HUMAN:INSR

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	INSR
Protein Name(s)	Insulin receptor IR Insulin receptor subunit alpha Insulin receptor subunit beta
External Links
UniProt	P06213
EMBL	M10051 X02160 M32972 M23100 M32823 M32824 M32825 M32826 M32827 M32828 M32829 M32830 M32831 M32832 M32833 M32834 M32835 M32836 M32837 M32838 M32839 M32840 M32841 M32842 AC010311 AC010526 AC010606 AC125387 BC117172 J03466 J05043 M76592 AB208861 M24555 M29929 M29930 M27197 M27195
CCDS	CCDS12176.1 CCDS42487.1
PIR	A37348
RefSeq	NP_000199.2 NP_001073285.1
UniGene	Hs.465744
PDB	1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2HR7 2MFR 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3W11 3W12 3W13 3W14 4IBM 4OGA 4XLV 4XSS 4XST 4ZXB 5E1S 5HHW 5J3H
PDBsum	1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2HR7 2MFR 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3W11 3W12 3W13 3W14 4IBM 4OGA 4XLV 4XSS 4XST 4ZXB 5E1S 5HHW 5J3H
ProteinModelPortal	P06213
SMR	P06213
BioGrid	109854
DIP	DIP-480N
IntAct	P06213
MINT	MINT-1516246
STRING	9606.ENSP00000303830
BindingDB	P06213
ChEMBL	CHEMBL1981
DrugBank	DB01306 DB01307 DB00047 DB01309 DB00046 DB00030 DB01277
GuidetoPHARMACOLOGY	1800
iPTMnet	P06213
PhosphoSitePlus	P06213
BioMuta	INSR
DMDM	308153655
EPD	P06213
MaxQB	P06213
PaxDb	P06213
PeptideAtlas	P06213
PRIDE	P06213
DNASU	3643
Ensembl	ENST00000302850 ENST00000341500
GeneID	3643
KEGG	hsa:3643
UCSC	uc002mgd.2
CTD	3643
DisGeNET	3643
GeneCards	INSR
H-InvDB	HIX0040111
HGNC	HGNC:6091
HPA	HPA036302 HPA036303
MalaCards	INSR
MIM	125853 147670 246200 262190 609968 610549
neXtProt	NX_P06213
OpenTargets	ENSG00000171105
Orphanet	263458 2297 508 769
PharmGKB	PA202
eggNOG	KOG4258 COG0515
GeneTree	ENSGT00760000118818
HOGENOM	HOG000038045
HOVERGEN	HBG006134
InParanoid	P06213
KO	K04527
OMA	GAAGHLY
OrthoDB	EOG0903025L
PhylomeDB	P06213
TreeFam	TF351636
BRENDA	2.7.10.1
Reactome	[www.reactome.org/content/detail/R-HSA-6811558 R-HSA-6811558] [www.reactome.org/content/detail/R-HSA-74713 R-HSA-74713] [www.reactome.org/content/detail/R-HSA-74749 R-HSA-74749] [www.reactome.org/content/detail/R-HSA-74751 R-HSA-74751] [www.reactome.org/content/detail/R-HSA-74752 R-HSA-74752] [www.reactome.org/content/detail/R-HSA-77387 R-HSA-77387]
SABIO-RK	P06213
SignaLink	P06213
SIGNOR	P06213
ChiTaRS	INSR
EvolutionaryTrace	P06213
GeneWiki	Insulin_receptor
GenomeRNAi	3643
PRO	PR:P06213
Proteomes	UP000005640
Bgee	ENSG00000171105
CleanEx	HS_INSR
ExpressionAtlas	P06213
Genevisible	P06213
GO	GO:0005901 GO:0010008 GO:0070062 GO:0005899 GO:0005887 GO:0043231 GO:0016020 GO:0005886 GO:0043235 GO:0005524 GO:0005525 GO:0043559 GO:0043560 GO:0005009 GO:0031994 GO:0031995 GO:0005159 GO:0043548 GO:0004713 GO:0051425 GO:0004716 GO:0000187 GO:0032147 GO:0032148 GO:0030325 GO:0005975 GO:0071363 GO:0032869 GO:0008544 GO:0031017 GO:0007186 GO:0042593 GO:0003007 GO:0008286 GO:0008584 GO:0030238 GO:0038083 GO:0018108 GO:0030335 GO:0008284 GO:0048639 GO:0045740 GO:0046326 GO:0045725 GO:0045821 GO:0043410 GO:0051446 GO:0045840 GO:0045429 GO:0051897 GO:0001934 GO:0060267 GO:0045893 GO:0046777 GO:0051290 GO:0045995 GO:2000194 GO:0006355 GO:0019087
CDD	cd00063
Gene3D	2.60.40.10 3.80.20.20
InterPro	IPR003961 IPR006211 IPR006212 IPR009030 IPR013783 IPR011009 IPR032675 IPR000719 IPR017441 IPR000494 IPR001245 IPR008266 IPR020635 IPR016246 IPR002011
Pfam	PF00757 PF07714 PF01030
PIRSF	PIRSF000620
PRINTS	PR00109
SMART	SM00060 SM00261 SM00219
SUPFAM	SSF49265 SSF52058 SSF56112 SSF57184
PROSITE	PS50853 PS00107 PS50011 PS00109 PS00239

