HUMAN:HMDH

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HMGCR
Protein Name(s)	3-hydroxy-3-methylglutaryl-coenzyme A reductase HMG-CoA reductase
External Links
UniProt	P04035
EMBL	M11058 AF273765 AF273754 AF273755 AF273756 AF273757 AF273758 AF273759 AF273760 AF273761 AF273762 AF273763 AF273764 AY321356 AK296499 AC008897 BC033692
CCDS	CCDS4027.1 CCDS47234.1
PIR	A00356
RefSeq	NP_000850.1 NP_001124468.1
UniGene	Hs.628096 Hs.643495
PDB	1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB
PDBsum	1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB
ProteinModelPortal	P04035
SMR	P04035
BioGrid	109399
IntAct	P04035
STRING	9606.ENSP00000287936
BindingDB	P04035
ChEMBL	CHEMBL402
DrugBank	DB01076 DB01095 DB00227 DB08860 DB00175 DB01098 DB00641
GuidetoPHARMACOLOGY	639
TCDB	2.A.6.6.5
PhosphoSite	P04035
DMDM	123343
MaxQB	P04035
PaxDb	P04035
PRIDE	P04035
DNASU	3156
Ensembl	ENST00000287936 ENST00000343975 ENST00000511206
GeneID	3156
KEGG	hsa:3156
UCSC	uc003kdp.3 uc003kdq.3
CTD	3156
GeneCards	GC05P074635
HGNC	HGNC:5006
HPA	CAB016797 HPA008338
MIM	142910
neXtProt	NX_P04035
PharmGKB	PA189
eggNOG	COG1257
GeneTree	ENSGT00760000119321
HOGENOM	HOG000183489
HOVERGEN	HBG000453
InParanoid	P04035
KO	K00021
OMA	VIKEAFD
OrthoDB	EOG7GXP9T
PhylomeDB	P04035
TreeFam	TF105362
BioCyc	MetaCyc:HS03652-MONOMER
Reactome	REACT_116145 REACT_147904 REACT_9405
SABIO-RK	P04035
UniPathway	UPA00058
ChiTaRS	HMGCR
EvolutionaryTrace	P04035
GeneWiki	HMG-CoA_reductase
GenomeRNAi	3156
NextBio	12500
PRO	PR:P04035
Proteomes	UP000005640
Bgee	P04035
CleanEx	HS_HMGCR
ExpressionAtlas	P04035
Genevestigator	P04035
GO	GO:0005783 GO:0005789 GO:0016021 GO:0005778 GO:0050662 GO:0004420 GO:0042282 GO:0070402 GO:0007568 GO:0044255 GO:0006695 GO:0015936 GO:0008299 GO:0045445 GO:0061179 GO:0043407 GO:0010664 GO:0045908 GO:0061045 GO:0010666 GO:0070374 GO:0048643 GO:0048661 GO:0032874 GO:0051262 GO:0045471 GO:0007584 GO:0044281 GO:0006743 GO:0008542
Gene3D	1.10.3270.10 3.30.70.420 3.90.770.10
InterPro	IPR002202 IPR023074 IPR023076 IPR004554 IPR004816 IPR023282 IPR009023 IPR009029 IPR000731
PANTHER	PTHR10572
Pfam	PF00368
PRINTS	PR00071
SUPFAM	SSF55035 SSF56542
TIGRFAMs	TIGR00920 TIGR00533
PROSITE	PS00066 PS00318 PS01192 PS50065 PS50156

