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HUMAN:HS71A
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | HSPA1A (synonyms: HSPA1, HSX70) | |
Protein Name(s) | Heat shock 70 kDa protein 1A (ECO:0000312 with HGNC:HGNC:5232)
Heat shock 70 kDa protein 1 HSP70-1 (ECO:0000303 with PMID:14656967[1], ECO:0000303 with PMID:2538825[2]) HSP70.1 | |
External Links | ||
UniProt | P0DMV8 | |
EMBL | M11717 M59828 BA000025 AF134726 AK304652 DQ451402 AL671762 BC002453 M24743 X04676 X04677 | |
CCDS | CCDS34414.1 | |
PIR | A29160 A45871 I59139 I79540 | |
RefSeq | NP_005336.3 NP_005337.2 | |
UniGene | Hs.274402 Hs.702139 Hs.719966 Hs.743411 | |
PDB | 1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 4IO8 4J8F 4PO2 4WV5 4WV7 | |
PDBsum | 1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 4IO8 4J8F 4PO2 4WV5 4WV7 | |
ProteinModelPortal | P0DMV8 | |
SMR | P0DMV8 | |
IntAct | P0DMV8 | |
MINT | MINT-96699 | |
BindingDB | P0DMV8 | |
ChEMBL | CHEMBL5460 | |
SwissPalm | P0DMV8 | |
DMDM | 147744565 | |
REPRODUCTION-2DPAGE | IPI00304925 | |
DNASU | 3303 | |
Ensembl | ENST00000375651 ENST00000400040 ENST00000430065 ENST00000433487 ENST00000441618 | |
GeneID | 3303 3304 | |
KEGG | hsa:3303 hsa:3304 | |
CTD | 3303 3304 | |
H-InvDB | HIX0058169 HIX0058187 HIX0166160 | |
HGNC | HGNC:5232 | |
HPA | CAB008640 CAB017451 CAB032815 HPA052504 | |
MIM | 140550 603012 | |
neXtProt | NX_P0DMV8 | |
HOGENOM | HOG000228135 | |
HOVERGEN | HBG051845 | |
KO | K03283 | |
OrthoDB | EOG7PCJGF | |
TreeFam | TF105042 | |
Reactome | R-HSA-168330 R-HSA-3371453 R-HSA-3371568 R-HSA-3371571 R-HSA-450408 | |
ChiTaRS | HSPA1A HSPA1B | |
GeneWiki | HSPA1A | |
NextBio | 13103 | |
PRO | PR:P0DMV8 | |
Proteomes | UP000005640 | |
CleanEx | HS_HSPA1A | |
ExpressionAtlas | P0DMV8 | |
GO | GO:0072562 GO:0005814 GO:0005737 GO:0005829 GO:0005925 GO:0016234 GO:0005739 GO:0005654 GO:0048471 GO:0005524 GO:0016887 GO:0042623 GO:0055131 GO:0019899 GO:0001664 GO:0031072 GO:0042826 GO:0044183 GO:0005102 GO:0031625 GO:0051082 GO:0001618 GO:0046034 GO:0070370 GO:0034605 GO:0034599 GO:0010467 GO:0060548 GO:1902236 GO:2001240 GO:0090084 GO:1901029 GO:0031397 GO:1902380 GO:0010628 GO:0032757 GO:1904722 GO:0051092 GO:0070434 GO:1903265 GO:0042026 GO:0050821 GO:1900034 GO:0043488 GO:0031396 | |
Gene3D | 1.20.1270.10 2.60.34.10 | |
InterPro | IPR018181 IPR029048 IPR029047 IPR013126 | |
Pfam | PF00012 | |
PRINTS | PR00301 | |
SUPFAM | SSF100920 SSF100934 | |
PROSITE | PS00297 PS00329 PS01036 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0007041 |
lysosomal transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034620 |
cellular response to unfolded protein |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051131 |
chaperone-mediated protein complex assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0097718 |
disordered domain specific binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0045296 |
cadherin binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031249 |
denatured protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050821 |
protein stabilization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031396 |
regulation of protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
enables |
GO:0042826 |
histone deacetylase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042026 |
protein refolding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090063 |
positive regulation of microtubule nucleation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1901673 |
regulation of mitotic spindle assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016234 |
inclusion body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0044183 |
protein folding chaperone |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016887 |
ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001240 |
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090084 |
negative regulation of inclusion body assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046034 |
ATP metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042026 |
protein refolding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q12809) |
Seeded From UniProt |
complete | ||
enables |
GO:0055131 |
C3HC4-type RING finger domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
occurs_in:(CL:0011108) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0070434 |
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0050821 |
protein stabilization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q9HC29) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903265 |
positive regulation of tumor necrosis factor-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0033120 |
positive regulation of RNA splicing |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P17861) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902380 |
positive regulation of endoribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:O75460) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1901029 |
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1902236 |
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0001664 |
G protein-coupled receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(UniProtKB:O15354) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0031982 |
vesicle |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0002202) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902236 |
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051082 |
unfolded protein binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
has_input:(UniProtKB:O15354) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031397 |
negative regulation of protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:O15354) |
Seeded From UniProt |
complete | ||
colocalizes_with |
GO:0000151 |
ubiquitin ligase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0000955) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005925 |
focal adhesion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090084 |
negative regulation of inclusion body assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0072562 |
blood microparticle |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070370 |
cellular heat acclimation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000639) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060548 |
negative regulation of cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
happens_during:(GO:0034605) |
