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HUMAN:NFYA

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NFYA
Protein Name(s) Nuclear transcription factor Y subunit alpha

CAAT box DNA-binding protein subunit A Nuclear transcription factor Y subunit A NF-YA

External Links
UniProt P23511
EMBL X59711
AL031778
AL031778
BC039244
M59079
CCDS CCDS4849.1
CCDS4850.1
PIR S22816
RefSeq NP_002496.1
NP_068351.1
UniGene Hs.10441
PDB 4AWL
PDBsum 4AWL
ProteinModelPortal P23511
SMR P23511
BioGrid 110866
IntAct P23511
MINT MINT-98352
STRING 9606.ENSP00000345702
iPTMnet P23511
PhosphoSitePlus P23511
BioMuta NFYA
DMDM 115844
EPD P23511
MaxQB P23511
PaxDb P23511
PeptideAtlas P23511
PRIDE P23511
DNASU 4800
Ensembl ENST00000341376
ENST00000353205
GeneID 4800
KEGG hsa:4800
UCSC uc003opo.4
CTD 4800
DisGeNET 4800
GeneCards NFYA
HGNC HGNC:7804
HPA CAB009250
HPA050779
MIM 189903
neXtProt NX_P23511
OpenTargets ENSG00000001167
PharmGKB PA31609
eggNOG KOG1561
COG5224
GeneTree ENSGT00390000015714
HOGENOM HOG000247016
HOVERGEN HBG005253
InParanoid P23511
KO K08064
OMA TQMIRVS
OrthoDB EOG091G0JVF
PhylomeDB P23511
TreeFam TF323257
Reactome [www.reactome.org/content/detail/R-HSA-1989781 R-HSA-1989781]
[www.reactome.org/content/detail/R-HSA-2426168 R-HSA-2426168]
[www.reactome.org/content/detail/R-HSA-380994 R-HSA-380994]
[www.reactome.org/content/detail/R-HSA-381183 R-HSA-381183]
SignaLink P23511
SIGNOR P23511
ChiTaRS NFYA
GeneWiki NFYA
GenomeRNAi 4800
PRO PR:P23511
Proteomes UP000005640
Bgee ENSG00000001167
CleanEx HS_NFYA
ExpressionAtlas P23511
Genevisible P23511
GO GO:0016602
GO:0005654
GO:0005634
GO:0032993
GO:0001046
GO:0003677
GO:0003700
GO:0045893
GO:0006355
GO:0048511
GO:0006366
InterPro IPR018362
IPR001289
PANTHER PTHR12632
Pfam PF02045
PRINTS PR00616
SMART SM00521
PROSITE PS00686
PS51152

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR001289

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:P23708

F

Seeded From UniProt

complete

part_of

GO:0090575

RNA polymerase II transcription factor complex

PMID:11256944[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

PMID:11256944[2]

ECO:0000314

direct assay evidence used in manual assertion

F

has_regulation_target:(NCBI_Gene:3309)

Seeded From UniProt

complete

contributes_to

GO:0044212

transcription regulatory region DNA binding

PMID:11256944[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:11256944[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P23708

F

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P23708

P

Seeded From UniProt

complete

part_of

GO:0016602

CCAAT-binding factor complex

PMID:15243141[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:15243141[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15243141[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:15243141[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15964792[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000981

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000981

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000981

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018362

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001289

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001289

P

Seeded From UniProt

complete

part_of

GO:0016602

CCAAT-binding factor complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018362

C

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

PMID:2000400[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:2266139[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:1774067[7]
PMID:2000400[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

involved_in

GO:0045540

regulation of cholesterol biosynthetic process

Reactome:R-HSA-1655829

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-2426164
Reactome:R-HSA-2426163
Reactome:R-HSA-2426162
Reactome:R-HSA-2426161
Reactome:R-HSA-2426157
Reactome:R-HSA-2426156
Reactome:R-HSA-2426155
Reactome:R-HSA-2426152
Reactome:R-HSA-2426151
Reactome:R-HSA-2426150
Reactome:R-HSA-2426148
Reactome:R-HSA-2426147
Reactome:R-HSA-2426146
Reactome:R-HSA-2065966

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0006366

transcription from RNA polymerase II promoter

PMID:27974701[8]

ECO:0000314

P

Fulfills roles as both activator and repressor. provides upregulation during transcription of RNA.

complete
CACAO 12847

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Haze, K et al. (2001) Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. Biochem. J. 355 19-28 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Chattopadhyay, C et al. (2004) Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. Nucleic Acids Res. 32 3632-41 PubMed GONUTS page
  4. ↑ Kahle, J et al. (2005) Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. Mol. Cell. Biol. 25 5339-54 PubMed GONUTS page
  5. ↑ 5.0 5.1 Becker, DM et al. (1991) A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast. Proc. Natl. Acad. Sci. U.S.A. 88 1968-72 PubMed GONUTS page
  6. ↑ Vuorio, T et al. (1990) Purification and molecular cloning of the "A" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor. J. Biol. Chem. 265 22480-6 PubMed GONUTS page
  7. ↑ Li, XY et al. (1991) One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes. Genomics 11 630-4 PubMed GONUTS page
  8. ↑ Cicchillitti, L et al. (2017) Prognostic role of NF-YA splicing isoforms and Lamin A status in low grade endometrial cancer. Oncotarget 8 7935-7945 PubMed GONUTS page
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