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HUMAN:KLF2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KLF2 (synonyms: LKLF)
Protein Name(s) Krueppel-like factor 2

Lung krueppel-like factor

External Links
UniProt Q9Y5W3
EMBL AF123344
AF134053
AF205849
EF078888
BC071983
CCDS CCDS12343.1
RefSeq NP_057354.1
UniGene Hs.685136
Hs.744182
ProteinModelPortal Q9Y5W3
SMR Q9Y5W3
BioGrid 115645
DIP DIP-41973N
IntAct Q9Y5W3
MINT MINT-199597
STRING 9606.ENSP00000248071
iPTMnet Q9Y5W3
PhosphoSitePlus Q9Y5W3
BioMuta KLF2
DMDM 20141620
MaxQB Q9Y5W3
PaxDb Q9Y5W3
PeptideAtlas Q9Y5W3
PRIDE Q9Y5W3
Ensembl ENST00000248071
GeneID 10365
KEGG hsa:10365
UCSC uc002ndw.4
CTD 10365
DisGeNET 10365
GeneCards KLF2
HGNC HGNC:6347
HPA HPA055964
MIM 602016
neXtProt NX_Q9Y5W3
OpenTargets ENSG00000127528
PharmGKB PA30136
eggNOG KOG1721
COG5048
GeneTree ENSGT00760000118998
HOGENOM HOG000060173
HOVERGEN HBG006220
InParanoid Q9Y5W3
KO K17845
OMA MSFEQPR
OrthoDB EOG091G1BN0
PhylomeDB Q9Y5W3
TreeFam TF350556
SIGNOR Q9Y5W3
ChiTaRS KLF2
GeneWiki KLF2
GenomeRNAi 10365
PRO PR:Q9Y5W3
Proteomes UP000005640
Bgee ENSG00000127528
CleanEx HS_KLF2
ExpressionAtlas Q9Y5W3
Genevisible Q9Y5W3
GO GO:0000790
GO:0003677
GO:0046872
GO:0000981
GO:0043565
GO:0003700
GO:0000902
GO:0071409
GO:0071498
GO:0070301
GO:0071347
GO:0071499
GO:1901653
GO:0071356
GO:0043249
GO:0001701
GO:0035264
GO:0032715
GO:0045429
GO:0051247
GO:0045944
GO:0036003
GO:0045893
GO:0040029
GO:0006351
GO:0060509
InterPro IPR013087
SMART SM00355
SUPFAM SSF57667
PROSITE PS00028
PS50157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0097533

cellular stress response to acid chemical

PMID:26299712[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(CHEBI:27226)

Seeded From UniProt

complete

GO:0048386

positive regulation of retinoic acid receptor signaling pathway

PMID:26416422[3]

ECO:0000314

P

In accordance with activation of RAR and suppression of PPAR-mediated activity by KLF2, analyses of cultured cells (Figure S1F-S1I) and of tumors that arose in NCr mice showed that overexpression of KLF2 upregulated levels of mRNA of the endogenous the RAR target genes BTG2 [26] and CYP26a [46, 47] (Figure 2H).

complete
CACAO 12298

involved_in

GO:1903671

negative regulation of sprouting angiogenesis

PMID:26299712[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:26299712[2]

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_transcription_of:(ENSEMBL:ENSG00000112715)
  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:22327366[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

has_direct_input:(ENSEMBL:ENSG00000249669)|has_direct_input:(ENSEMBL:ENSG00000276365)

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:22327366[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

  • coincident_with:(ENSEMBL:ENSG00000249669)
  • coincident_with:(SO:0000167)|coincident_with:(ENSEMBL:ENSG00000276365)
  • coincident_with:(SO:0000167)

Seeded From UniProt

complete

involved_in

GO:0071498

cellular response to fluid shear stress

PMID:22327366[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:22327366[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates_transcription_of:(ENSEMBL:ENSG00000249669)
  • part_of:(GO:0071498)|regulates_transcription_of(ENSEMBL:ENSG00000276365)
  • part_of:(GO:0071498)

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:22327366[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

has_direct_input:(ENSEMBL:ENSG00000249669)|has_direct_input:(ENSEMBL:ENSG00000276365)

Seeded From UniProt

complete

involved_in

GO:0045429

positive regulation of nitric oxide biosynthetic process

PMID:21768538[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:21063504[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21063504[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q9JHX2

F

Seeded From UniProt

complete

involved_in

GO:0071499

cellular response to laminar fluid shear stress

PMID:23043106[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051247

positive regulation of protein metabolic process

PMID:20551324[8]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q62862

P

has_regulation_target:(UniProtKB:P29474)

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20551324[8]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q62862

P

  • part_of:(GO:0000165)
  • regulates_transcription_of:(ENSEMBL:ENSG00000164867)

Seeded From UniProt

complete

involved_in

GO:0036003

positive regulation of transcription from RNA polymerase II promoter in response to stress

PMID:23043106[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1342771
MGI:MGI:1342772
PANTHER:PTN002555475
UniProtKB:Q9Y5W3

