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HUMAN:LHX2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) LHX2 (synonyms: LH2)
Protein Name(s) LIM/homeobox protein Lhx2

Homeobox protein LH-2 LIM homeobox protein 2

External Links
UniProt P50458
EMBL U11701
BC093662
BC112185
AK094511
AF124735
CCDS CCDS6853.1
RefSeq NP_004780.3
UniGene Hs.696425
ProteinModelPortal P50458
SMR P50458
BioGrid 114758
MINT MINT-112470
STRING 9606.ENSP00000362717
PhosphoSite P50458
DMDM 8247936
PaxDb P50458
PRIDE P50458
DNASU 9355
Ensembl ENST00000373615
GeneID 9355
KEGG hsa:9355
UCSC uc004boe.1
CTD 9355
GeneCards GC09P126763
HGNC HGNC:6594
MIM 603759
neXtProt NX_P50458
PharmGKB PA30365
eggNOG COG5576
GeneTree ENSGT00760000118921
HOGENOM HOG000034022
HOVERGEN HBG006262
InParanoid P50458
KO K09373
PhylomeDB P50458
TreeFam TF315442
ChiTaRS LHX2
GeneWiki LHX2
GenomeRNAi 9355
NextBio 35033
PRO PR:P50458
Proteomes UP000005640
Bgee P50458
CleanEx HS_LHX2
Genevestigator P50458
GO GO:0005634
GO:0003682
GO:0001076
GO:0043565
GO:0008270
GO:0048675
GO:0007411
GO:0021987
GO:0009953
GO:0007498
GO:2000678
GO:0001843
GO:0021772
GO:0045944
GO:0045893
GO:0060041
GO:0021978
Gene3D 1.10.10.60
2.10.110.10
InterPro IPR017970
IPR001356
IPR009057
IPR001781
Pfam PF00046
PF00412
SMART SM00389
SM00132
SUPFAM SSF46689
PROSITE PS00027
PS50071
PS00478
PS50023

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR001356
InterPro:IPR009057

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:P61374

F

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z0S2

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0267978
MGI:MGI:102673
MGI:MGI:1100513
MGI:MGI:1888519
MGI:MGI:96785
PANTHER:PTN000654232
UniProtKB:Q969G2
UniProtKB:Q9UBR4
WB:WBGene00000438
WB:WBGene00002988
WB:WBGene00003167
WB:WBGene00006654

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002023
FB:FBgn0267978
MGI:MGI:101776
MGI:MGI:102673
MGI:MGI:107792
MGI:MGI:1096343
MGI:MGI:1100513
MGI:MGI:1306803
MGI:MGI:1888519
MGI:MGI:96785
MGI:MGI:99783
PANTHER:PTN000654232
RGD:71076
UniProtKB:P53411
UniProtKB:Q90881
WB:WBGene00000438
WB:WBGene00002988
WB:WBGene00003000
WB:WBGene00003167
WB:WBGene00006654
ZFIN:ZDB-GENE-050114-2
ZFIN:ZDB-GENE-050114-3
ZFIN:ZDB-GENE-050417-210
ZFIN:ZDB-GENE-051220-1
ZFIN:ZDB-GENE-060728-1
ZFIN:ZDB-GENE-980526-131

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0267978
MGI:MGI:1096343
MGI:MGI:1100513
MGI:MGI:1306803
MGI:MGI:96785
MGI:MGI:99783
PANTHER:PTN000654232
RGD:71074
UniProtKB:O60663
UniProtKB:O97581
UniProtKB:P53411
UniProtKB:Q9UPM6
WB:WBGene00000438
WB:WBGene00002987
WB:WBGene00002988
WB:WBGene00003167

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1100513
MGI:MGI:1888519
MGI:MGI:96785
PANTHER:PTN000654232
UniProtKB:Q9UBR4

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0267978
MGI:MGI:1100513
MGI:MGI:1888519
MGI:MGI:96785
PANTHER:PTN000654232
WB:WBGene00000438
WB:WBGene00002987
WB:WBGene00006654

F

Seeded From UniProt

complete

involved_in

GO:2000678

negative regulation of transcription regulatory region DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:2000179

positive regulation of neural precursor cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0060041

retina development in camera-type eye

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0050768

negative regulation of neurogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0048675

axon extension

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0048646

anatomical structure formation involved in morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0045814

negative regulation of gene expression, epigenetic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0045199

maintenance of epithelial cell apical/basal polarity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

F

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0022008

neurogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0021987

cerebral cortex development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0021978

telencephalon regionalization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0021772

olfactory bulb development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0021537

telencephalon development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0009953

dorsal/ventral pattern formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

F

Seeded From UniProt

complete

involved_in

GO:0007498

mesoderm development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

F

Seeded From UniProt

complete

involved_in

GO:0001942

hair follicle development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

involved_in

GO:0001843

neural tube closure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

P

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0S2
ensembl:ENSMUSP00000000253

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001356
InterPro:IPR009057

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238
UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page