HUMAN:ITPR1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ITPR1 (synonyms: INSP3R1)
Protein Name(s)	Inositol 1,4,5-trisphosphate receptor type 1 IP3 receptor isoform 1 IP3R 1 InsP3R1 Type 1 inositol 1,4,5-trisphosphate receptor Type 1 InsP3 receptor
External Links
UniProt	Q14643
EMBL	D26070 L38019 U23850 AC018816 AC024168 AC069248 AC090944 S82269
CCDS	CCDS46740.2 CCDS54550.1 CCDS54551.1
PIR	A55713 S54974
RefSeq	NP_001093422.2 NP_002213.5
UniGene	Hs.567295 Hs.715765
ProteinModelPortal	Q14643
SMR	Q14643
BioGrid	109913
DIP	DIP-29714N
IntAct	Q14643
MINT	MINT-4991320
STRING	9606.ENSP00000405934
ChEMBL	CHEMBL2111451
DrugBank	DB00201
GuidetoPHARMACOLOGY	743
TCDB	1.A.3.2.6
PhosphoSite	Q14643
DMDM	519668682
MaxQB	Q14643
PaxDb	Q14643
PRIDE	Q14643
Ensembl	ENST00000302640 ENST00000354582 ENST00000357086 ENST00000443694 ENST00000456211
GeneID	3708
KEGG	hsa:3708
UCSC	uc003bqc.3 uc021wsi.1 uc021wsj.1
CTD	3708
GeneCards	GC03P004486
GeneReviews	ITPR1
HGNC	HGNC:6180
HPA	HPA014765 HPA016487
MIM	117360 147265 606658
neXtProt	NX_Q14643
Orphanet	98769 208513
PharmGKB	PA29978
eggNOG	NOG280601
GeneTree	ENSGT00760000119152
HOGENOM	HOG000007660
HOVERGEN	HBG052158
InParanoid	Q14643
KO	K04958
OMA	RKAFTTF
OrthoDB	EOG76HQ0M
PhylomeDB	Q14643
TreeFam	TF312815
Reactome	REACT_111064 REACT_118700 REACT_15426 REACT_160158 REACT_162 REACT_163834 REACT_172761 REACT_18274 REACT_18325 REACT_2202 REACT_228024 REACT_23767
SignaLink	Q14643
ChiTaRS	ITPR1
GeneWiki	ITPR1
GenomeRNAi	3708
NextBio	14533
PRO	PR:Q14643
Proteomes	UP000005640
Bgee	Q14643
CleanEx	HS_ITPR1
ExpressionAtlas	Q14643
Genevestigator	Q14643
GO	GO:0005955 GO:0005783 GO:0005789 GO:0016021 GO:0016020 GO:0005637 GO:0005730 GO:0031088 GO:0031094 GO:0031095 GO:0014069 GO:0016529 GO:0019855 GO:0015085 GO:0005220 GO:0005218 GO:0035091 GO:0007202 GO:0007596 GO:0006816 GO:0032469 GO:0006112 GO:0007173 GO:0038095 GO:0038096 GO:0008543 GO:0045087 GO:0048016 GO:0070059 GO:0050849 GO:0048011 GO:0030168 GO:0009791 GO:0050796 GO:0051209 GO:0001666 GO:0007165 GO:0044281 GO:0050882
Gene3D	1.25.10.30
InterPro	IPR016024 IPR014821 IPR000493 IPR005821 IPR016093 IPR013662 IPR000699 IPR015925
PANTHER	PTHR13715
Pfam	PF08709 PF00520 PF02815 PF08454 PF01365
PRINTS	PR00779
SMART	SM00472
SUPFAM	SSF100909 SSF48371 SSF82109
PROSITE	PS50919

