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PMID:6849137

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Citation

Roth, RA and Cassell, DJ (1983) Insulin receptor: evidence that it is a protein kinase. Science 219:299-301

Abstract

Highly purified preparations of insulin receptor catalyzed the phosphorylation of the 95,000-dalton subunit of the insulin receptor. This subunit of the insulin receptor was also labeled with [alpha-32P]8-azidoadenosine 5'-triphosphate, a photoaffinity label for adenosine triphosphate binding sites. The identity of the 95,000-dalton band was confirmed in both cases by precipitation with a monoclonal antibody to the insulin receptor. These results suggest that the insulin receptor is itself a protein kinase.

Links

PubMed

Keywords

Adenosine Triphosphate/metabolism; Cell Line; Cells, Cultured; Lymphocytes; Molecular Weight; Phosphoproteins/physiology; Protein Kinases/physiology; Receptor, Insulin/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:INSR

located_in

GO:0005886: plasma membrane

ECO:0000305: curator inference used in manual assertion

GO:0005009

C

Seeded From UniProt

complete

XENLA:INSR

enables

GO:0004714: transmembrane receptor protein tyrosine kinase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:INSR

involved_in

GO:0046777: protein autophosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:INSR

enables

GO:0005524: ATP binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:INSR

part_of

GO:0005886: plasma membrane

ECO:0000305: curator inference used in manual assertion

GO:0005009

C

Seeded From UniProt

complete

HUMAN:INSR

enables

GO:0005009: insulin-activated receptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:INSR

involved_in

GO:0008286: insulin receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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