HUMAN:MECP2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MECP2
Protein Name(s)	Methyl-CpG-binding protein 2 MeCp-2 protein MeCp2
External Links
UniProt	P51608
EMBL	L37298 X99686 AJ132917 AF158180 Y12643 AY541280 BX538060 AF030876 BC011612 X89430 X94628
CCDS	CCDS14741.1 CCDS48193.1
RefSeq	NP_001104262.1 NP_004983.1 XP_005274738.1
UniGene	Hs.200716 Hs.702514
PDB	1QK9 3C2I
PDBsum	1QK9 3C2I
DisProt	DP00539
ProteinModelPortal	P51608
SMR	P51608
BioGrid	110368
IntAct	P51608
MINT	MINT-3019066
STRING	9606.ENSP00000395535
PhosphoSite	P51608
DMDM	1708973
MaxQB	P51608
PaxDb	P51608
PRIDE	P51608
DNASU	4204
Ensembl	ENST00000303391 ENST00000453960
GeneID	4204
KEGG	hsa:4204
UCSC	uc004fjv.2 uc004fjw.2
CTD	4204
GeneCards	GC0XM153287
GeneReviews	MECP2
HGNC	HGNC:6990
HPA	HPA000593 HPA001341
MIM	105830 300005 300055 300260 300496 300673 312750
neXtProt	NX_P51608
Orphanet	3095 106 778 209370 536 1762 3077 777
PharmGKB	PA30729
eggNOG	NOG237320
GeneTree	ENSGT00530000063687
HOGENOM	HOG000015809
HOVERGEN	HBG052445
InParanoid	P51608
KO	K11588
OMA	KMPRAGS
PhylomeDB	P51608
TreeFam	TF332974
SignaLink	P51608
ChiTaRS	MECP2
EvolutionaryTrace	P51608
GeneWiki	MECP2
GenomeRNAi	4204
NextBio	16564
PRO	PR:P51608
Proteomes	UP000005640
Bgee	P51608
CleanEx	HS_MECP2
ExpressionAtlas	P51608
Genevestigator	P51608
GO	GO:0005829 GO:0005615 GO:0000792 GO:0005634 GO:0003682 GO:0003677 GO:0010385 GO:0008327 GO:0003729 GO:0044822 GO:0019904 GO:0047485 GO:0003700 GO:0035197 GO:0003714 GO:0008344 GO:0001662 GO:0032048 GO:0050432 GO:0021549 GO:0006342 GO:0016358 GO:0008211 GO:0006541 GO:0016573 GO:0016571 GO:0006020 GO:0007616 GO:0060291 GO:0006122 GO:0035067 GO:0031061 GO:0043524 GO:0000122 GO:0045892 GO:0001976 GO:0042551 GO:0009405 GO:0046470 GO:0008284 GO:0051965 GO:0045893 GO:0009791 GO:0019230 GO:0008104 GO:0060079 GO:0006349 GO:0002087 GO:0007585 GO:0001666 GO:0019233 GO:0035176 GO:0001964 GO:0007416 GO:0006351 GO:0021591 GO:0008542
Gene3D	3.30.890.10
InterPro	IPR017956 IPR016177 IPR017353 IPR001739
Pfam	PF01429
PIRSF	PIRSF038006
SMART	SM00384 SM00391
SUPFAM	SSF54171
PROSITE	PS50982

