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PMID:16280549

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Citation

Quarmby, LM and Mahjoub, MR (2005) Caught Nek-ing: cilia and centrioles. J. Cell. Sci. 118:5161-9

Abstract

The Nek family of cell-cycle kinases is widely represented in eukaryotes and includes numerous proteins that were described only recently and remain poorly characterized. Comparing Neks in the context of clades allows us to examine the question of whether microbial eukaryotic Neks, although not strictly orthologs of their vertebrate counterparts, can provide clues to ancestral functions that might be retained in the vertebrate Neks. Relatives of the Nek2/NIMA proteins play important roles at the G2-M transition in nuclear envelope breakdown and centromere separation. Nek6, Nek7 and Nek9 also seem to regulate mitosis. By contrast, Nek1 and Nek8 have been linked with polycystic kidney disease. Results of statistical analysis indicate that the family coevolved with centrioles that function as both microtubule-organizing centers and the basal bodies of cilia. This evolutionary perspective, taken together with functional studies of microbial Neks, provides new insights into the cellular roles of the proteins and disease with which some of them have been linked.

Links

PubMed Online version:10.1242/jcs.02681

Keywords

Animals; Biological Evolution; Cell Cycle; Cell Cycle Proteins/metabolism; Centrioles/metabolism; Cilia/metabolism; Polycystic Kidney Diseases/pathology; Protein-Serine-Threonine Kinases/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:NEK2

enables

GO:0004674: protein serine/threonine kinase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:NEK6

involved_in

GO:0007346: regulation of mitotic cell cycle

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NEK2

enables

GO:0004674: protein serine/threonine kinase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

HUMAN:NEK2

involved_in

GO:0051225: spindle assembly

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NEK2

involved_in

GO:0046602: regulation of mitotic centrosome separation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

See also

References

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