PMID:10409430

Citation	FitzGerald, KT and Diaz, MO (1999) MLL2: A new mammalian member of the trx/MLL family of genes. Genomics 59:187-92
Abstract	We have identified a gene at chromosome band 19q13.1, which is closely related to MLL. MLL is located in a region of chromosome 11q23 that has partial synteny with chromosome 19q. We have named this gene at 19q13.1, MLL2. MLL2 encodes a protein that exhibits a high level of similarity to MLL over several important protein domains. MLL2 is also ubiquitously expressed among adult human tissues, as is MLL. MLL is a homologue of the Drosophila gene trithorax (trx), which encodes a regulator of homeotic gene expression. MLL is involved in chromosome rearrangements associated with leukemia in mammals. However, no MLL2 rearrangements associated with leukemia have been recorded.
Links	PubMed Online version:10.1006/geno.1999.5860
Keywords	Amino Acid Sequence; Base Sequence; Blotting, Northern; DNA, Complementary/chemistry; DNA, Complementary/genetics; DNA-Binding Proteins/genetics; Female; Gene Expression; Genes/genetics; Histone-Lysine N-Methyltransferase; Humans; Male; Molecular Sequence Data; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Proto-Oncogenes; RNA, Messenger/genetics; RNA, Messenger/metabolism; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Tissue Distribution; Transcription Factors
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Significance

Gene product	Qualifier	GO Term	Evidence Code	Aspect	Notes	Status
HUMAN:KMT2B	enables	GO:0003700: DNA-binding transcription factor activity	ECO:0000303: author statement without traceable support used in manual assertion	F	Seeded From UniProt	complete
HUMAN:KMT2B	involved_in	GO:0048096: chromatin-mediated maintenance of transcription	ECO:0000303: author statement without traceable support used in manual assertion	P	Seeded From UniProt	complete

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