HUMAN:MMP2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MMP2 (synonyms: CLG4A)
Protein Name(s)	72 kDa type IV collagenase 72 kDa gelatinase Gelatinase A Matrix metalloproteinase-2 MMP-2 TBE-1 PEX
External Links
UniProt	P08253
EMBL	M55593 M58552 M55582 M55583 M55584 M55585 M55586 M55587 M55588 M55589 M55590 M55591 M55592 AK301536 AK310314 AK312711 AY738117 AC007336 AC092722 BC002576 M33789 J03210
CCDS	CCDS10752.1 CCDS45487.1
PIR	A28153
RefSeq	NP_001121363.1 NP_001289437.1 NP_001289438.1 NP_001289439.1 NP_004521.1
UniGene	Hs.513617
PDB	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
PDBsum	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
ProteinModelPortal	P08253
SMR	P08253
BioGrid	110457
DIP	DIP-26N
IntAct	P08253
STRING	9606.ENSP00000219070
BindingDB	P08253
ChEMBL	CHEMBL2095216
DrugBank	DB01197 DB00786
GuidetoPHARMACOLOGY	1629
MEROPS	M10.003
PhosphoSite	P08253
DMDM	116856
MaxQB	P08253
PaxDb	P08253
PeptideAtlas	P08253
PRIDE	P08253
DNASU	4313
Ensembl	ENST00000219070 ENST00000437642 ENST00000543485 ENST00000570308
GeneID	4313
KEGG	hsa:4313
UCSC	uc002ehz.4
CTD	4313
GeneCards	GC16P055424
HGNC	HGNC:7166
HPA	CAB002788 HPA001939
MIM	120360 259600
neXtProt	NX_P08253
Orphanet	85196 3460
PharmGKB	PA30877
eggNOG	NOG303159
GeneTree	ENSGT00760000119132
HOGENOM	HOG000217926
HOVERGEN	HBG052484
InParanoid	P08253
KO	K01398
OMA	PCKFPFR
OrthoDB	EOG70KGNX
PhylomeDB	P08253
TreeFam	TF315428
BioCyc	MetaCyc:HS01565-MONOMER
BRENDA	3.4.24.24
Reactome	REACT_118572 REACT_118682 REACT_150401 REACT_15428 REACT_228189
ChiTaRS	MMP2
EvolutionaryTrace	P08253
GeneWiki	MMP2
GenomeRNAi	4313
NextBio	16973
PMAP-CutDB	P08253
PRO	PR:P08253
Proteomes	UP000005640
Bgee	P08253
CleanEx	HS_MMP2
ExpressionAtlas	P08253
Genevestigator	P08253
GO	GO:0005576 GO:0005615 GO:0005739 GO:0005634 GO:0005886 GO:0005578 GO:0030017 GO:0004222 GO:0004252 GO:0008270 GO:0001525 GO:0001955 GO:0060346 GO:0044267 GO:0071230 GO:0030574 GO:0007566 GO:0035987 GO:0022617 GO:0030198 GO:0060325 GO:0001957 GO:0045089 GO:0006508 GO:0001666
Gene3D	1.10.101.10 2.10.10.10 2.110.10.10 3.40.390.10
InterPro	IPR028708 IPR000562 IPR000585 IPR018487 IPR018486 IPR013806 IPR024079 IPR001818 IPR021190 IPR021158 IPR006026 IPR002477
PANTHER	PTHR10201:SF29
Pfam	PF00040 PF00045 PF00413 PF01471
PRINTS	PR00138
SMART	SM00059 SM00120 SM00235
SUPFAM	SSF47090 SSF50923 SSF57440
PROSITE	PS00546 PS00023 PS51092 PS00024 PS51642 PS00142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010467	gene expression	PMID:24551192^[1]	ECO:0000314			P		Figure 4. Levels of change in MMP2 expression by quantitative RT-PCR.	complete CACAO 9548
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:28327460^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002540)	Seeded From UniProt	complete
involved_in	GO:1904645	response to amyloid-beta	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33434	P	happens_during:(GO:0007569) occurs_in:(CL:0000129)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24784232^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:23979707^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002543)	Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	PMID:18667463^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002012)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24236012^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	PMID:24236012^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:15863497^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P37840) occurs_in:(GO:0005576)	Seeded From UniProt	complete
involved_in	GO:0035987	endodermal cell differentiation	PMID:23154389^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:20551380^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001496)	Seeded From UniProt	complete
involved_in	GO:0048771	tissue remodeling	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002565602 RGD:621316	P		Seeded From UniProt	complete
involved_in	GO:0030574	collagen catabolic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101900 MGI:MGI:1276107 MGI:MGI:1340026 MGI:MGI:97008 MGI:MGI:97009 MGI:MGI:97011 PANTHER:PTN001303987 RGD:621316 RGD:621320 UniProtKB:P45452	P		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033438 FB:FBgn0035049 MGI:MGI:1340026 MGI:MGI:1353466 MGI:MGI:97008 MGI:MGI:97011 PANTHER:PTN001303987 UniProtKB:P45452 WB:WBGene00006987 ZFIN:ZDB-GENE-040426-2132	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97005 MGI:MGI:97009 PANTHER:PTN000810753 RGD:3100 RGD:620196 RGD:621316 RGD:621317 RGD:621320 RGD:631408 UniProtKB:B5DFD5 UniProtKB:P02790 UniProtKB:P08253 UniProtKB:P14780 UniProtKB:P22894 UniProtKB:P39900 UniProtKB:P50281 UniProtKB:Q90611	C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033438 MGI:MGI:101900 MGI:MGI:1340026 MGI:MGI:1341867 MGI:MGI:97009 MGI:MGI:97011 PANTHER:PTN001303987 