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1338056
MGI:MGI:1342287
MGI:MGI:1354948
MGI:MGI:2153049
MGI:MGI:2153568
MGI:MGI:2181068
MGI:MGI:98968
PANTHER:PTN001145452
RGD:3738
UniProtKB:A0A1D8PNL1
UniProtKB:Q02446
UniProtKB:Q7RTV3
ZFIN:ZDB-GENE-021115-9

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1342772
PANTHER:PTN002555475
UniProtKB:Q13351

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0043364
FB:FBgn0261434
FB:FBgn0263239
MGI:MGI:1101353
MGI:MGI:1277166
MGI:MGI:1333856
MGI:MGI:1338056
MGI:MGI:1342287
MGI:MGI:1342772
MGI:MGI:1346318
MGI:MGI:1929988
MGI:MGI:1932575
MGI:MGI:2153568
MGI:MGI:95295
MGI:MGI:95296
MGI:MGI:98372
MGI:MGI:98968
PANTHER:PTN001145452
RGD:1306768
RGD:2544
RGD:3738
RGD:3741
RGD:3974
RGD:621445
RGD:621652
RGD:62389
UniProtKB:A0A0B4KHC8
UniProtKB:A0A0G2K5M1
UniProtKB:P18146
UniProtKB:P19544
UniProtKB:Q02086
UniProtKB:Q13351
UniProtKB:Q13886
UniProtKB:Q7RTV3
UniProtKB:Q8TDD2
UniProtKB:Q99612
UniProtKB:Q9UIH9
WB:WBGene00007772
WB:WBGene00012735

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002555475
UniProtKB:Q9Y5W3

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001145452
UniProtKB:O14901
UniProtKB:Q9Y5W3
WB:WBGene00012735
ZFIN:ZDB-GENE-021115-9

F

Seeded From UniProt

complete

involved_in

GO:0060509

type I pneumocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60843
ensembl:ENSMUSP00000064823

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60843
ensembl:ENSMUSP00000064823

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60843
ensembl:ENSMUSP00000064823

P

Seeded From UniProt

complete

involved_in

GO:0043249

erythrocyte maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60843
ensembl:ENSMUSP00000064823

P

Seeded From UniProt

complete

involved_in

GO:0040029

regulation of gene expression, epigenetic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60843
ensembl:ENSMUSP00000064823

P

Seeded From UniProt

complete

involved_in

GO:0035264

multicellular organism growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60843
ensembl:ENSMUSP00000064823

P

Seeded From UniProt

complete

involved_in

GO:0034101

erythrocyte homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60843
ensembl:ENSMUSP00000064823

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60843
ensembl:ENSMUSP00000064823

C

Seeded From UniProt

complete

involved_in

GO:0001701

in utero embryonic development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60843
ensembl:ENSMUSP00000064823

P

Seeded From UniProt

complete

involved_in

GO:0000902

cell morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60843
ensembl:ENSMUSP00000064823

P

Seeded From UniProt

complete

involved_in

GO:1901653

cellular response to peptide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ET58
ensembl:ENSRNOP00000019052

P

Seeded From UniProt

complete

involved_in

GO:0071409

cellular response to cycloheximide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ET58
ensembl:ENSRNOP00000019052

P

Seeded From UniProt

complete

involved_in

GO:0071407

cellular response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ET58
ensembl:ENSRNOP00000019052

P

Seeded From UniProt

complete

involved_in

GO:0071356

cellular response to tumor necrosis factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ET58
ensembl:ENSRNOP00000019052

P

Seeded From UniProt

complete

involved_in

GO:0071347

cellular response to interleukin-1

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ET58
ensembl:ENSRNOP00000019052

P

Seeded From UniProt

complete

involved_in

GO:0070301

cellular response to hydrogen peroxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ET58
ensembl:ENSRNOP00000019052

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ET58
ensembl:ENSRNOP00000019052

P

Seeded From UniProt

complete

involved_in

GO:0034616

response to laminar fluid shear stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ET58
ensembl:ENSRNOP00000019052

P

Seeded From UniProt

complete

involved_in

GO:0032715

negative regulation of interleukin-6 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ET58
ensembl:ENSRNOP00000019052

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013087

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Yu, S et al. (2015) High concentrations of uric acid inhibit angiogenesis via regulation of the Krüppel-like factor 2-vascular endothelial growth factor-A axis by miR-92a. Circ. J. 79 2487-98 PubMed GONUTS page
  3. ↑ Zhang, W et al. (2015) Kruppel-like factor 2 suppresses mammary carcinoma growth by regulating retinoic acid signaling. Oncotarget 6 35830-42 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Hergenreider, E et al. (2012) Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat. Cell Biol. 14 249-56 PubMed GONUTS page
  5. ↑ Wu, W et al. (2011) Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation 124 633-41 PubMed GONUTS page
  6. ↑ 6.0 6.1 Lin, Z et al. (2010) A novel role of CCN3 in regulating endothelial inflammation. J Cell Commun Signal 4 141-53 PubMed GONUTS page
  7. ↑ 7.0 7.1 Kim, M et al. (2012) Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation. J. Biol. Chem. 287 40722-31 PubMed GONUTS page
  8. ↑ 8.0 8.1 Ohnesorge, N et al. (2010) Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4). J. Biol. Chem. 285 26199-210 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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