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HUMAN:LHX2
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | LHX2 (synonyms: LH2) | |
Protein Name(s) | LIM/homeobox protein Lhx2
Homeobox protein LH-2 LIM homeobox protein 2 | |
External Links | ||
UniProt | P50458 | |
EMBL | U11701 BC093662 BC112185 AK094511 AF124735 | |
CCDS | CCDS6853.1 | |
RefSeq | NP_004780.3 | |
UniGene | Hs.696425 | |
ProteinModelPortal | P50458 | |
SMR | P50458 | |
BioGrid | 114758 | |
MINT | MINT-112470 | |
STRING | 9606.ENSP00000362717 | |
PhosphoSite | P50458 | |
DMDM | 8247936 | |
PaxDb | P50458 | |
PRIDE | P50458 | |
DNASU | 9355 | |
Ensembl | ENST00000373615 | |
GeneID | 9355 | |
KEGG | hsa:9355 | |
UCSC | uc004boe.1 | |
CTD | 9355 | |
GeneCards | GC09P126763 | |
HGNC | HGNC:6594 | |
MIM | 603759 | |
neXtProt | NX_P50458 | |
PharmGKB | PA30365 | |
eggNOG | COG5576 | |
GeneTree | ENSGT00760000118921 | |
HOGENOM | HOG000034022 | |
HOVERGEN | HBG006262 | |
InParanoid | P50458 | |
KO | K09373 | |
PhylomeDB | P50458 | |
TreeFam | TF315442 | |
ChiTaRS | LHX2 | |
GeneWiki | LHX2 | |
GenomeRNAi | 9355 | |
NextBio | 35033 | |
PRO | PR:P50458 | |
Proteomes | UP000005640 | |
Bgee | P50458 | |
CleanEx | HS_LHX2 | |
Genevestigator | P50458 | |
GO | GO:0005634 GO:0003682 GO:0001076 GO:0043565 GO:0008270 GO:0048675 GO:0007411 GO:0021987 GO:0009953 GO:0007498 GO:2000678 GO:0001843 GO:0021772 GO:0045944 GO:0045893 GO:0060041 GO:0021978 | |
Gene3D | 1.10.10.60 2.10.110.10 | |
InterPro | IPR017970 IPR001356 IPR009057 IPR001781 | |
Pfam | PF00046 PF00412 | |
SMART | SM00389 SM00132 | |
SUPFAM | SSF46689 | |
PROSITE | PS00027 PS50071 PS00478 PS50023 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0267978 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0002023 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0267978 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1100513 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0267978 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000678 |
negative regulation of transcription regulatory region DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000179 |
positive regulation of neural precursor cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060041 |
retina development in camera-type eye |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050768 |
negative regulation of neurogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048675 |
axon extension |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048646 |
anatomical structure formation involved in morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045814 |
negative regulation of gene expression, epigenetic |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045199 |
maintenance of epithelial cell apical/basal polarity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0022008 |
neurogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0021987 |
cerebral cortex development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0021978 |
telencephalon regionalization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0021772 |
olfactory bulb development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0021537 |
telencephalon development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009953 |
dorsal/ventral pattern formation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007498 |
mesoderm development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007420 |
brain development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007411 |
axon guidance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007399 |
nervous system development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003682 |
chromatin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001942 |
hair follicle development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001843 |
neural tube closure |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0S2 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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- GO:0045814 ! negative regulation of gene expression, epigenetic
- GO:0050768 ! negative regulation of neurogenesis
- GO:2000678 ! negative regulation of transcription regulatory region DNA binding
- GO:0007399 ! nervous system development
- GO:0001843 ! neural tube closure
- GO:0022008 ! neurogenesis
- GO:0030182 ! neuron differentiation
- GO:0005634 ! nucleus
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