HUMAN:NGF

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NGF (synonyms: NGFB)
Protein Name(s)	Beta-nerve growth factor Beta-NGF
External Links
UniProt	P01138
EMBL	V01511 M21062 AF150960 AB037517 AF411526 CR541855 BT019733 AL049825 CH471122 BC032517 BC126148 BC126150 X52599
CCDS	CCDS882.1
PIR	A01399
RefSeq	NP_002497.2 XP_006710726.1 XP_006710727.1 XP_006710728.1
UniGene	Hs.2561
PDB	1SG1 1WWW 2IFG 4EDW 4EDX
PDBsum	1SG1 1WWW 2IFG 4EDW 4EDX
ProteinModelPortal	P01138
SMR	P01138
BioGrid	110869
DIP	DIP-5712N
IntAct	P01138
MINT	MINT-122414
STRING	9606.ENSP00000358525
BindingDB	P01138
ChEMBL	CHEMBL1649058
DrugBank	DB01407
PhosphoSite	P01138
PaxDb	P01138
PRIDE	P01138
DNASU	4803
Ensembl	ENST00000369512
GeneID	4803
KEGG	hsa:4803
UCSC	uc001efu.1
CTD	4803
GeneCards	GC01M115828
HGNC	HGNC:7808
MIM	162030 608654
neXtProt	NX_P01138
Orphanet	64752
PharmGKB	PA162397475
eggNOG	NOG44820
GeneTree	ENSGT00390000007725
HOGENOM	HOG000231516
HOVERGEN	HBG006494
InParanoid	P01138
KO	K02582
OMA	IFHRGEF
OrthoDB	EOG7RBZ8Z
PhylomeDB	P01138
TreeFam	TF106463
Reactome	REACT_11060 REACT_11062 REACT_12002 REACT_12033 REACT_12049 REACT_12076 REACT_12077 REACT_12079 REACT_12435 REACT_12464 REACT_13415 REACT_13526 REACT_13638 REACT_13643 REACT_13695 REACT_13696 REACT_13724 REACT_13779 REACT_13806
SignaLink	P01138
EvolutionaryTrace	P01138
GeneWiki	Nerve_growth_factor
GenomeRNAi	4803
NextBio	18514
PMAP-CutDB	P01138
PRO	PR:P01138
Proteomes	UP000005640
Bgee	P01138
CleanEx	HS_NGF
Genevestigator	P01138
GO	GO:0005768 GO:0005576 GO:0005615 GO:0005796 GO:0005163 GO:0005057 GO:0000186 GO:0007202 GO:0008344 GO:0097190 GO:0007623 GO:0097192 GO:0008625 GO:0006954 GO:0007613 GO:0043066 GO:0045786 GO:0043524 GO:2000675 GO:0032455 GO:0051402 GO:0048812 GO:0048011 GO:0007422 GO:0048015 GO:0043065 GO:0045773 GO:0050772 GO:0010628 GO:0014042 GO:0051388 GO:0031954 GO:0051091 GO:2000648 GO:0007265 GO:0050770 GO:0043281 GO:0046928 GO:0042493 GO:0051602 GO:0051384 GO:0032496 GO:0009612 GO:0035094 GO:0010193 GO:0043434 GO:0009314 GO:0019233 GO:0007264 GO:0007169
Gene3D	2.10.90.10
InterPro	IPR029034 IPR020408 IPR002072 IPR020425 IPR020437 IPR019846
PANTHER	PTHR11589
Pfam	PF00243
PIRSF	PIRSF001789
PRINTS	PR01925 PR00268 PR01913
ProDom	PD002052
SMART	SM00140
SUPFAM	SSF57501
PROSITE	PS00248 PS50270