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0038024	cargo receptor activity	PMID:19406747^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15127	F	has_target_end_location:(CL:0002609) part_of:(GO:0097242) has_target_start_location:(GO:0005576) has_input:(ComplexPortal:CPX-1134)\|has_target_end_location(CL:0002608) part_of:(GO:0097242) has_target_start_location:(GO:0005576) has_input:(ComplexPortal:CPX-1134)\|has_target_end_location(CL:0000127) part_of:(GO:0097242) has_target_start_location:(GO:0005576) has_input:(ComplexPortal:CPX-1134)	Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	PMID:19406747^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15127	P	has_target_end_location:(CL:0002609) part_of:(GO:0097242) has_target_start_location:(GO:0005576) has_input:(ComplexPortal:CPX-1134)\|has_target_end_location(CL:0002608) part_of:(GO:0097242) has_target_start_location:(GO:0005576) has_input:(ComplexPortal:CPX-1134)\|has_target_end_location(CL:0000127) part_of:(GO:0097242) has_target_start_location:(GO:0005576) has_input:(ComplexPortal:CPX-1134)	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:16246733^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14449	F		Seeded From UniProt	complete
colocalizes_with	GO:0005635	nuclear envelope	PMID:19406747^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	adjacent_to:(GO:0106003) exists_during:(GO:0008286) adjacent_to:(GO:0005899)	Seeded From UniProt	complete
colocalizes_with	GO:0031981	nuclear lumen	PMID:19406747^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	adjacent_to:(GO:0106003) exists_during:(GO:0008286) adjacent_to:(GO:0005899)	Seeded From UniProt	complete
part_of	GO:0032809	neuronal cell body membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15127	C	part_of:(CL:0002608) exists_during:(GO:1904646)	Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15127	C	part_of:(CL:0002608) part_of:(GO:0009897)	Seeded From UniProt	complete
involved_in	GO:1990535	neuron projection maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15127	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15127	C	part_of:(CL:0002608) part_of:(GO:0032590)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:19406747^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F	part_of:(GO:0008286)	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:19406747^[1]	ECO:0000353	physical interaction evidence used in manual assertion	ComplexPortal:CPX-1134	F	part_of:(GO:0008286)	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:20455999^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0008286)	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:20455999^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:0060267	positive regulation of respiratory burst	PMID:9092559^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:11500939^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048639	positive regulation of developmental growth	PMID:7693131^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:8496180^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:6849137^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	PMID:3518947^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	PMID:11001060^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045995	regulation of embryonic development	PMID:7693131^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	PMID:11500939^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045821	positive regulation of glycolytic process	PMID:7693131^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:12138094^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	PMID:17925406^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:10747347^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	PMID:7493946^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35568	F		Seeded From UniProt	complete
enables	GO:0043559	insulin binding	PMID:8452530^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01308	F		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:11500939^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:7693131^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:8440175^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	PMID:7556070^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:9819385^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031995	insulin-like growth factor II binding	PMID:12138094^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01344	F		Seeded From UniProt	complete
enables	GO:0031994	insulin-like growth factor I binding	PMID:8452530^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05019	F		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:12138094^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019087	transformation of host cell by virus	PMID:17001305^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:8496180^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8452530^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:6849137^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:17925406^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:11500939^[6]	ECO:0000305	curator inference used in manual assertion	GO:0045840	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:9092559^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:12881524^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:15182363^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005899	insulin receptor complex	PMID:15069075^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9092559^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:6849137^[9]	ECO:0000305	curator inference used in manual assertion	GO:0005009	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:9092559^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:6849137^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	PMID:8452530^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005009	insulin-activated receptor activity	PMID:6849137^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:8496180^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	PMID:7693131^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:7556070^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:17001305^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097242	amyloid-beta clearance	PMID:19406747^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15127	P	has_target_end_location:(CL:0002609) has_target_start_location:(GO:0005576) has_input:(ComplexPortal:CPX-1134)\|has_target_end_location(CL:0002608) has_target_start_location:(GO:0005576) has_input:(ComplexPortal:CPX-1134)\|has_target_end_location(CL:0000127) has_target_start_location:(GO:0005576) has_input:(ComplexPortal:CPX-1134)	Seeded From UniProt	complete
