HUMAN:KPCD

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PRKCD
Protein Name(s)	Protein kinase C delta type Tyrosine-protein kinase PRKCD nPKC-delta Protein kinase C delta type regulatory subunit Protein kinase C delta type catalytic subunit Sphingosine-dependent protein kinase-1 SDK1
External Links
UniProt	Q05655
EMBL	L07860 L07861 AK313216 CH471055 BC043350 Z22521 D10495 DQ516383
CCDS	CCDS2870.1
PIR	S35704
RefSeq	NP_006245.2 NP_997704.1 XP_006713321.1 XP_006713322.1
UniGene	Hs.155342
PDB	1YRK 2YUU
PDBsum	1YRK 2YUU
ProteinModelPortal	Q05655
SMR	Q05655
BioGrid	111566
DIP	DIP-29954N
IntAct	Q05655
MINT	MINT-1346366
STRING	9606.ENSP00000331602
BindingDB	Q05655
ChEMBL	CHEMBL2093867
DrugBank	DB05013 DB00675
GuidetoPHARMACOLOGY	1485
PhosphoSite	Q05655
DMDM	205371776
MaxQB	Q05655
PaxDb	Q05655
PRIDE	Q05655
DNASU	5580
Ensembl	ENST00000330452 ENST00000394729
GeneID	5580
KEGG	hsa:5580
UCSC	uc003dgl.3
CTD	5580
GeneCards	GC03P053190
HGNC	HGNC:9399
HPA	CAB010469 CAB013225 HPA001863 HPA001890
MIM	176977 615559
neXtProt	NX_Q05655
Orphanet	3261 300345 1572
PharmGKB	PA33763
eggNOG	COG0515
GeneTree	ENSGT00770000120449
HOGENOM	HOG000233022
HOVERGEN	HBG108317
InParanoid	Q05655
KO	K06068
OMA	GEDEAKF
OrthoDB	EOG77M8QM
PhylomeDB	Q05655
TreeFam	TF102004
BRENDA	2.7.11.13
Reactome	REACT_107 REACT_111064 REACT_160158 REACT_19333 REACT_2202 REACT_228024 REACT_25078 REACT_25218 REACT_9000
SignaLink	Q05655
ChiTaRS	PRKCD
EvolutionaryTrace	Q05655
GeneWiki	PRKCD
GenomeRNAi	5580
NextBio	21638
PMAP-CutDB	Q05655
PRO	PR:Q05655
Proteomes	UP000005640
Bgee	Q05655
CleanEx	HS_PRKCD
ExpressionAtlas	Q05655
Genevestigator	Q05655
GO	GO:0005911 GO:0005737 GO:0005829 GO:0005783 GO:0070062 GO:0005739 GO:0016363 GO:0005654 GO:0005634 GO:0048471 GO:0005886 GO:0005524 GO:0004699 GO:0008047 GO:0019899 GO:0043560 GO:0046872 GO:0004715 GO:0004697 GO:0004674 GO:0007202 GO:0006915 GO:0042100 GO:0007596 GO:0007049 GO:0006921 GO:0090398 GO:0019221 GO:0042742 GO:0007173 GO:0038096 GO:0008543 GO:0010467 GO:0016064 GO:0045087 GO:0060333 GO:0032613 GO:0032615 GO:0008631 GO:0016071 GO:0030837 GO:0051490 GO:0034351 GO:0050728 GO:0046627 GO:0043407 GO:0050732 GO:0090331 GO:0032091 GO:0048011 GO:0042119 GO:0018107 GO:0030168 GO:2001235 GO:2000304 GO:2000753 GO:1900163 GO:0035307 GO:2001022 GO:2000755 GO:0032930 GO:0006468 GO:0050821 GO:0010469 GO:0016070 GO:0007165 GO:0023021
Gene3D	2.60.40.150
InterPro	IPR000961 IPR000008 IPR020454 IPR011009 IPR002219 IPR027436 IPR017892 IPR014376 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00130 PF00069 PF00433
PIRSF	PIRSF000551 PIRSF501104
PRINTS	PR00008
SMART	SM00109 SM00239 SM00133 SM00220
SUPFAM	SSF49562 SSF56112
PROSITE	PS51285 PS00107 PS50011 PS00108 PS00479 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0019901	protein kinase binding	PMID:28428613^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9BZL6	F		Seeded From UniProt	complete
involved_in	GO:1904385	cellular response to angiotensin	PMID:18285462^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18285462^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:18285462^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18285462^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18285462^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:24008408^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000575)	Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:24008408^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_movement_of:(CL:0000575)\|results_in_movement_of:(CL:0000575)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:19059439^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(UniProtKB:P23396)	Seeded From UniProt	complete
involved_in	GO:0016572	histone phosphorylation	PMID:19059439^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:19059439^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23396	F	occurs_in:(GO:0005829)	Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:19059439^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12931	F		Seeded From UniProt	complete
involved_in	GO:0071447	cellular response to hydroperoxide	PMID:19059439^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032079	positive regulation of endodeoxyribonuclease activity	PMID:19059439^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P23396)	Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	PMID:19059439^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P23396)	Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	PMID:22554282^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:10713049^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:10713049^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P00519) part_of:(GO:0070301)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:10713049^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P00519) part_of:(GO:0032147) part_of:(GO:0070301)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:10713049^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P00519	F	part_of:(GO:0070301)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:2000755	positive regulation of sphingomyelin catabolic process	PMID:19279011^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000753	positive regulation of glucosylceramide catabolic process	PMID:19279011^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000304	positive regulation of ceramide biosynthetic process	PMID:19279011^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090398	cellular senescence	PMID:15282327^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	PMID:14583092^[10]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28867	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:19279008^[11]	ECO:0000305	curator inference used in manual assertion	GO:0043407	P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28867	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28867	F		Seeded From UniProt	complete
