HUMAN:IKBA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NFKBIA (synonyms: IKBA, MAD3, NFKBI)
Protein Name(s)	NF-kappa-B inhibitor alpha I-kappa-B-alpha IkB-alpha IkappaBalpha Major histocompatibility complex enhancer-binding protein MAD3
External Links
UniProt	P25963
EMBL	M69043 AJ249294 AJ249295 AJ249283 AJ249284 AJ249285 AJ249286 AY033600 BT007091 AY496422 AK313421 AL133163 CH471078 BC002601 BC004983
CCDS	CCDS9656.1
PIR	A39935
RefSeq	NP_065390.1
UniGene	Hs.81328
PDB	1IKN 1NFI
PDBsum	1IKN 1NFI
DisProt	DP00468
ProteinModelPortal	P25963
SMR	P25963
BioGrid	110859
DIP	DIP-139N
IntAct	P25963
MINT	MINT-120458
STRING	9606.ENSP00000216797
BindingDB	P25963
ChEMBL	CHEMBL2898
DrugBank	DB00945
PhosphoSite	P25963
DMDM	126682
MaxQB	P25963
PaxDb	P25963
PeptideAtlas	P25963
PRIDE	P25963
DNASU	4792
Ensembl	ENST00000216797
GeneID	4792
KEGG	hsa:4792
UCSC	uc001wtf.4
CTD	4792
GeneCards	GC14M035870
HGNC	HGNC:7797
HPA	CAB003815 HPA029207
MIM	164008 612132
neXtProt	NX_P25963
Orphanet	251579 251576 98813
PharmGKB	PA31601
eggNOG	COG0666
GeneTree	ENSGT00550000074527
HOGENOM	HOG000059576
HOVERGEN	HBG018875
InParanoid	P25963
KO	K04734
OMA	HNCLHLA
OrthoDB	EOG7W154S
PhylomeDB	P25963
TreeFam	TF320166
Reactome	REACT_118563 REACT_118656 REACT_12555 REACT_13696 REACT_163994 REACT_21281 REACT_24969
SABIO-RK	P25963
SignaLink	P25963
ChiTaRS	NFKBIA
EvolutionaryTrace	P25963
GeneWiki	I%CE%BAB%CE%B1
GenomeRNAi	4792
NextBio	18466
PMAP-CutDB	P25963
PRO	PR:P25963
Proteomes	UP000005640
Bgee	P25963
CleanEx	HS_NFKBIA
ExpressionAtlas	P25963
Genevestigator	P25963
GO	GO:0005737 GO:0005829 GO:0033256 GO:0005634 GO:0005886 GO:0019899 GO:0042802 GO:0051059 GO:0008139 GO:0008134 GO:0031625 GO:0006915 GO:0070417 GO:0007253 GO:0042994 GO:0038095 GO:0045087 GO:0031663 GO:0002755 GO:0002756 GO:0043066 GO:0043392 GO:0010888 GO:0010745 GO:0045638 GO:0032088 GO:0045746 GO:0048011 GO:0070427 GO:0070431 GO:0032270 GO:0010875 GO:0051092 GO:0045944 GO:0032481 GO:0000060 GO:0042127 GO:0042345 GO:0043330 GO:0032495 GO:0050852 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0035666 GO:0016032
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683
Pfam	PF00023
PRINTS	PR01415
SMART	SM00248
SUPFAM	SSF48403
PROSITE	PS50297 PS50088

