HUMAN:MRE11

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MRE11A (synonyms: HNGS1, MRE11)
Protein Name(s)	Double-strand break repair protein MRE11A Meiotic recombination 11 homolog 1 MRE11 homolog 1 Meiotic recombination 11 homolog A MRE11 homolog A
External Links
UniProt	P49959
EMBL	U37359 AF022778 AF073362 AF303395 AF303379 AF303380 AF303381 AF303382 AF303383 AF303384 AF303385 AF303386 AF303387 AF303388 AF303389 AF303390 AF303391 AF303392 AF303393 AF303394 AK095388 AY584241 AP000765 AP000786 KF455448 BC063458
CCDS	CCDS8298.1 CCDS8299.1
RefSeq	NP_005581.2 NP_005582.1 XP_005274064.1
UniGene	Hs.192649
PDB	3T1I
PDBsum	3T1I
ProteinModelPortal	P49959
SMR	P49959
BioGrid	110501
DIP	DIP-33238N
IntAct	P49959
MINT	MINT-131851
STRING	9606.ENSP00000325863
PhosphoSite	P49959
DMDM	17380137
MaxQB	P49959
PaxDb	P49959
PRIDE	P49959
DNASU	4361
Ensembl	ENST00000323929 ENST00000323977
GeneID	4361
KEGG	hsa:4361
UCSC	uc001peu.2 uc001pev.2
CTD	4361
GeneCards	GC11M094150
HGNC	HGNC:7230
HPA	CAB004081 HPA002691
MIM	600814 604391
neXtProt	NX_P49959
Orphanet	251347 145
PharmGKB	PA30934
eggNOG	COG0420
GeneTree	ENSGT00390000017288
HOGENOM	HOG000216581
HOVERGEN	HBG052508
InParanoid	P49959
KO	K10865
OrthoDB	EOG7VB2F1
PhylomeDB	P49959
TreeFam	TF101105
Reactome	REACT_163993 REACT_169185 REACT_27271 REACT_486
ChiTaRS	MRE11A
GeneWiki	MRE11A
GenomeRNAi	4361
NextBio	17163
PMAP-CutDB	P49959
PRO	PR:P49959
Proteomes	UP000005640
Bgee	P49959
CleanEx	HS_MRE11A
ExpressionAtlas	P49959
Genevestigator	P49959
GO	GO:0000785 GO:0005829 GO:0030870 GO:0005654 GO:0005634 GO:0035861 GO:0008408 GO:0003690 GO:0004520 GO:0004519 GO:0030145 GO:0004518 GO:0008022 GO:0000014 GO:0006284 GO:0008283 GO:0006974 GO:0000737 GO:0032508 GO:0006310 GO:0006281 GO:0006302 GO:0000724 GO:0006303 GO:0045087 GO:0031573 GO:0007095 GO:0032876 GO:0090305 GO:0006289 GO:0033674 GO:0031954 GO:0032481 GO:0007131 GO:0000019 GO:0007062 GO:0007129 GO:0000723 GO:0007004
Gene3D	3.60.21.10
InterPro	IPR004843 IPR003701 IPR029052 IPR007281
PANTHER	PTHR10139
Pfam	PF00149 PF04152
PIRSF	PIRSF000882
SUPFAM	SSF56300
TIGRFAMs	TIGR00583