Seeded From UniProt |
complete | ||
enables |
GO:0051082 |
unfolded protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042623 |
ATPase activity, coupled |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042026 |
protein refolding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_input:(UniProtKB:P04637) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034605 |
cellular response to heat |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
NOT|involved_in |
GO:0010941 |
regulation of cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005814 |
centriole |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000540) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032757 |
positive regulation of interleukin-8 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
enables |
GO:0003714 |
transcription corepressor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097201 |
negative regulation of transcription from RNA polymerase II promoter in response to stress |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0047485 |
protein N-terminus binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045648 |
positive regulation of erythrocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
part_of |
GO:1990904 |
ribonucleoprotein complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030308 |
negative regulation of cell growth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016607 |
nuclear speck |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000653) |
Seeded From UniProt |
complete | ||
part_of |
GO:0016235 |
aggresome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0008180 |
COP9 signalosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006986 |
response to unfolded protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006402 |
mRNA catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
exists_during:(GO:0030218) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:1901673 |
regulation of mitotic spindle assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000453125 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0051787 |
misfolded protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95835 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051085 |
chaperone cofactor-dependent protein refolding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10241 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0051082 |
unfolded protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10241 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0044183 |
protein folding chaperone |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10241 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042623 |
ATPase activity, coupled |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:105384 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042026 |
protein refolding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002321897 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034620 |
cellular response to unfolded protein |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10241 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034605 |
cellular response to heat |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
CGD:CAL0000184706 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000453103 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000453125 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000453103 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002321897 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0016887 |
ATPase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10241 |
F |
Seeded From UniProt |
complete | ||
colocalizes_with |
GO:0008180 |
COP9 signalosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000453103 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006986 |
response to unfolded protein |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002321897 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002321762 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10241 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000453103 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005524 |
ATP binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10241 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0001618 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050821 |
protein stabilization |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
has_input:(UniProtKB:P37840) |
Seeded From UniProt |
complete | ||
enables |
GO:0051082 |
unfolded protein binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:1904813 |
ficolin-1-rich granule lumen |
Reactome:R-HSA-6800434 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:1900034 |
regulation of cellular response to heat |
Reactome:R-HSA-3371571 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
involved_in |
GO:0043488 |
regulation of mRNA stability |
Reactome:R-HSA-450408 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042623 |
ATPase activity, coupled |
Reactome:R-HSA-3371422 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-5618110 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-5252041 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6800434 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0001618 |
virus receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Xie, T et al. (2003) Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. Genome Res. 13 2621-36 PubMed GONUTS page
- ↑ Sargent, CA et al. (1989) Human major histocompatibility complex contains genes for the major heat shock protein HSP70. Proc. Natl. Acad. Sci. U.S.A. 86 1968-72 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Gupta, S et al. (2010) HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction. PLoS Biol. 8 e1000410 PubMed GONUTS page
- ↑ Weaver, AJ et al. (2000) Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone. J. Biol. Chem. 275 23045-52 PubMed GONUTS page
- ↑ 5.0 5.1 Nakamura, T et al. (2002) HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors. Biochem. Biophys. Res. Commun. 290 858-64 PubMed GONUTS page
- ↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
- ↑ 7.0 7.1 Chakrabortee, S et al. (2012) Intrinsically disordered proteins as molecular shields. Mol Biosyst 8 210-9 PubMed GONUTS page
- ↑ Cloutier, P et al. (2013) A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. PLoS Genet. 9 e1003210 PubMed GONUTS page