	GO:0032956	regulation of actin cytoskeleton organization	PMID:22554282^[5]	ECO:0000315			P		Figure 4D	complete CACAO 8666
involved_in	GO:0043407	negative regulation of MAP kinase activity	PMID:19279008^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035307	positive regulation of protein dephosphorylation	PMID:19279008^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0023021	termination of signal transduction	PMID:19279008^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:18556656^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:18556656^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001022	positive regulation of response to DNA damage stimulus	PMID:17938203^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9NYF8) has_regulation_target:(UniProtKB:P04637)	Seeded From UniProt	complete
involved_in	GO:1900163	positive regulation of phospholipid scramblase activity	PMID:10770950^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090331	negative regulation of platelet aggregation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28867	P		Seeded From UniProt	complete
involved_in	GO:0051490	negative regulation of filopodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28867	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:16611985^[15]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28867	P		Seeded From UniProt	complete
involved_in	GO:0042119	neutrophil activation	PMID:10770950^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034351	negative regulation of glial cell apoptotic process	PMID:15774464^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032930	positive regulation of superoxide anion generation	PMID:19801500^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030837	negative regulation of actin filament polymerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28867	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:16611985^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02880	F		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:10770950^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008047	enzyme activator activity	PMID:16611985^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10770950^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000775)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16611985^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10770950^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15632189^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15774464^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:10770950^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:15774464^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15632189^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16611985^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15774464^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15632189^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16611985^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28867	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10770950^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003744 FB:FBgn0010379 MGI:MGI:97601 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAPB18E9.02c RGD:3395 RGD:3399 RGD:61925 RGD:620968 RGD:67383 SGD:S000000201 UniProtKB:O15530 UniProtKB:P31749 UniProtKB:Q15208 UniProtKB:Q9NRM7 UniProtKB:Q9Y2H1	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87986 PANTHER:PTN000683254 RGD:2081 RGD:3395 RGD:3399 RGD:3668 RGD:61925 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000005460 UniProtKB:A0A1D5PUY5 UniProtKB:P31749 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q05513 UniProtKB:Q05655 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004033 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003091 FB:FBgn0003744 FB:FBgn0010379 FB:FBgn0260399 FB:FBgn0261854 MGI:MGI:104874 MGI:MGI:2182368 MGI:MGI:87986 MGI:MGI:894676 MGI:MGI:97595 MGI:MGI:97596 MGI:MGI:97599 MGI:MGI:97602 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAC24B11.11c PomBase:SPAC821.12 PomBase:SPAPB18E9.02c PomBase:SPCC576.15c RGD:2081 RGD:2082 RGD:3399 RGD:3668 RGD:620146 RGD:620968 RGD:62390 SGD:S000001248 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000003324 SGD:S000005105 SGD:S000005460 SGD:S000006315 TAIR:locus:2088515 UniProtKB:O15530 UniProtKB:O95835 UniProtKB:P05771 UniProtKB:P17252 UniProtKB:P31749 UniProtKB:P31751 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q04759 UniProtKB:Q05513 UniProtKB:Q05655 UniProtKB:Q09013 UniProtKB:Q15208 UniProtKB:Q16512 UniProtKB:Q16513 UniProtKB:Q96GX5 UniProtKB:Q9NRM7 UniProtKB:Q9XF67 UniProtKB:Q9Y243 UniProtKB:Q9Y2H1 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599 dictyBase:DDB_G0268620	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18285462^[2]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12391145^[20]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004715	P		Seeded From UniProt	complete
involved_in	GO:2001235	positive regulation of apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	P		Seeded From UniProt	complete
involved_in	GO:0090331	negative regulation of platelet aggregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	P		Seeded From UniProt	complete
involved_in	GO:0051490	negative regulation of filopodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	P		Seeded From UniProt	complete
involved_in	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	F		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	P		Seeded From UniProt	complete