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008408	3'-5' exonuclease activity	PMID:9651580^[1]	ECO:0000314			F		Figure 2	complete CACAO 2030
	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:9651580^[1]	ECO:0000314			P		Figure 5	complete CACAO 2032
	GO:0004520	endodeoxyribonuclease activity	PMID:9705271^[2]	ECO:0000314			F		Figure 2	complete CACAO 2033
	GO:0000014	single-stranded DNA specific endodeoxyribonuclease activity	PMID:9705271^[2]	ECO:0000314			F		Figures 3,4,5	complete CACAO 2035
	GO:0008408	3'-5' exonuclease activity	PMID:9705271^[2]	ECO:0000314			F		Figure 5	complete CACAO 2036
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:29670289^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:29670289^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0110025	DNA strand resection involved in replication fork processing	PMID:29670289^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008409	5'-3' exonuclease activity	PMID:29670289^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:30612738^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:30612738^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005657	replication fork	PMID:29290612^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25468996^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031860	telomeric 3' overhang formation	PMID:16374507^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0000784	nuclear chromosome, telomeric region	PMID:24270157^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:16374507^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032206	positive regulation of telomere maintenance	PMID:16374507^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:19135898^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:10811102^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0007128)	Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:10811102^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61216	C		Seeded From UniProt	complete
colocalizes_with	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61216	C	part_of:(GO:0016605) exists_during:(GO:0000084)	Seeded From UniProt	complete
enables	GO:0008408	3'-5' exonuclease activity	PMID:9705271^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	PMID:9705271^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004520	endodeoxyribonuclease activity	PMID:9705271^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:9651580^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008408	3'-5' exonuclease activity	PMID:9651580^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033674	positive regulation of kinase activity	PMID:15790808^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032876	negative regulation of DNA endoreduplication	PMID:15917200^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	PMID:15790808^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031954	positive regulation of protein autophosphorylation	PMID:15790808^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030870	Mre11 complex	PMID:15790808^[11]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007062	sister chromatid cohesion	PMID:15917200^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0004003	ATP-dependent DNA helicase activity	PMID:15790808^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0003677	DNA binding	PMID:15790808^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0000781	chromosome, telomeric region	PMID:15149599^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:15916964^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:9590181^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60934	F		Seeded From UniProt	complete
involved_in	GO:0097552	mitochondrial double-strand break repair via homologous recombination	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000015644 SGD:S000004837	P		Seeded From UniProt	complete
involved_in	GO:0042138	meiotic DNA double-strand break formation	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000015644 PomBase:SPAC13C5.07	P		Seeded From UniProt	complete
involved_in	GO:0031573	intra-S DNA damage checkpoint	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1100512 PANTHER:PTN000015646 PomBase:SPAC13C5.07	P		Seeded From UniProt	complete
enables	GO:0008408	3'-5' exonuclease activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002228124 SGD:S000004837 UniProtKB:P49959	F		Seeded From UniProt	complete
enables	GO:0008296	3'-5'-exodeoxyribonuclease activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002228124 SGD:S000004837	F		Seeded From UniProt	complete
involved_in	GO:0007095	mitotic G2 DNA damage checkpoint	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0020270 MGI:MGI:1100512 PANTHER:PTN000015644	P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000015644 PomBase:SPAC13C5.07 SGD:S000004837 UniProtKB:P49959	P		Seeded From UniProt	complete
colocalizes_with	GO:0000784	nuclear chromosome, telomeric region	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1100512 PANTHER:PTN000015644 PomBase:SPAC13C5.07 UniProtKB:P49959	C		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000015644 PomBase:SPAC13C5.07 SGD:S000004837 UniProtKB:P49959	P		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0020270 PANTHER:PTN000015644 PomBase:SPAC13C5.07 SGD:S000004837 UniProtKB:P49959	P		Seeded From UniProt	complete
part_of	GO:0030870	Mre11 complex	PMID:19151086^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:17500065^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22078559^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49959	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051276	chromosome organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61216 ensembl:ENSMUSP00000034405	P		Seeded From UniProt	complete
involved_in	GO:0031573	intra-S DNA damage checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61216 ensembl:ENSMUSP00000034405	P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61216 ensembl:ENSMUSP00000034405	C		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61216 ensembl:ENSMUSP00000034405	P		Seeded From UniProt	complete
involved_in	GO:0007129	synapsis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61216 ensembl:ENSMUSP00000034405	P		Seeded From UniProt	complete
involved_in	GO:0007095	mitotic G2 DNA damage checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61216 ensembl:ENSMUSP00000034405	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61216 ensembl:ENSMUSP00000034405	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61216 ensembl:ENSMUSP00000034405	C		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61216 ensembl:ENSMUSP00000034405	C		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003701 InterPro:IPR007281	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007281	C		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003701 InterPro:IPR007281	P		Seeded From UniProt	complete
enables	GO:0008408	3'-5' exonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003701	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004843	F		Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007281	F		Seeded From UniProt	complete