involved_in	GO:0097062	dendritic spine maintenance	PMID:19406747^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15127	P	part_of:(GO:0008286) occurs_in:(CL:0002608) part_of:(GO:1904646)	Seeded From UniProt	complete
involved_in	GO:0043243	positive regulation of protein complex disassembly	PMID:19406747^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15127	P	occurs_in:(CL:0002609) part_of:(GO:0008286) regulates_o_occurs_in:(GO:0005576) has_input:(ComplexPortal:CPX-1134) has_output:(UniProtKB:P05067:PRO_0000000092)	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:19406747^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15127	P	occurs_in:(CL:0002609)\|occurs_in:(CL:0002608)	Seeded From UniProt	complete
enables	GO:0051425	PTB domain binding	PMID:7559478^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P29353	F		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	PMID:1898103^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:7537849^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	PMID:7537849^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35568	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	PMID:7559478^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35568	F		Seeded From UniProt	complete
enables	GO:0043559	insulin binding	PMID:8440175^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	PMID:8276809^[27]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	PMID:7537849^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:8440175^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005009	insulin-activated receptor activity	PMID:8440175^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:7537849^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96433 PANTHER:PTN000699611 UniProtKB:P06213	P		Seeded From UniProt	complete
involved_in	GO:0048856	anatomical structure development	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346037 MGI:MGI:96433 MGI:MGI:96575 PANTHER:PTN002521379 RGD:2869 RGD:2917 UniProtKB:P06213 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-020503-3 ZFIN:ZDB-GENE-020503-4	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 RGD:2869 RGD:2917 UniProtKB:P06213 UniProtKB:P08069	F		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96433 PANTHER:PTN000699611 UniProtKB:P06213	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283499 MGI:MGI:96433 PANTHER:PTN000699611 RGD:2869 RGD:2917 UniProtKB:P06213	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 RGD:2869 WB:WBGene00000898	C		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283499 PANTHER:PTN000699611 RGD:2869	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005899	insulin receptor complex	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 UniProtKB:P06213	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005009	insulin-activated receptor activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 RGD:2917 UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000194	regulation of female gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
involved_in	GO:0051446	positive regulation of meiotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
involved_in	GO:0031017	exocrine pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
involved_in	GO:0030325	adrenal gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
involved_in	GO:0030238	male sex determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	C		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
involved_in	GO:0008544	epidermis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15208 ensembl:ENSMUSP00000088837	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR016246	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR016246 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR016246	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR006211	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	C		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	P		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26853939^[30]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06213-1	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18278056^[31]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06213-1	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16957736^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06213-1	F		Seeded From UniProt	complete
colocalizes_with	GO:0044297	cell body	PMID:19406747^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15127:PRO_0000016696	C	part_of:(CL:0000127) exists_during:(GO:0097242) exists_during:(GO:0008286)	Seeded From UniProt	complete
colocalizes_with	GO:0043025	neuronal cell body	PMID:19406747^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15127:PRO_0000016696	C	part_of:(CL:0002608)	Seeded From UniProt	complete
colocalizes_with	GO:0030425	dendrite	PMID:19406747^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15127:PRO_0000016696	C	part_of:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:19188609^[33]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:19188609^[33]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	PMID:19188609^[33]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	Reactome:R-HSA-74734 Reactome:R-HSA-74733 Reactome:R-HSA-74726 Reactome:R-HSA-74718	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	Reactome:R-HSA-74752	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-74743 Reactome:R-HSA-74742 Reactome:R-HSA-74740 Reactome:R-HSA-74734 Reactome:R-HSA-74718 Reactome:R-HSA-74716 Reactome:R-HSA-74715 Reactome:R-HSA-74712 Reactome:R-HSA-74711 Reactome:R-HSA-74707 Reactome:R-HSA-110011	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
