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HUMAN:HCK
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | HCK | |
| Protein Name(s) | Tyrosine-protein kinase HCK
Hematopoietic cell kinase Hemopoietic cell kinase p59-HCK/p60-HCK p59Hck p61Hck | |
| External Links | ||
| UniProt | P08631 | |
| EMBL | M16591 M16592 AK026432 AK289896 AK298726 AL353092 AL049539 AL353092 AL049539 AL049539 AL353092 AL049539 AL353092 CH471077 CH471077 BC014435 BC094847 BC108930 BC108931 BC113854 BC114463 X58741 X58742 X58743 | |
| CCDS | CCDS33460.1 CCDS54453.1 CCDS54455.1 CCDS54456.1 | |
| PIR | A27811 A41263 | |
| RefSeq | NP_001165600.1 NP_001165601.1 NP_001165602.1 NP_001165604.1 NP_002101.2 | |
| UniGene | Hs.655210 | |
| PDB | 1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 4LUD 4LUE 4ORZ 4U5W 5HCK | |
| PDBsum | 1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 4LUD 4LUE 4ORZ 4U5W 5HCK | |
| ProteinModelPortal | P08631 | |
| SMR | P08631 | |
| BioGrid | 109305 | |
| DIP | DIP-1051N | |
| IntAct | P08631 | |
| MINT | MINT-135300 | |
| BindingDB | P08631 | |
| ChEMBL | CHEMBL3234 | |
| DrugBank | DB06616 | |
| GuidetoPHARMACOLOGY | 2032 | |
| PhosphoSite | P08631 | |
| DMDM | 20141296 | |
| MaxQB | P08631 | |
| PaxDb | P08631 | |
| PRIDE | P08631 | |
| DNASU | 3055 | |
| Ensembl | ENST00000518730 ENST00000520553 ENST00000538448 | |
| GeneID | 3055 | |
| KEGG | hsa:3055 | |
| UCSC | uc002wxh.3 uc002wxi.3 | |
| CTD | 3055 | |
| GeneCards | GC20P030652 | |
| HGNC | HGNC:4840 | |
| HPA | CAB005195 | |
| MIM | 142370 | |
| neXtProt | NX_P08631 | |
| PharmGKB | PA29216 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00760000118938 | |
| HOGENOM | HOG000233858 | |
| HOVERGEN | HBG008761 | |
| InParanoid | P08631 | |
| KO | K08893 | |
| OrthoDB | EOG7GTT2V | |
| PhylomeDB | P08631 | |
| BRENDA | 2.7.10.2 | |
| Reactome | REACT_11068 REACT_160274 REACT_23787 | |
| SignaLink | P08631 | |
| ChiTaRS | HCK | |
| EvolutionaryTrace | P08631 | |
| GeneWiki | HCK | |
| GenomeRNAi | 3055 | |
| NextBio | 12093 | |
| PRO | PR:P08631 | |
| Proteomes | UP000005640 | |
| Bgee | P08631 | |
| ExpressionAtlas | P08631 | |
| Genevestigator | P08631 | |
| GO | GO:0005901 GO:0042995 GO:0005856 GO:0005829 GO:0031234 GO:0005925 GO:0005794 GO:0005764 GO:0005634 GO:0030133 GO:0005524 GO:0004715 GO:0004713 GO:0007155 GO:0019221 GO:0038096 GO:0006954 GO:0045087 GO:0002758 GO:0007229 GO:0060333 GO:0043299 GO:0002522 GO:0031663 GO:0007498 GO:0043066 GO:0018108 GO:2000251 GO:0030838 GO:0008284 GO:0046777 GO:0006468 GO:0008360 GO:0050690 GO:0050727 GO:0050764 GO:0071801 GO:0051090 GO:0045728 GO:0016032 | |
| Gene3D | 3.30.505.10 | |
| InterPro | IPR011009 IPR000719 IPR017441 IPR001245 IPR000980 IPR001452 IPR008266 IPR020635 | |
| Pfam | PF07714 PF00017 PF00018 | |
| PRINTS | PR00401 PR00452 PR00109 | |
| SMART | SM00252 SM00326 SM00219 | |
| SUPFAM | SSF50044 SSF55550 SSF56112 | |
| PROSITE | PS00107 PS50011 PS00109 PS50001 PS50002 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0001784 |
phosphotyrosine residue binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000251 |
positive regulation of actin cytoskeleton reorganization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000251 |
positive regulation of actin cytoskeleton reorganization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071801 |
regulation of podosome assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051090 |
regulation of DNA-binding transcription factor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050764 |
regulation of phagocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046777 |
protein autophosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031234 |
extrinsic component of cytoplasmic side of plasma membrane |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008360 |
regulation of cell shape |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008360 |
regulation of cell shape |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005901 |
caveola |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0005884 |
actin filament |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0038083 |
peptidyl-tyrosine autophosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002521528 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031234 |
extrinsic component of cytoplasmic side of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002521528 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002521528 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002521528 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0262733 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95527 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000719 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007498 |
mesoderm development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060333 |
interferon-gamma-mediated signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050727 |
regulation of inflammatory response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045728 |
respiratory burst after phagocytosis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043299 |
leukocyte degranulation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030838 |
positive regulation of actin filament polymerization |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007229 |
integrin-mediated signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002758 |
innate immune response-activating signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002522 |
leukocyte migration involved in immune response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050690 |
regulation of defense response to virus by virus |
Reactome:R-HSA-164944 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0038096 |
Fc-gamma receptor signaling pathway involved in phagocytosis |
Reactome:R-HSA-2029480 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-2029459 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006887 |
exocytosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006909 |
phagocytosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-1003 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005901 |
caveola |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030133 |
transport vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Mehlitz, A et al. (2010) Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. J. Cell Biol. 190 143-57 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Carréno, S et al. (2002) p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner. J. Biol. Chem. 277 21007-16 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Cougoule, C et al. (2005) Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomes. Traffic 6 682-94 PubMed GONUTS page
- ↑ 4.0 4.1 Paliwal, P et al. (2007) Regulation of p73 by Hck through kinase-dependent and independent mechanisms. BMC Mol. Biol. 8 45 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Howlett, CJ et al. (1999) The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase. Biochem. Biophys. Res. Commun. 257 129-38 PubMed GONUTS page
- ↑ Robbins, SM et al. (1995) Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae. Mol. Cell. Biol. 15 3507-15 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Ziegler, SF et al. (1987) Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. Mol. Cell. Biol. 7 2276-85 PubMed GONUTS page
- ↑ 9.0 9.1 Quintrell, N et al. (1987) Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells. Mol. Cell. Biol. 7 2267-75 PubMed GONUTS page
- ↑ 10.00 10.01 10.02 10.03 10.04 10.05 10.06 10.07 10.08 10.09 10.10 Guiet, R et al. (2008) Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis. Eur. J. Cell Biol. 87 527-42 PubMed GONUTS page
c
- Catarrhini
- GO:0005901 ! caveola
- GO:0007155 ! cell adhesion
- GO:0030154 ! cell differentiation
- GO:0030054 ! cell junction
- GO:0042995 ! cell projection
- GO:0007169 ! cell surface receptor protein tyrosine kinase signaling pathway
- Chordata
- Craniata
- GO:0019221 ! cytokine-mediated signaling pathway
- GO:0005737 ! cytoplasm
- GO:0031410 ! cytoplasmic vesicle
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
e
f
i
l
n
p
- GO:0018108 ! peptidyl-tyrosine phosphorylation
- GO:0038083 ! peptidyl-tyrosine autophosphorylation
- GO:0006909 ! phagocytosis
- GO:0016310 ! phosphorylation
- GO:0001784 ! phosphotyrosine residue binding
- GO:0005886 ! plasma membrane
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0030838 ! positive regulation of actin filament polymerization
- Primates
- GO:0046777 ! protein autophosphorylation
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004713 ! protein tyrosine kinase activity
r
- GO:0050690 ! regulation of defense response to virus by virus
- GO:0071801 ! regulation of podosome assembly
- GO:0051090 ! regulation of DNA-binding transcription factor activity
- GO:0050764 ! regulation of phagocytosis
- GO:0008360 ! regulation of cell shape
- GO:0050727 ! regulation of inflammatory response
- GO:0045728 ! respiratory burst after phagocytosis
t
