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HUMAN:IFM3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IFITM3
Protein Name(s) Interferon-induced transmembrane protein 3

Dispanin subfamily A member 2b DSPA2b Interferon-inducible protein 1-8U

External Links
UniProt Q01628
EMBL X57352
JQ610571
JQ610572
JQ610573
JQ610574
JQ610575
JQ610576
JQ610577
JQ610578
JQ610579
JQ610580
JQ610581
JQ610582
JQ610583
JQ610585
JQ610586
JQ610587
JQ610588
JQ610589
JQ610590
JQ610591
JQ610592
JQ610593
JQ610594
JQ610595
JQ610596
JQ610597
JQ610598
JQ610599
JQ610600
JQ610601
JQ610602
JQ610603
JQ610604
JQ610605
JQ610606
JQ610607
JQ610608
JQ610609
JQ610610
JQ610611
JQ610613
JQ610614
JQ610615
JQ610616
JQ610617
JQ610618
JQ610620
JQ610621
BT006892
AK292173
AC136475
CH891444
BC006794
BC008417
BC022439
BC070243
CCDS CCDS41585.1
PIR S17182
RefSeq NP_066362.2
UniGene Hs.374650
ProteinModelPortal Q01628
BioGrid 115681
IntAct Q01628
MINT MINT-2805186
STRING 9606.ENSP00000382707
PhosphoSite Q01628
DMDM 20178301
MaxQB Q01628
PaxDb Q01628
PRIDE Q01628
DNASU 10410
Ensembl ENST00000399808
GeneID 10410
KEGG hsa:10410
UCSC uc001lpa.2
CTD 10410
GeneCards GC11M000319
HGNC HGNC:5414
HPA HPA004337
MIM 605579
614680
neXtProt NX_Q01628
PharmGKB PA29655
eggNOG NOG26698
GeneTree ENSGT00390000003476
HOGENOM HOG000115781
HOVERGEN HBG001182
InParanoid Q01628
KO K06566
OMA VLIFQAY
OrthoDB EOG7288T5
PhylomeDB Q01628
TreeFam TF334894
Reactome REACT_25162
GeneWiki IFITM3
GenomeRNAi 10410
NextBio 39457
PRO PR:Q01628
Proteomes UP000005640
Bgee Q01628
CleanEx HS_IFITM3
ExpressionAtlas Q01628
Genevestigator Q01628
GO GO:0070062
GO:0016021
GO:0031902
GO:0005765
GO:0005886
GO:0019221
GO:0051607
GO:0006955
GO:0046597
GO:0045071
GO:0032897
GO:0035455
GO:0035456
GO:0034341
GO:0009615
GO:0060337
InterPro IPR007593
Pfam PF04505

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0046597

negative regulation of viral entry into host cell

PMID:23358889[1]

ECO:0000315

P

Figues 1, particularly B, and 3 indicate that IFITM3 protein acts as a defense mechanism against viral membrane fusion.

complete
CACAO 6534

involved_in

GO:0051607

defense response to virus

PMID:21478870[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:21478870[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046597

negative regulation of viral entry into host cell

PMID:23358889[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000054

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046597

negative regulation of viral entry into host cell

PMID:21253575[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046597

negative regulation of viral entry into host cell

PMID:20943977[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:21253575[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:20943977[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035456

response to interferon-beta

PMID:21253575[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035455

response to interferon-alpha

PMID:22479637[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034341

response to interferon-gamma

PMID:21253575[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032897

negative regulation of viral transcription

PMID:20943977[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:21253575[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:20943977[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:22479637[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:20943977[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913391
PANTHER:PTN000360680

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913391
MGI:MGI:1915963
MGI:MGI:1933382
PANTHER:PTN000360680
UniProtKB:Q01628

P

Seeded From UniProt

complete

involved_in

GO:0046597

negative regulation of viral entry into host cell

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913391
MGI:MGI:1915963
MGI:MGI:1933382
PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

involved_in

GO:0035456

response to interferon-beta

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

involved_in

GO:0035455

response to interferon-alpha

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

involved_in

GO:0034341

response to interferon-gamma

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913391
MGI:MGI:1934923
PANTHER:PTN000360661
RGD:1307900
UniProtKB:Q01628

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:28246125[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007593

C

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:1906403[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

Reactome:R-HSA-909733

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-1015702

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0458

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0031902

late endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0151

C

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0157

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Li, K et al. (2013) IFITM proteins restrict viral membrane hemifusion. PLoS Pathog. 9 e1003124 PubMed GONUTS page
  2. ↑ 2.0 2.1 Schoggins, JW et al. (2011) A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 472 481-5 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Huang, IC et al. (2011) Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 7 e1001258 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Weidner, JM et al. (2010) Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. J. Virol. 84 12646-57 PubMed GONUTS page
  5. ↑ 5.0 5.1 Chan, YK et al. (2012) IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS ONE 7 e34508 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Fu, B et al. (2017) ZMPSTE24 defends against influenza and other pathogenic viruses. J. Exp. Med. 214 919-929 PubMed GONUTS page
  8. ↑ Lewin, AR et al. (1991) Molecular analysis of a human interferon-inducible gene family. Eur. J. Biochem. 199 417-23 PubMed GONUTS page
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