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0043388	positive regulation of DNA binding	PMID:10362258^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01139	P	has_regulation_target:(UniProtKB:Q09472) has_input:(ENSEMBL:ENSG00000124762) has_direct_input:(CHEBI:4705)\|has_regulation_target(UniProtKB:P08047) has_input:(ENSEMBL:ENSG00000124762) has_direct_input:(CHEBI:4705)\|has_regulation_target(UniProtKB:Q02447) has_input:(ENSEMBL:ENSG00000124762) has_direct_input:(CHEBI:4705)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:10362258^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01139	P	regulates_expression_of:(ENSEMBL:ENSMUSG00000023067)	Seeded From UniProt	complete
involved_in	GO:0046579	positive regulation of Ras protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01139	P	occurs_in:(CL:0000540) has_regulation_target:(UniProtKB:P70425)	Seeded From UniProt	complete
enables	GO:0008191	metalloendopeptidase inhibitor activity	PMID:20164177^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:14985763^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005163	nerve growth factor receptor binding	PMID:14985763^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99523	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:16153003^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q02765)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000904283 RGD:619728	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000904283 UniProtKB:P01138	P		Seeded From UniProt	complete
involved_in	GO:0048672	positive regulation of collateral sprouting	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97321 PANTHER:PTN000173499	P		Seeded From UniProt	complete
involved_in	GO:0045664	regulation of neuron differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97321 PANTHER:PTN000904283	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88145 MGI:MGI:97321 MGI:MGI:97380 PANTHER:PTN000904283 RGD:1598328	P		Seeded From UniProt	complete
involved_in	GO:0038180	nerve growth factor signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97321 PANTHER:PTN000904283	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88145 MGI:MGI:97380 PANTHER:PTN000904283	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88145 PANTHER:PTN000904283 RGD:2202	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88145 PANTHER:PTN000904283 RGD:2202	C		Seeded From UniProt	complete
involved_in	GO:0021675	nerve development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88145 MGI:MGI:97380 PANTHER:PTN000904283	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000904283 UniProtKB:P20783	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000904283 RGD:2202	C		Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000173497 RGD:1598328	P		Seeded From UniProt	complete
involved_in	GO:0007422	peripheral nervous system development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97321 MGI:MGI:97380 PANTHER:PTN000904283	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000904283 UniProtKB:P20783	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000904283 RGD:1598328 RGD:2202	C		Seeded From UniProt	complete
enables	GO:0005163	nerve growth factor receptor binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000173499 UniProtKB:P01138	F		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:17724343^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002072	F		Seeded From UniProt	complete
enables	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	PMID:11927634^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08138	F	positively_regulates:(GO:0051402)	Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:11927634^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08138	P	positively_regulates:(GO:0051402)	Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	PMID:11927634^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08138	P		Seeded From UniProt	complete
enables	GO:0038177	death receptor agonist activity	PMID:11927634^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08138	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0038177	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:10362258^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:10362258^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050772	positive regulation of axonogenesis	Reactome:R-HSA-209563	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	Reactome:R-HSA-198203	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048011	neurotrophin TRK receptor signaling pathway	Reactome:R-HSA-205017 Reactome:R-HSA-187042	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	Reactome:R-HSA-205025	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Reactome:R-HSA-204981	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	Reactome:R-HSA-193639	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	Reactome:R-HSA-205043	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032455	nerve growth factor processing	Reactome:R-HSA-167060	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Reactome:R-HSA-205117	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-190065 Reactome:R-HSA-170978 Reactome:R-HSA-170977 Reactome:R-HSA-170964	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-187035 Reactome:R-HSA-187020	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-209566 Reactome:R-HSA-205117 Reactome:R-HSA-205112 Reactome:R-HSA-204981 Reactome:R-HSA-198315 Reactome:R-HSA-193705 Reactome:R-HSA-193703 Reactome:R-HSA-193695 Reactome:R-HSA-193694 Reactome:R-HSA-193684 Reactome:R-HSA-193669 Reactome:R-HSA-193665 Reactome:R-HSA-193656 Reactome:R-HSA-193653 Reactome:R-HSA-193650 Reactome:R-HSA-193646 Reactome:R-HSA-193642 Reactome:R-HSA-193641 Reactome:R-HSA-190065 Reactome:R-HSA-187035 Reactome:R-HSA-177479 Reactome:R-HSA-169905 Reactome:R-HSA-169904 Reactome:R-HSA-169895 Reactome:R-HSA-166542 Reactome:R-HSA-166538	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	Reactome:R-HSA-169893	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
enables	GO:0008191	metalloendopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0483	F		Seeded From UniProt	complete
enables	GO:0004857	enzyme inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0481	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Billon, N et al. (1999) Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. Oncogene 18 2872-82 PubMed GONUTS page
↑ Wijeyewickrema, LC et al. (2010) Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI. J. Biol. Chem. 285 11793-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Nykjaer, A et al. (2004) Sortilin is essential for proNGF-induced neuronal cell death. Nature 427 843-8 PubMed GONUTS page
↑ Vattimo, Mde F & Santos, OF (2005) Functional interface between cathepsins and growth factors in the kidney development. Ren Fail 27 615-22 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 ^5.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Feng, L et al. (2007) Spatial regulation of Raf kinase signaling by RKTG. Proc. Natl. Acad. Sci. U.S.A. 104 14348-53 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Perini, G et al. (2002) Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines. J. Exp. Med. 195 907-18 PubMed GONUTS page

[PMID:10362258-1] 1.0 ^1.1 ^1.2 ^1.3 Billon, N et al. (1999) Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. Oncogene 18 2872-82 PubMed GONUTS page

[PMID:20164177-2] Wijeyewickrema, LC et al. (2010) Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI. J. Biol. Chem. 285 11793-9 PubMed GONUTS page

[PMID:14985763-3] 3.0 ^3.1 Nykjaer, A et al. (2004) Sortilin is essential for proNGF-induced neuronal cell death. Nature 427 843-8 PubMed GONUTS page

[PMID:16153003-4] Vattimo, Mde F & Santos, OF (2005) Functional interface between cathepsins and growth factors in the kidney development. Ren Fail 27 615-22 PubMed GONUTS page

[PMID:21873635-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 ^5.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17724343-6] Feng, L et al. (2007) Spatial regulation of Raf kinase signaling by RKTG. Proc. Natl. Acad. Sci. U.S.A. 104 14348-53 PubMed GONUTS page

[PMID:11927634-7] 7.0 ^7.1 ^7.2 ^7.3 Perini, G et al. (2002) Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines. J. Exp. Med. 195 907-18 PubMed GONUTS page

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HUMAN:NGF

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