- ↑ 9.0 9.1 Shang, Y et al. (2014) Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1. Biochem. Biophys. Res. Commun. 446 387-92 PubMed GONUTS page
- ↑ 10.0 10.1 Lee, H et al. (2006) Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation. Mol. Cell. Biol. 26 5259-69 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 11.6 Mohanan, V & Grimes, CL (2014) The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease. J. Biol. Chem. 289 18987-98 PubMed GONUTS page
- ↑ Seo, JH et al. (2016) ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation. Nat Commun 7 12882 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Fang, CT et al. (2016) HSP70 regulates the function of mitotic centrosomes. Cell. Mol. Life Sci. 73 3949-60 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 14.5 Kalia, SK et al. (2004) BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron 44 931-45 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 15.4 Jakobsson, ME et al. (2013) Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. J. Biol. Chem. 288 27752-63 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 Ribeil, JA et al. (2007) Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. Nature 445 102-5 PubMed GONUTS page
- ↑ 17.0 17.1 Roder, K et al. (2014) RING finger protein RNF207, a novel regulator of cardiac excitation. J. Biol. Chem. 289 33730-40 PubMed GONUTS page
- ↑ Han, C et al. (2007) HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain. Biochem. Biophys. Res. Commun. 353 280-5 PubMed GONUTS page
- ↑ 19.0 19.1 19.2 19.3 19.4 19.5 Imai, Y et al. (2002) CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol. Cell 10 55-67 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Kesimer, M et al. (2009) Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 23 1858-68 PubMed GONUTS page
- ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
- ↑ 23.00 23.01 23.02 23.03 23.04 23.05 23.06 23.07 23.08 23.09 23.10 23.11 23.12 23.13 23.14 23.15 23.16 23.17 Hageman, J et al. (2011) The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. Biochem. J. 435 127-42 PubMed GONUTS page
- ↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ 26.0 26.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
- ↑ 27.0 27.1 27.2 Khalouei, S et al. (2014) Stress-induced localization of HSPA6 (HSP70B') and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells. Cell Stress Chaperones 19 321-7 PubMed GONUTS page
- ↑ 28.0 28.1 Shi, Y et al. (1998) Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev. 12 654-66 PubMed GONUTS page
- ↑ 29.0 29.1 29.2 Laroia, G et al. (1999) Control of mRNA decay by heat shock-ubiquitin-proteasome pathway. Science 284 499-502 PubMed GONUTS page
- ↑ 30.0 30.1 30.2 30.3 30.4 Maheswaran, S et al. (1998) Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70. Genes Dev. 12 1108-20 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
- ↑ Jønson, L et al. (2007) Molecular composition of IMP1 ribonucleoprotein granules. Mol. Cell Proteomics 6 798-811 PubMed GONUTS page
- ↑ Kallijärvi, J et al. (2005) TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase. Exp. Cell Res. 308 146-55 PubMed GONUTS page
- ↑ Fang, L et al. (2008) Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. J. Proteome Res. 7 4914-25 PubMed GONUTS page
- ↑ 36.0 36.1 Cuesta, R et al. (2000) Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes. Genes Dev. 14 1460-70 PubMed GONUTS page
- ↑ 37.00 37.01 37.02 37.03 37.04 37.05 37.06 37.07 37.08 37.09 37.10 37.11 37.12 37.13 37.14 37.15 37.16 37.17 37.18 37.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 38.0 38.1 Dias, V et al. (2013) The role of oxidative stress in Parkinson's disease. J Parkinsons Dis 3 461-91 PubMed GONUTS page
- ↑ 39.0 39.1 39.2 39.3 39.4 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page
a
c
- GO:0055131 ! C3HC4-type RING finger domain binding
- GO:0045296 ! cadherin binding
- Catarrhini
- GO:0070370 ! cellular heat acclimation
- GO:0034599 ! cellular response to oxidative stress
- GO:0034605 ! cellular response to heat
- GO:0034620 ! cellular response to unfolded protein
- GO:0071356 ! cellular response to tumor necrosis factor
- GO:0005814 ! centriole
- GO:0005813 ! centrosome
- GO:0051131 ! chaperone-mediated protein complex assembly
- GO:0051085 ! chaperone cofactor-dependent protein refolding
- Chordata
- GO:0008180 ! COP9 signalosome
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
e
h
m
n
- GO:2001240 ! negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- GO:0008285 ! negative regulation of cell population proliferation
- GO:0030308 ! negative regulation of cell growth
- GO:0043066 ! negative regulation of apoptotic process
- GO:0090084 ! negative regulation of inclusion body assembly
- GO:1902236 ! negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
- GO:1901029 ! negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
- GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway
- GO:0031397 ! negative regulation of protein ubiquitination
- GO:0043312 ! neutrophil degranulation
- GO:0016607 ! nuclear speck
- GO:0005654 ! nucleoplasm
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
o
p
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0090063 ! positive regulation of microtubule nucleation
- GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- GO:0010628 ! positive regulation of gene expression
- GO:1902380 ! positive regulation of endoribonuclease activity
- GO:0033120 ! positive regulation of RNA splicing
- GO:0051092 ! positive regulation of NF-kappaB transcription factor activity
- GO:1903265 ! positive regulation of tumor necrosis factor-mediated signaling pathway
- GO:0032757 ! positive regulation of interleukin-8 production
- GO:0070434 ! positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- GO:0045648 ! positive regulation of erythrocyte differentiation
- Primates
- GO:0032991 ! protein-containing complex
- GO:0044183 ! protein folding chaperone
- GO:0042026 ! protein refolding
- GO:0050821 ! protein stabilization
r
- GO:1901673 ! regulation of mitotic spindle assembly
- GO:0031647 ! regulation of protein stability
- GO:0031396 ! regulation of protein ubiquitination
- GO:0043488 ! regulation of mRNA stability
- GO:1900034 ! regulation of cellular response to heat
- GO:0032495 ! response to muramyl dipeptide
- GO:0006986 ! response to unfolded protein
- GO:1990904 ! ribonucleoprotein complex
- GO:0003723 ! RNA binding
u