HUMAN:K6PF

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PFKM (synonyms: PFKX)
Protein Name(s)	6-phosphofructokinase, muscle type Phosphofructo-1-kinase isozyme A PFK-A Phosphofructokinase-M Phosphofructokinase 1 Phosphohexokinase
External Links
UniProt	P08237
EMBL	M59741 M59720 M59721 M59722 M59723 M59724 M59725 M59726 M59727 M59728 M59729 M59730 M59731 M59732 M59733 M59734 M59735 M59736 M59737 M59738 M59739 M59740 M26066 Y00698 AK126229 AC004801 AC074029 BC000534 BC012799 BC013298 BC021203 J05533 M24925
PIR	A91605
RefSeq	NP_000280.1 NP_001160158.1 NP_001160159.1 NP_001160160.1 XP_005269034.1 XP_005269035.1 XP_005269036.1 XP_006719526.1 XP_006719527.1
UniGene	Hs.75160
ProteinModelPortal	P08237
SMR	P08237
BioGrid	111234
IntAct	P08237
MINT	MINT-5005297
STRING	9606.ENSP00000352842
BindingDB	P08237
ChEMBL	CHEMBL3291
PhosphoSite	P08237
DMDM	125126
UCD-2DPAGE	P08237
MaxQB	P08237
PaxDb	P08237
PRIDE	P08237
DNASU	5213
Ensembl	ENST00000312352 ENST00000340802 ENST00000359794 ENST00000395233 ENST00000547587 ENST00000551804
GeneID	5213
KEGG	hsa:5213
UCSC	uc001rra.2 uc001rrg.2
CTD	5213
GeneCards	GC12P048501
HGNC	HGNC:8877
HPA	HPA002117
MIM	232800 610681
neXtProt	NX_P08237
Orphanet	371
PharmGKB	PA33216
eggNOG	COG0205
HOGENOM	HOG000200154
HOVERGEN	HBG000976
InParanoid	P08237
KO	K00850
OMA	VYHMASK
OrthoDB	EOG7ZSHV5
PhylomeDB	P08237
TreeFam	TF300411
BioCyc	MetaCyc:HS07832-MONOMER
Reactome	REACT_111217 REACT_116125
SABIO-RK	P08237
UniPathway	UPA00109
ChiTaRS	PFKM
GeneWiki	PFKM
GenomeRNAi	5213
NextBio	20164
PMAP-CutDB	P08237
PRO	PR:P08237
ArrayExpress	P08237
Bgee	P08237
CleanEx	HS_PFKM
Genevestigator	P08237
GO	GO:0005945 GO:0016324 GO:0005829 GO:0003872 GO:0005524 GO:0070061 GO:0042802 GO:0019900 GO:0046872 GO:0005515 GO:0008022 GO:0005975 GO:0046835 GO:0006002 GO:0042593 GO:0006006 GO:0006096 GO:0046716 GO:0032024 GO:0051259 GO:0044281
HAMAP	MF_00339
InterPro	IPR009161 IPR022953 IPR015912 IPR000023
Pfam	PF00365
PIRSF	PIRSF000533
PRINTS	PR00476
SUPFAM	SSF53784
TIGRFAMs	TIGR02478
PROSITE	PS00433