involved_in	GO:0042100	B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	P		Seeded From UniProt	complete
involved_in	GO:0032615	interleukin-12 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	P		Seeded From UniProt	complete
involved_in	GO:0032613	interleukin-10 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	P		Seeded From UniProt	complete
involved_in	GO:0030837	negative regulation of actin filament polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	P		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	C		Seeded From UniProt	complete
involved_in	GO:0016064	immunoglobulin mediated immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	C		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28867 ensembl:ENSMUSP00000107830	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961 InterPro:IPR017892	F		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014376 InterPro:IPR027436 InterPro:IPR034667	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR017441 InterPro:IPR017892	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271 InterPro:IPR014376 InterPro:IPR017892 InterPro:IPR034667	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002219	P		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.13	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
involved_in	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	PMID:24522549^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8357834^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:14583092^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:14583092^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	PMID:14583092^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004699	calcium-independent protein kinase C activity	PMID:14583092^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	Reactome:R-HSA-877300	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	Reactome:R-HSA-450520	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	Reactome:R-HSA-2029480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035578	azurophil granule lumen	Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	Reactome:R-HSA-76002	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5607746 Reactome:R-HSA-5607740 Reactome:R-HSA-198314	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9626817 Reactome:R-HSA-909552 Reactome:R-HSA-5607746 Reactome:R-HSA-5607734 Reactome:R-HSA-5218823 Reactome:R-HSA-5218821 Reactome:R-HSA-5218813 Reactome:R-HSA-5218805 Reactome:R-HSA-425861 Reactome:R-HSA-212552 Reactome:R-HSA-198314 Reactome:R-HSA-111970	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-450533	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Cobbaut, M et al. (2017) Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. Sci Rep 7 887 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Doller, A et al. (2008) Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA. Mol. Cell. Biol. 28 2608-25 PubMed GONUTS page
↑ ^3.0 ^3.1 Griffith, GL et al. (2013) CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis. Invest. Ophthalmol. Vis. Sci. 54 6712-23 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Kim, TS et al. (2009) PKCdelta-dependent functional switch of rpS3 between translation and DNA repair. Biochim. Biophys. Acta 1793 395-405 PubMed GONUTS page
↑ ^5.0 ^5.1 Contreras, X et al. (2012) Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages. Retrovirology 9 37 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Sun, X et al. (2000) Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J. Biol. Chem. 275 7470-3 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Kitatani, K et al. (2009) Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation. J. Biol. Chem. 284 12972-8 PubMed GONUTS page
↑ Wheaton, K & Riabowol, K (2004) Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. Mol. Cell. Biol. 24 7298-311 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Greene, MW et al. (2004) Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta. Biochem. J. 378 105-16 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Kitatani, K et al. (2009) Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J. Biol. Chem. 284 12979-88 PubMed GONUTS page
↑ ^12.0 ^12.1 Basu, NK et al. (2008) The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C. J. Biol. Chem. 283 23048-61 PubMed GONUTS page
↑ Liu, H et al. (2007) Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. Mol. Cell. Biol. 27 8480-91 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Frasch, SC et al. (2000) Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta. J. Biol. Chem. 275 23065-73 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Yoshida, K et al. (2006) Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage. Mol. Cell. Biol. 26 3414-31 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Okhrimenko, H et al. (2005) Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis. J. Biol. Chem. 280 23643-52 PubMed GONUTS page
↑ Kilpatrick, LE et al. (2010) Regulation of TNF-induced oxygen radical production in human neutrophils: role of delta-PKC. J. Leukoc. Biol. 87 153-64 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 van Baal, J et al. (2005) Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C. J. Biol. Chem. 280 9870-8 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Shu, X et al. (2002) Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol. Cell. Biol. 22 7758-68 PubMed GONUTS page
↑ Gaki, GS & Papavassiliou, AG (2014) Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease. Neuromolecular Med. 16 217-30 PubMed GONUTS page
↑ Aris, JP et al. (1993) Molecular and biochemical characterization of a recombinant human PKC-delta family member. Biochim. Biophys. Acta 1174 171-81 PubMed GONUTS page

