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HUMAN:LEUK

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SPN (synonyms: CD43)
Protein Name(s) Leukosialin

Galactoglycoprotein GALGP Leukocyte sialoglycoprotein Sialophorin

External Links
UniProt P16150
EMBL J04168
J04536
X52075
M61827
AK292626
AK313750
CH471238
BC012350
CCDS CCDS10650.1
PIR A39822
RefSeq NP_001025459.1
NP_003114.1
UniGene Hs.632188
ProteinModelPortal P16150
BioGrid 112571
IntAct P16150
STRING 9606.ENSP00000353238
iPTMnet P16150
PhosphoSitePlus P16150
UniCarbKB P16150
BioMuta SPN
DMDM 126213
EPD P16150
MaxQB P16150
PaxDb P16150
PeptideAtlas P16150
PRIDE P16150
DNASU 6693
Ensembl ENST00000360121
ENST00000395389
ENST00000563039
GeneID 6693
KEGG hsa:6693
UCSC uc002dtm.5
CTD 6693
DisGeNET 6693
GeneCards SPN
HGNC HGNC:11249
HPA CAB002666
HPA055244
MalaCards SPN
MIM 182160
neXtProt NX_P16150
OpenTargets ENSG00000197471
PharmGKB PA36079
eggNOG ENOG410J161
ENOG410YXQE
GeneTree ENSGT00390000017626
HOGENOM HOG000294199
HOVERGEN HBG006258
InParanoid P16150
KO K06477
OMA GPPLTMA
OrthoDB EOG091G0MEV
PhylomeDB P16150
TreeFam TF337688
Reactome [www.reactome.org/content/detail/R-HSA-202733 R-HSA-202733]
[www.reactome.org/content/detail/R-HSA-210991 R-HSA-210991]
GeneWiki CD43
PMAP-CutDB P16150
PRO PR:P16150
Proteomes UP000005640
Bgee ENSG00000197471
CleanEx HS_SPN
ExpressionAtlas P16150
Genevisible P16150
GO GO:0005604
GO:0009986
GO:0009897
GO:0070062
GO:0005615
GO:0005887
GO:0016020
GO:0005886
GO:0001931
GO:0004888
GO:0097190
GO:0007166
GO:0006968
GO:0006935
GO:0042742
GO:0007163
GO:0006955
GO:0050900
GO:0007162
GO:0042130
GO:0001808
GO:0045060
GO:0001934
GO:0042102
GO:0042535
GO:0050688
GO:0001562
GO:0007165
GO:0031295

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0009986

cell surface

PMID:12354383[1]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13838

C

Seeded From UniProt

complete

part_of

GO:0001931

uropod

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15702

C

Seeded From UniProt

complete

involved_in

GO:2000406

positive regulation of T cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15702

P

Seeded From UniProt

complete

involved_in

GO:2000404

regulation of T cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15702

P

Seeded From UniProt

complete

involved_in

GO:0050901

leukocyte tethering or rolling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15702

P

Seeded From UniProt

complete

involved_in

GO:0042130

negative regulation of T cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15702

P

Seeded From UniProt

complete

involved_in

GO:0032609

interferon-gamma production

PMID:18036228[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002296

T-helper 1 cell lineage commitment

PMID:18036228[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030544

Hsp70 protein binding

PMID:20633027[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:A0A0H3L5C8

F

Seeded From UniProt

complete

enables

GO:0031072

heat shock protein binding

PMID:20633027[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:A0A0H3LCC3

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:20605918[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

PMID:10899905[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042535

positive regulation of tumor necrosis factor biosynthetic process

PMID:10899905[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:10899905[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038829

F

Seeded From UniProt

complete

involved_in

GO:0032609

interferon-gamma production

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038829

P

Seeded From UniProt

complete

involved_in

GO:0050863

regulation of T cell activation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038829

P

Seeded From UniProt

complete

involved_in

GO:2000404

regulation of T cell migration

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR038829

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:2023632[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007163

establishment or maintenance of cell polarity

PMID:10753822[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007162

negative regulation of cell adhesion

PMID:10753822[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006968

cellular defense response

PMID:1683685[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:2023632[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

PMID:10753822[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:2023632[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

PMID:1683685[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0050900

leukocyte migration

Reactome:R-HSA-202733

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-2870221
Reactome:R-HSA-204465

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0001931

uropod

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0141

C

Seeded From UniProt

complete

part_of

GO:0016605

PML body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0465

C

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0293

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Pradhan, D & Morrow, J (2002) The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production. Immunity 17 303-15 PubMed GONUTS page
  2. ↑ 2.0 2.1 Ramírez-Pliego, O et al. (2007) CD43 signals induce Type One lineage commitment of human CD4+ T cells. BMC Immunol. 8 30 PubMed GONUTS page
  3. ↑ 3.0 3.1 Hickey, TB et al. (2010) Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface. Cell. Microbiol. 12 1634-47 PubMed GONUTS page
  4. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  5. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  6. ↑ Obata, Y et al. (2010) The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association. J. Cell. Sci. 123 2649-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Fratazzi, C et al. (2000) A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. J. Exp. Med. 192 183-92 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Park, JK et al. (1991) Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome. Nature 350 706-9 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Seveau, S et al. (2000) Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule. Blood 95 2462-70 PubMed GONUTS page
  10. ↑ 10.0 10.1 Rosenstein, Y et al. (1991) CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1. Nature 354 233-5 PubMed GONUTS page
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