RGD:620196 TAIR:locus:2020548 TAIR:locus:2025891 TAIR:locus:2032467 TAIR:locus:2055605 TAIR:locus:2130928 UniProtKB:O60882 UniProtKB:O75900 UniProtKB:P03956 UniProtKB:P14780 UniProtKB:P39900 UniProtKB:P45452 UniProtKB:P51512 UniProtKB:Q90611 UniProtKB:Q99542	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97009 PANTHER:PTN002565602 RGD:621316	P		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	PMID:17428795^[11]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18492766^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904645	response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0060346	bone trabecula formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0048705	skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0030574	collagen catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	C		Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	F		Seeded From UniProt	complete
involved_in	GO:0001957	intramembranous ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0001955	blood vessel maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33434 ensembl:ENSMUSP00000034187	P		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR021158 InterPro:IPR021190 InterPro:IPR028708	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR006026 InterPro:IPR021158 InterPro:IPR021190 InterPro:IPR028708	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006026 InterPro:IPR024079 InterPro:IPR033739	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR006026 InterPro:IPR021158 InterPro:IPR021190 InterPro:IPR033739	F		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR021158 InterPro:IPR021190	C		Seeded From UniProt	complete
involved_in	GO:0022617	extracellular matrix disassembly	PMID:24970228^[13] Reactome:R-HSA-1474228	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:2834383^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:2834383^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:2834383^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:2834383^[14] Reactome:R-HSA-8940554	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	Reactome:R-HSA-2682334	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030574	collagen catabolic process	Reactome:R-HSA-1442490	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-3814821 Reactome:R-NUL-2484869 Reactome:R-NUL-2484859 Reactome:R-HSA-8943959 Reactome:R-HSA-8940554 Reactome:R-HSA-6789615 Reactome:R-HSA-3928657 Reactome:R-HSA-381435 Reactome:R-HSA-3791149 Reactome:R-HSA-2534248 Reactome:R-HSA-2485148 Reactome:R-HSA-1604368 Reactome:R-HSA-1604360 Reactome:R-HSA-1604359 Reactome:R-HSA-1604350 Reactome:R-HSA-1592297 Reactome:R-HSA-1592278 Reactome:R-HSA-1566962 Reactome:R-HSA-1564164 Reactome:R-HSA-1564142 Reactome:R-HSA-1564120 Reactome:R-HSA-1564112 Reactome:R-HSA-1454822 Reactome:R-HSA-1454791 Reactome:R-HSA-1454757	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	Reactome:R-HSA-1604368 Reactome:R-HSA-1592278	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0030574	collagen catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0177	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Patel, P et al. (2014) The expression of HIV-1 Vpu in monocytes causes increased secretion of TGF-β that activates profibrogenic genes in hepatic stellate cells. PLoS ONE 9 e88934 PubMed GONUTS page
↑ Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
↑ Marchant, DJ et al. (2014) A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat. Med. 20 493-502 PubMed GONUTS page
↑ Zanivan, S et al. (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Mol. Cell Proteomics 12 3599-611 PubMed GONUTS page
↑ El-Bizri, N et al. (2008) SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. Development 135 2981-91 PubMed GONUTS page
↑ ^6.0 ^6.1 De Clercq, S et al. (2013) L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages. PLoS ONE 8 e78108 PubMed GONUTS page
↑ Sung, JY et al. (2005) Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. J. Biol. Chem. 280 25216-24 PubMed GONUTS page
↑ Brafman, DA et al. (2013) Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 20 369-81 PubMed GONUTS page
↑ Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Litterst, C et al. (2007) Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. J. Biol. Chem. 282 16155-63 PubMed GONUTS page
↑ Wu, Y & Smas, CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am. J. Physiol. Endocrinol. Metab. 295 E205-15 PubMed GONUTS page
↑ Kojima, A et al. (2014) Prion fragment peptides are digested with membrane type matrix metalloproteinases and acquire enzyme resistance through Cu²⁺-binding. Biomolecules 4 510-26 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Collier, IE et al. (1988) H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen. J. Biol. Chem. 263 6579-87 PubMed GONUTS page

