HUMAN:HGF

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HGF (synonyms: HPTA)
Protein Name(s)	Hepatocyte growth factor Hepatopoietin-A Scatter factor SF Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain
External Links
UniProt	P14210
EMBL	M29145 X16323 M60718 D90334 X57574 M55379 M73239 M73240 M77227 L02931 U46010 AY246560 AC004960 CH236949 BC022308 BC063485 BC105797 BC130284 BC130286 M75971 M75967 M75966 M75968 M75969 M75983 M75972 M75973 M75974 M75975 M75976 M75977 M75978 M75979 M75980 M75981 M75982
CCDS	CCDS47626.1 CCDS47627.1 CCDS47628.1 CCDS47629.1 CCDS5597.1
PIR	JH0579
RefSeq	NP_000592.3 NP_001010931.1 NP_001010932.1 NP_001010933.1 NP_001010934.1 XP_006716019.1
UniGene	Hs.396530
PDB	1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2HGF 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4K3J 4O3T 4O3U
PDBsum	1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2HGF 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4K3J 4O3T 4O3U
ProteinModelPortal	P14210
SMR	P14210
BioGrid	109330
DIP	DIP-37535N
IntAct	P14210
MINT	MINT-219560
BindingDB	P14210
ChEMBL	CHEMBL5479
MEROPS	S01.976
PhosphoSite	P14210
UniCarbKB	P14210
DMDM	123116
MaxQB	P14210
PaxDb	P14210
PRIDE	P14210
DNASU	3082
Ensembl	ENST00000222390 ENST00000423064 ENST00000444829 ENST00000453411 ENST00000457544
GeneID	3082
KEGG	hsa:3082
UCSC	uc003uhl.3 uc003uhm.3 uc003uhn.1 uc003uho.1 uc003uhp.3
CTD	3082
GeneCards	GC07M081328
GeneReviews	HGF
HGNC	HGNC:4893
HPA	CAB010333 HPA040360 HPA044088
MIM	142409 608265
neXtProt	NX_P14210
Orphanet	90636
PharmGKB	PA29269
eggNOG	COG5640
GeneTree	ENSGT00760000119133
HOVERGEN	HBG004381
InParanoid	P14210
KO	K05460
OMA	GSESPWC
OrthoDB	EOG75B84T
PhylomeDB	P14210
TreeFam	TF329901
Reactome	REACT_115529
SignaLink	P14210
ChiTaRS	HGF
EvolutionaryTrace	P14210
GeneWiki	Hepatocyte_growth_factor
GenomeRNAi	3082
NextBio	12211
PMAP-CutDB	P14210
PRO	PR:P14210
Proteomes	UP000005640
Bgee	P14210
ExpressionAtlas	P14210
Genevestigator	P14210
GO	GO:0005576 GO:0005615 GO:0016020 GO:0031093 GO:0003824 GO:0042056 GO:0008083 GO:0042802 GO:0000187 GO:0007596 GO:0060326 GO:0035729 GO:0001837 GO:0048012 GO:0030212 GO:0001889 GO:0007067 GO:0051450 GO:0043154 GO:1902042 GO:1901299 GO:0090201 GO:0031100 GO:0030168 GO:0002576 GO:0050918 GO:0045766 GO:0030335 GO:2000573 GO:0031643 GO:0070572 GO:0045669 GO:0050731 GO:0014068 GO:0045944 GO:0060665
Gene3D	2.40.20.10
InterPro	IPR027284 IPR024174 IPR000001 IPR013806 IPR018056 IPR003014 IPR003609 IPR001254 IPR001314 IPR009003
Pfam	PF00051 PF00024 PF00089
PIRSF	PIRSF500183 PIRSF001152
PRINTS	PR00722
SMART	SM00130 SM00473 SM00020
SUPFAM	SSF50494 SSF57440
PROSITE	PS00021 PS50070 PS50948 PS50240

