HUMAN:NEK2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NEK2 (synonyms: NEK2A, NLK1)
Protein Name(s)	Serine/threonine-protein kinase Nek2 HSPK 21 Never in mitosis A-related kinase 2 NimA-related protein kinase 2 NimA-like protein kinase 1
External Links
UniProt	P51955
EMBL	Z29066 AY045701 U11050 BT019729 AK223353 AL356310 AC096637 BC043502 BC052807 BC065932 Z25425 AY863109
CCDS	CCDS1500.1 CCDS55682.1
PIR	G01452 I38215
RefSeq	NP_001191111.1 NP_001191112.1 NP_002488.1 XP_005273204.1
UniGene	Hs.153704
PDB	2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE
PDBsum	2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE
ProteinModelPortal	P51955
SMR	P51955
BioGrid	110826
IntAct	P51955
MINT	MINT-3019433
STRING	9606.ENSP00000355966
BindingDB	P51955
ChEMBL	CHEMBL3835
GuidetoPHARMACOLOGY	2117
PhosphoSite	P51955
DMDM	1709252
MaxQB	P51955
PaxDb	P51955
PRIDE	P51955
DNASU	4751
Ensembl	ENST00000366998 ENST00000366999
GeneID	4751
KEGG	hsa:4751
UCSC	uc001hir.2 uc001his.4
CTD	4751
GeneCards	GC01M211836
HGNC	HGNC:7745
HPA	CAB017530 HPA047522
MIM	604043 615565
neXtProt	NX_P51955
Orphanet	791
PharmGKB	PA31546
eggNOG	COG0515
GeneTree	ENSGT00760000118997
HOVERGEN	HBG006461
InParanoid	P51955
KO	K08857
OMA	SKCKDLK
OrthoDB	EOG715Q40
PhylomeDB	P51955
TreeFam	TF101184
BRENDA	2.7.11.1
Reactome	REACT_15296 REACT_15364 REACT_15451 REACT_160315
SignaLink	P51955
EvolutionaryTrace	P51955
GeneWiki	NEK2
GenomeRNAi	4751
NextBio	18310
PMAP-CutDB	P51955
PRO	PR:P51955
Proteomes	UP000005640
Bgee	P51955
CleanEx	HS_NEK2
ExpressionAtlas	P51955
Genevestigator	P51955
GO	GO:0005813 GO:0000777 GO:0000794 GO:0005737 GO:0005829 GO:0045171 GO:0000776 GO:0005874 GO:0030496 GO:0005730 GO:0005634 GO:0043234 GO:0000922 GO:0005524 GO:0046872 GO:0004672 GO:0019903 GO:0004674 GO:0001824 GO:0051299 GO:0007059 GO:0000086 GO:0051321 GO:0000278 GO:0007067 GO:0000070 GO:1903126 GO:0043392 GO:0046777 GO:0006468 GO:0051988 GO:0007088 GO:0046602 GO:0051225 GO:0090307
InterPro	IPR011009 IPR000719 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1904355	positive regulation of telomere capping	PMID:21531765^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0032212) part_of:(GO:0051973)	Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	PMID:21531765^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	PMID:21531765^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:26220856^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046602	regulation of mitotic centrosome separation	PMID:26220856^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:26220856^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903126	negative regulation of centriole-centriole cohesion	PMID:24554434^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:24554434^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q76N32)\|has_direct_input:(UniProtKB:Q9NXG0)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:24554434^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q76N32)\|has_direct_input:(UniProtKB:Q9NXG0)	Seeded From UniProt	complete
involved_in	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	PMID:18297113^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051299	centrosome separation	PMID:18086858^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:10880350^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:17626005^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:10880350^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:10880350^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P36873	F		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	PMID:14978040^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21076410^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21399614^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10880350^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q9BV73)\|has_direct_input:(UniProtKB:P36873)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:18086858^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:14978040^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0000776	kinetochore	PMID:17621308^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903126	negative regulation of centriole-centriole cohesion	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002884430 UniProtKB:P51955	P		Seeded From UniProt	complete
involved_in	GO:0090307	mitotic spindle assembly	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109359 PANTHER:PTN002884430 PomBase:SPAC19E9.02	P		Seeded From UniProt	complete
involved_in	GO:0046602	regulation of mitotic centrosome separation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002884430 UniProtKB:P51955	P		Seeded From UniProt	complete
involved_in	GO:0007088	regulation of mitotic nuclear division	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029970 PANTHER:PTN002884430 PomBase:SPAC19E9.02 UniProtKB:P11837 UniProtKB:P51955	P		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109359 PANTHER:PTN002884430 SGD:S000000071 UniProtKB:P11837 UniProtKB:P51955	P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029970 PANTHER:PTN002884429 UniProtKB:P51955 dictyBase:DDB_G0270814	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109359 PANTHER:PTN002884429 UniProtKB:P11837 UniProtKB:P51955	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029970 PANTHER:PTN002462863 UniProtKB:P11837 UniProtKB:P9WI63 UniProtKB:Q8NG66 dictyBase:DDB_G0270814	F		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090307	mitotic spindle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35942 ensembl:ENSMUSP00000027931	P		Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35942 ensembl:ENSMUSP00000027931	P		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35942 ensembl:ENSMUSP00000027931	C		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35942 ensembl:ENSMUSP00000027931	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35942 ensembl:ENSMUSP00000027931	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35942 ensembl:ENSMUSP00000027931	F		Seeded From UniProt	complete
involved_in	GO:0001824	blastocyst development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35942 ensembl:ENSMUSP00000027931	P		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35942 ensembl:ENSMUSP00000027931	C		Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35942 ensembl:ENSMUSP00000027931	C		Seeded From UniProt	complete
involved_in	GO:0000070	mitotic sister chromatid segregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35942 ensembl:ENSMUSP00000027931	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007088	regulation of mitotic nuclear division	PMID:9430639^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:9430639^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:9430639^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9430639^[13] PMID:16280549^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051225	spindle assembly	PMID:16280549^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046602	regulation of mitotic centrosome separation	PMID:16280549^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097711	ciliary basal body-plasma membrane docking	Reactome:R-HSA-5620912	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010389	regulation of G2/M transition of mitotic cell cycle	Reactome:R-HSA-8854518	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8853419 Reactome:R-HSA-8853405 Reactome:R-HSA-5638009 Reactome:R-HSA-5626699 Reactome:R-HSA-5626681 Reactome:R-HSA-5626228 Reactome:R-HSA-5626227 Reactome:R-HSA-5626223 Reactome:R-HSA-5626220 Reactome:R-HSA-5617816 Reactome:R-HSA-380508 Reactome:R-HSA-380455 Reactome:R-HSA-380316 Reactome:R-HSA-380311 Reactome:R-HSA-380303 Reactome:R-HSA-380294 Reactome:R-HSA-380283 Reactome:R-HSA-380272 Reactome:R-HSA-3000319 Reactome:R-HSA-3000310 Reactome:R-HSA-2574845 Reactome:R-HSA-2574840 Reactome:R-HSA-179421 Reactome:R-HSA-179417 Reactome:R-HSA-179410	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	Reactome:R-HSA-69275	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
involved_in	GO:0051321	meiotic cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0469	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137 UniProtKB-SubCell:SL-0047	C		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0159	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0995	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0448	C		Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0149	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Chen, C et al. (2015) Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. J. Cell. Sci. 128 3290-303 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Fang, G et al. (2014) Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion. J. Cell. Sci. 127 1631-9 PubMed GONUTS page
↑ Du, J et al. (2008) The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability. Oncogene 27 4107-14 PubMed GONUTS page
↑ ^5.0 ^5.1 Bahmanyar, S et al. (2008) beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev. 22 91-105 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Helps, NR et al. (2000) NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1. Biochem. J. 349 509-18 PubMed GONUTS page
↑ Wu, W et al. (2007) Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase. J. Biol. Chem. 282 26431-40 PubMed GONUTS page
↑ ^8.0 ^8.1 Lou, Y et al. (2004) NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling. J. Biol. Chem. 279 20049-57 PubMed GONUTS page
↑ Mardin, BR et al. (2010) Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nat. Cell Biol. 12 1166-76 PubMed GONUTS page
↑ Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
↑ Fu, G et al. (2007) Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis. Cell Res. 17 608-18 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Fry, AM et al. (1998) A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. EMBO J. 17 470-81 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Quarmby, LM & Mahjoub, MR (2005) Caught Nek-ing: cilia and centrioles. J. Cell. Sci. 118 5161-9 PubMed GONUTS page

