HUMAN:ITF2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TCF4 (synonyms: BHLHB19, ITF2, SEF2)
Protein Name(s)	Transcription factor 4 TCF-4 Class B basic helix-loop-helix protein 19 bHLHb19 Immunoglobulin transcription factor 2 ITF-2 SL3-3 enhancer factor 2 SEF-2
External Links
UniProt	P15884
EMBL	M74718 M74719 M74720 FR748210 FR748211 FR748212 FR748213 FR748214 FR748215 FR748216 FR748217 FR748218 FR748219 FR748220 FR748221 FR748222 FR748223 AK095041 AK096862 AK299169 AK300636 AK300038 AK301144 AK300612 AK316165 AC013587 AC018994 AC090383 AC090684 AC091103 CH471096 CH471096 BC125084 BC125085 AV761952 U75701 X52079
CCDS	CCDS11960.1 CCDS42438.1 CCDS58624.1 CCDS58625.1 CCDS58626.1 CCDS58627.1 CCDS58628.1 CCDS58629.1 CCDS59321.1
PIR	A41311
RefSeq	NP_001077431.1 NP_001230155.2 NP_001230156.1 NP_001230157.1 NP_001230159.1 NP_001230160.1 NP_001230161.1 NP_001230162.1 NP_001230163.1 NP_001230164.1 NP_001230165.1 NP_003190.1 XP_005266800.1 XP_005266801.1 XP_005266803.1 XP_005266807.1 XP_006722599.1 XP_006722600.1 XP_006722603.1
UniGene	Hs.605153 Hs.742885
PDB	2KWF
PDBsum	2KWF
DisProt	DP00224
ProteinModelPortal	P15884
SMR	P15884
BioGrid	112787
DIP	DIP-163N
IntAct	P15884
MINT	MINT-4508073
STRING	9606.ENSP00000346440
PhosphoSite	P15884
MaxQB	P15884
PaxDb	P15884
PRIDE	P15884
Ensembl	ENST00000354452 ENST00000356073 ENST00000457482 ENST00000537578 ENST00000537856 ENST00000540999 ENST00000543082 ENST00000544241 ENST00000561831 ENST00000561992 ENST00000564228 ENST00000564999 ENST00000565018 ENST00000566279 ENST00000566286 ENST00000567880 ENST00000568673 ENST00000570177 ENST00000570287 ENST00000616053
GeneID	6925
KEGG	hsa:6925
UCSC	uc002lfw.4 uc002lfx.2 uc002lfy.2 uc002lfz.2 uc010dph.1 uc021ukh.1 uc021uki.1 uc021ukj.1 uc021ukk.1
CTD	6925
GeneCards	GC18M052889
GeneReviews	TCF4
HGNC	HGNC:11634
HPA	CAB020722 HPA025958
MIM	602272 610954
neXtProt	NX_P15884
Orphanet	178469 98974 2896 171 3140
PharmGKB	PA164742621
eggNOG	NOG282899
GeneTree	ENSGT00510000046438
HOVERGEN	HBG003854
InParanoid	P15884
KO	K15603
OrthoDB	EOG72G16Q
PhylomeDB	P15884
TreeFam	TF321672
Reactome	REACT_21402
SignaLink	P15884
ChiTaRS	TCF4
EvolutionaryTrace	P15884
GeneWiki	TCF4
GenomeRNAi	6925
NextBio	27093
PRO	PR:P15884
Proteomes	UP000005640
Bgee	P15884
CleanEx	HS_TCF4
ExpressionAtlas	P15884
Genevestigator	P15884
GO	GO:0005634 GO:0005667 GO:0003677 GO:0070888 GO:0008022 GO:0046982 GO:0000978 GO:0001077 GO:0001011 GO:0003700 GO:0001087 GO:0001093 GO:0006352 GO:0045666 GO:0045944 GO:0045893 GO:0065004 GO:0006367
Gene3D	4.10.280.10
InterPro	IPR011598
Pfam	PF00010
SMART	SM00353
SUPFAM	SSF47459
PROSITE	PS50888