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:25038658^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	PMID:25038658^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:25038658^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070417	cellular response to cold	PMID:16750872^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16938301^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	PMID:16938301^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010888	negative regulation of lipid storage	PMID:16938301^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	PMID:16938301^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010745	negative regulation of macrophage derived foam cell differentiation	PMID:16938301^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007253	cytoplasmic sequestering of NF-kappaB	PMID:16938301^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	PMID:7739562^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04206	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19245366^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	PMID:3140380^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042994	cytoplasmic sequestering of transcription factor	PMID:1493333^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901222	regulation of NIK/NF-kappaB signaling	PMID:3140380^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:9859996^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y297	F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:16648481^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
enables	GO:0008139	nuclear localization sequence binding	PMID:1493333^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04206	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:3140380^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16648481^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7679069^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	PMID:11931770^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:11931770^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16951195^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P25963	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0045746	negative regulation of Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0045638	negative regulation of myeloid cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0043330	response to exogenous dsRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0035994	response to muscle stretch	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0034142	toll-like receptor 4 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0032495	response to muramyl dipeptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1E3 ensembl:ENSMUSP00000021413	C	Seeded From UniProt	complete
involved_in	GO:0042994	cytoplasmic sequestering of transcription factor	PMID:9865694^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:10928981^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10747850^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0033256	I-kappaB/NF-kappaB complex	PMID:16938301^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	Reactome:R-HSA-9020702	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	Reactome:R-HSA-193639	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-6781897 Reactome:R-HSA-5607728 Reactome:R-HSA-5607724 Reactome:R-HSA-5228811 Reactome:R-HSA-209536 Reactome:R-HSA-209125 Reactome:R-HSA-209087 Reactome:R-HSA-209063 Reactome:R-HSA-209061 Reactome:R-HSA-202541 Reactome:R-HSA-193705 Reactome:R-HSA-168140 Reactome:R-HSA-1168643 Reactome:R-HSA-1168642 Reactome:R-HSA-1168640 Reactome:R-HSA-1168638	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-4656914	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Malinowski, J et al. (2014) Identification of a NFκB inhibitory peptide from tryptic β-casein hydrolysate. Food Chem 165 129-33 PubMed GONUTS page
↑ Yenari, MA & Han, HS (2006) Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB). Neurochem. Int. 49 164-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Ferreira, V et al. (2007) Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation. Atherosclerosis 192 283-90 PubMed GONUTS page
↑ Brockman, JA et al. (1995) Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation. Mol. Cell. Biol. 15 2809-18 PubMed GONUTS page
↑ Webb, JD et al. (2009) MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH). Biochem. J. 420 327-33 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Baeuerle, PA & Baltimore, D (1988) I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 242 540-6 PubMed GONUTS page
↑ ^7.0 ^7.1 Ganchi, PA et al. (1992) I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding. Mol. Biol. Cell 3 1339-52 PubMed GONUTS page
↑ Yaron, A et al. (1998) Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature 396 590-4 PubMed GONUTS page
↑ ^9.0 ^9.1 Ganesh, L et al. (2006) Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis. Mol. Cell. Biol. 26 3864-74 PubMed GONUTS page
↑ Zabel, U et al. (1993) Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus. EMBO J. 12 201-11 PubMed GONUTS page
↑ ^11.0 ^11.1 Fiorini, E et al. (2002) Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor. Mol. Cell 9 637-48 PubMed GONUTS page
↑ Mann, AP et al. (2006) Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway. Cancer Res. 66 8788-95 PubMed GONUTS page
↑ Huxford, T et al. (1998) The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell 95 759-70 PubMed GONUTS page
↑ Schulte, R et al. (2000) Yersinia enterocolitica invasin protein triggers IL-8 production in epithelial cells via activation of Rel p65-p65 homodimers. FASEB J. 14 1471-84 PubMed GONUTS page
↑ Anto, RJ et al. (2000) L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis. J. Biol. Chem. 275 15601-4 PubMed GONUTS page

[PMID:25038658-1] 1.0 ^1.1 ^1.2 Malinowski, J et al. (2014) Identification of a NFκB inhibitory peptide from tryptic β-casein hydrolysate. Food Chem 165 129-33 PubMed GONUTS page

[PMID:16750872-2] Yenari, MA & Han, HS (2006) Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB). Neurochem. Int. 49 164-9 PubMed GONUTS page

[PMID:16938301-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Ferreira, V et al. (2007) Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation. Atherosclerosis 192 283-90 PubMed GONUTS page

[PMID:7739562-4] Brockman, JA et al. (1995) Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation. Mol. Cell. Biol. 15 2809-18 PubMed GONUTS page

[PMID:19245366-5] Webb, JD et al. (2009) MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH). Biochem. J. 420 327-33 PubMed GONUTS page

[PMID:3140380-6] 6.0 ^6.1 ^6.2 Baeuerle, PA & Baltimore, D (1988) I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 242 540-6 PubMed GONUTS page

[PMID:1493333-7] 7.0 ^7.1 Ganchi, PA et al. (1992) I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding. Mol. Biol. Cell 3 1339-52 PubMed GONUTS page

[PMID:9859996-8] Yaron, A et al. (1998) Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature 396 590-4 PubMed GONUTS page

[PMID:16648481-9] 9.0 ^9.1 Ganesh, L et al. (2006) Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis. Mol. Cell. Biol. 26 3864-74 PubMed GONUTS page

[PMID:7679069-10] Zabel, U et al. (1993) Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus. EMBO J. 12 201-11 PubMed GONUTS page

[PMID:11931770-11] 11.0 ^11.1 Fiorini, E et al. (2002) Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor. Mol. Cell 9 637-48 PubMed GONUTS page

[PMID:16951195-12] Mann, AP et al. (2006) Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway. Cancer Res. 66 8788-95 PubMed GONUTS page

[PMID:9865694-13] Huxford, T et al. (1998) The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell 95 759-70 PubMed GONUTS page

[PMID:10928981-14] Schulte, R et al. (2000) Yersinia enterocolitica invasin protein triggers IL-8 production in epithelial cells via activation of Rel p65-p65 homodimers. FASEB J. 14 1471-84 PubMed GONUTS page

[PMID:10747850-15] Anto, RJ et al. (2000) L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis. J. Biol. Chem. 275 15601-4 PubMed GONUTS page

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HUMAN:IKBA

Contents

Annotations

Notes

References

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