HUMAN:GATA5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GATA5
Protein Name(s)	Transcription factor GATA-5 GATA-binding factor 5
External Links
UniProt	Q9BWX5
EMBL	HM015595 AL499627 CH471077 CH471077 BC047790 BC117356 BC117358
CCDS	CCDS13499.1
RefSeq	NP_536721.1 XP_006723762.1
UniGene	Hs.352250
ProteinModelPortal	Q9BWX5
SMR	Q9BWX5
BioGrid	126640
STRING	9606.ENSP00000252997
PhosphoSite	Q9BWX5
DMDM	20138325
PaxDb	Q9BWX5
PRIDE	Q9BWX5
Ensembl	ENST00000252997
GeneID	140628
KEGG	hsa:140628
UCSC	uc002ycx.1
CTD	140628
GeneCards	GC20M061038
HGNC	HGNC:15802
MIM	611496
neXtProt	NX_Q9BWX5
Orphanet	334 99097 3303
PharmGKB	PA28588
eggNOG	COG5641
GeneTree	ENSGT00760000119221
HOVERGEN	HBG051703
InParanoid	Q9BWX5
KO	K17896
OMA	GHFESSV
OrthoDB	EOG7CCBRF
PhylomeDB	Q9BWX5
TreeFam	TF315391
Reactome	REACT_24970
GeneWiki	GATA5
GenomeRNAi	140628
NextBio	84201
PRO	PR:Q9BWX5
Proteomes	UP000005640
Bgee	Q9BWX5
CleanEx	HS_GATA5
Genevestigator	Q9BWX5
GO	GO:0005654 GO:0005634 GO:0001158 GO:0003705 GO:0003700 GO:0044212 GO:0008270 GO:0007596 GO:0071773 GO:0060575 GO:0045944
Gene3D	3.30.50.10
InterPro	IPR008013 IPR028372 IPR016375 IPR000679 IPR013088
PANTHER	PTHR10071:SF148
Pfam	PF00320 PF05349
PIRSF	PIRSF003028
PRINTS	PR00619
SMART	SM00401
PROSITE	PS00344 PS50114