[PMID:28428613-1] Cobbaut, M et al. (2017) Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. Sci Rep 7 887 PubMed GONUTS page

[PMID:18285462-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Doller, A et al. (2008) Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA. Mol. Cell. Biol. 28 2608-25 PubMed GONUTS page

[PMID:24008408-3] 3.0 ^3.1 Griffith, GL et al. (2013) CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis. Invest. Ophthalmol. Vis. Sci. 54 6712-23 PubMed GONUTS page

[PMID:19059439-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Kim, TS et al. (2009) PKCdelta-dependent functional switch of rpS3 between translation and DNA repair. Biochim. Biophys. Acta 1793 395-405 PubMed GONUTS page

[PMID:22554282-5] 5.0 ^5.1 Contreras, X et al. (2012) Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages. Retrovirology 9 37 PubMed GONUTS page

[PMID:10713049-6] 6.0 ^6.1 ^6.2 ^6.3 Sun, X et al. (2000) Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J. Biol. Chem. 275 7470-3 PubMed GONUTS page

[PMID:19056867-7] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:19279011-8] 8.0 ^8.1 ^8.2 Kitatani, K et al. (2009) Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation. J. Biol. Chem. 284 12972-8 PubMed GONUTS page

[PMID:15282327-9] Wheaton, K & Riabowol, K (2004) Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. Mol. Cell. Biol. 24 7298-311 PubMed GONUTS page

[PMID:14583092-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Greene, MW et al. (2004) Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta. Biochem. J. 378 105-16 PubMed GONUTS page

[PMID:19279008-11] 11.0 ^11.1 ^11.2 ^11.3 Kitatani, K et al. (2009) Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J. Biol. Chem. 284 12979-88 PubMed GONUTS page

[PMID:18556656-12] 12.0 ^12.1 Basu, NK et al. (2008) The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C. J. Biol. Chem. 283 23048-61 PubMed GONUTS page

[PMID:17938203-13] Liu, H et al. (2007) Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. Mol. Cell. Biol. 27 8480-91 PubMed GONUTS page

[PMID:10770950-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Frasch, SC et al. (2000) Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta. J. Biol. Chem. 275 23065-73 PubMed GONUTS page

[PMID:16611985-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Yoshida, K et al. (2006) Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage. Mol. Cell. Biol. 26 3414-31 PubMed GONUTS page

[PMID:15774464-16] 16.0 ^16.1 ^16.2 ^16.3 Okhrimenko, H et al. (2005) Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis. J. Biol. Chem. 280 23643-52 PubMed GONUTS page

[PMID:19801500-17] Kilpatrick, LE et al. (2010) Regulation of TNF-induced oxygen radical production in human neutrophils: role of delta-PKC. J. Leukoc. Biol. 87 153-64 PubMed GONUTS page

[PMID:15632189-18] 18.0 ^18.1 ^18.2 van Baal, J et al. (2005) Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C. J. Biol. Chem. 280 9870-8 PubMed GONUTS page

[PMID:21873635-19] 19.0 ^19.1 ^19.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12391145-20] Shu, X et al. (2002) Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol. Cell. Biol. 22 7758-68 PubMed GONUTS page

[PMID:24522549-21] Gaki, GS & Papavassiliou, AG (2014) Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease. Neuromolecular Med. 16 217-30 PubMed GONUTS page

[PMID:8357834-22] Aris, JP et al. (1993) Molecular and biochemical characterization of a recombinant human PKC-delta family member. Biochim. Biophys. Acta 1174 171-81 PubMed GONUTS page

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HUMAN:KPCD

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