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HUMAN:HGF

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) HGF (synonyms: HPTA)
Protein Name(s) Hepatocyte growth factor

Hepatopoietin-A Scatter factor SF Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain

External Links
UniProt P14210
EMBL M29145
X16323
M60718
D90334
X57574
M55379
M73239
M73240
M77227
L02931
U46010
AY246560
AC004960
CH236949
BC022308
BC063485
BC105797
BC130284
BC130286
M75971
M75967
M75966
M75968
M75969
M75983
M75972
M75973
M75974
M75975
M75976
M75977
M75978
M75979
M75980
M75981
M75982
CCDS CCDS47626.1
CCDS47627.1
CCDS47628.1
CCDS47629.1
CCDS5597.1
PIR JH0579
RefSeq NP_000592.3
NP_001010931.1
NP_001010932.1
NP_001010933.1
NP_001010934.1
XP_006716019.1
UniGene Hs.396530
PDB 1BHT
1GMN
1GMO
1GP9
1NK1
1SHY
1SI5
2HGF
2QJ2
3HMS
3HMT
3HN4
3MKP
3SP8
4K3J
4O3T
4O3U
PDBsum 1BHT
1GMN
1GMO
1GP9
1NK1
1SHY
1SI5
2HGF
2QJ2
3HMS
3HMT
3HN4
3MKP
3SP8
4K3J
4O3T
4O3U
ProteinModelPortal P14210
SMR P14210
BioGrid 109330
DIP DIP-37535N
IntAct P14210
MINT MINT-219560
BindingDB P14210
ChEMBL CHEMBL5479
MEROPS S01.976
PhosphoSite P14210
UniCarbKB P14210
DMDM 123116
MaxQB P14210
PaxDb P14210
PRIDE P14210
DNASU 3082
Ensembl ENST00000222390
ENST00000423064
ENST00000444829
ENST00000453411
ENST00000457544
GeneID 3082
KEGG hsa:3082
UCSC uc003uhl.3
uc003uhm.3
uc003uhn.1
uc003uho.1
uc003uhp.3
CTD 3082
GeneCards GC07M081328
GeneReviews HGF
HGNC HGNC:4893
HPA CAB010333
HPA040360
HPA044088
MIM 142409
608265
neXtProt NX_P14210
Orphanet 90636
PharmGKB PA29269
eggNOG COG5640
GeneTree ENSGT00760000119133
HOVERGEN HBG004381
InParanoid P14210
KO K05460
OMA GSESPWC
OrthoDB EOG75B84T
PhylomeDB P14210
TreeFam TF329901
Reactome REACT_115529
SignaLink P14210
ChiTaRS HGF
EvolutionaryTrace P14210
GeneWiki Hepatocyte_growth_factor
GenomeRNAi 3082
NextBio 12211
PMAP-CutDB P14210
PRO PR:P14210
Proteomes UP000005640
Bgee P14210
ExpressionAtlas P14210
Genevestigator P14210
GO GO:0005576
GO:0005615
GO:0016020
GO:0031093
GO:0003824
GO:0042056
GO:0008083
GO:0042802
GO:0000187
GO:0007596
GO:0060326
GO:0035729
GO:0001837
GO:0048012
GO:0030212
GO:0001889
GO:0007067
GO:0051450
GO:0043154
GO:1902042
GO:1901299
GO:0090201
GO:0031100
GO:0030168
GO:0002576
GO:0050918
GO:0045766
GO:0030335
GO:2000573
GO:0031643
GO:0070572
GO:0045669
GO:0050731
GO:0014068
GO:0045944
GO:0060665
Gene3D 2.40.20.10
InterPro IPR027284
IPR024174
IPR000001
IPR013806
IPR018056
IPR003014
IPR003609
IPR001254
IPR001314
IPR009003
Pfam PF00051
PF00024
PF00089
PIRSF PIRSF500183
PIRSF001152
PRINTS PR00722
SMART SM00130
SM00473
SM00020
SUPFAM SSF50494
SSF57440
PROSITE PS00021
PS50070
PS50948
PS50240

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0010507

negative regulation of autophagy

PMID:24743740[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

occurs_in:(CL:0010021)

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1901299

negative regulation of hydrogen peroxide-mediated programmed cell death

PMID:20655899[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090201

negative regulation of release of cytochrome c from mitochondria

PMID:20655899[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060326

cell chemotaxis

PMID:21245381[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

PMID:21245381[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048012

hepatocyte growth factor receptor signaling pathway

PMID:21245381[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:22521434[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045669

positive regulation of osteoblast differentiation

PMID:22521434[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:20655899[3]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P42574)

Seeded From UniProt

complete

enables

GO:0042056

chemoattractant activity

PMID:21245381[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035729

cellular response to hepatocyte growth factor stimulus

PMID:21245381[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:21245381[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

PMID:20655899[3]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates:(GO:0010421)

Seeded From UniProt

complete

involved_in

GO:2000573

positive regulation of DNA biosynthetic process

PMID:2531289[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

PMID:2531289[6]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:2531289[6]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:0006508

proteolysis

PMID:2531289[6]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

NOT|enables

GO:0004252

serine-type endopeptidase activity

PMID:2531289[6]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0048012

hepatocyte growth factor receptor signaling pathway

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96079
PANTHER:PTN000668443
UniProtKB:P14210

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000668443
RGD:2794

P

Seeded From UniProt

complete

involved_in

GO:0035729

cellular response to hepatocyte growth factor stimulus

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000668443
UniProtKB:P14210

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000668443
UniProtKB:P14210

P

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001207579
UniProtKB:P00747
UniProtKB:P08519

F

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000668443
UniProtKB:A0A1D5PAR6

P

Seeded From UniProt

complete

involved_in

GO:0060665

regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

PMID:14517989[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:20624990[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P14210

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:17804794[10]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P14210

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004252

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004252

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0050918

positive chemotaxis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0042056

P

Seeded From UniProt

complete

involved_in

GO:0070572

positive regulation of neuron projection regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17945
ensembl:ENSRNOP00000009764

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17945
ensembl:ENSRNOP00000009764

F

Seeded From UniProt

complete

involved_in

GO:0045766

positive regulation of angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17945
ensembl:ENSRNOP00000009764

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17945
ensembl:ENSRNOP00000009764

P

Seeded From UniProt

complete

involved_in

GO:0031643

positive regulation of myelination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17945
ensembl:ENSRNOP00000009764

P

Seeded From UniProt

complete

involved_in

GO:0031100

animal organ regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17945
ensembl:ENSRNOP00000009764

P

Seeded From UniProt

complete

involved_in

GO:0030212

hyaluronan metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17945
ensembl:ENSRNOP00000009764

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17945
ensembl:ENSRNOP00000009764

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17945
ensembl:ENSRNOP00000009764

C

Seeded From UniProt

complete

involved_in

GO:1902947

regulation of tau-protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

involved_in

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

involved_in

GO:1900744

regulation of p38MAPK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

involved_in

GO:0060665

regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

involved_in

GO:0051450

myoblast proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

involved_in

GO:0050728

negative regulation of inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

involved_in

GO:0050673

epithelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

involved_in

GO:0048012

hepatocyte growth factor receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

involved_in

GO:0033137

negative regulation of peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

involved_in

GO:0032733

positive regulation of interleukin-10 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

involved_in

GO:0032715

negative regulation of interleukin-6 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

involved_in

GO:0001889

liver development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

involved_in

GO:0000902

cell morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

involved_in

GO:0000187

activation of MAPK activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08048
ensembl:ENSMUSP00000143424

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22897854[11]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P14210-6

F

Seeded From UniProt

complete

involved_in

GO:0001837

epithelial to mesenchymal transition

PMID:14679171[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051897

positive regulation of protein kinase B signaling

Reactome:R-HSA-2316434

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031093

platelet alpha granule lumen

Reactome:R-HSA-481007

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

Reactome:R-HSA-6785807

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-8875817
Reactome:R-HSA-8875816
Reactome:R-HSA-8875661
Reactome:R-HSA-8875659
Reactome:R-HSA-8875591
Reactome:R-HSA-8875576
Reactome:R-HSA-8875568
Reactome:R-HSA-8875558
Reactome:R-HSA-8875540
Reactome:R-HSA-8875531
Reactome:R-HSA-8875523
Reactome:R-HSA-8875490
Reactome:R-HSA-8875482
Reactome:R-HSA-8875451
Reactome:R-HSA-8875183
Reactome:R-HSA-8874685
Reactome:R-HSA-8874083
Reactome:R-HSA-8874082
Reactome:R-HSA-8874080
Reactome:R-HSA-8874079
Reactome:R-HSA-8874078
Reactome:R-HSA-8865994
Reactome:R-HSA-8852019
Reactome:R-HSA-8851954
Reactome:R-HSA-8851933
Reactome:R-HSA-8851919
Reactome:R-HSA-8851908
Reactome:R-HSA-8851900
Reactome:R-HSA-8851899
Reactome:R-HSA-8851890
Reactome:R-HSA-8851888
Reactome:R-HSA-8851877
Reactome:R-HSA-8851866
Reactome:R-HSA-8851859
Reactome:R-HSA-8851842
Reactome:R-HSA-8851827
Reactome:R-HSA-8851804
Reactome:R-HSA-6807027
Reactome:R-HSA-6807008
Reactome:R-HSA-6806974
Reactome:R-HSA-6806957
Reactome:R-HSA-6800299
Reactome:R-HSA-6800298
Reactome:R-HSA-6800200
Reactome:R-HSA-6789615
Reactome:R-HSA-5672965
Reactome:R-HSA-481007
Reactome:R-HSA-2400009
Reactome:R-HSA-2316434

ECO:0000304

author statement supported by traceable reference used in manual assertion

















































C

Seeded From UniProt

complete

involved_in

GO:0002576

platelet degranulation

Reactome:R-HSA-114608

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000165

MAPK cascade

Reactome:R-HSA-5673001

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Gallo, S et al. (2014) Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy. Cell Death Dis 5 e1185 PubMed GONUTS page
  2. Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Hu, ZX et al. (2010) Hepatocyte growth factor protects human embryonic stem cell derived-neural progenitors from hydrogen peroxide-induced apoptosis. Eur. J. Pharmacol. 645 23-31 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Evans, IM et al. (2011) Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol. Cell. Biol. 31 1174-85 PubMed GONUTS page
  5. 5.0 5.1 Chen, K et al. (2012) Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. Bone 51 69-77 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Nakamura, T et al. (1989) Molecular cloning and expression of human hepatocyte growth factor. Nature 342 440-3 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. Ikari, T et al. (2003) Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland. Dev. Dyn. 228 173-84 PubMed GONUTS page
  9. Tolbert, WD et al. (2010) Structural basis for agonism and antagonism of hepatocyte growth factor. Proc. Natl. Acad. Sci. U.S.A. 107 13264-9 PubMed GONUTS page
  10. Tolbert, WD et al. (2007) A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist. Proc. Natl. Acad. Sci. U.S.A. 104 14592-7 PubMed GONUTS page
  11. Cecchi, F et al. (2012) Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling. Cancer Cell 22 250-62 PubMed GONUTS page
  12. Kalluri, R & Neilson, EG (2003) Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112 1776-84 PubMed GONUTS page