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HUMAN:KMT2B
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | KMT2B (synonyms: HRX2, KIAA0304, MLL2, MLL4, TRX2, WBP7) | |
| Protein Name(s) | Histone-lysine N-methyltransferase 2B
Lysine N-methyltransferase 2B Myeloid/lymphoid or mixed-lineage leukemia protein 4 Trithorax homolog 2 WW domain-binding protein 7 WBP-7 | |
| External Links | ||
| UniProt | Q9UMN6 | |
| EMBL | AJ007041 AD000671 AF186605 AB002302 BC009337 BC007353 AF104918 AF105279 AF105280 | |
| CCDS | CCDS46055.1 | |
| RefSeq | NP_055542.1 | |
| UniGene | Hs.676457 Hs.92236 | |
| PDB | 3UVM 4ERZ 4PZI | |
| PDBsum | 3UVM 4ERZ 4PZI | |
| ProteinModelPortal | Q9UMN6 | |
| SMR | Q9UMN6 | |
| BioGrid | 115104 | |
| DIP | DIP-34598N | |
| IntAct | Q9UMN6 | |
| MINT | MINT-1187865 | |
| BindingDB | Q9UMN6 | |
| ChEMBL | CHEMBL2189112 | |
| PhosphoSite | Q9UMN6 | |
| DMDM | 12643900 | |
| MaxQB | Q9UMN6 | |
| PaxDb | Q9UMN6 | |
| PRIDE | Q9UMN6 | |
| Ensembl | ENST00000420124 | |
| GeneID | 9757 | |
| KEGG | hsa:9757 | |
| UCSC | uc021usu.2 | |
| CTD | 9757 | |
| GeneCards | GC19P036216 GC19P036217 | |
| HGNC | HGNC:15840 | |
| HPA | HPA006487 | |
| MIM | 606834 | |
| neXtProt | NX_Q9UMN6 | |
| eggNOG | COG2940 | |
| GeneTree | ENSGT00760000119228 | |
| HOVERGEN | HBG100043 | |
| InParanoid | Q9UMN6 | |
| KO | K14959 | |
| OMA | YEKGNYC | |
| PhylomeDB | Q9UMN6 | |
| GeneWiki | MLL4 | |
| GenomeRNAi | 9757 | |
| NextBio | 36724 | |
| PRO | PR:Q9UMN6 | |
| Proteomes | UP000005640 | |
| Bgee | Q9UMN6 | |
| CleanEx | HS_MLL2 | |
| Genevestigator | Q9UMN6 | |
| GO | GO:0035097 GO:0005634 GO:0003677 GO:0042800 GO:0003700 GO:0008270 GO:0048096 GO:0016458 GO:0051568 GO:0080182 GO:0009994 GO:0001541 GO:0030728 GO:0051569 GO:0006351 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR017956 IPR003889 IPR003888 IPR016569 IPR003616 IPR001214 IPR002857 IPR011011 IPR001965 IPR019787 IPR013083 | |
| Pfam | PF05965 PF05964 PF00628 PF00856 PF02008 | |
| PIRSF | PIRSF010354 | |
| SMART | SM00384 SM00542 SM00541 SM00249 SM00508 SM00317 | |
| SUPFAM | SSF57903 | |
| PROSITE | PS51543 PS51542 PS50868 PS50280 PS51058 PS01359 PS50016 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0097692 |
histone H3-K4 monomethylation |
ECO:0000314 |
P |
Figure 2C |
complete | |||||
| GO:0044648 |
histone H3-K4 dimethylation |
ECO:0000314 |
P |
Figure 2C |
complete | |||||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051568 |
histone H3-K4 methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048096 |
chromatin-mediated maintenance of transcription |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042800 |
histone methyltransferase activity (H3-K4 specific) |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0035097 |
histone methyltransferase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0000981 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0080182 |
histone H3-K4 trimethylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08550 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051569 |
regulation of histone H3-K4 methylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08550 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034968 |
histone lysine methylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08550 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030728 |
ovulation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08550 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016458 |
gene silencing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08550 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009994 |
oocyte differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08550 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007613 |
memory |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08550 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001541 |
ovarian follicle development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08550 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0035097 |
histone methyltransferase complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042800 |
histone methyltransferase activity (H3-K4 specific) |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051568 |
histone H3-K4 methylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0018024 |
histone-lysine N-methyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045652 |
regulation of megakaryocyte differentiation |
Reactome:R-HSA-8936459 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-8937050 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Shinsky, SA et al. (2015) Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation. J. Biol. Chem. 290 6361-75 PubMed GONUTS page
- ↑ Nightingale, KP et al. (2007) Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation. J. Biol. Chem. 282 4408-16 PubMed GONUTS page
- ↑ 3.0 3.1 FitzGerald, KT & Diaz, MO (1999) MLL2: A new mammalian member of the trx/MLL family of genes. Genomics 59 187-92 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page
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- GO:0016458 ! obsolete gene silencing
- GO:0097692 ! obsolete histone H3-K4 monomethylation
- GO:0044648 ! obsolete histone H3-K4 dimethylation
- GO:0018024 ! obsolete histone lysine N-methyltransferase activity
- GO:0034968 ! obsolete histone lysine methylation
- GO:0080182 ! obsolete histone H3-K4 trimethylation
- GO:0051568 ! obsolete histone H3-K4 methylation
- GO:0051569 ! obsolete regulation of histone H3-K4 methylation
- GO:0009994 ! oocyte differentiation
- GO:0001541 ! ovarian follicle development
- GO:0030728 ! ovulation
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