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0007420	DNA methylation	PMID:17486179^[1]	ECO:0000315			P		Figure 3. Bisulfite sequencing analysis of MECP2 promoter methylation in frontal cortex DNA from autism and control postmortem brain samples.	complete
involved_in	GO:1905643	positive regulation of DNA methylation	PMID:23960241^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q96EB6)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23960241^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618) regulates_expression_of:(ENSEMBL:ENSG00000096717)	Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:23960241^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	PMID:23960241^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_movement_of:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0090063	positive regulation of microtubule nucleation	PMID:25527496^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007052	mitotic spindle organization	PMID:25527496^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	PMID:25527496^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:25527496^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:25527496^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:22664934^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:11441023^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q60974	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:11441023^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:11441023^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12755	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11441023^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:11441023^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99918 PANTHER:PTN001806349 RGD:3075 UniProtKB:P51608	F		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1333850 PANTHER:PTN000386636	P		Seeded From UniProt	complete
enables	GO:0008327	methyl-CpG binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99918 PANTHER:PTN001806349 RGD:3075	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99918 PANTHER:PTN001806349 RGD:3075	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1333850 MGI:MGI:99918 PANTHER:PTN001431162 RGD:3075 UniProtKB:P51608	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1333850 MGI:MGI:99918 PANTHER:PTN000386636	F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99918 PANTHER:PTN001806349 UniProtKB:P51608	C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1333850 PANTHER:PTN001431162	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001806349 RGD:3075	P		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	PMID:17296936^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21782149^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0006122	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
involved_in	GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:1900114	positive regulation of histone H3-K9 trimethylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0051151	negative regulation of smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0050905	neuromuscular process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0050884	neuromuscular process controlling posture	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0050432	catecholamine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0046470	phosphatidylcholine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0042551	neuron maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0040029	regulation of gene expression, epigenetic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
enables	GO:0035197	siRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	F		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0033555	multicellular organismal response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0032048	cardiolipin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0021591	ventricular system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0019230	proprioception	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0016571	histone methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	F		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
enables	GO:0008327	methyl-CpG binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0008211	glucocorticoid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	F		Seeded From UniProt	complete
involved_in	GO:0008104	protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0007585	respiratory gaseous exchange	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0006576	cellular biogenic amine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0006541	glutamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0006349	regulation of gene expression by genetic imprinting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0006342	chromatin silencing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0006020	inositol metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	C		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	F		Seeded From UniProt	complete
involved_in	GO:0002087	regulation of respiratory gaseous exchange by neurological system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0001964	startle response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
involved_in	GO:0001662	behavioral fear response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2D6 ensembl:ENSMUSP00000033770	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017353	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001739 InterPro:IPR016177	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001739 InterPro:IPR017353	C		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017353	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10773092^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:10773092^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9620804^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9620804^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-212436	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9005752 Reactome:R-NUL-9005747 Reactome:R-HSA-9023461 Reactome:R-HSA-9022465 Reactome:R-HSA-9022462 Reactome:R-HSA-9022456 Reactome:R-HSA-9022453 Reactome:R-HSA-9022314 Reactome:R-HSA-9018594 Reactome:R-HSA-9006588 Reactome:R-HSA-9005995 Reactome:R-HSA-8986943	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Nagarajan, RP et al. () Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation. Epigenetics 1 e1-11 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Volkmann, I et al. (2013) MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses. Circ. Res. 113 997-1003 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Bergo, A et al. (2015) Methyl-CpG binding protein 2 (MeCP2) localizes at the centrosome and is required for proper mitotic spindle organization. J. Biol. Chem. 290 3223-37 PubMed GONUTS page
↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Kokura, K et al. (2001) The Ski protein family is required for MeCP2-mediated transcriptional repression. J. Biol. Chem. 276 34115-21 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Nan, X et al. (2007) Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc. Natl. Acad. Sci. U.S.A. 104 2709-14 PubMed GONUTS page
↑ Sirmaci, A et al. (2011) Mutations in ANKRD11 cause KBG syndrome, characterized by intellectual disability, skeletal malformations, and macrodontia. Am. J. Hum. Genet. 89 289-94 PubMed GONUTS page
↑ ^10.0 ^10.1 Yu, F et al. (2000) Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. Nucleic Acids Res. 28 2201-6 PubMed GONUTS page
↑ ^11.0 ^11.1 Nan, X et al. (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393 386-9 PubMed GONUTS page

[PMID:17486179-1] Nagarajan, RP et al. () Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation. Epigenetics 1 e1-11 PubMed GONUTS page

[PMID:23960241-2] 2.0 ^2.1 ^2.2 ^2.3 Volkmann, I et al. (2013) MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses. Circ. Res. 113 997-1003 PubMed GONUTS page

[PMID:25527496-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Bergo, A et al. (2015) Methyl-CpG binding protein 2 (MeCP2) localizes at the centrosome and is required for proper mitotic spindle organization. J. Biol. Chem. 290 3223-37 PubMed GONUTS page

[PMID:22664934-4] Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page

[PMID:11441023-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Kokura, K et al. (2001) The Ski protein family is required for MeCP2-mediated transcriptional repression. J. Biol. Chem. 276 34115-21 PubMed GONUTS page

[PMID:22658674-6] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17296936-8] Nan, X et al. (2007) Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc. Natl. Acad. Sci. U.S.A. 104 2709-14 PubMed GONUTS page

[PMID:21782149-9] Sirmaci, A et al. (2011) Mutations in ANKRD11 cause KBG syndrome, characterized by intellectual disability, skeletal malformations, and macrodontia. Am. J. Hum. Genet. 89 289-94 PubMed GONUTS page

[PMID:10773092-10] 10.0 ^10.1 Yu, F et al. (2000) Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. Nucleic Acids Res. 28 2201-6 PubMed GONUTS page

[PMID:9620804-11] 11.0 ^11.1 Nan, X et al. (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393 386-9 PubMed GONUTS page

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