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0003180	aortic valve morphogenesis	PMID:24638895^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	PMID:22641149^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000679 InterPro:IPR016375	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000120156) occurs_in:(UBERON:0000948) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000179776) occurs_in:(UBERON:0000948) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000157168) occurs_in:(UBERON:0000948) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000141736) occurs_in:(UBERON:0000948) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000125378) occurs_in:(UBERON:0000948) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000081189) occurs_in:(UBERON:0000948) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000101384) occurs_in:(UBERON:0000948) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000164683) occurs_in:(UBERON:0000948) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000196411) occurs_in:(UBERON:0000948) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000168214) occurs_in:(UBERON:0000948) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000175206) occurs_in:(UBERON:0002084) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000175206) occurs_in:(UBERON:0002094) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000120937) occurs_in:(UBERON:0002084) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000120937) occurs_in:(UBERON:0002094) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000148400) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000164532) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:1901228	positive regulation of transcription from RNA polymerase II promoter involved in heart development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	regulates_expression_of:(ENSEMBL:ENSG00000164867) occurs_in:(UBERON:0004145) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0003274	endocardial cushion fusion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	part_of:(GO:0003180)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P17679	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	C	coincident_with:(ENSEMBL:ENSG00000164867) coincident_with:(SO:0000170)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	F	has_direct_input:(ENSEMBL:ENSG00000164867) occurs_in:(UBERON:0000922) occurs_in:(UBERON:0004145) occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0062000	positive regulation of cardiac endothelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P	part_of:(GO:0003180) occurs_in:(UBERON:0000922) occurs_in:(UBERON:0004145)\|part_of(GO:0003180) occurs_in:(UBERON:0000922) occurs_in:(UBERON:0002087)	Seeded From UniProt	complete
involved_in	GO:0035481	positive regulation of Notch signaling pathway involved in heart induction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P		Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97489	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14986113^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14986113^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0072359	circulatory system development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109497 PANTHER:PTN002560179 UniProtKB:Q9BWX5 ZFIN:ZDB-GENE-980526-340	P		Seeded From UniProt	complete
involved_in	GO:0048738	cardiac muscle tissue development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002560179 ZFIN:ZDB-GENE-980526-340	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003117 FB:FBgn0032223 FB:FBgn0038391 MGI:MGI:107516 MGI:MGI:109497 MGI:MGI:95661 MGI:MGI:95662 MGI:MGI:95663 MGI:MGI:95664 PANTHER:PTN001600628 PomBase:SPAC23E2.01 PomBase:SPCC1902.01 RGD:2663 RGD:2664 RGD:2665 RGD:2666 RGD:621250 SGD:S000000842 SGD:S000001742 SGD:S000001873 SGD:S000003646 UniProtKB:E1C9C6 UniProtKB:I3LUZ9 UniProtKB:P15976 UniProtKB:P17429 UniProtKB:P23769 UniProtKB:P23771 UniProtKB:P43691 UniProtKB:P43692 UniProtKB:P43694 UniProtKB:Q92908 UniProtKB:Q9BWX5 WB:WBGene00001186 WB:WBGene00001249 WB:WBGene00001250 WB:WBGene00001251 WB:WBGene00001252 WB:WBGene00001253 WB:WBGene00001310 WB:WBGene00001311 WB:WBGene00015981 ZFIN:ZDB-GENE-980526-340	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003117 MGI:MGI:95661 MGI:MGI:95664 PANTHER:PTN001600628 RGD:2665 SGD:S000001742 SGD:S000003646 UniProtKB:P23769 UniProtKB:P43694 UniProtKB:Q92908 WB:WBGene00001249 WB:WBGene00001310	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107516 MGI:MGI:95661 MGI:MGI:95662 MGI:MGI:95663 MGI:MGI:95664 PANTHER:PTN001600628 PomBase:SPAC23E2.01 PomBase:SPCC1902.01 SGD:S000000842 UniProtKB:P15976 UniProtKB:P23771	F		Seeded From UniProt	complete
involved_in	GO:0060575	intestinal epithelial cell differentiation	PMID:9566909^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:9566909^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9566909^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901228	positive regulation of transcription from RNA polymerase II promoter involved in heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	P		Seeded From UniProt	complete
involved_in	GO:0062000	positive regulation of cardiac endothelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	F		Seeded From UniProt	complete
involved_in	GO:0035481	positive regulation of Notch signaling pathway involved in heart induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	P		Seeded From UniProt	complete
involved_in	GO:0010614	negative regulation of cardiac muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	F		Seeded From UniProt	complete
involved_in	GO:0003274	endocardial cushion fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	P		Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	P		Seeded From UniProt	complete
enables	GO:0001158	enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97489 ensembl:ENSMUSP00000015771	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008013	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039355	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008013	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679 InterPro:IPR013088 InterPro:IPR016375	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679 InterPro:IPR008013 InterPro:IPR013088 InterPro:IPR039355	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000679	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008013	P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	Reactome:R-HSA-109582	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-996755	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Shi, LM et al. (2014) GATA5 loss-of-function mutations associated with congenital bicuspid aortic valve. Int. J. Mol. Med. 33 1219-26 PubMed GONUTS page
↑ Padang, R et al. (2012) Rare non-synonymous variations in the transcriptional activation domains of GATA5 in bicuspid aortic valve disease. J. Mol. Cell. Cardiol. 53 277-81 PubMed GONUTS page
↑ ^3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^4.0 ^4.1 Ren, CY et al. (2004) Transcription factor GATA-5 selectively up-regulates mucin gene expression. J. Cancer Res. Clin. Oncol. 130 245-52 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Gao, X et al. (1998) Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol. Cell. Biol. 18 2901-11 PubMed GONUTS page

[PMID:24638895-1] Shi, LM et al. (2014) GATA5 loss-of-function mutations associated with congenital bicuspid aortic valve. Int. J. Mol. Med. 33 1219-26 PubMed GONUTS page

[PMID:22641149-2] Padang, R et al. (2012) Rare non-synonymous variations in the transcriptional activation domains of GATA5 in bicuspid aortic valve disease. J. Mol. Cell. Cardiol. 53 277-81 PubMed GONUTS page

[PMID:19274049-3] 3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:14986113-4] 4.0 ^4.1 Ren, CY et al. (2004) Transcription factor GATA-5 selectively up-regulates mucin gene expression. J. Cancer Res. Clin. Oncol. 130 245-52 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9566909-6] 6.0 ^6.1 ^6.2 Gao, X et al. (1998) Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol. Cell. Biol. 18 2901-11 PubMed GONUTS page

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HUMAN:GATA5

Contents

Annotations

Notes

References

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