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR011598	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q61286	F		Seeded From UniProt	complete
part_of	GO:0070369	beta-catenin-TCF7L2 complex	PMID:12651860^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:12651860^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12651860^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21880741^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0000167) coincident_with:(ENSEMBL:ENSG00000168646)	Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:8978694^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60722	F		Seeded From UniProt	complete
involved_in	GO:0065004	protein-DNA complex assembly	PMID:8978694^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60722	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8978694^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60722	P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	PMID:8978694^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60722	P		Seeded From UniProt	complete
involved_in	GO:0006352	DNA-templated transcription, initiation	PMID:8978694^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60722	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:8978694^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60722	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21828274^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11802795^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001093	TFIIB-class transcription factor binding	PMID:8978694^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60722	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:8978694^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60722	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:8978694^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60722	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:8978694^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60722	F		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60722	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:2105528^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60722	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:2105528^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60722	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:10903890^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P50553	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:1681116^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:2105528^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:1681116^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:101877 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 UniProtKB:P15923 UniProtKB:Q70IK3 WB:WBGene00001949	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 RGD:3829 RGD:69271 UniProtKB:P15923 UniProtKB:Q99081 WB:WBGene00001949	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101877 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455	P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000927455 RGD:620914 RGD:69271 UniProtKB:P15923 UniProtKB:Q99081 WB:WBGene00001949	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:98510 PANTHER:PTN000927455 UniProtKB:P15923 WB:WBGene00001949	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:101877 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 RGD:620914 UniProtKB:P15923 UniProtKB:Q70IK3	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 RGD:3829 UniProtKB:P15884 UniProtKB:P15923 UniProtKB:Q99081 WB:WBGene00001949	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267821 MGI:MGI:98510 PANTHER:PTN000927455 UniProtKB:P15884 UniProtKB:P15923 UniProtKB:Q99081	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98506 MGI:MGI:98510 PANTHER:PTN000927455 UniProtKB:P15884 UniProtKB:P15923 UniProtKB:Q99081	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16950124^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25609649^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15884	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10903890^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15884	F		Seeded From UniProt	complete
part_of	GO:1990907	beta-catenin-TCF complex	PMID:11955446^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O00512,UniProtKB:P35222	C		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
	GO:0007399	nervous system development	PMID:28118661^[14]	ECO:0000315			P		Involved in process of transcription, E-box adherence and immunoglobulin adherence.	complete CACAO 12833
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Ghiselli, G et al. (2003) The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway. J. Biol. Chem. 278 20259-67 PubMed GONUTS page
↑ Huang, T et al. (2011) Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation. J. Biol. Chem. 286 37399-405 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Pscherer, A et al. (1996) The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene. EMBO J. 15 6680-90 PubMed GONUTS page
↑ Yoon, SJ et al. (2011) HEB and E2A function as SMAD/FOXH1 cofactors. Genes Dev. 25 1654-61 PubMed GONUTS page
↑ Knöfler, M et al. (2002) Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains. Biochem. J. 361 641-51 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Henthorn, P et al. (1990) Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif. Science 247 467-70 PubMed GONUTS page
↑ ^8.0 ^8.1 Persson, P et al. (2000) HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex. Biochem. Biophys. Res. Commun. 274 22-31 PubMed GONUTS page
↑ ^9.0 ^9.1 Corneliussen, B et al. (1991) Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers. J. Virol. 65 6084-93 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Lei, Q et al. (2006) Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev. Cell 11 325-37 PubMed GONUTS page
↑ Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page
↑ Kramps, T et al. (2002) Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell 109 47-60 PubMed GONUTS page
↑ Wieben, ED et al. (2017) Trinucleotide Repeat Expansion in the Transcription Factor 4 (TCF4) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy. Invest. Ophthalmol. Vis. Sci. 58 343-352 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:12651860-2] 2.0 ^2.1 ^2.2 Ghiselli, G et al. (2003) The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway. J. Biol. Chem. 278 20259-67 PubMed GONUTS page

[PMID:21880741-3] Huang, T et al. (2011) Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation. J. Biol. Chem. 286 37399-405 PubMed GONUTS page

[PMID:8978694-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Pscherer, A et al. (1996) The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene. EMBO J. 15 6680-90 PubMed GONUTS page

[PMID:21828274-5] Yoon, SJ et al. (2011) HEB and E2A function as SMAD/FOXH1 cofactors. Genes Dev. 25 1654-61 PubMed GONUTS page

[PMID:11802795-6] Knöfler, M et al. (2002) Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains. Biochem. J. 361 641-51 PubMed GONUTS page

[PMID:2105528-7] 7.0 ^7.1 ^7.2 Henthorn, P et al. (1990) Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif. Science 247 467-70 PubMed GONUTS page

[PMID:10903890-8] 8.0 ^8.1 Persson, P et al. (2000) HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex. Biochem. Biophys. Res. Commun. 274 22-31 PubMed GONUTS page

[PMID:1681116-9] 9.0 ^9.1 Corneliussen, B et al. (1991) Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers. J. Virol. 65 6084-93 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16950124-11] Lei, Q et al. (2006) Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev. Cell 11 325-37 PubMed GONUTS page

[PMID:25609649-12] Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page

[PMID:11955446-13] Kramps, T et al. (2002) Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell 109 47-60 PubMed GONUTS page

[PMID:28118661-14] Wieben, ED et al. (2017) Trinucleotide Repeat Expansion in the Transcription Factor 4 (TCF4) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy. Invest. Ophthalmol. Vis. Sci. 58 343-352 PubMed GONUTS page

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HUMAN:ITF2

Contents

Annotations

Notes

References

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