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HUMAN:IFM2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IFITM2
Protein Name(s) Interferon-induced transmembrane protein 2

Dispanin subfamily A member 2c DSPA2c Interferon-inducible protein 1-8D

External Links
UniProt Q01629
EMBL X57351
CR541874
AC136475
BC009696
CCDS CCDS41583.1
PIR S17183
RefSeq NP_006426.2
UniGene Hs.709321
ProteinModelPortal Q01629
BioGrid 115832
IntAct Q01629
MINT MINT-1432250
STRING 9606.ENSP00000382714
PhosphoSite Q01629
DMDM 290457648
MaxQB Q01629
PaxDb Q01629
PRIDE Q01629
DNASU 10581
Ensembl ENST00000399817
ENST00000616316
GeneID 10581
KEGG hsa:10581
UCSC uc001lox.4
CTD 10581
GeneCards GC11P000300
HGNC HGNC:5413
HPA HPA004337
MIM 605578
neXtProt NX_Q01629
PharmGKB PA29654
eggNOG NOG26698
GeneTree ENSGT00390000003476
HOGENOM HOG000115781
HOVERGEN HBG001182
InParanoid Q01629
KO K06566
OMA RTPHSGF
PhylomeDB Q01629
TreeFam TF334894
Reactome REACT_25162
ChiTaRS IFITM2
GenomeRNAi 10581
NextBio 40181
PRO PR:Q01629
Proteomes UP000005640
Bgee Q01629
CleanEx HS_IFITM2
ExpressionAtlas Q01629
Genevestigator Q01629
GO GO:0016021
GO:0005886
GO:0019221
GO:0051607
GO:0006955
GO:0046597
GO:0045071
GO:0035455
GO:0035456
GO:0034341
GO:0009615
GO:0060337
InterPro IPR007593
Pfam PF04505

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0046597

negative regulation of viral entry into host cell

PMID:23358889[1]

ECO:0000314

P

Figues 1, particularly B, and 3 indicate that IFITM2 protein acts as a defense mechanism against viral membrane fusion.

complete
CACAO 6532

involved_in

GO:0046597

negative regulation of viral entry into host cell

PMID:23358889[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046597

negative regulation of viral entry into host cell

PMID:21253575[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:21253575[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035456

response to interferon-beta

PMID:21253575[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035455

response to interferon-alpha

PMID:22479637[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034341

response to interferon-gamma

PMID:21253575[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:21253575[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:20943977[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:22479637[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913391
PANTHER:PTN000360680

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913391
MGI:MGI:1915963
MGI:MGI:1933382
PANTHER:PTN000360680
UniProtKB:Q01628

P

Seeded From UniProt

complete

involved_in

GO:0046597

negative regulation of viral entry into host cell

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913391
MGI:MGI:1915963
MGI:MGI:1933382
PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

involved_in

GO:0035456

response to interferon-beta

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

involved_in

GO:0035455

response to interferon-alpha

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

involved_in

GO:0034341

response to interferon-gamma

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913391
MGI:MGI:1934923
PANTHER:PTN000360661
RGD:1307900
UniProtKB:Q01628

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:28246125[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007593

C

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:1906403[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

Reactome:R-HSA-909733

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-1015702

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Li, K et al. (2013) IFITM proteins restrict viral membrane hemifusion. PLoS Pathog. 9 e1003124 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Huang, IC et al. (2011) Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 7 e1001258 PubMed GONUTS page
  3. ↑ 3.0 3.1 Chan, YK et al. (2012) IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS ONE 7 e34508 PubMed GONUTS page
  4. ↑ Weidner, JM et al. (2010) Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. J. Virol. 84 12646-57 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Fu, B et al. (2017) ZMPSTE24 defends against influenza and other pathogenic viruses. J. Exp. Med. 214 919-929 PubMed GONUTS page
  7. ↑ Lewin, AR et al. (1991) Molecular analysis of a human interferon-inducible gene family. Eur. J. Biochem. 199 417-23 PubMed GONUTS page
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