	GO:0002092	positive regulation of receptor internalization	PMID:25401701^[34]	ECO:0000314			P		Figure 1B, 1C: Cells coexpressing human insulin receptor and beta-2-adrenergic receptor show increased internalization of beta-2-adrenergic receptor as compared to cells expressing only beta-2-adrenergic receptor	complete CACAO 12292
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Zhao, WQ et al. (2009) Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}. J. Biol. Chem. 284 18742-53 PubMed GONUTS page
↑ Depetris, RS et al. (2005) Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Mol. Cell 20 325-33 PubMed GONUTS page
↑ ^3.0 ^3.1 Kwon, H et al. (2011) A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2. J. Cell. Mol. Med. 15 888-908 PubMed GONUTS page
↑ ^4.0 ^4.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Krieger-Brauer, HI et al. (1997) Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2. J. Biol. Chem. 272 10135-43 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Scalia, P et al. (2001) Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A. J. Cell. Biochem. 82 610-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Wertheimer, E et al. (1993) Homozygous deletion of the human insulin receptor gene results in leprechaunism. Nat. Genet. 5 71-3 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Feener, EP et al. (1993) Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor. J. Biol. Chem. 268 11256-64 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Roth, RA & Cassell, DJ (1983) Insulin receptor: evidence that it is a protein kinase. Science 219 299-301 PubMed GONUTS page
↑ Ellis, L et al. (1986) Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Cell 45 721-32 PubMed GONUTS page
↑ Baumann, CA et al. (2000) CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature 407 202-7 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Pandini, G et al. (2002) Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J. Biol. Chem. 277 39684-95 PubMed GONUTS page
↑ ^13.0 ^13.1 Jensen, M et al. (2007) Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. J. Biol. Chem. 282 35179-86 PubMed GONUTS page
↑ Zeng, G et al. (2000) Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation 101 1539-45 PubMed GONUTS page
↑ Kharitonenkov, A et al. (1995) Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction. J. Biol. Chem. 270 29189-93 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Soos, MA et al. (1993) Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem. J. 290 ( Pt 2) 419-26 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Yamaguchi, Y et al. (1993) Ligand-binding properties of the two isoforms of the human insulin receptor. Endocrinology 132 1132-8 PubMed GONUTS page
↑ ^18.0 ^18.1 Kohn, AD et al. (1995) Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase. EMBO J. 14 4288-95 PubMed GONUTS page
↑ Kotani, K et al. (1998) Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes. Mol. Cell. Biol. 18 6971-82 PubMed GONUTS page
↑ ^20.0 ^20.1 Rose, PP et al. (2007) The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma. Oncogene 26 1995-2005 PubMed GONUTS page
↑ Pandini, G et al. (2003) Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A. J. Biol. Chem. 278 42178-89 PubMed GONUTS page
↑ Karlsson, M et al. (2004) Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control. Eur. J. Biochem. 271 2471-9 PubMed GONUTS page
↑ Moeschel, K et al. (2004) Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. J. Biol. Chem. 279 25157-63 PubMed GONUTS page
↑ ^24.0 ^24.1 He, W et al. (1995) Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains. J. Biol. Chem. 270 23258-62 PubMed GONUTS page
↑ Schenker, E & Kohanski, RA (1991) The native alpha 2 beta 2 tetramer is the only subunit structure of the insulin receptor in intact cells and purified receptor preparations. Arch. Biochem. Biophys. 290 79-85 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 Gustafson, TA et al. (1995) Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell. Biol. 15 2500-8 PubMed GONUTS page
↑ Van Horn, DJ et al. (1994) Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor. J. Biol. Chem. 269 29-32 PubMed GONUTS page
↑ ^28.00 ^28.01 ^28.02 ^28.03 ^28.04 ^28.05 ^28.06 ^28.07 ^28.08 ^28.09 ^28.10 ^28.11 ^28.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ Croll, TI et al. (2016) Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain. Structure 24 469-76 PubMed GONUTS page
↑ Wu, J et al. (2008) Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat. Struct. Mol. Biol. 15 251-8 PubMed GONUTS page
↑ McKern, NM et al. (2006) Structure of the insulin receptor ectodomain reveals a folded-over conformation. Nature 443 218-21 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 De Felice, FG et al. (2009) Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc. Natl. Acad. Sci. U.S.A. 106 1971-6 PubMed GONUTS page
↑ Mandić, M et al. (2014) Demonstration of a direct interaction between β2-adrenergic receptor and insulin receptor by BRET and bioinformatics. PLoS ONE 9 e112664 PubMed GONUTS page

[PMID:19406747-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Zhao, WQ et al. (2009) Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}. J. Biol. Chem. 284 18742-53 PubMed GONUTS page

[PMID:16246733-2] Depetris, RS et al. (2005) Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Mol. Cell 20 325-33 PubMed GONUTS page

[PMID:20455999-3] 3.0 ^3.1 Kwon, H et al. (2011) A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2. J. Cell. Mol. Med. 15 888-908 PubMed GONUTS page

[PMID:20458337-4] 4.0 ^4.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:9092559-5] 5.0 ^5.1 ^5.2 ^5.3 Krieger-Brauer, HI et al. (1997) Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2. J. Biol. Chem. 272 10135-43 PubMed GONUTS page

[PMID:11500939-6] 6.0 ^6.1 ^6.2 ^6.3 Scalia, P et al. (2001) Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A. J. Cell. Biochem. 82 610-8 PubMed GONUTS page

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