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0050796	regulation of insulin secretion	PMID:23302634^[1]	ECO:0000269			P		Figure 3(g) shows that insulin secretion induced by glatifloxation and levofloxin were reduced by xestospongin (containing the IP3r)showing that there is some effect on insulin secretion when using this inhibitor	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11881	C		Seeded From UniProt	complete
involved_in	GO:0050849	negative regulation of calcium-mediated signaling	PMID:16793548^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019855	calcium channel inhibitor activity	PMID:16793548^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q14643)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031094	platelet dense tubular network	PMID:10828023^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031088	platelet dense granule membrane	PMID:10828023^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:19120137^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11881	P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11881	P		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11881	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8648241^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:7852357^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:8648241^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11881	F		Seeded From UniProt	complete
enables	GO:0015278	calcium-release channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11881	F		Seeded From UniProt	complete
enables	GO:0070679	inositol 1,4,5 trisphosphate binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001010185 RGD:2934 RGD:69649 UniProtKB:Q14573	F		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010051 MGI:MGI:96623 MGI:MGI:99659 PANTHER:PTN001416417 RGD:1586637 RGD:2933 RGD:69649 UniProtKB:P21817 UniProtKB:Q92736	P		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96623 MGI:MGI:96624 MGI:MGI:99418 PANTHER:PTN001010185	F		Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001010185 RGD:2933 UniProtKB:Q8WN96	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000346459 dictyBase:DDB_G0292564	C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96623 MGI:MGI:99418 PANTHER:PTN001010185 RGD:2933 RGD:69649	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001416417 RGD:2933 RGD:620314 UniProtKB:P21817 UniProtKB:Q14571 UniProtKB:Q14573	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96623 MGI:MGI:96624 PANTHER:PTN001010185 RGD:2933 RGD:2934 RGD:69649 UniProtKB:Q14573	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001416417 RGD:2934 RGD:69649	F		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010051 MGI:MGI:96623 MGI:MGI:96624 MGI:MGI:99418 PANTHER:PTN001010185 RGD:2933 RGD:2934 RGD:69649 UniProtKB:Q14573	F		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
involved_in	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0098695	P		Seeded From UniProt	complete
enables	GO:0098695	inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	F		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	C		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	P		Seeded From UniProt	complete
involved_in	GO:0050882	voluntary musculoskeletal movement	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	P		Seeded From UniProt	complete
involved_in	GO:0042045	epithelial fluid transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	P		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	C		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	P		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	C		Seeded From UniProt	complete
enables	GO:0015278	calcium-release channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	C		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	P		Seeded From UniProt	complete
part_of	GO:0005955	calcineurin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	C		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11881 ensembl:ENSMUSP00000032192	P		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000493	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000493	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000493 InterPro:IPR015925	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699 InterPro:IPR005821 InterPro:IPR016093 InterPro:IPR036300	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699	P		Seeded From UniProt	complete
enables	GO:0070679	inositol 1,4,5 trisphosphate binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000493	F		Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	PMID:22770472^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015085	calcium ion transmembrane transporter activity	PMID:7500840^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	PMID:8648241^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1903779	regulation of cardiac conduction	Reactome:R-HSA-5578775	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	Reactome:R-HSA-422356	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031095	platelet dense tubular network membrane	Reactome:R-HSA-418442 Reactome:R-HSA-139941 Reactome:R-HSA-139854	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	Reactome:R-HSA-76002	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-5226904 Reactome:R-HSA-381644 Reactome:R-HSA-1168376	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0030658	transport vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0245	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bito, M et al. (2013) The mechanisms of insulin secretion and calcium signaling in pancreatic β-cells exposed to fluoroquinolones. Biol. Pharm. Bull. 36 31-5 PubMed GONUTS page
↑ ^2.0 ^2.1 Ando, H et al. (2006) IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor. Mol. Cell 22 795-806 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^4.0 ^4.1 El-Daher, SS et al. (2000) Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes. Blood 95 3412-22 PubMed GONUTS page
↑ Jurkovicova, D et al. (2008) Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line. Ann. N. Y. Acad. Sci. 1148 421-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Yan, J et al. (1996) Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation. Int. J. Radiat. Biol. 69 539-46 PubMed GONUTS page
↑ Harnick, DJ et al. (1995) The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation. J. Biol. Chem. 270 2833-40 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Parys, JB et al. (2012) Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy. Cell Commun. Signal 10 17 PubMed GONUTS page
↑ Nucifora, FC Jr et al. (1995) Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant. Brain Res. Mol. Brain Res. 32 291-6 PubMed GONUTS page

[PMID:23302634-1] Bito, M et al. (2013) The mechanisms of insulin secretion and calcium signaling in pancreatic β-cells exposed to fluoroquinolones. Biol. Pharm. Bull. 36 31-5 PubMed GONUTS page

[PMID:16793548-2] 2.0 ^2.1 Ando, H et al. (2006) IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor. Mol. Cell 22 795-806 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:10828023-4] 4.0 ^4.1 El-Daher, SS et al. (2000) Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes. Blood 95 3412-22 PubMed GONUTS page

[PMID:19120137-5] Jurkovicova, D et al. (2008) Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line. Ann. N. Y. Acad. Sci. 1148 421-7 PubMed GONUTS page

[PMID:8648241-6] 6.0 ^6.1 ^6.2 Yan, J et al. (1996) Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation. Int. J. Radiat. Biol. 69 539-46 PubMed GONUTS page

[PMID:7852357-7] Harnick, DJ et al. (1995) The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation. J. Biol. Chem. 270 2833-40 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22770472-9] Parys, JB et al. (2012) Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy. Cell Commun. Signal 10 17 PubMed GONUTS page

[PMID:7500840-10] Nucifora, FC Jr et al. (1995) Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant. Brain Res. Mol. Brain Res. 32 291-6 PubMed GONUTS page

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