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0061615	glycolytic process through fructose-6-phosphate	PMID:25796446^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	PMID:25796446^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25796446^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:25796446^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0070061	fructose binding	PMID:8780720^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:6444721^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	PMID:6444532^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:6444721^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08237	F	Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:6444721^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17858	F	Seeded From UniProt	complete
involved_in	GO:0006002	fructose 6-phosphate metabolic process	PMID:6444532^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006002	fructose 6-phosphate metabolic process	PMID:6444721^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:8780720^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	PMID:8780720^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:12649290^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HBG4	F	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:12649290^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:6444532^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005945	6-phosphofructokinase complex	PMID:6444532^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005945	6-phosphofructokinase complex	PMID:6444721^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	PMID:6444532^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	PMID:8780720^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	PMID:6444721^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00511	F	Seeded From UniProt	complete
enables	GO:0070095	fructose-6-phosphate binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000344216 PomBase:SPBC16H5.02 RGD:3311 RGD:61893 RGD:68419 UniProtKB:P17858	F	Seeded From UniProt	complete
involved_in	GO:0061621	canonical glycolysis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97548 PANTHER:PTN000344216	P	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10699 PANTHER:PTN000344216 RGD:3311 RGD:61893 RGD:68419	P	Seeded From UniProt	complete
enables	GO:0048029	monosaccharide binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000344216 RGD:3311	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10699 MGI:MGI:97548 PANTHER:PTN000344216 UniProtKB:P08237 UniProtKB:P17858 UniProtKB:Q01813	F	Seeded From UniProt	complete
involved_in	GO:0030388	fructose 1,6-bisphosphate metabolic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000344216 PomBase:SPBC16H5.02 RGD:3311 RGD:61893 RGD:68419 UniProtKB:P17858	P	Seeded From UniProt	complete
enables	GO:0016208	AMP binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000344216 RGD:68419	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000344223 UniProtKB:P08237	C	Seeded From UniProt	complete
involved_in	GO:0006007	glucose catabolic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10699 PANTHER:PTN000344216 dictyBase:DDB_G0274111	P	Seeded From UniProt	complete
involved_in	GO:0006002	fructose 6-phosphate metabolic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97547 PANTHER:PTN000344216 PomBase:SPBC16H5.02 RGD:3311 RGD:61893 RGD:68419 UniProtKB:P08237 UniProtKB:P17858 dictyBase:DDB_G0274111	P	Seeded From UniProt	complete
part_of	GO:0005945	6-phosphofructokinase complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10699 PANTHER:PTN000344216 PomBase:SPBC16H5.02 SGD:S000003472 SGD:S000004818 UniProtKB:P08237 UniProtKB:P17858 dictyBase:DDB_G0274111	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10699 PANTHER:PTN000344216 PomBase:SPBC16H5.02 RGD:3311 RGD:61893 RGD:68419 UniProtKB:P08237 UniProtKB:P17858	F	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10699 FB:FBgn0003071 MGI:MGI:97548 PANTHER:PTN000344216 PomBase:SPBC16H5.02 RGD:61893 RGD:68419 UniProtKB:P08237 UniProtKB:Q01813 dictyBase:DDB_G0274111	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:6444721^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08237	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25416956^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08237	F	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000023 InterPro:IPR009161 InterPro:IPR015912 InterPro:IPR022953 InterPro:IPR035966	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009161	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009161	C	Seeded From UniProt	complete
involved_in	GO:0006002	fructose 6-phosphate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022953	P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000023 InterPro:IPR009161 InterPro:IPR015912 InterPro:IPR022953 InterPro:IPR035966	P	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.11	F	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000166259	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000166259	C	Seeded From UniProt	complete
enables	GO:0003872	6-phosphofructokinase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000166259	F	Seeded From UniProt	complete
involved_in	GO:0061621	canonical glycolysis	Reactome:R-HSA-70171	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-70467	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324 UniPathway:UPA00109	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Enzo, E et al. (2015) Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J. 34 1349-70 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Durante, P et al. (1996) Isozyme analysis of human polymorphonuclear leukocyte phosphofructokinase from insulin resistant individuals. Biochem. Biophys. Res. Commun. 225 975-82 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Vora, S et al. (1980) Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system. Proc. Natl. Acad. Sci. U.S.A. 77 62-6 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Vora, S et al. (1980) The molecular mechanism of the inherited phosphofructokinase deficiency associated with hemolysis and myopathy. Blood 55 629-35 PubMed GONUTS page
↑ ^5.0 ^5.1 Su, Y et al. (2003) The a-subunit of the V-type H+-ATPase interacts with phosphofructokinase-1 in humans. J. Biol. Chem. 278 20013-8 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

[PMID:25796446-1] 1.0 ^1.1 ^1.2 ^1.3 Enzo, E et al. (2015) Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J. 34 1349-70 PubMed GONUTS page

[PMID:8780720-2] 2.0 ^2.1 ^2.2 ^2.3 Durante, P et al. (1996) Isozyme analysis of human polymorphonuclear leukocyte phosphofructokinase from insulin resistant individuals. Biochem. Biophys. Res. Commun. 225 975-82 PubMed GONUTS page

[PMID:6444721-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Vora, S et al. (1980) Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system. Proc. Natl. Acad. Sci. U.S.A. 77 62-6 PubMed GONUTS page

[PMID:6444532-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Vora, S et al. (1980) The molecular mechanism of the inherited phosphofructokinase deficiency associated with hemolysis and myopathy. Blood 55 629-35 PubMed GONUTS page

[PMID:12649290-5] 5.0 ^5.1 Su, Y et al. (2003) The a-subunit of the V-type H+-ATPase interacts with phosphofructokinase-1 in humans. J. Biol. Chem. 278 20013-8 PubMed GONUTS page

[PMID:21873635-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25416956-7] Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

HUMAN:K6PF

Contents

Annotations

Notes

References

6

a

c

e

f

g

h

i

k

m

n

o

p

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools