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HUMAN:IF5
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | EIF5 | |
| Protein Name(s) | Eukaryotic translation initiation factor 5
eIF-5 | |
| External Links | ||
| UniProt | P55010 | |
| EMBL | U49436 AL080102 AK026933 BX537367 CH471061 BC007728 BC032866 | |
| CCDS | CCDS9980.1 | |
| PIR | T12450 | |
| RefSeq | NP_001960.2 NP_892116.2 | |
| UniGene | Hs.433702 Hs.741278 | |
| PDB | 2E9H 2G2K 2IU1 | |
| PDBsum | 2E9H 2G2K 2IU1 | |
| ProteinModelPortal | P55010 | |
| SMR | P55010 | |
| BioGrid | 108298 | |
| IntAct | P55010 | |
| MINT | MINT-5004352 | |
| STRING | 9606.ENSP00000216554 | |
| PhosphoSite | P55010 | |
| DMDM | 27735202 | |
| MaxQB | P55010 | |
| PaxDb | P55010 | |
| PeptideAtlas | P55010 | |
| PRIDE | P55010 | |
| DNASU | 1983 | |
| Ensembl | ENST00000216554 ENST00000392715 ENST00000558506 | |
| GeneID | 1983 | |
| KEGG | hsa:1983 | |
| UCSC | uc001ymq.4 | |
| CTD | 1983 | |
| GeneCards | GC14P103800 | |
| HGNC | HGNC:3299 | |
| HPA | CAB004226 HPA000867 | |
| MIM | 601710 | |
| neXtProt | NX_P55010 | |
| PharmGKB | PA27725 | |
| eggNOG | COG1601 | |
| GeneTree | ENSGT00390000016478 | |
| HOGENOM | HOG000214327 | |
| HOVERGEN | HBG006132 | |
| InParanoid | P55010 | |
| KO | K03262 | |
| OMA | MHQAQLL | |
| OrthoDB | EOG7FV3QF | |
| PhylomeDB | P55010 | |
| TreeFam | TF101533 | |
| Reactome | REACT_2085 REACT_931 | |
| ChiTaRS | EIF5 | |
| EvolutionaryTrace | P55010 | |
| GeneWiki | EIF5 | |
| GenomeRNAi | 1983 | |
| NextBio | 8031 | |
| PRO | PR:P55010 | |
| Proteomes | UP000005640 | |
| Bgee | P55010 | |
| CleanEx | HS_EIF5 | |
| ExpressionAtlas | P55010 | |
| Genevestigator | P55010 | |
| GO | GO:0005737 GO:0005829 GO:0005886 GO:0005525 GO:0003924 GO:0044822 GO:0008135 GO:0003743 GO:0044267 GO:0010467 GO:0006184 GO:0006446 GO:0006412 GO:0006413 | |
| Gene3D | 1.25.40.180 3.30.30.50 | |
| InterPro | IPR016024 IPR016021 IPR002735 IPR016189 IPR016190 IPR003307 | |
| Pfam | PF01873 PF02020 | |
| SMART | SM00653 SM00515 | |
| SUPFAM | SSF100966 SSF48371 SSF75689 | |
| PROSITE | PS51363 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006446 |
regulation of translational initiation |
ECO:0000314 |
P |
Fig 2-C,D Show that that over expression of EIF5 protein leads to increased expression of firefly luciferase constructs downstream of a poor-context AUG start codons and other non-AUG start codons. |
complete | |||||
|
enables |
GO:0045296 |
cadherin binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
NOT|part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006446 |
regulation of translational initiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006413 |
translational initiation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090630 |
activation of GTPase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07205 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0071074 |
eukaryotic initiation factor eIF2 binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07205 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07205 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001731 |
formation of translation preinitiation complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07205 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006413 |
translational initiation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008135 |
translation factor activity, RNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006446 |
regulation of translational initiation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003924 |
GTPase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-72697 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006412 |
translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006413 |
translational initiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Loughran, G et al. (2012) Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5. Nucleic Acids Res. 40 2898-906 PubMed GONUTS page
- ↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
- ↑ 3.0 3.1 Bohnsack, MT et al. (2002) Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. EMBO J. 21 6205-15 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Si, K et al. (1996) Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5). J. Biol. Chem. 271 16934-8 PubMed GONUTS page
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