO:0000287
GO:0042803
GO:0004842
GO:0006919
GO:0002218
GO:0042742
GO:0016045
GO:0006954
GO:1990001
GO:0045087
GO:0050702
GO:0090307
GO:0035872
GO:0043065
GO:0051092
GO:0051260
GO:0016567
GO:0070269
GO:0009966
Gene3D 1.10.533.10
3.80.10.10
InterPro IPR001315
IPR011029
IPR032675
IPR007111
IPR027417
Pfam PF00619
SUPFAM SSF47986
SSF52540
PROSITE PS50209
PS50837

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0050702

interleukin-1 beta secretion

PMID:15882992[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0050713

negative regulation of interleukin-1 beta secretion

PMID:15107016[2]

ECO:0000314

P

As shown in Figure 7(B), the NACHT domain of CLAN is sufficient to inhibit Nod2-induced IL-1β secretion, while the NB-ARC domain of Apaf-1 had no inhibitory effects when co-expressed with Nod2

complete
CACAO 11294

enables

GO:0042803

protein homodimerization activity

PMID:15107016[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0097202

activation of cysteine-type endopeptidase activity

PMID:15882992[1]

ECO:0000315

P

Fig 6

complete
CACAO 11414

involved_in

GO:0042742

defense response to bacterium

PMID:15107016[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016045

detection of bacterium

PMID:15107016[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:15030775[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:15882992[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0072557

IPAF inflammasome complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UP24

C

Seeded From UniProt

complete

involved_in

GO:0070269

pyroptosis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UP24

P

Seeded From UniProt

complete

involved_in

GO:0051260

protein homooligomerization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UP24

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:12646168[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:12646168[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UP24

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UP24

C

Seeded From UniProt

complete

involved_in

GO:0002218

activation of innate immune response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UP24

P

Seeded From UniProt

complete

involved_in

GO:0050702

interleukin-1 beta secretion

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:3036243
PANTHER:PTN000005175
UniProtKB:Q9NPP4

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:3036243
PANTHER:PTN000005175
UniProtKB:Q9NPP4

P

Seeded From UniProt

complete

involved_in

GO:0016045

detection of bacterium

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:3036243
PANTHER:PTN000005175
UniProtKB:Q9NPP4

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:11390368[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NPP4

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:11374873[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NPP4

F

Seeded From UniProt

complete

part_of

GO:0072557

IPAF inflammasome complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UP24
ensembl:ENSMUSP00000059637

C

Seeded From UniProt

complete

involved_in

GO:0070269

pyroptosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UP24
ensembl:ENSMUSP00000059637

P

Seeded From UniProt

complete

involved_in

GO:0051260

protein homooligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UP24
ensembl:ENSMUSP00000059637

P

Seeded From UniProt

complete

involved_in

GO:0050702

interleukin-1 beta secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UP24
ensembl:ENSMUSP00000059637

P

Seeded From UniProt

complete

involved_in

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UP24
ensembl:ENSMUSP00000059637

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UP24
ensembl:ENSMUSP00000059637

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UP24
ensembl:ENSMUSP00000059637

F

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UP24
ensembl:ENSMUSP00000059637

P

Seeded From UniProt

complete

involved_in

GO:0016045

detection of bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UP24
ensembl:ENSMUSP00000059637

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UP24
ensembl:ENSMUSP00000059637

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UP24
ensembl:ENSMUSP00000059637

C

Seeded From UniProt

complete

involved_in

GO:0002218

activation of innate immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UP24
ensembl:ENSMUSP00000059637

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001315

P

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

PMID:15882992[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

Reactome:R-HSA-5633008

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-844617
Reactome:R-HSA-6801415

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Lu, C et al. (2005) Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation. Biochem. Biophys. Res. Commun. 331 1114-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Damiano, JS et al. (2004) Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem. J. 381 213-9 PubMed GONUTS page
  3. ↑ Agostini, L et al. (2004) NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20 319-25 PubMed GONUTS page
  4. ↑ 4.0 4.1 Masumoto, J et al. (2003) ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. Biochem. Biophys. Res. Commun. 303 69-73 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Poyet, JL et al. (2001) Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J. Biol. Chem. 276 28309-13 PubMed GONUTS page
  7. ↑ Geddes, BJ et al. (2001) Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. Biochem. Biophys. Res. Commun. 284 77-82 PubMed GONUTS page
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