part_of	GO:0030870	Mre11 complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003701	C		Seeded From UniProt	complete
part_of	GO:0030870	Mre11 complex	PMID:27918544^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008408	3'-5' exonuclease activity	PMID:9651580^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007131	reciprocal meiotic recombination	PMID:8530104^[21] PMID:9931460^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:9931460^[22] PMID:9705271^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	PMID:9705271^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:9651580^[1] Reactome:R-HSA-5693571	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:10612394^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:9705271^[2] PMID:9931460^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:9651580^[1] Reactome:R-HSA-75174 Reactome:R-HSA-75172 Reactome:R-HSA-69891 Reactome:R-HSA-6799332 Reactome:R-HSA-6792712 Reactome:R-HSA-5693620 Reactome:R-HSA-5693612 Reactome:R-HSA-5693608 Reactome:R-HSA-5693602 Reactome:R-HSA-5693599 Reactome:R-HSA-5693598 Reactome:R-HSA-5693593 Reactome:R-HSA-5693589 Reactome:R-HSA-5693584 Reactome:R-HSA-5693583 Reactome:R-HSA-5693580 Reactome:R-HSA-5693566 Reactome:R-HSA-5693564 Reactome:R-HSA-5693561 Reactome:R-HSA-5693551 Reactome:R-HSA-5693549 Reactome:R-HSA-5693542 Reactome:R-HSA-5693540 Reactome:R-HSA-5693539 Reactome:R-HSA-5693536 Reactome:R-HSA-5687675 Reactome:R-HSA-5687673 Reactome:R-HSA-5687664 Reactome:R-HSA-5687653 Reactome:R-HSA-5687640 Reactome:R-HSA-5687484 Reactome:R-HSA-5687465 Reactome:R-HSA-5687464 Reactome:R-HSA-5686900 Reactome:R-HSA-5686704 Reactome:R-HSA-5686685 Reactome:R-HSA-5686657 Reactome:R-HSA-5686642 Reactome:R-HSA-5686483 Reactome:R-HSA-5686469 Reactome:R-HSA-5686440 Reactome:R-HSA-5686410 Reactome:R-HSA-5685994 Reactome:R-HSA-5685985 Reactome:R-HSA-5685838 Reactome:R-HSA-5685341 Reactome:R-HSA-5685156 Reactome:R-HSA-5685011 Reactome:R-HSA-5684887 Reactome:R-HSA-5684882 Reactome:R-HSA-5684875 Reactome:R-HSA-5684140 Reactome:R-HSA-5684108 Reactome:R-HSA-5684096 Reactome:R-HSA-5684081 Reactome:R-HSA-5684071 Reactome:R-HSA-5684052 Reactome:R-HSA-5683986 Reactome:R-HSA-5683967 Reactome:R-HSA-5683964 Reactome:R-HSA-5683801 Reactome:R-HSA-5683735 Reactome:R-HSA-5683425 Reactome:R-HSA-5683405 Reactome:R-HSA-5683385 Reactome:R-HSA-5683384 Reactome:R-HSA-5683077 Reactome:R-HSA-5682992 Reactome:R-HSA-5682983 Reactome:R-HSA-5682967 Reactome:R-HSA-5682965 Reactome:R-HSA-5682863 Reactome:R-HSA-5682858 Reactome:R-HSA-5682629 Reactome:R-HSA-5682607 Reactome:R-HSA-5682598 Reactome:R-HSA-5682588 Reactome:R-HSA-5682586 Reactome:R-HSA-5682044 Reactome:R-HSA-5682026 Reactome:R-HSA-5682020 Reactome:R-HSA-5682018 Reactome:R-HSA-3785768	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10802669^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004520	endodeoxyribonuclease activity	PMID:9651580^[1] Reactome:R-HSA-5693608	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:10802669^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000019	regulation of mitotic recombination	PMID:8530104^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	PMID:9705271^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	PMID:15790808^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	Reactome:R-HSA-1834949	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	Reactome:R-HSA-5684887 Reactome:R-HSA-5684875	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-3204303	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000729	DNA double-strand break processing	Reactome:R-HSA-5693608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	Reactome:R-HSA-5693538	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0779 UniProtKB-SubCell:SL-0276	C		Seeded From UniProt	complete
enables	GO:0004527	exonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0269	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F		Seeded From UniProt	complete
involved_in	GO:0051321	meiotic cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0469	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Paull, TT & Gellert, M (1998) The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol. Cell 1 969-79 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Trujillo, KM et al. (1998) Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J. Biol. Chem. 273 21447-50 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Coquel, F et al. (2018) SAMHD1 acts at stalled replication forks to prevent interferon induction. Nature 557 57-61 PubMed GONUTS page
↑ ^4.0 ^4.1 Jachimowicz, RD et al. (2019) UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell 176 505-519.e22 PubMed GONUTS page
↑ Kottemann, MC et al. (2018) Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity. Mol. Cell 69 24-35.e5 PubMed GONUTS page
↑ ^6.0 ^6.1 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Chai, W et al. (2006) The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. EMBO Rep. 7 225-30 PubMed GONUTS page
↑ Grolimund, L et al. (2013) A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Nat Commun 4 2848 PubMed GONUTS page
↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
↑ ^10.0 ^10.1 Lombard, DB & Guarente, L (2000) Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres. Cancer Res. 60 2331-4 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Lee, JH & Paull, TT (2005) ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308 551-4 PubMed GONUTS page
↑ ^12.0 ^12.1 Strachan, T (2005) Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation. Curr. Opin. Genet. Dev. 15 258-64 PubMed GONUTS page
↑ Herbig, U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 501-13 PubMed GONUTS page
↑ Bhoumik, A et al. (2005) ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol. Cell 18 577-87 PubMed GONUTS page
↑ Carney, JP et al. (1998) The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93 477-86 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 ^16.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ van der Linden, E et al. (2009) RAD50 and NBS1 form a stable complex functional in DNA binding and tethering. Nucleic Acids Res. 37 1580-8 PubMed GONUTS page
↑ Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page
↑ Park, YB et al. (2011) Crystal structure of human Mre11: understanding tumorigenic mutations. Structure 19 1591-602 PubMed GONUTS page
↑ Rivera, T et al. (2017) A balance between elongation and trimming regulates telomere stability in stem cells. Nat. Struct. Mol. Biol. 24 30-39 PubMed GONUTS page
↑ ^21.0 ^21.1 Petrini, JH et al. (1995) Isolation and characterization of the human MRE11 homologue. Genomics 29 80-6 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Chamankhah, M et al. (1998) Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions. Gene 225 107-16 PubMed GONUTS page
↑ Stewart, GS et al. (1999) The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 99 577-87 PubMed GONUTS page
↑ ^24.0 ^24.1 Gatei, M et al. (2000) ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat. Genet. 25 115-9 PubMed GONUTS page