[PMID:21531765-1] 1.0 ^1.1 ^1.2 Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page

[PMID:26220856-2] 2.0 ^2.1 ^2.2 Chen, C et al. (2015) Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. J. Cell. Sci. 128 3290-303 PubMed GONUTS page

[PMID:24554434-3] 3.0 ^3.1 ^3.2 Fang, G et al. (2014) Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion. J. Cell. Sci. 127 1631-9 PubMed GONUTS page

[PMID:18297113-4] Du, J et al. (2008) The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability. Oncogene 27 4107-14 PubMed GONUTS page

[PMID:18086858-5] 5.0 ^5.1 Bahmanyar, S et al. (2008) beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev. 22 91-105 PubMed GONUTS page

[PMID:10880350-6] 6.0 ^6.1 ^6.2 ^6.3 Helps, NR et al. (2000) NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1. Biochem. J. 349 509-18 PubMed GONUTS page

[PMID:17626005-7] Wu, W et al. (2007) Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase. J. Biol. Chem. 282 26431-40 PubMed GONUTS page

[PMID:14978040-8] 8.0 ^8.1 Lou, Y et al. (2004) NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling. J. Biol. Chem. 279 20049-57 PubMed GONUTS page

[PMID:21076410-9] Mardin, BR et al. (2010) Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nat. Cell Biol. 12 1166-76 PubMed GONUTS page

[PMID:21399614-10] Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page

[PMID:17621308-11] Fu, G et al. (2007) Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis. Cell Res. 17 608-18 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9430639-13] 13.0 ^13.1 ^13.2 ^13.3 Fry, AM et al. (1998) A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. EMBO J. 17 470-81 PubMed GONUTS page

[PMID:16280549-14] 14.0 ^14.1 ^14.2 Quarmby, LM & Mahjoub, MR (2005) Caught Nek-ing: cilia and centrioles. J. Cell. Sci. 118 5161-9 PubMed GONUTS page

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HUMAN:NEK2

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