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045541	negative regulation of cholesterol biosynthetic process	PMID:23063590^[1]	ECO:0000314			P		Figure 3: Artemisinic acid inhibits cholesterol synthesis by downregulating the hydroxymethylglutaryl CoA (HMG CoA) reductase gene.	complete CACAO 5357
	GO:0006695	cholesterol biosynthetic process	PMID:23063590^[1]	ECO:0000314			P		Figure 3 shows artemisinic acid treatment reduces HMG-CoA reductase amounts at the RNA and protein levels, and it causes a reduction in cholesterol synthesis; this suggests that HMG-CoA reductase plays a part in the cholesterol biosynthetic process	complete CACAO 5575
involved_in	GO:1900222	negative regulation of amyloid-beta clearance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01237	P	occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0050709	negative regulation of protein secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01237	P	has_agent:(CL:0000129) occurs_in:(GO:0005615) part_of:(GO:1900222) has_regulation_target:(UniProtKB:P14735) part_of:(GO:0042177)	Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01237	P	has_agent:(CL:0000129) occurs_in:(GO:0005615) part_of:(GO:1900222) has_regulation_target:(UniProtKB:P14735)	Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	PMID:23063590^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070402	NADPH binding	PMID:10698924^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	PMID:10698924^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050662	coenzyme binding	PMID:10698924^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:15467)	Seeded From UniProt	complete
enables	GO:0042282	hydroxymethylglutaryl-CoA reductase activity	PMID:2991281^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:17180682^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005778	peroxisomal membrane	PMID:17180682^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042282	hydroxymethylglutaryl-CoA reductase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000060346 RGD:2803 TAIR:locus:2011656 UniProtKB:P04035	F		Seeded From UniProt	complete
involved_in	GO:0016126	sterol biosynthetic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000060346 TAIR:locus:2011656 TAIR:locus:2827622	P		Seeded From UniProt	complete
involved_in	GO:0008299	isoprenoid biosynthetic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000060346 RGD:2803	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000060347 SGD:S000004442 SGD:S000004540 TAIR:locus:2011656	C		Seeded From UniProt	complete
part_of	GO:0005778	peroxisomal membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000060347 UniProtKB:P04035	C		Seeded From UniProt	complete
enables	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96159 PANTHER:PTN000060346 PomBase:SPCC162.09c SGD:S000004442 SGD:S000004540	F		Seeded From UniProt	complete
involved_in	GO:0097756	negative regulation of blood vessel diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0061045	negative regulation of wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
enables	GO:0051721	protein phosphatase 2A binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	F		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0048643	positive regulation of skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0045445	myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	F		Seeded From UniProt	complete
enables	GO:0042282	hydroxymethylglutaryl-CoA reductase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	F		Seeded From UniProt	complete
involved_in	GO:0032874	positive regulation of stress-activated MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0010664	negative regulation of striated muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0008299	isoprenoid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0006743	ubiquinone metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51639 ensembl:ENSRNOP00000022055	P		Seeded From UniProt	complete
involved_in	GO:1900222	negative regulation of amyloid-beta clearance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01237 ensembl:ENSMUSP00000022176	P		Seeded From UniProt	complete
involved_in	GO:0050709	negative regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01237 ensembl:ENSMUSP00000022176	P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01237 ensembl:ENSMUSP00000022176	P		Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01237 ensembl:ENSMUSP00000022176	P		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01237 ensembl:ENSMUSP00000022176	P		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01237 ensembl:ENSMUSP00000022176	P		Seeded From UniProt	complete
enables	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q01237 ensembl:ENSMUSP00000022176	F		Seeded From UniProt	complete
enables	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002202 InterPro:IPR004554 InterPro:IPR004816 InterPro:IPR023074 InterPro:IPR023076 InterPro:IPR023282	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004816	C		Seeded From UniProt	complete
involved_in	GO:0008299	isoprenoid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004554 InterPro:IPR004816	P		Seeded From UniProt	complete
involved_in	GO:0015936	coenzyme A metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002202 InterPro:IPR009029	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004554	C		Seeded From UniProt	complete
enables	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009029	F		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004554 InterPro:IPR004816	F		Seeded From UniProt	complete
enables	GO:0050662	coenzyme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002202 InterPro:IPR009023 InterPro:IPR009029	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002202 InterPro:IPR004554 InterPro:IPR004816 InterPro:IPR009029 InterPro:IPR023074 InterPro:IPR023076	P		Seeded From UniProt	complete
enables	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.34	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:2991281^[3] Reactome:R-HSA-191352 Reactome:R-HSA-1655826	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045540	regulation of cholesterol biosynthetic process	Reactome:R-HSA-1655829	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	Reactome:R-HSA-400206	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	Reactome:R-HSA-191273	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0006694	steroid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0752	P		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0152	P		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0016126	sterol biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0756	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Lee, J et al. (2013) Artemisinic acid inhibits melanogenesis through downregulation of C/EBP α-dependent expression of HMG-CoA reductase gene. Food Chem. Toxicol. 51 225-30 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Istvan, ES et al. (2000) Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. EMBO J. 19 819-30 PubMed GONUTS page
↑ ^3.0 ^3.1 Luskey, KL & Stevens, B (1985) Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation. J. Biol. Chem. 260 10271-7 PubMed GONUTS page
↑ ^4.0 ^4.1 Kovacs, WJ et al. (2007) Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes. Histochem. Cell Biol. 127 273-90 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23063590-1] 1.0 ^1.1 ^1.2 Lee, J et al. (2013) Artemisinic acid inhibits melanogenesis through downregulation of C/EBP α-dependent expression of HMG-CoA reductase gene. Food Chem. Toxicol. 51 225-30 PubMed GONUTS page

[PMID:10698924-2] 2.0 ^2.1 ^2.2 Istvan, ES et al. (2000) Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. EMBO J. 19 819-30 PubMed GONUTS page

[PMID:2991281-3] 3.0 ^3.1 Luskey, KL & Stevens, B (1985) Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation. J. Biol. Chem. 260 10271-7 PubMed GONUTS page

[PMID:17180682-4] 4.0 ^4.1 Kovacs, WJ et al. (2007) Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes. Histochem. Cell Biol. 127 273-90 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:HMDH

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Annotations

Notes

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