[PMID:24551192-1] Patel, P et al. (2014) The expression of HIV-1 Vpu in monocytes causes increased secretion of TGF-β that activates profibrogenic genes in hepatic stellate cells. PLoS ONE 9 e88934 PubMed GONUTS page

[PMID:28327460-2] Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page

[PMID:24784232-3] Marchant, DJ et al. (2014) A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat. Med. 20 493-502 PubMed GONUTS page

[PMID:23979707-4] Zanivan, S et al. (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Mol. Cell Proteomics 12 3599-611 PubMed GONUTS page

[PMID:18667463-5] El-Bizri, N et al. (2008) SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. Development 135 2981-91 PubMed GONUTS page

[PMID:24236012-6] 6.0 ^6.1 De Clercq, S et al. (2013) L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages. PLoS ONE 8 e78108 PubMed GONUTS page

[PMID:15863497-7] Sung, JY et al. (2005) Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. J. Biol. Chem. 280 25216-24 PubMed GONUTS page

[PMID:23154389-8] Brafman, DA et al. (2013) Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 20 369-81 PubMed GONUTS page

[PMID:20551380-9] Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17428795-11] Litterst, C et al. (2007) Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. J. Biol. Chem. 282 16155-63 PubMed GONUTS page

[PMID:18492766-12] Wu, Y & Smas, CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am. J. Physiol. Endocrinol. Metab. 295 E205-15 PubMed GONUTS page

[PMID:24970228-13] Kojima, A et al. (2014) Prion fragment peptides are digested with membrane type matrix metalloproteinases and acquire enzyme resistance through Cu²⁺-binding. Biomolecules 4 510-26 PubMed GONUTS page

[PMID:2834383-14] 14.0 ^14.1 ^14.2 ^14.3 Collier, IE et al. (1988) H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen. J. Biol. Chem. 263 6579-87 PubMed GONUTS page

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HUMAN:MMP2

Contents

Annotations

Notes

References

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