[PMID:9651580-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Paull, TT & Gellert, M (1998) The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol. Cell 1 969-79 PubMed GONUTS page

[PMID:9705271-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Trujillo, KM et al. (1998) Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J. Biol. Chem. 273 21447-50 PubMed GONUTS page

[PMID:29670289-3] 3.0 ^3.1 ^3.2 ^3.3 Coquel, F et al. (2018) SAMHD1 acts at stalled replication forks to prevent interferon induction. Nature 557 57-61 PubMed GONUTS page

[PMID:30612738-4] 4.0 ^4.1 Jachimowicz, RD et al. (2019) UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell 176 505-519.e22 PubMed GONUTS page

[PMID:29290612-5] Kottemann, MC et al. (2018) Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity. Mol. Cell 69 24-35.e5 PubMed GONUTS page

[PMID:25468996-6] 6.0 ^6.1 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:16374507-7] 7.0 ^7.1 ^7.2 Chai, W et al. (2006) The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. EMBO Rep. 7 225-30 PubMed GONUTS page

[PMID:24270157-8] Grolimund, L et al. (2013) A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Nat Commun 4 2848 PubMed GONUTS page

[PMID:19135898-9] Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page

[PMID:10811102-10] 10.0 ^10.1 Lombard, DB & Guarente, L (2000) Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres. Cancer Res. 60 2331-4 PubMed GONUTS page

[PMID:15790808-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Lee, JH & Paull, TT (2005) ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308 551-4 PubMed GONUTS page

[PMID:15917200-12] 12.0 ^12.1 Strachan, T (2005) Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation. Curr. Opin. Genet. Dev. 15 258-64 PubMed GONUTS page

[PMID:15149599-13] Herbig, U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 501-13 PubMed GONUTS page

[PMID:15916964-14] Bhoumik, A et al. (2005) ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol. Cell 18 577-87 PubMed GONUTS page

[PMID:9590181-15] Carney, JP et al. (1998) The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93 477-86 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 ^16.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19151086-17] van der Linden, E et al. (2009) RAD50 and NBS1 form a stable complex functional in DNA binding and tethering. Nucleic Acids Res. 37 1580-8 PubMed GONUTS page

[PMID:17500065-18] Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page

[PMID:22078559-19] Park, YB et al. (2011) Crystal structure of human Mre11: understanding tumorigenic mutations. Structure 19 1591-602 PubMed GONUTS page

[PMID:27918544-20] Rivera, T et al. (2017) A balance between elongation and trimming regulates telomere stability in stem cells. Nat. Struct. Mol. Biol. 24 30-39 PubMed GONUTS page

[PMID:8530104-21] 21.0 ^21.1 Petrini, JH et al. (1995) Isolation and characterization of the human MRE11 homologue. Genomics 29 80-6 PubMed GONUTS page

[PMID:9931460-22] 22.0 ^22.1 ^22.2 Chamankhah, M et al. (1998) Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions. Gene 225 107-16 PubMed GONUTS page

[PMID:10612394-23] Stewart, GS et al. (1999) The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 99 577-87 PubMed GONUTS page

[PMID:10802669-24] 24.0 ^24.1 Gatei, M et al. (2000) ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat. Genet. 25 115-9 PubMed GONUTS page

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HUMAN:MRE11

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