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010507	negative regulation of autophagy	PMID:24743740^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P	occurs_in:(CL:0010021)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death	PMID:20655899^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090201	negative regulation of release of cytochrome c from mitochondria	PMID:20655899^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:21245381^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:21245381^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048012	hepatocyte growth factor receptor signaling pathway	PMID:21245381^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22521434^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:22521434^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:20655899^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P42574)	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:21245381^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035729	cellular response to hepatocyte growth factor stimulus	PMID:21245381^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:21245381^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:20655899^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates:(GO:0010421)	Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	PMID:2531289^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:2531289^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:2531289^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0006508	proteolysis	PMID:2531289^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
NOT\|enables	GO:0004252	serine-type endopeptidase activity	PMID:2531289^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048012	hepatocyte growth factor receptor signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96079 PANTHER:PTN000668443 UniProtKB:P14210	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000668443 RGD:2794	P		Seeded From UniProt	complete
involved_in	GO:0035729	cellular response to hepatocyte growth factor stimulus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000668443 UniProtKB:P14210	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000668443 UniProtKB:P14210	P		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001207579 UniProtKB:P00747 UniProtKB:P08519	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000668443 UniProtKB:A0A1D5PAR6	P		Seeded From UniProt	complete
involved_in	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	PMID:14517989^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20624990^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14210	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17804794^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14210	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004252	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004252	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042056	P		Seeded From UniProt	complete
involved_in	GO:0070572	positive regulation of neuron projection regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17945 ensembl:ENSRNOP00000009764	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17945 ensembl:ENSRNOP00000009764	F		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17945 ensembl:ENSRNOP00000009764	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17945 ensembl:ENSRNOP00000009764	P		Seeded From UniProt	complete
involved_in	GO:0031643	positive regulation of myelination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17945 ensembl:ENSRNOP00000009764	P		Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17945 ensembl:ENSRNOP00000009764	P		Seeded From UniProt	complete
involved_in	GO:0030212	hyaluronan metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17945 ensembl:ENSRNOP00000009764	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17945 ensembl:ENSRNOP00000009764	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17945 ensembl:ENSRNOP00000009764	C		Seeded From UniProt	complete
involved_in	GO:1902947	regulation of tau-protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
involved_in	GO:1900744	regulation of p38MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
involved_in	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
involved_in	GO:0051450	myoblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
involved_in	GO:0050673	epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
involved_in	GO:0048012	hepatocyte growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
involved_in	GO:0033137	negative regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q08048 ensembl:ENSMUSP00000143424	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22897854^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14210-6	F		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:14679171^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031093	platelet alpha granule lumen	Reactome:R-HSA-481007	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-8875817 Reactome:R-HSA-8875816 Reactome:R-HSA-8875661 Reactome:R-HSA-8875659 Reactome:R-HSA-8875591 Reactome:R-HSA-8875576 Reactome:R-HSA-8875568 Reactome:R-HSA-8875558 Reactome:R-HSA-8875540 Reactome:R-HSA-8875531 Reactome:R-HSA-8875523 Reactome:R-HSA-8875490 Reactome:R-HSA-8875482 Reactome:R-HSA-8875451 Reactome:R-HSA-8875183 Reactome:R-HSA-8874685 Reactome:R-HSA-8874083 Reactome:R-HSA-8874082 Reactome:R-HSA-8874080 Reactome:R-HSA-8874079 Reactome:R-HSA-8874078 Reactome:R-HSA-8865994 Reactome:R-HSA-8852019 Reactome:R-HSA-8851954 Reactome:R-HSA-8851933 Reactome:R-HSA-8851919 Reactome:R-HSA-8851908 Reactome:R-HSA-8851900 Reactome:R-HSA-8851899 Reactome:R-HSA-8851890 Reactome:R-HSA-8851888 Reactome:R-HSA-8851877 Reactome:R-HSA-8851866 Reactome:R-HSA-8851859 Reactome:R-HSA-8851842 Reactome:R-HSA-8851827 Reactome:R-HSA-8851804 Reactome:R-HSA-6807027 Reactome:R-HSA-6807008 Reactome:R-HSA-6806974 Reactome:R-HSA-6806957 Reactome:R-HSA-6800299 Reactome:R-HSA-6800298 Reactome:R-HSA-6800200 Reactome:R-HSA-6789615 Reactome:R-HSA-5672965 Reactome:R-HSA-481007 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gallo, S et al. (2014) Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy. Cell Death Dis 5 e1185 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Hu, ZX et al. (2010) Hepatocyte growth factor protects human embryonic stem cell derived-neural progenitors from hydrogen peroxide-induced apoptosis. Eur. J. Pharmacol. 645 23-31 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Evans, IM et al. (2011) Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol. Cell. Biol. 31 1174-85 PubMed GONUTS page
↑ ^5.0 ^5.1 Chen, K et al. (2012) Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. Bone 51 69-77 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Nakamura, T et al. (1989) Molecular cloning and expression of human hepatocyte growth factor. Nature 342 440-3 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ikari, T et al. (2003) Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland. Dev. Dyn. 228 173-84 PubMed GONUTS page
↑ Tolbert, WD et al. (2010) Structural basis for agonism and antagonism of hepatocyte growth factor. Proc. Natl. Acad. Sci. U.S.A. 107 13264-9 PubMed GONUTS page
↑ Tolbert, WD et al. (2007) A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist. Proc. Natl. Acad. Sci. U.S.A. 104 14592-7 PubMed GONUTS page
↑ Cecchi, F et al. (2012) Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling. Cancer Cell 22 250-62 PubMed GONUTS page
↑ Kalluri, R & Neilson, EG (2003) Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112 1776-84 PubMed GONUTS page

[PMID:24743740-1] Gallo, S et al. (2014) Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy. Cell Death Dis 5 e1185 PubMed GONUTS page

[PMID:19946888-2] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:20655899-3] 3.0 ^3.1 ^3.2 ^3.3 Hu, ZX et al. (2010) Hepatocyte growth factor protects human embryonic stem cell derived-neural progenitors from hydrogen peroxide-induced apoptosis. Eur. J. Pharmacol. 645 23-31 PubMed GONUTS page

[PMID:21245381-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Evans, IM et al. (2011) Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol. Cell. Biol. 31 1174-85 PubMed GONUTS page

[PMID:22521434-5] 5.0 ^5.1 Chen, K et al. (2012) Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. Bone 51 69-77 PubMed GONUTS page

[PMID:2531289-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Nakamura, T et al. (1989) Molecular cloning and expression of human hepatocyte growth factor. Nature 342 440-3 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14517989-8] Ikari, T et al. (2003) Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland. Dev. Dyn. 228 173-84 PubMed GONUTS page

[PMID:20624990-9] Tolbert, WD et al. (2010) Structural basis for agonism and antagonism of hepatocyte growth factor. Proc. Natl. Acad. Sci. U.S.A. 107 13264-9 PubMed GONUTS page

[PMID:17804794-10] Tolbert, WD et al. (2007) A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist. Proc. Natl. Acad. Sci. U.S.A. 104 14592-7 PubMed GONUTS page

[PMID:22897854-11] Cecchi, F et al. (2012) Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling. Cancer Cell 22 250-62 PubMed GONUTS page

[PMID:14679171-12] Kalluri, R & Neilson, EG (2003) Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112 1776-84 PubMed GONUTS page

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HUMAN:HGF

Contents

Annotations

Notes

References

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